LOCUS       NM_001100978            4388 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus transmembrane protein 127 (Tmem127), mRNA.
ACCESSION   NM_001100978 XM_001057254 XM_001081091 XM_230574
VERSION     NM_001100978.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4388)
  AUTHORS   Qin Y, Deng Y, Ricketts CJ, Srikantan S, Wang E, Maher ER and Dahia
            PL.
  TITLE     The tumor susceptibility gene TMEM127 is mutated in renal cell
            carcinomas and modulates endolysosomal function
  JOURNAL   Hum Mol Genet 23 (9), 2428-2439 (2014)
   PUBMED   24334765
REFERENCE   2  (bases 1 to 4388)
  AUTHORS   Qin Y, Yao L, King EE, Buddavarapu K, Lenci RE, Chocron ES,
            Lechleiter JD, Sass M, Aronin N, Schiavi F, Boaretto F, Opocher G,
            Toledo RA, Toledo SP, Stiles C, Aguiar RC and Dahia PL.
  TITLE     Germline mutations in TMEM127 confer susceptibility to
            pheochromocytoma
  JOURNAL   Nat Genet 42 (3), 229-233 (2010)
   PUBMED   20154675
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC131850.1.
            
            On or before Aug 12, 2007 this sequence version replaced
            XM_001057254.1, XM_230574.4, XM_001081091.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC131850.1, FQ230469.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4388
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..4388
                     /gene="Tmem127"
                     /gene_synonym="RGD1309744"
                     /note="transmembrane protein 127"
                     /db_xref="GeneID:311405"
                     /db_xref="RGD:1309744"
     exon            1..133
                     /gene="Tmem127"
                     /gene_synonym="RGD1309744"
                     /inference="alignment:Splign:2.1.0"
     exon            134..451
                     /gene="Tmem127"
                     /gene_synonym="RGD1309744"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..924
                     /gene="Tmem127"
                     /gene_synonym="RGD1309744"
                     /codon_start=1
                     /product="transmembrane protein 127"
                     /protein_id="NP_001094448.1"
                     /db_xref="GeneID:311405"
                     /db_xref="RGD:1309744"
                     /translation="MYAPGGAGLPGGRRRRSPGSSALPKQPERSLASALPGALSITAL
                     CTALAEPAWLHIHGGTCSRQELGVSDVLGYVHPDLLKDFCMNPQTVLLLRVIAAFCFL
                     GILCSLSAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFSYWASELILAQQQQ
                     HKKYHGSQVYVTFAVSFYLVAGAGGASILATAANLLRHYPTEEEEQALELLSEMEEND
                     PYPAEYEVINQFQPPPAYTP"
     exon            452..616
                     /gene="Tmem127"
                     /gene_synonym="RGD1309744"
                     /inference="alignment:Splign:2.1.0"
     exon            617..4361
                     /gene="Tmem127"
                     /gene_synonym="RGD1309744"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagccggaa gtgcatcggc cagggtccgt ctgggcgttg cgggattggg gcctgggatc
       61 tcttggcccc ggcagctaag aagcctgtga ccgggcgaag cggcgccatc ccagccctga
      121 ggcctgctga ccgacaggct ctgcgttccc cgctgaggtc ggcggccact accagcgacc
      181 gcagagctac agcgggcagc cccgggcatg tatgcccctg gaggcgccgg gctgccggga
      241 gggcgccggc ggagaagccc gggaagcagc gctcttccta agcagccgga gcggagcctg
      301 gcttcggccc tgcctggcgc cctgtccatc acagcgctgt gcactgccct cgcggagccc
      361 gcttggttgc acatccatgg aggcacctgt tcccgccagg agctgggggt ctcagacgtg
      421 ctgggctatg tgcacccgga tctgctaaaa gatttctgca tgaaccccca aacagttctt
      481 ctcctgaggg tcatcgctgc cttctgcttc ttgggcatcc tgtgtagtct ctctgcattc
      541 ctgttggatg tctttgggcc caagcatcca gctctgaaga ttactcgtcg ctatgccttc
      601 gctcacatcc tcactgtcct acagtgtgct acggtcattg gcttttccta ctgggcttct
      661 gagctcatcc tggcccagca gcaacagcat aagaagtacc acggctccca agtctatgtc
      721 acctttgctg ttagcttcta cctggtggca ggagctggcg gagcctcaat cctggctact
      781 gcagccaacc tcctgcgcca ctatccaaca gaggaagaag aacaagcact ggagctgcta
      841 tctgagatgg aggagaatga cccctaccca gcagagtatg aggtcatcaa ccaattccag
      901 ccaccccctg cctacacacc ataatgccag caggggctct cttcctcagc agcccttccc
      961 cccagtgcca cagctccttt tatacccaga ggagccactt cccccagcag gtctcacctg
     1021 taggaccctg accatcttca ccaaaccttc tccaggagac actctgcctt taggcttgtc
     1081 catgtgtccc tgctctgcag agctgggact ctgattttat ataatgtact ctttccctcc
     1141 cagcaccctc tgctcctttc ctattcacta gctccttcca accagggatg gtcagataag
     1201 tttcctctcc ttgggttgct gctggtagtg gccagtccct aagagaggta ccaacagagc
     1261 acaaggggaa gggactgtgc catgcaggtt cactttgcca ggcccagcat ttgtgccact
     1321 tgtgtatctc tgggctgatc cctcttttct tctagagtgc ccaggcccag ccatccacat
     1381 tgtggattct ctgcacttta gtctccaggc cactcctcat gtgtgttctg gttttctgga
     1441 gagaaggaat cactgctggg gagcaataca actgttctcc tgcccggccc tggcttcctg
     1501 tggttagaac caggcaagga agcagaacca gacaagagac tgactctttt gaggacccca
     1561 gtgaaggggg ctgagtgccc tagccccttc accttttaat gtgagtggtt ttgaaaggag
     1621 aaaaacaaaa ccaagcaata gcagccatac tctctttcta aaacagggat aaagctgctg
     1681 ttgttcagaa atgtagccca tcctttatgg ctctgcaata ttttggacca tagctccctc
     1741 tgagcctata gtcacgcctc ccagtctcca acagaatgca ggctttctgt cctggctcct
     1801 tcttccaggc agctgtggct ccctggggcc tttctgtgga actagggcca catggccccc
     1861 acggggctga gaactatggc ctggctggct ggccagcgtg gtgctcctca gaactgtggc
     1921 actgagatgt aacctggcct cagttcaggg acagggggcc aagtagggca ggaccctcca
     1981 ctctccacac aggtactcca cccagaggcc caataggttg gtgtcaggac cctgtcagat
     2041 gtgcaggcct ggctgtagcc ttcagagtca atgtggccct agactgtgac ttggggctac
     2101 agcttgctgc atgcccctct cccgttctgg aatgtatgct ggtcttgtgg tgtgctactg
     2161 ggctgttact ctagctattc tgtttgcctt gggtccagtt ttttttgggg ggtggggggt
     2221 gttttttttt ccccctggag atctggggca taaggtaggt gagacctgag aggcctgcag
     2281 catggatcca ggtaggcaag ctgttcttgt tcagttatga gcttctctgg agtaagagtc
     2341 tagtgctaac tgaagggaaa atgaatccca atctcctacc acccataaga caacagacat
     2401 tttgaacaag aatggagaat gaatacagtt gttgaactgt gactacaaga agactgtcaa
     2461 ctccccattc tttggccaga aagagtggtg aatatgtgga caaatgccta tgcagatgaa
     2521 gaccaagtgt gcccataaga aagcatctgc ctggagttcc ctgctgtaat gccaaagtgt
     2581 gccccaggat gactctccca ttcttcagac ccctctctga ggcaagaaag gctgccaggt
     2641 gatgcctgag cacagaatca aggggctaag ttatgactgc ctgtctgatg ttctgagctc
     2701 atcatagaca ggcttctggt gtgtgtccag ctctctaaca tggcacctga gggagcaggc
     2761 cagaagtcca gcaccaaaca tgcatgccaa agtgaatgag gactggaccc tgtggaccgt
     2821 tccttgtgat ttggaaccca ctttttacta gcttcccgtt cctctggcct ttctcttttc
     2881 cctgccattc tcacactggt agtttgtcat atagattact ctggttgtgt ttttcttttc
     2941 tagggaaaaa attaaaaggc aaaacaaaaa ccaggaacta caaatgagaa tgcaaatgcc
     3001 agtggctgac tgtcattttt gtcacaattt tccagatgtt tgttctcttc ctctcagaga
     3061 agcagaaggc attcactgat gaagcttgta atatggagca gaggtaggag ggacttggca
     3121 tgcgcctgca acacgcacaa cattttggtc cttgggagcc tcccattcct gacacctttc
     3181 acagaggaag ttctcaaagc ccacagctag aaacagtagg tggctgtgcc caaaatctca
     3241 gttccagacc ttgagctgcc tctctgcatg tcctgattag ctgcagaaga gatgtttcag
     3301 acctctactg gtacttactg ggagaagcct gaaaataaaa atgactctgg gagcaagacc
     3361 tgcggtcact ctccaggcag ttgttgggtg aaaccttgat ggctacccac acttttagtt
     3421 cattcattct caacccacgc actggacccc aagtgtgtga aaacatttag ggctctcttt
     3481 ggcaagtgtt ccattcctag caggatgcat gtctttcctg gaaactgata atcttctcct
     3541 tatgtgtcca ctcacacatg tctaagaagg gtccattgga ttatgcacaa aacactgagc
     3601 cccatgaaag aaataggaag actgacagga ccctctctcc taggacttac ttagcccagg
     3661 agacagactc agccacaagg aaacagtgaa atgagtagtc tcctggacac gttgggaaag
     3721 ccctatgcta gaaatgggag gctggatcta accagaataa ttactaacat cttccaggtg
     3781 gggagcctgg gttgtgtggg agagcatttc agggaggggc tgttccctct gagggaatgg
     3841 caatagtggt caggatgtgc tgtgaagtgg gatggtgcag acccatctaa tgttcctcaa
     3901 agcaatggga agccatagga gggcgctaaa agaaaagggg atccagtttt atggtgaggt
     3961 ggaggggctg ctgatactaa gaaaagcacc tgagagtgtg agaattgggg ggcaggtata
     4021 cattggagga ccctcaggcc tggtaagagg aggaaagaat gatcacagct aggtgctggg
     4081 gtagagaacc caggatctcc atccctgtca tatgcactag aagatgggat cagccttgta
     4141 actcaagcgt gcctcaaaaa gagagctgtg ttgggtaagg acagcaaaga caagcctttg
     4201 aaaacacaaa gtgactgatg tacctagagg aaaggccgtt ctgtctagat tattctcact
     4261 cagaggtgcc tgtgccctgg gccaggacag tatggaatat aaagttctgt ggggagacaa
     4321 aaaagaacta ataaacttta tatagccttt gttttcaaat aaaaaaaaaa aaaaaaaaaa
     4381 aaaaaaaa
//
