LOCUS       NP_001094448             238 aa            linear   ROD 23-MAR-2023
DEFINITION  transmembrane protein 127 [Rattus norvegicus].
ACCESSION   NP_001094448 XP_001057254 XP_001081091 XP_230574
VERSION     NP_001094448.1
DBSOURCE    REFSEQ: accession NM_001100978.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 238)
  AUTHORS   Qin Y, Deng Y, Ricketts CJ, Srikantan S, Wang E, Maher ER and Dahia
            PL.
  TITLE     The tumor susceptibility gene TMEM127 is mutated in renal cell
            carcinomas and modulates endolysosomal function
  JOURNAL   Hum Mol Genet 23 (9), 2428-2439 (2014)
   PUBMED   24334765
REFERENCE   2  (residues 1 to 238)
  AUTHORS   Qin Y, Yao L, King EE, Buddavarapu K, Lenci RE, Chocron ES,
            Lechleiter JD, Sass M, Aronin N, Schiavi F, Boaretto F, Opocher G,
            Toledo RA, Toledo SP, Stiles C, Aguiar RC and Dahia PL.
  TITLE     Germline mutations in TMEM127 confer susceptibility to
            pheochromocytoma
  JOURNAL   Nat Genet 42 (3), 229-233 (2010)
   PUBMED   20154675
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC131850.1.
            
            On or before Aug 12, 2007 this sequence version replaced
            XP_001057254.1, XP_230574.2, XP_001081091.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC131850.1, FQ230469.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..238
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     Protein         1..238
                     /product="transmembrane protein 127"
                     /calculated_mol_wt=25727
     Region          84..196
                     /region_name="TMEM127"
                     /note="Transmembrane protein 127; pfam20517"
                     /db_xref="CDD:466666"
     CDS             1..238
                     /gene="Tmem127"
                     /gene_synonym="RGD1309744"
                     /coded_by="NM_001100978.1:208..924"
                     /db_xref="GeneID:311405"
                     /db_xref="RGD:1309744"
ORIGIN      
        1 myapggaglp ggrrrrspgs salpkqpers lasalpgals italctalae pawlhihggt
       61 csrqelgvsd vlgyvhpdll kdfcmnpqtv lllrviaafc flgilcslsa flldvfgpkh
      121 palkitrrya fahiltvlqc atvigfsywa selilaqqqq hkkyhgsqvy vtfavsfylv
      181 agaggasila taanllrhyp teeeeqalel lsemeendpy paeyevinqf qpppaytp
//
