LOCUS       NM_001024992            1311 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus transmembrane protein 199 (Tmem199), mRNA.
ACCESSION   NM_001024992 XM_220724
VERSION     NM_001024992.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1311)
  AUTHORS   Miles,A.L., Burr,S.P., Grice,G.L. and Nathan,J.A.
  TITLE     The vacuolar-ATPase complex and assembly factors, TMEM199 and
            CCDC115, control HIF1alpha prolyl hydroxylation by regulating
            cellular iron levels
  JOURNAL   Elife 6, e22693 (2017)
   PUBMED   28296633
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1311)
  AUTHORS   Jansen,J.C., Timal,S., van Scherpenzeel,M., Michelakakis,H.,
            Vicogne,D., Ashikov,A., Moraitou,M., Hoischen,A., Huijben,K.,
            Steenbergen,G., van den Boogert,M.A., Porta,F., Calvo,P.L.,
            Mavrikou,M., Cenacchi,G., van den Bogaart,G., Salomon,J.,
            Holleboom,A.G., Rodenburg,R.J., Drenth,J.P., Huynen,M.A.,
            Wevers,R.A., Morava,E., Foulquier,F., Veltman,J.A. and Lefeber,D.J.
  TITLE     TMEM199 Deficiency Is a Disorder of Golgi Homeostasis Characterized
            by Elevated Aminotransferases, Alkaline Phosphatase, and
            Cholesterol and Abnormal Glycosylation
  JOURNAL   Am J Hum Genet 98 (2), 322-330 (2016)
   PUBMED   26833330
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091246.1.
            
            On Jun 25, 2005 this sequence version replaced XM_220724.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091246.1, FQ216010.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676807 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1311
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q25"
     gene            1..1311
                     /gene="Tmem199"
                     /note="transmembrane protein 199"
                     /db_xref="GeneID:303332"
                     /db_xref="RGD:1566425"
     CDS             1..627
                     /gene="Tmem199"
                     /codon_start=1
                     /product="transmembrane protein 199"
                     /protein_id="NP_001020163.1"
                     /db_xref="GeneID:303332"
                     /db_xref="RGD:1566425"
                     /translation="MASSLLAGERLVRALDPGGELEREQLPRKLRAQLEAALGKKHAG
                     SDNATGPRRLVSFRLIRDLHQHLRERNSMLYLHELLEGSEIYFPEIVKPPRNPELVAR
                     LEKIKIQLANEEYKRITRNVTCQDAQCGGTLSDLGKQVRSVKALVITIFNFIVTVAAA
                     FVCTYLGSQYIFTEMASRVLAALIVASVVGLAELYVMVRAMEGELGEL"
     exon            1..211
                     /gene="Tmem199"
                     /inference="alignment:Splign:2.1.0"
     exon            212..285
                     /gene="Tmem199"
                     /inference="alignment:Splign:2.1.0"
     exon            286..375
                     /gene="Tmem199"
                     /inference="alignment:Splign:2.1.0"
     exon            376..418
                     /gene="Tmem199"
                     /inference="alignment:Splign:2.1.0"
     exon            419..531
                     /gene="Tmem199"
                     /inference="alignment:Splign:2.1.0"
     exon            532..1282
                     /gene="Tmem199"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcgtcct ccttgcttgc tggcgaacga ctcgttcgcg ctttggatcc tggcggagaa
       61 ctggaacggg agcagctgcc ccgaaagctg cgtgcccagc tcgaggctgc tctggggaag
      121 aaacacgcgg gcagtgataa cgccacgggc ccccggcgcc tggtttcctt ccgtctgatc
      181 cgagatctgc atcagcacct gagagaaaga aattccatgc tataccttca tgaactccta
      241 gaaggcagtg aaatctactt tccagagatt gtgaagcctc cccggaatcc agagctagtt
      301 gcccggctag agaagattaa gatacagcta gccaatgagg agtataagcg gatcactcga
      361 aacgtcactt gtcaggatgc acagtgtggg gggactctca gtgacctagg aaagcaagtg
      421 aggtcagtga aggctctggt catcaccatc ttcaacttca ttgtcacagt ggcagctgcc
      481 tttgtctgca cttacctagg aagccagtat atcttcacag aaatggcctc gagagtgctg
      541 gctgcattga tcgttgcctc ggtggtaggt ctggcagagc tgtacgtcat ggtaagggca
      601 atggaaggag aactgggcga gctgtgacgt gcttcaccat cagtgtctgg aaggagtttg
      661 gggagcccca ggctctcctt tgcccatcac tgactctcag tcatcccacc gtgctctctg
      721 tattcatctc caattagtca gaggaccagg tcaggttctt tggggagccc tgtctgctgt
      781 gaatttcctt ggggagggat agaggagatt caaacagtgt ttctttaaaa gaactgatct
      841 cagtaacttt tgaatccagt gcccatctgc ctttgctggt ccattctggg gtctactgag
      901 tctggctttt ctcattagaa gtaagtagaa tccaggcctt tcccccagat ggactatact
      961 gccttgaact ggcccaataa tcagaagaca ggcatcaatc agtagaagaa aaaccagttg
     1021 atacaggatg atggaactag aagcgaggca gctaactctt tatagaaaag gaaatggtgt
     1081 cagaccattt tccagaagtc aaacagcctg agagaaatca gatgatgagc tatggccctc
     1141 ctccaaatgg agccaaagat gtctaccttg tcccgttgtc ttcattttgt tatacttttc
     1201 agaacttagg taagttagag aatctgttta aggcacttga aagatgttat ttattcaata
     1261 aatatttatt gtgttcagtg taaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
