LOCUS       NM_134390               1683 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus transmembrane protein 176B (Tmem176b), transcript
            variant 1, mRNA.
ACCESSION   NM_134390
VERSION     NM_134390.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1683)
  AUTHORS   Condamine,T., Le Texier,L., Howie,D., Lavault,A., Hill,M.,
            Halary,F., Cobbold,S., Waldmann,H., Cuturi,M.C. and Chiffoleau,E.
  TITLE     Tmem176B and Tmem176A are associated with the immature state of
            dendritic cells
  JOURNAL   J Leukoc Biol 88 (3), 507-515 (2010)
   PUBMED   20501748
REFERENCE   2  (bases 1 to 1683)
  AUTHORS   Louvet,C., Chiffoleau,E., Heslan,M., Tesson,L., Heslan,J.M.,
            Brion,R., Beriou,G., Guillonneau,C., Khalife,J., Anegon,I. and
            Cuturi,M.C.
  TITLE     Identification of a new member of the CD20/FcepsilonRIbeta family
            overexpressed in tolerated allografts
  JOURNAL   Am J Transplant 5 (9), 2143-2153 (2005)
   PUBMED   16095493
  REMARK    GeneRIF: TORID may be involved in the control of DC maturation and
            may, therefore, play a role in the induction or maintenance of
            allograft tolerance
REFERENCE   3  (bases 1 to 1683)
  AUTHORS   Lurton,J., Rose,T.M., Raghu,G. and Narayanan,A.S.
  TITLE     Isolation of a gene product expressed by a subpopulation of human
            lung fibroblasts by differential display
  JOURNAL   Am J Respir Cell Mol Biol 20 (2), 327-331 (1999)
   PUBMED   9922225
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1 and BC059116.1.
            
            On Jul 19, 2012 this sequence version replaced NM_134390.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All seven variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ226357.1, FQ220000.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMN09345329 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-560               JAXUCZ010000004.1  79104704-79105263   c
            561-1423            BC059116.1         60-922
            1424-1683           JAXUCZ010000004.1  79097808-79098067   c
FEATURES             Location/Qualifiers
     source          1..1683
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..1683
                     /gene="Tmem176b"
                     /gene_synonym="Lr8; Torid"
                     /note="transmembrane protein 176B"
                     /db_xref="GeneID:171411"
                     /db_xref="RGD:708403"
     exon            1..639
                     /gene="Tmem176b"
                     /gene_synonym="Lr8; Torid"
                     /inference="alignment:Splign:2.1.0"
     exon            640..833
                     /gene="Tmem176b"
                     /gene_synonym="Lr8; Torid"
                     /inference="alignment:Splign:2.1.0"
     CDS             648..1439
                     /gene="Tmem176b"
                     /gene_synonym="Lr8; Torid"
                     /note="tolerance-related and induced transcript protein;
                     TORID"
                     /codon_start=1
                     /product="transmembrane protein 176B"
                     /protein_id="NP_599217.1"
                     /db_xref="GeneID:171411"
                     /db_xref="RGD:708403"
                     /translation="MAQATVTVDGVKVTSTRPQSAQISIHIHHKSALEQLLGAMGSLK
                     KFLSYPQARIHYGQLSLGVTQILLGLVSCVLGVCLYFGPWTELCASGCAFWSGSVAIL
                     AGVGIVIHEMGQGKLSGHISRLLLLACSATAAAATVMGVKSLIWQTSASYYFEISSTC
                     DSLQPSIVDRFRSVRFTDDSDWRTERCREYLRMMMNLFLAFCILFTVICILKIVVSVA
                     SLGLSLRSMCGRNSQVLNDEETEKKLLGGDSAPASPTKEKIPVTP"
     exon            834..944
                     /gene="Tmem176b"
                     /gene_synonym="Lr8; Torid"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1001
                     /gene="Tmem176b"
                     /gene_synonym="Lr8; Torid"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1232
                     /gene="Tmem176b"
                     /gene_synonym="Lr8; Torid"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1352
                     /gene="Tmem176b"
                     /gene_synonym="Lr8; Torid"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1683
                     /gene="Tmem176b"
                     /gene_synonym="Lr8; Torid"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttccagcc ccacccatct ctgaggacag caggtgaggc aggatccttc atggccccag
       61 ggtagcccct ttttggagta cagggacctt tctctggagg agtctccaag cctactcctc
      121 aagcatcatc ctggctcagg atgtttcttc tttggtccct ctctgctttt ctgtaggact
      181 ctggggaggg agggacatgt tggacagagg atgtgactct agaaacaggg ctgaggctgg
      241 agaagccaga ttctggcttt gccttccatg attaccagtg cctcacatct gtgttctgag
      301 aacagagtct gagaccacac agaggtggga tggctatgga gtgaagacac agggtgtttc
      361 ttttctccgt ttctgggcac tgggaggagg ggtgtcaaag agagctgcta tctggagtcc
      421 tggccgcagt ggtgagaggg ttcttggtgc ctaagggttt agttcctgct ctgtagagga
      481 agcaacagga ttctgagtgg ccagggcagt ggtagcacta ggggtctgga ggggggcagc
      541 acacaactaa ggctttattc ctggaacctc aagggaaggg gagaacctaa ggccttcatt
      601 tgcatttctg tgaagtctct ccgtccctcc tgaagagagc aggaaaaatg gcccaagcca
      661 cagtgactgt ggatggagtc aaagtgactt ccacacgccc tcagtctgcc cagatcagca
      721 tccacatcca ccacaaatca gccttggagc agctgctggg agctatgggc tccctgaaga
      781 agtttctctc ctaccctcag gccagaatcc actatgggca gctgtctcta ggggtgaccc
      841 agatattgct ggggcttgtg agctgtgttc ttggagtgtg tctctacttc gggccttgga
      901 cagagctgtg tgcctctggt tgtgccttct ggtcagggtc tgtggcaatt ttggctggag
      961 tgggtatcgt catccatgag atgggacagg gaaaactgtc cggccacata tcacggctgc
     1021 tcctcctggc ttgctctgct acagctgcag ctgctaccgt tatgggtgtg aaaagcctca
     1081 tctggcaaac cagtgcttcc tactacttcg agatcagttc cacatgtgac tccttacaac
     1141 caagcattgt cgataggttt cggtcagtgc gattcactga cgactcagac tggaggacag
     1201 agaggtgcag agagtacctg agaatgatga tgaacttgtt cctggcattc tgcatcctgt
     1261 tcacggttat ctgtatcctg aagattgttg tgtctgtggc ttccctggga ctaagtctcc
     1321 ggagtatgtg tggccggaac tcccaggtct tgaatgatga agagacagag aagaagcttc
     1381 ttggggggga ttcggcaccg gcctccccga ccaaagagaa gattcctgtt accccatgag
     1441 ctgtccaaac ccacatgtgt ccctgtccag agtaatccag ggagaacggc actgatccta
     1501 aggcctcttc tggccccgca gcacatgctt acttctgatg tagccactgt ccagcccttt
     1561 ttctcttcct gtctccccgc tgtcctcaca ccaatgtcct ttcttccatg aacagatatt
     1621 atgtcatttt ctccaatgct gataaagcag aaacaactag aaaaaaatac cctctcacag
     1681 aaa
//
