LOCUS       NM_001399760            4174 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus transmembrane protein 30A (Tmem30a), transcript
            variant 1, mRNA.
ACCESSION   NM_001399760 XM_006243435
VERSION     NM_001399760.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4174)
  AUTHORS   Kato,U., Inadome,H., Yamamoto,M., Emoto,K., Kobayashi,T. and
            Umeda,M.
  TITLE     Role for phospholipid flippase complex of ATP8A1 and CDC50A
            proteins in cell migration
  JOURNAL   J Biol Chem 288 (7), 4922-4934 (2013)
   PUBMED   23269685
REFERENCE   2  (bases 1 to 4174)
  AUTHORS   Xu,Q., Yang,G.Y., Liu,N., Xu,P., Chen,Y.L., Zhou,Z., Luo,Z.G. and
            Ding,X.
  TITLE     P4-ATPase ATP8A2 acts in synergy with CDC50A to enhance neurite
            outgrowth
  JOURNAL   FEBS Lett 586 (13), 1803-1812 (2012)
   PUBMED   22641037
REFERENCE   3  (bases 1 to 4174)
  AUTHORS   Takatsu,H., Baba,K., Shima,T., Umino,H., Kato,U., Umeda,M.,
            Nakayama,K. and Shin,H.W.
  TITLE     ATP9B, a P4-ATPase (a putative aminophospholipid translocase),
            localizes to the trans-Golgi network in a CDC50 protein-independent
            manner
  JOURNAL   J Biol Chem 286 (44), 38159-38167 (2011)
   PUBMED   21914794
  REMARK    Erratum:[J Biol Chem. 2015 Jan 9;290(2):886]
REFERENCE   4  (bases 1 to 4174)
  AUTHORS   Munoz-Martinez,F., Torres,C., Castanys,S. and Gamarro,F.
  TITLE     CDC50A plays a key role in the uptake of the anticancer drug
            perifosine in human carcinoma cells
  JOURNAL   Biochem Pharmacol 80 (6), 793-800 (2010)
   PUBMED   20510206
REFERENCE   5  (bases 1 to 4174)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jan 14, 2022 this sequence version replaced XM_006243435.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.74512.1,
                                           SRR26360186.2746676.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676786, SAMN16676807
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               JAXUCZ010000008.1  89632944-89633291   c
            349-456             JAXUCZ010000008.1  89620441-89620548   c
            457-564             JAXUCZ010000008.1  89617468-89617575   c
            565-652             JAXUCZ010000008.1  89616695-89616782   c
            653-802             JAXUCZ010000008.1  89615667-89615816   c
            803-1012            JAXUCZ010000008.1  89614690-89614899   c
            1013-4174           JAXUCZ010000008.1  89608975-89612136   c
FEATURES             Location/Qualifiers
     source          1..4174
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..4174
                     /gene="Tmem30a"
                     /note="transmembrane protein 30A"
                     /db_xref="GeneID:300857"
                     /db_xref="RGD:1303315"
     exon            1..348
                     /gene="Tmem30a"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1206
                     /gene="Tmem30a"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     cycle control protein 50A; P4-ATPase flippase complex beta
                     subunit TMEM30A"
                     /codon_start=1
                     /product="cell cycle control protein 50A isoform 1"
                     /protein_id="NP_001386689.1"
                     /db_xref="GeneID:300857"
                     /db_xref="RGD:1303315"
                     /translation="MAMNYSAKDEVDGGPTGPPGGAAKTRRPDNTAFKQQRLPAWQPI
                     LTAGTVLPTFFIIGLIFIPIGIGIFVTSNNIREIEIDYTGTEPSSPCNKCLSPNVTSC
                     VCIINFTLEQSFEGNVFMYYGLSNFYQNHRRYVKSRDDSQLNGDPSALLNPSKECEPY
                     RRNEDKPIAPCGAIANSMFNDTLELFLVANESDPKPVPILLKKKGIAWWTDKNVKFRN
                     PPGKDSLQEKFKDTTKPVNWHKPVYELDPDDESNNGFINEDFIVWMRTAALPTFRKLY
                     RLIERTDDLHPTLPAGQYYLNITYNYPVHFFDGRKRMILSTISWMGGKNPFLGIAYIT
                     IGSISFLLGVVLLVINHKYRNSSNTADITI"
     exon            349..456
                     /gene="Tmem30a"
                     /inference="alignment:Splign:2.1.0"
     exon            457..564
                     /gene="Tmem30a"
                     /inference="alignment:Splign:2.1.0"
     exon            565..652
                     /gene="Tmem30a"
                     /inference="alignment:Splign:2.1.0"
     exon            653..802
                     /gene="Tmem30a"
                     /inference="alignment:Splign:2.1.0"
     exon            803..1012
                     /gene="Tmem30a"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..4174
                     /gene="Tmem30a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtggcgga ggtagtagcg gcagcggcga ctgcgtgtct cctgtcagga tcggcaggca
       61 ggtcctctgg gcggcccagc tggacggggc cgagccgaag cccgggggcc aatggcgatg
      121 aactatagcg cgaaggatga ggtggacggc gggcccacgg gtcctccggg gggcgccgcc
      181 aagacccgga ggccggataa cacggccttc aaacagcaac ggttgcctgc ctggcagccc
      241 atcctcaccg ccggcacggt gctgcccacc ttcttcatca tcggcctcat cttcattccc
      301 atcggcatcg gcatcttcgt cacctccaac aacatccgtg agatcgagat tgattacact
      361 ggaacagaac cttccagccc ctgcaataaa tgtttgtctc cgaatgtgac atcttgtgtt
      421 tgtatcatta acttcacact ggaacagtcg tttgagggca atgtgtttat gtattatgga
      481 ctgtctaatt tctatcaaaa ccatcgtcgt tatgtgaaat cccgagatga tagccagtta
      541 aacggagacc ctagtgcttt gcttaatcca agtaaggaat gtgaacccta tcgaagaaat
      601 gaagacaaac cgattgctcc atgtggggcc attgccaaca gcatgtttaa cgatacgtta
      661 gagttgtttc tggttgccaa tgaatctgat cccaagcctg tgccaattct tttgaagaaa
      721 aaaggtattg cttggtggac agataaaaat gtgaaattca gaaatccacc tggaaaagac
      781 agccttcaag aaaagtttaa agatacaaca aagccagtaa actggcataa accagtatat
      841 gagctagacc ctgatgatga aagtaataat ggattcataa atgaagactt tattgtttgg
      901 atgcgtactg cagctttacc tacttttcgt aagttatatc gtcttataga gcggacagat
      961 gatttacacc caacactacc agctggacag tactatttga acatcacata caattaccct
     1021 gtacattttt ttgatggacg aaaacggatg atcttgagca ctatttcatg gatgggagga
     1081 aagaatccat ttttgggaat tgcttacatc actattggat ccatctcctt ccttctggga
     1141 gttgtactgc tagtaattaa tcataaatat agaaacagta gtaatactgc tgacatcacc
     1201 atttaatttt ctattctgaa accaaatcta ctgcatgtgc atcaaggcca gtcctgttca
     1261 acctagcttt tgaatgccga tgtctggtta gtatgtcatt ttgaagttgg cacataacaa
     1321 aaaacagcct ttgttctttg cttcttacat atggatgact tatgaaaata tatgatgggt
     1381 ataaaaatta gccatattga ttatatcaat attataactg ctaaaatgac attctaatgt
     1441 ctgctcttta ttgggacagg ccatgtgatg catagagcct ctttcatgtg aaatgcgtct
     1501 actgcttaaa ctgtttatgc tgtgtggata acattatatt gacatgatgc tgtatatgtg
     1561 tgcctactgt gtgatgaaag ggattatgag atgtatgagt gtaatgactt gctaaccttt
     1621 gaaaatttgg ttacagttca gattgaagaa agactaaata taaataaaac acttcatcat
     1681 tttcatgtgt cgtgtgtaaa aggcttaaag tctccccgtg ttgaggtggt tcatatgttc
     1741 agtttctctg ttataatcct ctgataatga ctttcagact ttaggttgtc cagcatagaa
     1801 attaatatct aaagaggtca ggtgggtctt ggatagaatt ttaaattcct tctcatttgg
     1861 ctaaaatatt gcattctgga gtcctgagct actagaaatg tttatatgtg atccaattcc
     1921 ctggaagctt ccacttcata agggaagaag ggacatagat gagatgggac agctgcttgg
     1981 caaatccttt cctatgcctc aactgtaaac cagacataaa tgttcaaagg agactgtttt
     2041 cattattgtg gtttgtagtg ttaagatgat tgcttctgcc ttggaaatac ctcaagctgt
     2101 tcttacttag caggtaagtg atttgactta gtattaatat tatattccag aaaattttga
     2161 aatcctaatt tcttccatat ttcattaaat ttttgcatac aggtcaaaca aatgtggata
     2221 tgtatacaca ttctctttaa tgaaggtaat attttggtta attatcctaa gatatacctt
     2281 aaaagatgtt ctatacattt cctacttaaa ttcttgggga tttggagtat gtacatgata
     2341 gaaaaagatt ataatatatt gattgaagtt actttatttt ctaactagaa ttattttaat
     2401 agtcctttat tgaataagtg ctgtaatttg tttgctatga gacttattcc tgaagtggat
     2461 gtaaattatt tttccacatg catgaaaatg tattaatcag agttgtctcc attgcattga
     2521 aattacttgt ttttgaacta aagtaactca tatttatgta gtagaatgct tgtgttttca
     2581 gactttgtaa tgatttcctt tggttgtatt ttaaatcaaa cagtctgggt aaatatatca
     2641 gttttgatta atatgtgctt aaaagaagaa aaaaattcaa tggttcatgg tagaaatgtg
     2701 ccacacttaa ataagctttg tatgacatga aattctgtta aaagcttgta attcatggtg
     2761 acttttaact tataaaaata ctacttgcac gggttacttg atttatggat atataaaacc
     2821 tcaggacaaa agttctttct ctaaaactat tcttttgtca atcattcaga atgctgttat
     2881 tctgaaaagt gcccctgttg catatgatag tttacttggg ggattcttta taaggcatgg
     2941 gatgctgttg ccagtctttc ctgagtaagt gctggtgaaa gaggactact aacttgcctg
     3001 catctgtctc taactgggga ccaaggggtc tgctgaagga aactgaagag ctctaacatt
     3061 tccacagctt ggagaagata gaatctttaa aagtacagtt gaagcttgat cagttttcta
     3121 agtgcactga tggttcctgt cttccatggt tcctgtcatt tgaaaccaac tcctgttgtg
     3181 tatatgaaga atctgggact ttcatatttt aaaaaaagtt gatgtcatta agggactaag
     3241 tagaaggctt agaaaaatgc attaatttgc aagtattttg gcacaggaaa ctttccaact
     3301 gaaaaaatta tttagtaagc aaaagctgat gtttctttga aatcataagg cagtttaaaa
     3361 taaactgaag aaaataactg tgttctaata gagaataatc caattaagag tcaagtgaat
     3421 gttatttatt cgatagtaac aaaatttatt tgtaaactta attatattaa aagttattct
     3481 gttaggatgt tttgtattaa taaacatgaa caaaattaat tgtgctgttt atgtgtctta
     3541 ctgaaataac aatgcccatc tttcctcgct aatgcttagt gttcattttt aacccagtct
     3601 tagtccacag tttaacttgt ccatggtaca tttgaaaaac atcattaatt gttaaaatta
     3661 ttgtacttat atttattagt cactgacaac ataatcatac gacttattaa tgttactgag
     3721 ggttcttacc aggaagtagt gagactgtta tgttctcggc ggactgactg aagttggggt
     3781 tctatccagg agagtggacc gtgagagcag tgaagcccag caggcagtaa atgaaaccct
     3841 tacctaagag aggggcaggt gagaggtgag gcttggaagg ctgctctgtg gctgcccctc
     3901 catctgtgtg taagcattgc ctgagggtca gtataggctc tttacgtagc aaagttttgt
     3961 tttttgtaaa catgaacatt ggagttttaa gtgtaaaggg ggtaaaagtg ctgtagtcac
     4021 aaagttttga tgtataaaag cctgttgtaa agtgaatgat ctagaaaagt attttaaagt
     4081 ccaattgagc ccatgcaccc atcagttagt aaatgtgaaa agcacatttt tcctgatgtc
     4141 attttatttt aaaataaaca ttgtctaaaa ccaa
//
