LOCUS       NM_001013991            1836 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus transmembrane protein 175 (Tmem175), mRNA.
ACCESSION   NM_001013991 XM_223740
VERSION     NM_001013991.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1836)
  AUTHORS   Zhang,M., Lu,H., Xie,X., Shen,H., Li,X., Zhang,Y., Wu,J., Ni,J.,
            Li,H. and Chen,G.
  TITLE     TMEM175 mediates Lysosomal function and participates in neuronal
            injury induced by cerebral ischemia-reperfusion
  JOURNAL   Mol Brain 13 (1), 113 (2020)
   PUBMED   32799888
  REMARK    GeneRIF: TMEM175 mediates Lysosomal function and participates in
            neuronal injury induced by cerebral ischemia-reperfusion.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1836)
  AUTHORS   Lee,C., Guo,J., Zeng,W., Kim,S., She,J., Cang,C., Ren,D. and
            Jiang,Y.
  TITLE     The lysosomal potassium channel TMEM175 adopts a novel tetrameric
            architecture
  JOURNAL   Nature 547 (7664), 472-475 (2017)
   PUBMED   28723891
REFERENCE   3  (bases 1 to 1836)
  AUTHORS   Jinn,S., Drolet,R.E., Cramer,P.E., Wong,A.H., Toolan,D.M.,
            Gretzula,C.A., Voleti,B., Vassileva,G., Disa,J., Tadin-Strapps,M.
            and Stone,D.J.
  TITLE     TMEM175 deficiency impairs lysosomal and mitochondrial function and
            increases alpha-synuclein aggregation
  JOURNAL   Proc Natl Acad Sci U S A 114 (9), 2389-2394 (2017)
   PUBMED   28193887
  REMARK    GeneRIF: TMEM175 deficiency impairs lysosomal and mitochondrial
            function and increases alpha-synuclein aggregation.
REFERENCE   4  (bases 1 to 1836)
  AUTHORS   Cang,C., Aranda,K., Seo,Y.J., Gasnier,B. and Ren,D.
  TITLE     TMEM175 Is an Organelle K(+) Channel Regulating Lysosomal Function
  JOURNAL   Cell 162 (5), 1101-1112 (2015)
   PUBMED   26317472
REFERENCE   5  (bases 1 to 1836)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079245.1.
            
            On Apr 20, 2005 this sequence version replaced XM_223740.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079245.1, SRR8487226.56509.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1836
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1836
                     /gene="Tmem175"
                     /gene_synonym="RGD1309712"
                     /note="transmembrane protein 175"
                     /db_xref="GeneID:305623"
                     /db_xref="RGD:1309712"
     exon            1..35
                     /gene="Tmem175"
                     /gene_synonym="RGD1309712"
                     /inference="alignment:Splign:2.1.0"
     exon            36..289
                     /gene="Tmem175"
                     /gene_synonym="RGD1309712"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1645
                     /gene="Tmem175"
                     /gene_synonym="RGD1309712"
                     /note="endosomal/lysomomal potassium channel TMEM175;
                     endosomal/lysosomal potassium channel TMEM175"
                     /codon_start=1
                     /product="endosomal/lysosomal proton channel TMEM175"
                     /protein_id="NP_001014013.1"
                     /db_xref="GeneID:305623"
                     /db_xref="RGD:1309712"
                     /translation="MSRLQVQEQAVDSEGDSSLYRRDEEGTQSSHRMLGFSDALLSII
                     ATVMILPVTHTEISPEQQFDKSIQKLLATRIAVYLMTFLIVTVAWAAHTRLFQVVGKI
                     DDTLALLNLACMMTITLLPYTFSLMVTFPDVPLGIFLFCMCVIAIGSVQAMIVGYAFH
                     FPHLLNPQIQCSTHRALSRRHILHLVLRGPALCFVAAVFSLFFFPLSYLLMVTVIFLP
                     HISKATTWCKDKFMGHRESPAHNVEPFSIDLHAPLSKERVEAFSDGVYAIVATLLILD
                     ICEDNVPDPKDVQQKFSGSLVAALGAYGPQFLAYFGSFATVGLLWFAHHSLFLHVRKA
                     TQTMGLFNILSLAFVGGLPLAYQQTSAFARQPRDELERVRVSCAIIFFASIFQFAIWT
                     TALLHQRETLQPAVQFGGQEHAFMFAKLALYPCASLLAFAATCLLSRFSTAIFHLMQI
                     AVPFAFLLLRLLVRLALAGLQVLWDLWPERPQQDQGEPETQSQLLPASC"
     exon            290..328
                     /gene="Tmem175"
                     /gene_synonym="RGD1309712"
                     /inference="alignment:Splign:2.1.0"
     exon            329..426
                     /gene="Tmem175"
                     /gene_synonym="RGD1309712"
                     /inference="alignment:Splign:2.1.0"
     exon            427..478
                     /gene="Tmem175"
                     /gene_synonym="RGD1309712"
                     /inference="alignment:Splign:2.1.0"
     exon            479..514
                     /gene="Tmem175"
                     /gene_synonym="RGD1309712"
                     /inference="alignment:Splign:2.1.0"
     exon            515..598
                     /gene="Tmem175"
                     /gene_synonym="RGD1309712"
                     /inference="alignment:Splign:2.1.0"
     exon            599..763
                     /gene="Tmem175"
                     /gene_synonym="RGD1309712"
                     /inference="alignment:Splign:2.1.0"
     exon            764..842
                     /gene="Tmem175"
                     /gene_synonym="RGD1309712"
                     /inference="alignment:Splign:2.1.0"
     exon            843..978
                     /gene="Tmem175"
                     /gene_synonym="RGD1309712"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1811
                     /gene="Tmem175"
                     /gene_synonym="RGD1309712"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccagagcc cgccgctcgc gcctgacgcc tcaagccctt gtctctgcat cgaaatggct
       61 gaagtctaca gggttgaaac atccctctga tatgctcaga gctacacttc ttcccaggct
      121 gctgtgacaa cttggtgact ccaccatgtc caggctccag gtccaggagc aggcagtgga
      181 ttccgaggga gactcatccc tatacaggag agatgaggag gggacacaga gctcccaccg
      241 catgctgggc tttagtgatg ccttactatc catcatcgcc actgtcatga tcctgcctgt
      301 gacccacaca gagatctcac cagaacagca gtttgacaaa agtatacaga aacttctagc
      361 aactaggatt gctgtctacc tcatgacatt tctaatcgta actgtggcct gggcagcaca
      421 taccagattg ttccaggttg ttggaaaaat agatgataca cttgccttgc tcaacctggc
      481 ctgtatgatg accatcaccc ttctgcccta cacattttcg ctaatggtaa cattccctga
      541 tgtgcccctg ggcatcttcc tgttctgcat gtgtgtgatt gccattggat ctgtgcaggc
      601 aatgatcgtg ggttatgcct tccacttccc acatctgctg aatccacaaa tccagtgctc
      661 tacacatagg gccctgtccc ggcggcacat tctgcaccta gtcctccgtg gcccagcact
      721 ctgttttgtt gcagctgtct tttccctctt cttcttcccc ttgtcatacc tgctgatggt
      781 gactgtcatc ttcctccctc acatcagcaa ggctaccacc tggtgtaaag acaagtttat
      841 gggccacagg gagtctccag ctcacaatgt agagcccttc agtattgacc tgcatgcgcc
      901 cctcagcaaa gaacgggtgg aagctttcag tgacggtgtc tatgccattg tggccacact
      961 cctcatcttg gacatctgtg aggacaatgt tccggatccc aaggatgtgc aacagaagtt
     1021 cagtggcagc cttgtggctg ccctgggtgc atatgggcca cagttcctgg catacttcgg
     1081 ctccttcgcc acagtgggtc tgctctggtt tgcccaccac tcactcttcc tgcatgtccg
     1141 gaaggctaca cagaccatgg ggttgttcaa catactgtca ctggcctttg tggggggcct
     1201 ccctctggcc taccagcaga cctcggcgtt tgcccggcaa ccccgtgatg aacttgagcg
     1261 tgtgcgtgtc agctgtgcca tcatcttctt tgccagcatc ttccagtttg ccatctggac
     1321 tacagccctg ctgcaccaga gagaaacact gcagccagct gtgcagtttg gtgggcagga
     1381 acatgctttc atgtttgcca agctcgcact gtacccctgt gccagcctgc tggcctttgc
     1441 cgccacctgc ctactgagtc ggttcagcac agccatcttc cacctcatgc agattgcagt
     1501 gccctttgcg ttcctgttgc tccggctcct ggtacgcctt gccctggcag gccttcaagt
     1561 cctatgggac ctctggccag agcgtcccca acaagaccag ggtgaacccg agacacagtc
     1621 ccagctcttg cctgcctcct gctaatgcca agaaagccac tcctgcctat cgtagtcata
     1681 ctgcaaaggg tcttgtggag atgtcttagt acaagtttat cgcgacactg gagttgtgga
     1741 tatattggcc cgagtattgt ttacactgtg aaatatcaat atctatttca aaactatgaa
     1801 cattgttcac aaaaaaaaaa aaaaaaaaaa aaaaaa
//
