LOCUS       NM_001415950            3462 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus transmembrane protein 132A (Tmem132a), transcript
            variant 1, mRNA.
ACCESSION   NM_001415950 XM_006231041
VERSION     NM_001415950.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3462)
  AUTHORS   Liu,X.R., Li,T., Cao,L., Yu,Y.Y., Chen,L.L., Fan,X.H., Yang,B.B.
            and Tan,X.Q.
  TITLE     Dexmedetomidine attenuates H2O2-induced neonatal rat cardiomyocytes
            apoptosis through mitochondria- and ER-medicated oxidative stress
            pathways
  JOURNAL   Mol Med Rep 17 (5), 7258-7264 (2018)
   PUBMED   29568958
REFERENCE   2  (bases 1 to 3462)
  AUTHORS   Zhang,Y., Ye,L., Wang,B., Li,Y. and Sun,L.
  TITLE     Chelation of GRP78 with lead and its localization changes in the
            astroglia of rats exposed to lead
  JOURNAL   J Huazhong Univ Sci Technolog Med Sci 29 (4), 492-497 (2009)
   PUBMED   19662369
  REMARK    GeneRIF: GRP78 in astroglia could strongly chelate with Pb ions.
REFERENCE   3  (bases 1 to 3462)
  AUTHORS   Qian,Y., Zheng,Y., Weber,D. and Tiffany-Castiglioni,E.
  TITLE     A 78-kDa glucose-regulated protein is involved in the decrease of
            interleukin-6 secretion by lead treatment from astrocytes
  JOURNAL   Am J Physiol Cell Physiol 293 (3), C897-C905 (2007)
   PUBMED   17567751
  REMARK    GeneRIF: GRP78 is involved in IL-6 secretion from astrocytes, and
            lead can block IL-6 secretion from astrocytes via targeting GRP78
REFERENCE   4  (bases 1 to 3462)
  AUTHORS   Ohse,T., Inagi,R., Tanaka,T., Ota,T., Miyata,T., Kojima,I.,
            Ingelfinger,J.R., Ogawa,S., Fujita,T. and Nangaku,M.
  TITLE     Albumin induces endoplasmic reticulum stress and apoptosis in renal
            proximal tubular cells
  JOURNAL   Kidney Int 70 (8), 1447-1455 (2006)
   PUBMED   16955111
  REMARK    GeneRIF: ER stress proteins (GRP78 and ORP150), respectively) were
            upregulated at PTCs in experimental proteinuric rats.
REFERENCE   5  (bases 1 to 3462)
  AUTHORS   Oh-hashi,K., Hirata,Y., Koga,H. and Kiuchi,K.
  TITLE     GRP78-binding protein regulates cAMP-induced glial fibrillary
            acidic protein expression in rat C6 glioblastoma cells
  JOURNAL   FEBS Lett 580 (16), 3943-3947 (2006)
   PUBMED   16806201
  REMARK    GeneRIF: These results suggest a novel function of GBP in
            regulating GFAP gene expression via STAT3 phosphorylation.
REFERENCE   6  (bases 1 to 3462)
  AUTHORS   Oh-hashi,K., Naruse,Y., Amaya,F., Shimosato,G. and Tanaka,M.
  TITLE     Cloning and characterization of a novel GRP78-binding protein in
            the rat brain
  JOURNAL   J Biol Chem 278 (12), 10531-10537 (2003)
   PUBMED   12514190
  REMARK    GeneRIF: cloning and characterization of GRP78-binding protein that
            plays a role in embryonic and postnatal development of the brain
REFERENCE   7  (bases 1 to 3462)
  AUTHORS   Chang,W.M., Chen,K.D., Chen,L.Y., Lai,M.T. and Lai,Y.K.
  TITLE     Mitochondrial calcium-mediated reactive oxygen species are
            essential for the rapid induction of the grp78 gene in 9L rat brain
            tumour cells
  JOURNAL   Cell Signal 15 (1), 57-64 (2003)
   PUBMED   12401520
  REMARK    GeneRIF: Mitochondrial calcium-mediated reactive oxygen species are
            essential for the rapid transactivation of the grp78 gene.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 5, 2023 this sequence version replaced XM_006231041.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.4752.1,
                                           SRR26643296.4081.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760433,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-230               JAXUCZ010000001.1  216943415-216943644 c
            231-445             JAXUCZ010000001.1  216940906-216941120 c
            446-664             JAXUCZ010000001.1  216940405-216940623 c
            665-996             JAXUCZ010000001.1  216939468-216939799 c
            997-1146            JAXUCZ010000001.1  216938131-216938280 c
            1147-1345           JAXUCZ010000001.1  216937620-216937818 c
            1346-1489           JAXUCZ010000001.1  216937378-216937521 c
            1490-1692           JAXUCZ010000001.1  216935579-216935781 c
            1693-1966           JAXUCZ010000001.1  216934197-216934470 c
            1967-2158           JAXUCZ010000001.1  216933674-216933865 c
            2159-3462           JAXUCZ010000001.1  216931962-216933265 c
FEATURES             Location/Qualifiers
     source          1..3462
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..3462
                     /gene="Tmem132a"
                     /gene_synonym="Gbp; Hspa5bp1"
                     /note="transmembrane protein 132A"
                     /db_xref="GeneID:338474"
                     /db_xref="RGD:727936"
     exon            1..230
                     /gene="Tmem132a"
                     /gene_synonym="Gbp; Hspa5bp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..3211
                     /gene="Tmem132a"
                     /gene_synonym="Gbp; Hspa5bp1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; GRP78-binding protein; HSPA5-binding protein 1;
                     heat shock 70kDa protein 5 binding protein 1"
                     /codon_start=1
                     /product="transmembrane protein 132A isoform 1 precursor"
                     /protein_id="NP_001402879.1"
                     /db_xref="GeneID:338474"
                     /db_xref="RGD:727936"
                     /translation="MTERAAAAPRGPYGAWLCLLVALALEVVRVGSNQDTLDPIYLPV
                     ALELLDAPEHFRVQQVGHYPPANSSLGSRSETFLLMQPWPRAQPLLRASYPPFATQQV
                     VPPRVTEPHRRPVPWDVRAVSVEAAVTPAEPYARVLFHLKGQDWPPGPGSLPCARLHA
                     THPAGTAHQACRFQPSLGACVVELEFPSQWFSQSATTRAELAYTLEPAGEGPGGCGPG
                     TEEEPKEQALPVGSVELHPEDPPQYQEVPLDEVVTLRAPDVPVRPGQLFTATLLLRHN
                     FTASLLTLRIKVKKGLQVTAARPAQPTFWTAKLDRFKGSKHHTSLITCHRTGPAGPDS
                     SSPLELSEFLWVDFAVENSTGGGVAVTRPVTWQLEYPGQAPEAEKDKMVWEILVSERD
                     IRALIPLAKAEELVNTAPLTGVPQRIPVRLVTVDSGGALEEVTEHIGCESANTQVLQV
                     SEACDAVFVAGQESRGAKGVRVDFWWRRLRASLKLTVWAPLLPLRIELTDTTLEQIRG
                     WRVPGPAEGQLEPEAAAEEVERRSRGCRLQYQRAGVRFLVPFAAHPLDGGRRLTHLLG
                     PDWLLDVSHLVAAHAHVQDPRIATLEGGRILVGREPGVTSIEVRSPLSDSILGEQALA
                     VTDDKVSVLDLRVQPVMGISLSLSRGVSHPGEVTATCWAQSALPAPKQEVALSLWLSF
                     SDHTLAPAELYDRNDLGLSVSAEEPSAVVPAEEQRAQLGVVVSGVGAEGLPLHVALHP
                     PEPCRRGRHRVPLASGTAWLGLPPLPTPAPALPSSPARTPPFTEASVEGKRQVAGDMG
                     SHVGPGIRGKFERAEEEAGKEENEAKEEEEDEEEMVPAPQRVTDLELGMYALLGIFCL
                     AFLIFLVNGVVFVLRYQRKEPPDSATDPASPQPHNWVWLGTNQEELSRQLDRCSSSSP
                     PKGEGGCPCESGAGGDTSTVAPSASESPAGSSSTLARKEAGGRRKRVEFVTFAPAPPA
                     QEVPEEPVGAPAVQSILVAGEEDIRWVCEDMGLKDPEELRNYMERIRGSS"
     exon            231..445
                     /gene="Tmem132a"
                     /gene_synonym="Gbp; Hspa5bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..664
                     /gene="Tmem132a"
                     /gene_synonym="Gbp; Hspa5bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            665..996
                     /gene="Tmem132a"
                     /gene_synonym="Gbp; Hspa5bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1146
                     /gene="Tmem132a"
                     /gene_synonym="Gbp; Hspa5bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1345
                     /gene="Tmem132a"
                     /gene_synonym="Gbp; Hspa5bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1489
                     /gene="Tmem132a"
                     /gene_synonym="Gbp; Hspa5bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1692
                     /gene="Tmem132a"
                     /gene_synonym="Gbp; Hspa5bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1966
                     /gene="Tmem132a"
                     /gene_synonym="Gbp; Hspa5bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2158
                     /gene="Tmem132a"
                     /gene_synonym="Gbp; Hspa5bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..3462
                     /gene="Tmem132a"
                     /gene_synonym="Gbp; Hspa5bp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgtctggg aactgcagcc gcgagccggc ggcgcaggaa acaggctggc cggagcggcg
       61 ggcgcgggag atgtggggcc agatcgcagc cacctgagcc gcgcgccggt tacctgcctt
      121 tggtgggaag gagtgcgcct cgatgacgga acgtgcggca gcggcccctc gggggcccta
      181 cggtgcctgg ctctgcctcc tggtggctct cgccctggaa gtcgtgagag ttggcagtaa
      241 ccaagatacc ctggacccca tctacctgcc agtggccctg gaactcctgg atgcccctga
      301 acattttcgg gtgcagcagg tgggccacta cccacctgcc aactcttctc tgggctcccg
      361 ctctgagacc ttcctgctca tgcagccctg gcccagggca cagccacttc tccgggcctc
      421 ctacccacct tttgccactc agcaggtggt ccctcctagg gtcactgagc cccaccggcg
      481 acctgtccct tgggatgtgc gggctgtttc cgtggaagca gcggtgactc cagcagagcc
      541 ctatgcccgt gtcctcttcc acctcaaagg gcaggattgg ccaccaggac ctggcagctt
      601 gccctgtgcc cgactacatg ccacacaccc tgcaggcact gctcaccaag cctgccgctt
      661 ccagccatct ctgggtgcct gtgtagtgga actggagttc ccctctcaat ggttctccca
      721 aagtgccacc acaagggcag aactggccta cactctggag cctgcaggtg agggccctgg
      781 gggctgtggc cctggcacgg aggaggaacc caaggagcag gctcttccag tgggtagtgt
      841 ggagctgcac cctgaagacc ccccacagta ccaggaggtc ccgctggatg aagtagtcac
      901 tttacgtgca cccgatgtgc cagtgaggcc tggccagctc ttcactgcca cccttctgct
      961 tcgacacaat ttcacagcca gccttcttac tctgcggatc aaggtgaaga aagggctaca
     1021 ggtgacagct gcccgcccag cccagcccac cttctggacc gctaagctgg accgcttcaa
     1081 gggctcaaag caccacacca gtctgatcac ctgtcaccgc actgggcctg cagggccgga
     1141 ttccagtagt cccctggagc tgtccgagtt cctgtgggta gactttgcgg tggagaatag
     1201 caccggtggg ggtgtggcag tcactcgacc tgtcacgtgg cagctggagt acccaggtca
     1261 ggcccctgaa gcagagaagg acaaaatggt gtgggagatc ctggtgtctg agcgggacat
     1321 cagagccctc atccctctgg ccaaggctga ggagctggtg aacacggctc ccttgactgg
     1381 agtgccacag cgtatccctg tgcgtcttgt cactgtggac agtgggggag ccctggagga
     1441 ggtgacagag cacattggct gtgaatcagc caatacccag gtcctgcagg tatctgaggc
     1501 ctgtgatgct gtgttcgtgg ctggtcagga gagtcgggga gccaaggggg tgcgggtgga
     1561 cttctggtgg cgccgcctcc gggcctcact gaagctgact gtatgggccc cactcctacc
     1621 cttgcgcatt gagctgactg acaccactct tgaacaaatc cgaggctggc gggtcccagg
     1681 cccagcagaa gggcagttag agccggaggc tgctgctgag gaagtggagc ggcgctcccg
     1741 cggctgccgc ctgcagtacc agagagctgg tgtacgcttc ttagtgccct ttgcggctca
     1801 cccgctggac ggtggccgcc gcctcaccca cctactcggt cctgactggt tgctggatgt
     1861 gagtcacctc gtggcagccc atgcccacgt gcaggatcct cgcatagcca ccttggaagg
     1921 tggccgcatc ctagtgggac gagagcctgg agtcacctct atcgaggttc gatccccgct
     1981 atctgactcc atcctggggg agcaggcact ggctgtgaca gatgacaagg tctcggtgct
     2041 ggatctgcga gtgcaaccgg tgatgggcat ctcactgtcc ctgagccggg gcgtgtccca
     2101 ccctggagag gtcacagcga cttgctgggc ccagtcagct cttccagccc caaagcagga
     2161 ggtggccctc tccctgtggc tgtccttttc tgaccacact ttggctccag ccgagctcta
     2221 cgaccgcaat gacctgggac tgtcggtctc agctgaggaa cccagtgctg ttgtgccagc
     2281 tgaagagcag agagcccaac ttggtgtggt ggtgagtggc gtgggtgccg aagggctgcc
     2341 cctacacgtg gctctgcacc caccggaacc ctgccgccgg ggccgccatc gtgttcccct
     2401 agcctcaggc acagcctggc tggggctgcc ccctttgccc acaccagctc ctgcactccc
     2461 atccagccct gcccggaccc caccattcac agaagcctct gtggaaggaa agcggcaggt
     2521 agcaggtgat atggggagcc atgtgggtcc gggcattagg ggcaagtttg agcgggcaga
     2581 ggaggaagct gggaaggaag agaatgaggc caaagaagag gaggaagatg aggaagagat
     2641 ggtgcctgcc cctcagcgtg tcaccgacct agagctggga atgtatgctc tgctgggcat
     2701 cttctgtttg gccttcctca tcttcctggt caatggtgtg gtctttgtgt tgcgctacca
     2761 gcgcaaagag cctcccgaca gcgctacaga ccctgcctcc cctcagccac ataactgggt
     2821 ctggctgggc accaatcagg aggaactgag tcggcagctg gaccgatgct cttcctcgag
     2881 cccacccaag ggggaggggg gctgcccctg tgaaagtggg gcaggagggg atacttcaac
     2941 cgtggctccc agtgcttcag agagccctgc tggctcctcg agcaccctgg cccgcaaaga
     3001 agctggggga cgtcggaagc gagtcgaatt tgtgacattt gcaccagcac ccccagccca
     3061 ggaggtgcct gaggagcctg taggggcccc ggctgtacag tccatcctgg tagcaggtga
     3121 ggaggacatc cgctgggtgt gcgaggacat ggggctgaag gacccagagg agcttcggaa
     3181 ctacatggag aggatccggg gcagctcctg ataccccagg cctgccaggt gcagctttgc
     3241 ccagcagctc aggcttgggg accaatggga tatctggcta tacttcttgc ctgaccctca
     3301 tgctcatcct ctggtgcttg ttgatctgag tccccatccc aggccctttc acccccaccc
     3361 cttgtcatgg actatggtca agagggaggg cgcatgcccc ttatttatgg gaaccacttc
     3421 attctaatgt tgggtacaga ataaatgata aaagaatggg ca
//
