LOCUS       NM_001399754            3640 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus transmembrane protein 196 (Tmem196), transcript
            variant 1, mRNA.
ACCESSION   NM_001399754 XM_006240701
VERSION     NM_001399754.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3640)
  AUTHORS   Liu,W.B., Han,F., Jiang,X., Chen,H.Q., Zhao,H., Liu,Y., Li,Y.H.,
            Huang,C., Cao,J. and Liu,J.Y.
  TITLE     TMEM196 acts as a novel functional tumour suppressor inactivated by
            DNA methylation and is a potential prognostic biomarker in lung
            cancer
  JOURNAL   Oncotarget 6 (25), 21225-21239 (2015)
   PUBMED   26056045
  REMARK    GeneRIF: TMEM196 acts as a novel functional tumour suppressor
            inactivated by DNA methylation and is an independent prognostic
            factor of lung cancer
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Dec 16, 2022 this sequence version replaced NM_001399754.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211598.1, SRR26360176.2255915.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-511               JAXUCZ010000006.1  147039841-147040351
            512-568             JAXUCZ010000006.1  147092435-147092491
            569-823             JAXUCZ010000006.1  147095930-147096184
            824-897             JAXUCZ010000006.1  147097338-147097411
            898-3640            JAXUCZ010000006.1  147099722-147102464
FEATURES             Location/Qualifiers
     source          1..3640
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q33"
     gene            1..3640
                     /gene="Tmem196"
                     /gene_synonym="RGD1562527"
                     /note="transmembrane protein 196"
                     /db_xref="GeneID:500750"
                     /db_xref="RGD:1562527"
     exon            1..511
                     /gene="Tmem196"
                     /gene_synonym="RGD1562527"
                     /inference="alignment:Splign:2.1.0"
     CDS             347..904
                     /gene="Tmem196"
                     /gene_synonym="RGD1562527"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane protein 196 isoform 1"
                     /protein_id="NP_001386683.1"
                     /db_xref="GeneID:500750"
                     /db_xref="RGD:1562527"
                     /translation="MCTSGQIIGSLLVLSVLEIGLGVSSVAVGAVSFSLALREHTPQL
                     GDSSPVWSGVCFLLCGICGILCAKKKSGLVMILFSACCICGLIGGILNFQFLRAVTKK
                     TSSLYPLHLASMSLACIGIGGCTVSSWLTCRLASYEQRRMFSEREHSLHHSHEMAEKR
                     LRAIEITDLPSCPVVPPTPELPTRK"
     exon            512..568
                     /gene="Tmem196"
                     /gene_synonym="RGD1562527"
                     /inference="alignment:Splign:2.1.0"
     exon            569..823
                     /gene="Tmem196"
                     /gene_synonym="RGD1562527"
                     /inference="alignment:Splign:2.1.0"
     exon            824..897
                     /gene="Tmem196"
                     /gene_synonym="RGD1562527"
                     /inference="alignment:Splign:2.1.0"
     exon            898..3640
                     /gene="Tmem196"
                     /gene_synonym="RGD1562527"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaactctgg actgcgcctc cgacaccgac aaggctcaga tccagggttt gctctccaga
       61 gcctggctcc tccgtaaaag cttctggact cccacccatc gcccgcggtc cccgggtgaa
      121 cgcgccacgg gctggatcag ctctgtcctc tctggccccg ccacggaaat ggttctctgg
      181 ttctggaaat ccagaccctt tggataatgt tttgctggtg aagaaagaaa agtttgagga
      241 gctggactgt ggtagggggc ggaaagggct gaagaggact ttgaaagaaa gaaggtagat
      301 gatcagcttc catctctgag ctggaaggaa tgatgaccca aggagaatgt gcaccagcgg
      361 ccagatcatt gggagccttt tggtgctctc tgtgctggag atagggctgg gggtgtccag
      421 cgtggccgtg ggggcggtca gcttcagcct ggctctccga gagcacacgc cgcagctcgg
      481 agactcgtcc ccggtatgga gcggggtgtg ttttcttctt tgcggcatat gtggaatact
      541 gtgcgccaag aaaaagtcag gacttgtcat gatcctcttt tcagcctgct gcatctgtgg
      601 actcatcgga ggcatcctga attttcagtt tcttcgggca gtcacaaaaa agacctcatc
      661 cctgtaccca ctgcatctcg cctccatgtc tttggcatgt atcggcattg gcggctgcac
      721 tgtctcttct tggctcactt gtcgtctagc cagctatgag caaaggagga tgttctcaga
      781 aagggaacat tccctgcatc actctcatga aatggctgag aaaagattga gggctattga
      841 aataaccgac ttgcccagct gcccggtggt gcccccgaca ccagagttac ctacaaggaa
      901 gtgacagaca acatgagcaa tggagcacca caactgatat ttaatggaag agtacaatca
      961 atgttttaaa gaactgacca tttttcaggt tgaccgtgag gcaggagagg ctgaagacct
     1021 gggagcagca gttgaaatgg ttcctggatt tgctgttatt tctcctgggc gtccactcaa
     1081 tttggtctca ctcacccttt atccctttct agagggtata aactttccag aaatgtagct
     1141 tagtcatctc agcagaatga ccaattattc tgaagaagat tattccaaaa aaaagtggca
     1201 aagtgattaa tactgtacac aaacatcatt tgactagcat gagctttaga attgtaattg
     1261 catattttat gaataattca aaagtaaaca catcaagaac taacaataac ttattgatgt
     1321 ctttgttttg aaagacaaat gacttcaagt atgctaaaat caagacctca gcaatgcctt
     1381 gttgcaacaa cattgtaatt aatttcaatt tgtgaatgaa ctgtatttca taatttattt
     1441 gtaaattata aaaaaactaa agcttaaaag atgatttttt agtgagagaa agaatattaa
     1501 tctgtatgat atttttgcac ttttgaacaa gttaatatta tgtaagaaaa ataaatgttt
     1561 tcattatgct gtgcaaattg gtcttcatgt tcatgaataa ttctgagaat aaagcattgt
     1621 gtatacgtag gtgtatatat actgtaaata cagaaaatac atacagcata tatttatagc
     1681 tacatgaatg taactaggta atagggaaga aattgtggca gtatgagatt attccactgg
     1741 ctctgagaag gccagcactc aaagctctct aaacccgcaa ggtcacatat ttaattccta
     1801 ctctatctga ccattttcta ctttttctta aaccaattgt gtggtagata agcattgtag
     1861 ctgatacata tggagctgag tgacttgaat gttgaagcat gaatgtaaac tacttagttg
     1921 ttggtatttt gctgtgacta tgatgtttat gtaaaagtaa ttgttaaaat tgatttataa
     1981 gcataacttc aatcattttt ttctctaaga ttattcctaa tatgcttatt tcatagaact
     2041 ttcagccaaa ttaagctctg taattgagaa atggtaaccc aagggaagtt aacactccct
     2101 ttgttatact ttaggtgttt tatctccttt ggtgattaac atgaaggtca tgtattggaa
     2161 aatatatatt cgaaatgtct gaaggagttc tcagtataat aaatatgaaa gataaactga
     2221 cattcatgtg gctagagcca attcttctct tccacaatgg aatattaaaa taccaaccaa
     2281 caatatgtat aaaagatcaa acatcatgga ctctggagat atttatgaaa attaatctct
     2341 gacaacgtac aaattaatat tattttattt ttcattggat ttttttattt acatttcaaa
     2401 tgctattccc tttctcagtt ttccagacat aagcccccct cccatacacc tccccttctg
     2461 taagggtgtt cccctcccca atcaccccct actattttta aataagtaac attgcactgt
     2521 atatttttat taattcccaa atctaagcaa atttcagttc aattttctga gttactaatc
     2581 acagttaaat tgatacattt catgcttggt ttgagaacac cgtataatca caagcaaaac
     2641 atgagttttc attgtgctaa caaaacagca ataattgggt ctaaggttcc atgagccttt
     2701 gacaacgtca tcattaaacc ttgtgatgaa ctccttagaa aattctggct gaacagaaat
     2761 aaatggcctc tgcttcattt tggttatagt tttgaactct tcctcactcg tttggatcct
     2821 tcattgtctg gtatattaca aatcgtctcc atagatttga tctcaagtaa tgaatcatga
     2881 tcatcactac tcatttcctg ctacacgtaa gcatgatact tgcctctaaa tacgcaaact
     2941 gtaaactcgt agaaatctca cacatacatg gttatactaa atttacgctg ggggtggctt
     3001 aatctttaag gaagaaacca gtaactttaa ttttgttagc atttctctgt aggcatgtaa
     3061 aatacagagt acatcaacac atttaatgac ttttaaattt atttataaaa acacatatta
     3121 aaaatcaaag taggctatca tttctttgaa aacagttaaa agagattcaa tcactgcggt
     3181 tatctaaata gttcacagtg tgtgtgtgta atcaatttta gacacatctt taaatgtgat
     3241 tatttcaaac ttgtgctttc ttagctcaaa ttggagtgtt tacttagggt ataagggtat
     3301 tctgagataa gtggggggag ttagaagaca ttattcaagt aattaaaatt ttaattttga
     3361 caacaaactg acaaagaata aaaaaaaaca tgagtgcctc catcatagtt tctgtataca
     3421 tctaccattg aagaaatctg atctgatatt aaattaggaa aatatatgtg aagcttggtg
     3481 tggagtatgc tttaagtgca aaaaggaaaa gctgtcactt ctaggaaatt ttaaaatata
     3541 tttgtatgtg tatatatgtg ttatatacac acatctgttt tgaagtggag cattgtatga
     3601 tgactcttga tgtttatgta ataaaaccat atgctttgaa
//
