LOCUS       NM_001013896            3420 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus transmembrane protein 135 (Tmem135), mRNA.
ACCESSION   NM_001013896 XM_218880
VERSION     NM_001013896.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3420)
  AUTHORS   Lee,W.H., Higuchi,H., Ikeda,S., Macke,E.L., Takimoto,T.,
            Pattnaik,B.R., Liu,C., Chu,L.F., Siepka,S.M., Krentz,K.J.,
            Rubinstein,C.D., Kalejta,R.F., Thomson,J.A., Mullins,R.F.,
            Takahashi,J.S., Pinto,L.H. and Ikeda,A.
  TITLE     Mouse Tmem135 mutation reveals a mechanism involving mitochondrial
            dynamics that leads to age-dependent retinal pathologies
  JOURNAL   Elife 5, e19264 (2016)
   PUBMED   27863209
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3420)
  AUTHORS   Exil,V.J., Silva Avila,D., Benedetto,A., Exil,E.A., Adams,M.R.,
            Au,C. and Aschner,M.
  TITLE     Stressed-induced TMEM135 protein is part of a conserved genetic
            network involved in fat storage and longevity regulation in
            Caenorhabditis elegans
  JOURNAL   PLoS One 5 (12), e14228 (2010)
   PUBMED   21151927
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3420)
  AUTHORS   Wiese,S., Gronemeyer,T., Ofman,R., Kunze,M., Grou,C.P.,
            Almeida,J.A., Eisenacher,M., Stephan,C., Hayen,H.,
            Schollenberger,L., Korosec,T., Waterham,H.R., Schliebs,W.,
            Erdmann,R., Berger,J., Meyer,H.E., Just,W., Azevedo,J.E.,
            Wanders,R.J. and Warscheid,B.
  TITLE     Proteomics characterization of mouse kidney peroxisomes by tandem
            mass spectrometry and protein correlation profiling
  JOURNAL   Mol Cell Proteomics 6 (12), 2045-2057 (2007)
   PUBMED   17768142
REFERENCE   4  (bases 1 to 3420)
  AUTHORS   Islinger,M., Luers,G.H., Li,K.W., Loos,M. and Volkl,A.
  TITLE     Rat liver peroxisomes after fibrate treatment. A survey using
            quantitative mass spectrometry
  JOURNAL   J Biol Chem 282 (32), 23055-23069 (2007)
   PUBMED   17522052
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085115.1.
            
            On Apr 1, 2005 this sequence version replaced XM_218880.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085115.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3420
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..3420
                     /gene="Tmem135"
                     /gene_synonym="PMP52; RGD1309948"
                     /note="transmembrane protein 135"
                     /db_xref="GeneID:293098"
                     /db_xref="RGD:1309948"
     exon            1..303
                     /gene="Tmem135"
                     /gene_synonym="PMP52; RGD1309948"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..1539
                     /gene="Tmem135"
                     /gene_synonym="PMP52; RGD1309948"
                     /note="peroxisomal membrane protein 52"
                     /codon_start=1
                     /product="transmembrane protein 135"
                     /protein_id="NP_001013918.1"
                     /db_xref="GeneID:293098"
                     /db_xref="RGD:1309948"
                     /translation="MAALSKSIPHNCYEIGHTWNPSCRVSFLQITWGALEESLRIYAP
                     LYLIAAVLRKRKLEYYLYKLLPEILQSASFLTANGALYITFFCVLRKILGKFYSWTPG
                     FGAALPASYVAILIERKSRRGLLTIYMANLATETLFRMGVARGTITTLRNGEVLLFCI
                     TAAMYMFFFRCKDGLKGFTFSALRFIVGKEEIPTHSYSPETAYAKVEQKREKHRGTTR
                     AMSLIALVRSLVDSICKHGPRHRCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPS
                     AFRHLFTEPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIVAG
                     FLAGVSMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPQADTIIYSISTAICFHA
                     AVMEVQNLRPSYWKFLLRLTKGRFALMNRKALDVFGTGASREFHNFIPRLDPRYTVVT
                     PELPIDFS"
     exon            304..431
                     /gene="Tmem135"
                     /gene_synonym="PMP52; RGD1309948"
                     /inference="alignment:Splign:2.1.0"
     exon            432..524
                     /gene="Tmem135"
                     /gene_synonym="PMP52; RGD1309948"
                     /inference="alignment:Splign:2.1.0"
     exon            525..558
                     /gene="Tmem135"
                     /gene_synonym="PMP52; RGD1309948"
                     /inference="alignment:Splign:2.1.0"
     exon            559..624
                     /gene="Tmem135"
                     /gene_synonym="PMP52; RGD1309948"
                     /inference="alignment:Splign:2.1.0"
     exon            625..671
                     /gene="Tmem135"
                     /gene_synonym="PMP52; RGD1309948"
                     /inference="alignment:Splign:2.1.0"
     exon            672..713
                     /gene="Tmem135"
                     /gene_synonym="PMP52; RGD1309948"
                     /inference="alignment:Splign:2.1.0"
     exon            714..860
                     /gene="Tmem135"
                     /gene_synonym="PMP52; RGD1309948"
                     /inference="alignment:Splign:2.1.0"
     exon            861..930
                     /gene="Tmem135"
                     /gene_synonym="PMP52; RGD1309948"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1098
                     /gene="Tmem135"
                     /gene_synonym="PMP52; RGD1309948"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1162
                     /gene="Tmem135"
                     /gene_synonym="PMP52; RGD1309948"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1239
                     /gene="Tmem135"
                     /gene_synonym="PMP52; RGD1309948"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1338
                     /gene="Tmem135"
                     /gene_synonym="PMP52; RGD1309948"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1406
                     /gene="Tmem135"
                     /gene_synonym="PMP52; RGD1309948"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..3396
                     /gene="Tmem135"
                     /gene_synonym="PMP52; RGD1309948"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccaacatc cgacgactcc ggccttgaat aacccgctcc cgtgaccttt tcgcaccccg
       61 caagcccagg cccgcgcggc gtctgccccg ccgttgcgtg tctgccgctc ccgcctagcc
      121 ccgcgttccc acgaccacgc acagctgcca ccgcggctcg tcatggcggc cctcagcaag
      181 tccatccctc ataactgcta cgagatcggc cacacttgga acccctcctg ccgggtctcc
      241 ttcttgcaaa tcacttgggg cgccctggaa gagtccctca ggatctacgc acccctgtac
      301 ctgatcgcag ctgttctccg gaagcggaag ctggaatatt acttgtacaa gctgcttcct
      361 gagatcctcc agtctgcctc cttcctgact gctaatgggg ccttgtacat tactttcttc
      421 tgtgttttaa ggaagattct tggaaaattc tactcatgga ctcctggctt tggtgctgct
      481 ctgccagcct cctatgtggc cattctaatt gaaaggaaaa gcaggagagg gctgctcaca
      541 atttatatgg ccaacttggc cacagaaaca ctatttagaa tgggtgttgc aagaggaacc
      601 atcacaacat taagaaatgg agaagtcctt ttgttctgca tcacagcggc catgtacatg
      661 ttctttttca ggtgcaaaga tggcttaaaa ggctttacgt tttctgcgct taggtttatt
      721 gtagggaagg aagaaattcc cacacactct tactcaccgg agacagcata tgcaaaagtg
      781 gagcagaaga gggagaagca cagggggacg acgagagcga tgagtctaat tgctctggtt
      841 cgcagtctcg tggactccat atgcaagcat ggaccacggc acagatgctg caagcattat
      901 gaagacaact gcatctccta ctgtattaaa ggcttcatca ggatgttcag cgtgggttac
      961 ttgatccagt gctgtctccg gatcccttct gcatttaggc atctgtttac agaaccatcc
     1021 cggctcctct ctctcttcta caacaaagaa aacttccagc tgggtgcttt tcttggatct
     1081 tttgttagta tatacaaggg cacaagttgt ttcctccgct ggatcaggaa cctggatgat
     1141 gagctgcatg ctattgtggc tgggtttttg gcaggtgtgt cgatgatgtt ttataaaagc
     1201 acaacaattt ccatgtacct agcttccaag ctggtggaga caatgtactt caagggcatc
     1261 gaggctggaa aggttcccta tttccctcaa gcagatacta tcatctactc catctccaca
     1321 gcgatttgtt tccatgcagc tgttatggaa gttcagaact tgcgaccatc gtactggaag
     1381 ttccttttaa ggctcaccaa gggcaggttt gcactcatga acagaaaagc cctggatgtg
     1441 tttggtactg gtgcatctag agaatttcac aacttcatcc ccagactaga cccacgatac
     1501 acagttgtca caccagagct gcccatagac ttttcctgaa gacgactgta acttattgac
     1561 tgtctcacca ttttctcctg aagagttaat tatgttcaac acagaagggg cccaagctga
     1621 acctcagtgt tatgtcaacg agagatgctt tttctttctt tccataccaa tcagaaatac
     1681 agaagctttt tagaaaggcg ttgcttaata attaagcttc ctctgtagcc agaatctcat
     1741 tctggatcat gtagtgttga caacattatg atatattgtt gattaaatta tgtccacaaa
     1801 gaatattgaa taatctatgt agaaatataa taagaagagt atacttaaaa attactttaa
     1861 aagatgtctt tagttcattc caatagaatt cttggtcaaa actaagaata tttcttcact
     1921 ttaggatttg cagaggatca cggatgtgtg gattctgtct gtgattttta tgcttttgaa
     1981 tggatttctg tagctgtggg gtgttggata tggggagaaa cctctgtggg cattgctgct
     2041 ttactgtgga gcaatgtgga ggaagtggcc attcttattt cagggataca aacatgggtt
     2101 tcagaccatt tgggccaatg tcatggtggt acccatactc ttgtgcagct gacagtcctg
     2161 tctgccttcg tgaccagacg ggctgttggg cagcctagtg accttacatg ctagtagcag
     2221 gttaggagca aatggaaact gatatgtgct gcagtaagga atctctgtgt ccacaggagt
     2281 gttacacttg aatattgtca agcagacaac ttagaaccca gcctttacac cgcaggcgta
     2341 gtgcgtttat ttccaccaca atgactgtgc tctctgtagc tcggcgtgaa tgccattgat
     2401 gttttagaaa gggttaatat cctatggaac aaaagagctt tgggccagtt tgacagttgg
     2461 tgccctctct aatgcctccc ctaaatggga tgttttatgt ctaaaaatgt gaaaacacag
     2521 tgattgttgg gagttcgtct ctcgctaagt ggattcctgt tcattgacca gtttactctg
     2581 gagttaggga caacagacag ttggtgctga ttatagaagc agtcctggac agctagctgt
     2641 ctgaaatatg atcacttggg ttttctgggg aaagttgtac ttttctaagt taatatagaa
     2701 gtctaaagtg gttgtgatgt ctacagttaa tgtaatatat aggaattatc tttaaatata
     2761 taattttgtt gctaaaaagg tgtcaggcca ttgtaagtta tgcagtagac cttgtgttag
     2821 gacaggaatt acaacccaga cattaaaaat acttaatctc ccatattcag ttgcatcagc
     2881 acttgtattt ctatgtaatc ctatccttgg ttgttatggt aaattgaatc cctacagaga
     2941 gacagactct agtgccatca tgtaacagaa ccactttagt ttggtcagaa ttcacattgt
     3001 aattagcttc tagcgtggac ttacctactt ggtaatactg ttgaagggtc atttggtttt
     3061 ggacttcaac accgattaat taatacagtt ttaggttgtt attcactgga attgaattga
     3121 tgattagtac tgtgtttact tttgaaaatg aagtattaaa gcactgagaa cacctggcta
     3181 catgtacctc attttctcct ctcagatttt atgtctgctg catttttctt gtcaggttaa
     3241 aaaaaaatct attttaagcc ataagtcatt cttttcattg acattaaaag actgtgataa
     3301 tgattaatcc tattgaaatg tacttaaaaa atgtttagta aaatcctgct ggtcaaaaag
     3361 atgcatttct atgagagata tatttttaac aaattaaaaa aaaaaaaaaa aaaaaaaaaa
//
