LOCUS       NM_001271039            1310 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus transmembrane protein 216 (Tmem216), mRNA.
ACCESSION   NM_001271039 XM_002725784 XM_002728865
VERSION     NM_001271039.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1310)
  AUTHORS   Lee,J.H., Silhavy,J.L., Lee,J.E., Al-Gazali,L., Thomas,S.,
            Davis,E.E., Bielas,S.L., Hill,K.J., Iannicelli,M., Brancati,F.,
            Gabriel,S.B., Russ,C., Logan,C.V., Sharif,S.M., Bennett,C.P.,
            Abe,M., Hildebrandt,F., Diplas,B.H., Attie-Bitach,T., Katsanis,N.,
            Rajab,A., Koul,R., Sztriha,L., Waters,E.R., Ferro-Novick,S.,
            Woods,C.G., Johnson,C.A., Valente,E.M., Zaki,M.S. and Gleeson,J.G.
  TITLE     Evolutionarily assembled cis-regulatory module at a human
            ciliopathy locus
  JOURNAL   Science 335 (6071), 966-969 (2012)
   PUBMED   22282472
REFERENCE   2  (bases 1 to 1310)
  AUTHORS   Garcia-Gonzalo,F.R., Corbit,K.C., Sirerol-Piquer,M.S.,
            Ramaswami,G., Otto,E.A., Noriega,T.R., Seol,A.D., Robinson,J.F.,
            Bennett,C.L., Josifova,D.J., Garcia-Verdugo,J.M., Katsanis,N.,
            Hildebrandt,F. and Reiter,J.F.
  TITLE     A transition zone complex regulates mammalian ciliogenesis and
            ciliary membrane composition
  JOURNAL   Nat Genet 43 (8), 776-784 (2011)
   PUBMED   21725307
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1310)
  AUTHORS   Valente,E.M., Logan,C.V., Mougou-Zerelli,S., Lee,J.H.,
            Silhavy,J.L., Brancati,F., Iannicelli,M., Travaglini,L., Romani,S.,
            Illi,B., Adams,M., Szymanska,K., Mazzotta,A., Lee,J.E.,
            Tolentino,J.C., Swistun,D., Salpietro,C.D., Fede,C., Gabriel,S.,
            Russ,C., Cibulskis,K., Sougnez,C., Hildebrandt,F., Otto,E.A.,
            Held,S., Diplas,B.H., Davis,E.E., Mikula,M., Strom,C.M.,
            Ben-Zeev,B., Lev,D., Sagie,T.L., Michelson,M., Yaron,Y., Krause,A.,
            Boltshauser,E., Elkhartoufi,N., Roume,J., Shalev,S., Munnich,A.,
            Saunier,S., Inglehearn,C., Saad,A., Alkindy,A., Thomas,S.,
            Vekemans,M., Dallapiccola,B., Katsanis,N., Johnson,C.A.,
            Attie-Bitach,T. and Gleeson,J.G.
  TITLE     Mutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel
            and related syndromes
  JOURNAL   Nat Genet 42 (7), 619-625 (2010)
   PUBMED   20512146
REFERENCE   4  (bases 1 to 1310)
  AUTHORS   Edvardson,S., Shaag,A., Zenvirt,S., Erlich,Y., Hannon,G.J.,
            Shanske,A.L., Gomori,J.M., Ekstein,J. and Elpeleg,O.
  TITLE     Joubert syndrome 2 (JBTS2) in Ashkenazi Jews is associated with a
            TMEM216 mutation
  JOURNAL   Am J Hum Genet 86 (1), 93-97 (2010)
   PUBMED   20036350
  REMARK    Erratum:[Am J Hum Genet. 2010 Feb;86(2):294. Shanske, Alan L
            [added]]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Aug 31, 2012 this sequence version replaced
            XM_002728865.2, XM_002725784.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB568391.1, SRR26360186.1412169.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                JAXUCZ010000001.1  216626491-216626519 c
            30-131              JAXUCZ010000001.1  216625834-216625935 c
            132-224             JAXUCZ010000001.1  216625341-216625433 c
            225-426             JAXUCZ010000001.1  216622953-216623154 c
            427-1310            JAXUCZ010000001.1  216621376-216622259 c
FEATURES             Location/Qualifiers
     source          1..1310
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1310
                     /gene="Tmem216"
                     /gene_synonym="RGD1304607"
                     /note="transmembrane protein 216"
                     /db_xref="GeneID:361727"
                     /db_xref="RGD:1304607"
     exon            1..29
                     /gene="Tmem216"
                     /gene_synonym="RGD1304607"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..442
                     /gene="Tmem216"
                     /gene_synonym="RGD1304607"
                     /codon_start=1
                     /product="transmembrane protein 216"
                     /protein_id="NP_001257968.1"
                     /db_xref="GeneID:361727"
                     /db_xref="RGD:1304607"
                     /translation="MAPRDKRLSSTPLEILFFLNGWYYATYFLLELLIFLYKGLLLPY
                     PTANLVLDVVMLLLYLGIEVIRLFFGTKGNLCQRKMPLGISVALTFPSAMMASYYLLL
                     QTYVLRLEAIMNSILLFFCGSELLLEMLTLATFSSMDRI"
     exon            30..131
                     /gene="Tmem216"
                     /gene_synonym="RGD1304607"
                     /inference="alignment:Splign:2.1.0"
     exon            132..224
                     /gene="Tmem216"
                     /gene_synonym="RGD1304607"
                     /inference="alignment:Splign:2.1.0"
     exon            225..426
                     /gene="Tmem216"
                     /gene_synonym="RGD1304607"
                     /inference="alignment:Splign:2.1.0"
     exon            427..1310
                     /gene="Tmem216"
                     /gene_synonym="RGD1304607"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccatgggga ctgaacatgg cgccgcgaga taaaagattg tcctcaaccc ctctggaaat
       61 cctgttcttt ctgaatgggt ggtactatgc tacctatttc ctgctggagc tccttatttt
      121 cctgtacaaa ggtctcctgc tgccataccc aacagccaac ctagtcctag atgtggtgat
      181 gctgctcctt tatcttggca ttgaagtaat acgattgttt tttggtacaa agggaaacct
      241 ctgccagcga aagatgcccc ttggcatcag tgtggccctg accttccctt ctgccatgat
      301 ggcttcctat tacctgctgc tgcagaccta cgtgctccgc ctagaagcta ttatgaacag
      361 tatcttgctc ttcttttgtg gctcagagct gctgcttgag atgctcacgc tggccacttt
      421 ctccagtatg gacaggatct gaagtacaag aattccagtt ggtagcccat caggtcacaa
      481 cccatatccg tctggtactt cagccacact tgtgaaaagt ggtaggtcga gctgacctgg
      541 gaaaggtttg tgtggttttt cctcagcaca gacatttggg cattgagcac ctacctgagg
      601 ccagtggcac catctttaaa ccgggatgga tcatcagcag gagactcttt ccttttgttg
      661 aaggggcaag gctgtcccca tcttggtgtt tctaacagct tcctaatgac ttcaagttct
      721 cttttgtggt cattatggcc agagagagct ccttgtgtgg cccatctagt tttgtctggc
      781 ttccagcaga acctgagcca cagtaccctg tacgtaacac atctgcccta catgaccatg
      841 caaagaaagc ctcataatgg tgggctctta agcggattcc aatgtgtgtt ccccgtaccc
      901 tcctcctcat cctgctcaag gagatggtga tctagaaccc atttagtagt tcacagtagt
      961 atttttctaa ttctgatcat gaagcaaaca caaatttttt aaataaaaag tattttctgg
     1021 tatggggctg gttgtctttt ccctaagatg cctctttttt ttttttttct gacttaaaag
     1081 tgttattcat attatgtttt attaggttaa ggttttgtct acagagctgt ttgtggccat
     1141 gggaccgagg agggccttac agcctctgga ttattagtta caggtggtta aaaactctcc
     1201 tgtgtgctgg gaatgtaacc agagttctct gagaacagta attgcttttg cagctgagtt
     1261 cccacaaact gaatctttac aaataaagtc ttcattttct tttccttctc
//
