LOCUS       NM_001126274            2372 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus transmembrane protein 129, E3 ubiquitin ligase
            (Tmem129), mRNA.
ACCESSION   NM_001126274 XM_001061814 XM_223542
VERSION     NM_001126274.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2372)
  AUTHORS   van den Boomen DJ, Timms RT, Grice GL, Stagg HR, Skodt K, Dougan G,
            Nathan JA and Lehner PJ.
  TITLE     TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for
            virus-induced degradation of MHC-I
  JOURNAL   Proc Natl Acad Sci U S A 111 (31), 11425-11430 (2014)
   PUBMED   25030448
REFERENCE   2  (bases 1 to 2372)
  AUTHORS   van de Weijer ML, Bassik MC, Luteijn RD, Voorburg CM, Lohuis MA,
            Kremmer E, Hoeben RC, LeProust EM, Chen S, Hoelen H, Ressing ME,
            Patena W, Weissman JS, McManus MT, Wiertz EJ and Lebbink RJ.
  TITLE     A high-coverage shRNA screen identifies TMEM129 as an E3 ligase
            involved in ER-associated protein degradation
  JOURNAL   Nat Commun 5, 3832 (2014)
   PUBMED   24807418
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC161857.1.
            
            On or before Sep 7, 2008 this sequence version replaced
            XM_001061814.1, XM_223542.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161857.1, SRR8487231.26888.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2372
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..2372
                     /gene="Tmem129"
                     /gene_synonym="RGD1310828"
                     /note="transmembrane protein 129, E3 ubiquitin ligase"
                     /db_xref="GeneID:305458"
                     /db_xref="RGD:1310828"
     exon            1..282
                     /gene="Tmem129"
                     /gene_synonym="RGD1310828"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1166
                     /gene="Tmem129"
                     /gene_synonym="RGD1310828"
                     /EC_number="2.3.2.27"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TM129"
                     /protein_id="NP_001119746.1"
                     /db_xref="GeneID:305458"
                     /db_xref="RGD:1310828"
                     /translation="MDSPEVTFTLAYLVFAVCFVFTPNEFYSAGLTVQNLLSGWLGSE
                     DAAFVPYHLRRTSATLLCHSLLPLGYYMGMCFAASEKQLYSPGQAPEAWQLFLLLAVT
                     LPLVSCTLIYYWSWDRWARHPLAQTLALYALPQSGWQAVASSINTEFRRIDKFATGAP
                     GARVIVTDTWVMKVTTYRVHVAQQQDVHLTVTESRQHDLSPDSNLPVQLLTIHVASTS
                     PGAQPFDIRLNSSEYGELCEKLRAPIRSAANVVIRQSLGDLFLETFASLVEVNPAYSA
                     PSNQELEACIGCMQTRASVKLVKTCQEPAVGECQQCYCRPMWCLTCMGKWFASRQDPQ
                     RPDTWLASRVPCPTCRARFCILDVCCVR"
     exon            283..757
                     /gene="Tmem129"
                     /gene_synonym="RGD1310828"
                     /inference="alignment:Splign:2.1.0"
     exon            758..917
                     /gene="Tmem129"
                     /gene_synonym="RGD1310828"
                     /inference="alignment:Splign:2.1.0"
     exon            918..2348
                     /gene="Tmem129"
                     /gene_synonym="RGD1310828"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggtggctg cggcaaccta ccaactgtcc agaagtagaa gctgctaccc ctgcctggcc
       61 cggtgagcgg cggcgggatg gacagccctg aggtgacctt cacgttggcc tacctggtct
      121 tcgcagtgtg cttcgtgttc acgcccaacg agttctactc ggccgggctc acagtgcaga
      181 atctgttgtc gggctggctg ggcagcgagg acgccgcctt cgtgccttac caccttcgtc
      241 gtacttccgc cacactactg tgccactcac tgctgccgtt gggctactac atgggcatgt
      301 gctttgcagc ctcagaaaag cagctctact cccccggtca ggccccagaa gcctggcagc
      361 tcttccttct cctggctgtg acccttcccc ttgtctcctg taccctgatc tactattggt
      421 cctgggatag gtgggcccgg cacccactgg cccaaaccct ggccctctat gcccttccac
      481 agtctggttg gcaggcggtt gcctcttcca tcaacacaga gttccgacgg attgacaagt
      541 ttgctaccgg ggcacctggt gccagagtga ttgtgacaga cacatgggta atgaaggtga
      601 ccacataccg tgtgcatgtg gcccagcaac aggatgttca tttgactgtg acagagtctc
      661 ggcagcacga tctctcgcca gactcaaacc tacctgtgca gcttcttacc atacatgtgg
      721 caagcaccag ccctggtgca cagccctttg atattaggct gaactcctca gaatatggcg
      781 aactgtgtga gaagctccgt gccccaatcc gaagtgcagc caatgtggtc atccgccaga
      841 gtctaggcga cctcttccta gaaacatttg cttctcttgt ggaggtcaac ccagcctatt
      901 cagcacccag caaccaggag ctcgaggctt gtataggctg catgcaaaca cgggccagcg
      961 tgaagctggt gaagacctgc caggagccag cggtgggcga gtgccagcag tgctactgcc
     1021 gacccatgtg gtgtctcact tgcatgggca agtggtttgc cagccgccag gatccccagc
     1081 gccctgacac ttggctagca agccgtgtgc cctgccccac ctgccgtgcc cgcttctgca
     1141 tcctggatgt gtgttgtgta cgctgagcat cacagtatat tctgtgtctc cactagccac
     1201 ttagggagtg gctacagctc cttgacttcg gcaagatgtc ctagttaaag cacacactta
     1261 atctacagcc actctctacc ttgagtctat ggtcagttga agagttttag aagaaattct
     1321 catggaaatg ctctatccct gaccttcagc gggatcccct cttcctgttt acctccaggt
     1381 ggggctgata tgccacatag gatgctccaa agccccagga cattggagtt tggcccaaga
     1441 gccttcattt ggcctgtttg ccttactttc tattacagag catacctgta cctcagttac
     1501 caaccagacc tgcgtctgtc ccaggccctg tggtggtggg tagacgctga ccattaagag
     1561 cgggtcaccg gggtgccact ctagtgtgaa ggccttttct agggtgtctt ggtgactgta
     1621 gccagccaag ggaccacttc ttggtaggaa ggcaagggca gcaacctagt ccatccagta
     1681 cagagtaccc tcccaagtta ctcatgaggc ttgcatatgt tttagaggat ccacaatact
     1741 tttggggtct tgcttctcca gtcctgggaa ggattttagg gaagccaagg agaagagagc
     1801 cacagtacta cccagaaaga aacccaccag gaatgcagta cagggtgagc caaggccctg
     1861 tggggagctt ggctcaggag aggatacctc agtggttagg gttctgatgg actactactc
     1921 acatatctat ggaacagatg ggtggggaaa aggctgccct ttaccctcca tctctgacac
     1981 aagtatagct gctagagggg aagacctctc cttcaacttg tagtcctgaa gcacctacac
     2041 tgagttgttg aaagcagcag tgacagacca agctagcccc ttatccagcc aacactgcac
     2101 ctaaccccag ggatttgcaa gctcagttct gccagtcccc aagtatgact cagagtcagc
     2161 cagtttcaag ggctgtctgc ccagcagagg ccaagtggtt tgaagttatt tttttaacca
     2221 cagaagagtt aattttatac agataaatgt aaatgtagct aaatgacacc gtatttaata
     2281 aagtgttcct tttcaagtga tgtacttcat tttgtttaac ctgtgagtaa aaccaaacgt
     2341 ttacaataaa aaaaaaaaaa aaaaaaaaaa aa
//
