LOCUS       NM_001106280             870 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus transmembrane protein 126B (Tmem126b), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001106280 XM_001062219 XM_214995
VERSION     NM_001106280.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 870)
  AUTHORS   Sanchez-Caballero,L., Ruzzenente,B., Bianchi,L., Assouline,Z.,
            Barcia,G., Metodiev,M.D., Rio,M., Funalot,B., van den Brand,M.A.,
            Guerrero-Castillo,S., Molenaar,J.P., Koolen,D., Brandt,U.,
            Rodenburg,R.J., Nijtmans,L.G. and Rotig,A.
  TITLE     Mutations in Complex I Assembly Factor TMEM126B Result in Muscle
            Weakness and Isolated Complex I Deficiency
  JOURNAL   Am J Hum Genet 99 (1), 208-216 (2016)
   PUBMED   27374773
REFERENCE   2  (bases 1 to 870)
  AUTHORS   Heide,H., Bleier,L., Steger,M., Ackermann,J., Drose,S., Schwamb,B.,
            Zornig,M., Reichert,A.S., Koch,I., Wittig,I. and Brandt,U.
  TITLE     Complexome profiling identifies TMEM126B as a component of the
            mitochondrial complex I assembly complex
  JOURNAL   Cell Metab 16 (4), 538-549 (2012)
   PUBMED   22982022
  REMARK    GeneRIF: TMEM126B as a previously overlooked component of the
            mitochondrial complex I assembly factor (MCIA) complex and show
            that this protein is indeed required for the formation of
            respiratory chain complex I.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC167111.1.
            
            On May 11, 2008 this sequence version replaced NM_001106280.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC167111.1, FQ223509.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..870
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..870
                     /gene="Tmem126b"
                     /gene_synonym="RGD1308371"
                     /note="transmembrane protein 126B"
                     /db_xref="GeneID:293114"
                     /db_xref="RGD:1308371"
     exon            1..88
                     /gene="Tmem126b"
                     /gene_synonym="RGD1308371"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..700
                     /gene="Tmem126b"
                     /gene_synonym="RGD1308371"
                     /codon_start=1
                     /product="complex I assembly factor TMEM126B,
                     mitochondrial"
                     /protein_id="NP_001099750.2"
                     /db_xref="GeneID:293114"
                     /db_xref="RGD:1308371"
                     /translation="MASERPTGSESGDAGVVLEGNREASQDIKMALYKHGRLIPSLGE
                     AKFGRPMIAEILEKKFESYRNDQTLNIRGTLFFGVSSSLSGVMANLVFRYSFKVKYEA
                     LRTYASLTTLPFVATAVTYKLFVTDALQSGNISQESCVLRSSLIGVACGVSYPSALAF
                     YKNGRLAVKYHTVPVPPKGRVMLHWLLLCQTGMKAMAVPLLFQIIFGVFNGLYHYAVC
                     EKAYARIVPDD"
     exon            89..210
                     /gene="Tmem126b"
                     /gene_synonym="RGD1308371"
                     /inference="alignment:Splign:2.1.0"
     exon            211..404
                     /gene="Tmem126b"
                     /gene_synonym="RGD1308371"
                     /inference="alignment:Splign:2.1.0"
     exon            405..516
                     /gene="Tmem126b"
                     /gene_synonym="RGD1308371"
                     /inference="alignment:Splign:2.1.0"
     exon            517..848
                     /gene="Tmem126b"
                     /gene_synonym="RGD1308371"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcgccaaa atggcgtccg agcgaccaac tgggtctgaa tcgggggatg ctggtgtggt
       61 gctggaggga aatagggaag catcccagga catcaagatg gcactttaca agcatggtcg
      121 gctgattccc tctctaggag aagcgaagtt cggaagacca atgatcgctg aaatcttaga
      181 gaagaagttt gagtcttata gaaacgacca gactttaaat atacgtggaa ctttattctt
      241 tggagtaagt agtagtttgt ctggcgttat ggcaaactta gtattcagat acagtttcaa
      301 ggttaagtat gaagctttga ggacctatgc atccctgact acccttccat ttgtggctac
      361 cgccgttact tacaagctct ttgtgactga tgctctgcaa tcaggtaata taagccagga
      421 aagctgtgtt ctgagaagct cactgatcgg cgtagcctgt ggggtctcct atcccagtgc
      481 tttggctttt tataaaaatg gacgcttagc agttaagtat cacactgttc cagtgccgcc
      541 aaagggaaga gttatgctcc attggttact cctttgtcaa actgggatga aagcaatggc
      601 cgttcctctg ttgtttcaga taatatttgg agtgtttaat ggcttatatc actatgctgt
      661 atgtgaaaaa gcatatgcaa gaattgtgcc tgatgattaa cccaagaatc agtggaggct
      721 agttcagtag aatgaacctc tttataaaag gtctttggca ctggtgtaaa agtgaaaagg
      781 aactctgcta ctttcaccta gcattatgag atcctcagta attataaatg ttataaatgt
      841 taaacaaaaa aaaaaaaaaa aaaaaaaaaa
//
