LOCUS       NP_001014013             499 aa            linear   ROD 27-APR-2025
DEFINITION  endosomal/lysosomal proton channel TMEM175 [Rattus norvegicus].
ACCESSION   NP_001014013 XP_223740
VERSION     NP_001014013.1
DBSOURCE    REFSEQ: accession NM_001013991.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 499)
  AUTHORS   Zhang,M., Lu,H., Xie,X., Shen,H., Li,X., Zhang,Y., Wu,J., Ni,J.,
            Li,H. and Chen,G.
  TITLE     TMEM175 mediates Lysosomal function and participates in neuronal
            injury induced by cerebral ischemia-reperfusion
  JOURNAL   Mol Brain 13 (1), 113 (2020)
   PUBMED   32799888
  REMARK    GeneRIF: TMEM175 mediates Lysosomal function and participates in
            neuronal injury induced by cerebral ischemia-reperfusion.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 499)
  AUTHORS   Lee,C., Guo,J., Zeng,W., Kim,S., She,J., Cang,C., Ren,D. and
            Jiang,Y.
  TITLE     The lysosomal potassium channel TMEM175 adopts a novel tetrameric
            architecture
  JOURNAL   Nature 547 (7664), 472-475 (2017)
   PUBMED   28723891
REFERENCE   3  (residues 1 to 499)
  AUTHORS   Jinn,S., Drolet,R.E., Cramer,P.E., Wong,A.H., Toolan,D.M.,
            Gretzula,C.A., Voleti,B., Vassileva,G., Disa,J., Tadin-Strapps,M.
            and Stone,D.J.
  TITLE     TMEM175 deficiency impairs lysosomal and mitochondrial function and
            increases alpha-synuclein aggregation
  JOURNAL   Proc Natl Acad Sci U S A 114 (9), 2389-2394 (2017)
   PUBMED   28193887
  REMARK    GeneRIF: TMEM175 deficiency impairs lysosomal and mitochondrial
            function and increases alpha-synuclein aggregation.
REFERENCE   4  (residues 1 to 499)
  AUTHORS   Cang,C., Aranda,K., Seo,Y.J., Gasnier,B. and Ren,D.
  TITLE     TMEM175 Is an Organelle K(+) Channel Regulating Lysosomal Function
  JOURNAL   Cell 162 (5), 1101-1112 (2015)
   PUBMED   26317472
REFERENCE   5  (residues 1 to 499)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079245.1.
            
            On Apr 20, 2005 this sequence version replaced XP_223740.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079245.1, SRR8487226.56509.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     Protein         1..499
                     /product="endosomal/lysosomal proton channel TMEM175"
                     /note="endosomal/lysomomal potassium channel TMEM175;
                     endosomal/lysosomal potassium channel TMEM175"
                     /calculated_mol_wt=55576
     Region          1..26
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY05.1)"
     Site            31..53
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY05.1)"
     Region          32..121
                     /region_name="TMEM175"
                     /note="Endosomal/lysosomal potassium channel TMEM175;
                     pfam06736"
                     /db_xref="CDD:429088"
     Region          32..38
                     /region_name="RxxxFSD motif 1.
                     /evidence=ECO:0000250|UniProtKB:Q9BSA9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY05.1)"
     Site            43
                     /site_type="other"
                     /note="Hydrophobic filter residue 1-1.
                     /evidence=ECO:0000250|UniProtKB:Q9BSA9; propagated from
                     UniProtKB/Swiss-Prot (Q6AY05.1)"
     Site            47
                     /site_type="other"
                     /note="Hydrophobic filter residue 2-1.
                     /evidence=ECO:0000250|UniProtKB:K9UJK2; propagated from
                     UniProtKB/Swiss-Prot (Q6AY05.1)"
     Site            50
                     /site_type="other"
                     /note="Hydrophobic filter residue 3-1.
                     /evidence=ECO:0000250|UniProtKB:K9UJK2; propagated from
                     UniProtKB/Swiss-Prot (Q6AY05.1)"
     Region          55..60
                     /region_name="Short helix H1-1.
                     /evidence=ECO:0000250|UniProtKB:K9UJK2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY05.1)"
     Region          62..68
                     /region_name="Short helix H2-1.
                     /evidence=ECO:0000250|UniProtKB:K9UJK2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY05.1)"
     Site            75..97
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY05.1)"
     Site            104..125
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY05.1)"
     Site            136..157
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY05.1)"
     Site            182..202
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY05.1)"
     Site            208..227
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY05.1)"
     Site            255..279
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY05.1)"
     Region          257..353
                     /region_name="TMEM175"
                     /note="Endosomal/lysosomal potassium channel TMEM175;
                     pfam06736"
                     /db_xref="CDD:429088"
     Region          257..263
                     /region_name="RxxxFSD motif 2.
                     /evidence=ECO:0000250|UniProtKB:Q9BSA9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY05.1)"
     Site            268
                     /site_type="other"
                     /note="Hydrophobic filter residue 1-2.
                     /evidence=ECO:0000250|UniProtKB:Q9BSA9; propagated from
                     UniProtKB/Swiss-Prot (Q6AY05.1)"
     Site            272
                     /site_type="other"
                     /note="Hydrophobic filter residue 2-2.
                     /evidence=ECO:0000250|UniProtKB:K9UJK2; propagated from
                     UniProtKB/Swiss-Prot (Q6AY05.1)"
     Site            275
                     /site_type="other"
                     /note="Hydrophobic filter residue 3-2.
                     /evidence=ECO:0000250|UniProtKB:K9UJK2; propagated from
                     UniProtKB/Swiss-Prot (Q6AY05.1)"
     Region          285..293
                     /region_name="Short helix H1-2.
                     /evidence=ECO:0000250|UniProtKB:K9UJK2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY05.1)"
     Region          295..301
                     /region_name="Short helix H2-2.
                     /evidence=ECO:0000250|UniProtKB:K9UJK2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY05.1)"
     Site            307..329
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY05.1)"
     Site            336..357
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY05.1)"
     Site            373..393
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY05.1)"
     Site            414..437
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY05.1)"
     Site            440..466
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AY05.1)"
     CDS             1..499
                     /gene="Tmem175"
                     /gene_synonym="RGD1309712"
                     /coded_by="NM_001013991.1:146..1645"
                     /db_xref="GeneID:305623"
                     /db_xref="RGD:1309712"
ORIGIN      
        1 msrlqvqeqa vdsegdssly rrdeegtqss hrmlgfsdal lsiiatvmil pvthteispe
       61 qqfdksiqkl latriavylm tflivtvawa ahtrlfqvvg kiddtlalln lacmmtitll
      121 pytfslmvtf pdvplgiflf cmcviaigsv qamivgyafh fphllnpqiq csthralsrr
      181 hilhlvlrgp alcfvaavfs lfffplsyll mvtviflphi skattwckdk fmghrespah
      241 nvepfsidlh aplskervea fsdgvyaiva tllildiced nvpdpkdvqq kfsgslvaal
      301 gaygpqflay fgsfatvgll wfahhslflh vrkatqtmgl fnilslafvg glplayqqts
      361 afarqprdel ervrvscaii ffasifqfai wttallhqre tlqpavqfgg qehafmfakl
      421 alypcaslla faatcllsrf staifhlmqi avpfaflllr llvrlalagl qvlwdlwper
      481 pqqdqgepet qsqllpasc
//
