LOCUS       NP_001257968             141 aa            linear   ROD 27-MAR-2024
DEFINITION  transmembrane protein 216 [Rattus norvegicus].
ACCESSION   NP_001257968 XP_002725830 XP_002728911
VERSION     NP_001257968.1
DBSOURCE    REFSEQ: accession NM_001271039.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 141)
  AUTHORS   Lee,J.H., Silhavy,J.L., Lee,J.E., Al-Gazali,L., Thomas,S.,
            Davis,E.E., Bielas,S.L., Hill,K.J., Iannicelli,M., Brancati,F.,
            Gabriel,S.B., Russ,C., Logan,C.V., Sharif,S.M., Bennett,C.P.,
            Abe,M., Hildebrandt,F., Diplas,B.H., Attie-Bitach,T., Katsanis,N.,
            Rajab,A., Koul,R., Sztriha,L., Waters,E.R., Ferro-Novick,S.,
            Woods,C.G., Johnson,C.A., Valente,E.M., Zaki,M.S. and Gleeson,J.G.
  TITLE     Evolutionarily assembled cis-regulatory module at a human
            ciliopathy locus
  JOURNAL   Science 335 (6071), 966-969 (2012)
   PUBMED   22282472
REFERENCE   2  (residues 1 to 141)
  AUTHORS   Garcia-Gonzalo,F.R., Corbit,K.C., Sirerol-Piquer,M.S.,
            Ramaswami,G., Otto,E.A., Noriega,T.R., Seol,A.D., Robinson,J.F.,
            Bennett,C.L., Josifova,D.J., Garcia-Verdugo,J.M., Katsanis,N.,
            Hildebrandt,F. and Reiter,J.F.
  TITLE     A transition zone complex regulates mammalian ciliogenesis and
            ciliary membrane composition
  JOURNAL   Nat Genet 43 (8), 776-784 (2011)
   PUBMED   21725307
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 141)
  AUTHORS   Valente,E.M., Logan,C.V., Mougou-Zerelli,S., Lee,J.H.,
            Silhavy,J.L., Brancati,F., Iannicelli,M., Travaglini,L., Romani,S.,
            Illi,B., Adams,M., Szymanska,K., Mazzotta,A., Lee,J.E.,
            Tolentino,J.C., Swistun,D., Salpietro,C.D., Fede,C., Gabriel,S.,
            Russ,C., Cibulskis,K., Sougnez,C., Hildebrandt,F., Otto,E.A.,
            Held,S., Diplas,B.H., Davis,E.E., Mikula,M., Strom,C.M.,
            Ben-Zeev,B., Lev,D., Sagie,T.L., Michelson,M., Yaron,Y., Krause,A.,
            Boltshauser,E., Elkhartoufi,N., Roume,J., Shalev,S., Munnich,A.,
            Saunier,S., Inglehearn,C., Saad,A., Alkindy,A., Thomas,S.,
            Vekemans,M., Dallapiccola,B., Katsanis,N., Johnson,C.A.,
            Attie-Bitach,T. and Gleeson,J.G.
  TITLE     Mutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel
            and related syndromes
  JOURNAL   Nat Genet 42 (7), 619-625 (2010)
   PUBMED   20512146
REFERENCE   4  (residues 1 to 141)
  AUTHORS   Edvardson,S., Shaag,A., Zenvirt,S., Erlich,Y., Hannon,G.J.,
            Shanske,A.L., Gomori,J.M., Ekstein,J. and Elpeleg,O.
  TITLE     Joubert syndrome 2 (JBTS2) in Ashkenazi Jews is associated with a
            TMEM216 mutation
  JOURNAL   Am J Hum Genet 86 (1), 93-97 (2010)
   PUBMED   20036350
  REMARK    Erratum:[Am J Hum Genet. 2010 Feb;86(2):294. Shanske, Alan L
            [added]]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Aug 31, 2012 this sequence version replaced
            XP_002728911.2, XP_002725830.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB568391.1, SRR26360186.1412169.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..141
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     Protein         1..141
                     /product="transmembrane protein 216"
                     /calculated_mol_wt=16042
     Region          15..121
                     /region_name="Transmemb_17"
                     /note="Predicted membrane protein; pfam09799"
                     /db_xref="CDD:462907"
     Site            15..35
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (B6ID01.2)"
     Site            49..69
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (B6ID01.2)"
     Site            82..102
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (B6ID01.2)"
     Site            115..135
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (B6ID01.2)"
     CDS             1..141
                     /gene="Tmem216"
                     /gene_synonym="RGD1304607"
                     /coded_by="NM_001271039.1:17..442"
                     /db_xref="GeneID:361727"
                     /db_xref="RGD:1304607"
ORIGIN      
        1 maprdkrlss tpleilffln gwyyatyfll elliflykgl llpyptanlv ldvvmlllyl
       61 gievirlffg tkgnlcqrkm plgisvaltf psammasyyl llqtyvlrle aimnsillff
      121 cgsellleml tlatfssmdr i
//
