LOCUS       NM_001007748            1469 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus transmembrane protein 18 (Tmem18), mRNA.
ACCESSION   NM_001007748 XM_343043
VERSION     NM_001007748.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1469)
  AUTHORS   Rask-Andersen,M., Jacobsson,J.A., Moschonis,G., Chavan,R.A.,
            Sikder,M.A., Allzen,E., Alsio,J., Chrousos,G.P., Manios,Y.,
            Fredriksson,R. and Schioth,H.B.
  TITLE     Association of TMEM18 variants with BMI and waist circumference in
            children and correlation of mRNA expression in the PFC with body
            weight in rats
  JOURNAL   Eur J Hum Genet 20 (2), 192-197 (2012)
   PUBMED   21952719
  REMARK    GeneRIF: We observed a strong positive correlation between TMEM18
            expression and body weight in the prefrontal cortex (PFC) (r =
            0.5694, P = 0.0003) indicating a potential role for TMEM18 in
            higher functions related to feeding involving the PFC.
REFERENCE   2  (bases 1 to 1469)
  AUTHORS   Gutierrez-Aguilar,R., Kim,D.H., Woods,S.C. and Seeley,R.J.
  TITLE     Expression of new loci associated with obesity in diet-induced
            obese rats: from genetics to physiology
  JOURNAL   Obesity (Silver Spring) 20 (2), 306-312 (2012)
   PUBMED   21779089
  REMARK    GeneRIF: Long-Evans rats maintained on chow or a high-fat diet
            (HFD) for 6 weeks. From a total of 19 genes analyzed, seven genes
            (ETV5, FTO, GNPDA2, KCTD15, TMEM18, MC4R, and SH2B1) were
            down-regulated in the hypothalamus of HFD compared to chow-fed rats
REFERENCE   3  (bases 1 to 1469)
  AUTHORS   Jurvansuu,J., Zhao,Y., Leung,D.S., Boulaire,J., Yu,Y.H., Ahmed,S.
            and Wang,S.
  TITLE     Transmembrane protein 18 enhances the tropism of neural stem cells
            for glioma cells
  JOURNAL   Cancer Res 68 (12), 4614-4622 (2008)
   PUBMED   18559506
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC076388.1.
            
            On Nov 29, 2004 this sequence version replaced XM_343043.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC076388.1, CK483675.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132293
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1469
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..1469
                     /gene="Tmem18"
                     /note="transmembrane protein 18"
                     /db_xref="GeneID:362722"
                     /db_xref="RGD:1359389"
     exon            1..97
                     /gene="Tmem18"
                     /inference="alignment:Splign:2.1.0"
     exon            98..208
                     /gene="Tmem18"
                     /inference="alignment:Splign:2.1.0"
     exon            209..343
                     /gene="Tmem18"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..709
                     /gene="Tmem18"
                     /codon_start=1
                     /product="transmembrane protein 18"
                     /protein_id="NP_001007749.1"
                     /db_xref="GeneID:362722"
                     /db_xref="RGD:1359389"
                     /translation="MASPYSVRVFPVSIPAVIMETDWTEPWLLGLLAFHLLCLLLTCF
                     SAQRYKLQIGHFLCLVVLVYCAEYINEVAAMNWRLFAKYQYFDSRGMFISLVFSAPLL
                     FNAMVIVIMWVRKTLTVMSDLKNLQERRKERKRRRKEE"
     exon            344..464
                     /gene="Tmem18"
                     /inference="alignment:Splign:2.1.0"
     exon            465..519
                     /gene="Tmem18"
                     /inference="alignment:Splign:2.1.0"
     exon            520..613
                     /gene="Tmem18"
                     /inference="alignment:Splign:2.1.0"
     exon            614..1444
                     /gene="Tmem18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatgccagtc tgtacggagg acgtggatgc tgagctcacc ccgattctgt ggggctgacg
       61 gcaggcagat ccaccccagg tctatgagga gcacgctgtc tgtaaagagc tgaccaagat
      121 gccccgggct gtgggggaaa ggtgccgtac ggctgcatct gtggaaccta cgaaccctcc
      181 gctttccggg gagtttggga gaaactagat ctcgcgagaa gactaggcga ctttcgtggc
      241 tgtcggaagc ggcggacttg tcctggctgt tgggatcccc ggcgcgatgg cgtctccgta
      301 ttcagtcaga gtcttcccag tcagcatccc tgcagtgatc atggagacgg actggacaga
      361 gccctggctc ctagggctcc ttgccttcca cctgctgtgc ctacttctca catgcttctc
      421 cgcacagagg tataaactac agattggcca tttcctttgt ctggtagtgt tagtctattg
      481 tgccgagtac atcaacgaag tggctgcaat gaactggaga ttgttcgcaa agtatcagta
      541 ctttgactcc cggggaatgt ttatttctct tgtgttctca gcaccgctgc tcttcaacgc
      601 catggtcatt gtgattatgt gggtacggaa gactttgact gtgatgagtg acctgaagaa
      661 cttacaggag aggagaaagg agaggaagag gcgaagaaaa gaagaatagc actgagctgg
      721 ccacaccgtg tttgtcctct gacttggttg tttccatctg ggagctgcat atggcccaga
      781 tgtcttctgt cagctgactc atggttggaa aaacacacca caaatggttc ttatatttta
      841 ctctgtttgg agccctcgta aagctgttct taaaaaacta atgacatgac ctggaagcat
      901 ggtgaatggg gacccatcct ttacatgggg agctttctgg ctcagccaca tcatatacag
      961 cttctcacaa gttgctggta gatctcacga tgtgactaga ggtcacgcag gtttgagtgt
     1021 ggaaactggg aaataaacag ccccatcctt ctgtgagcac tacctgctcc ctcttctgtc
     1081 tctagcctgc agtggtggct atcagctaaa ggtgggtgtg ttccccagaa atttgctgat
     1141 ggttgtcacc tcaggtggac gtggcacttg tgtccatagg atagagccta ggttgctgaa
     1201 atcctacagg gtacaagaca gccccaccat ggagtattgc tgtgtatata atgtcagcag
     1261 tacccaggct gagggagcag tgggcaggtc tggaaaagaa tgcagtgtgt ttcagttccc
     1321 atgaagctag gcctctaaat aatttagttg gggctatgcc actggaaatg ttttgtttaa
     1381 aaatattaag ctagaatgaa agctgtaaaa tcaagactcc gtggaaaata gtatgtcaaa
     1441 tgaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
