LOCUS       NM_001007736            1924 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus transmembrane protein 109 (Tmem109), mRNA.
ACCESSION   NM_001007736 XM_342025
VERSION     NM_001007736.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1924)
  AUTHORS   Reilly-O'Donnell,B., Robertson,G.B., Karumbi,A., McIntyre,C.,
            Bal,W., Nishi,M., Takeshima,H., Stewart,A.J. and Pitt,S.J.
  TITLE     Dysregulated Zn2+ homeostasis impairs cardiac type-2 ryanodine
            receptor and mitsugumin 23 functions, leading to sarcoplasmic
            reticulum Ca2+ leakage
  JOURNAL   J Biol Chem 292 (32), 13361-13373 (2017)
   PUBMED   28630041
  REMARK    GeneRIF: Data, including data from studies in vesicles of knockout
            mice, suggest pathophysiological levels of Zn2+ (>2nM) cause
            dysregulation of RyR2 opening; in sarcoplasmic reticulum, RyR2 are
            not the only Ca2+-channels regulated by Zn2+; in cardiomyocytes
            exposed to ischemic/hypoxic conditions, intracellular Zn2+ levels
            are elevated, coinciding with increased MG23 expression. (RyR2 =
            ryanodine receptor 2; MG23 = mitsugumin 23)
REFERENCE   2  (bases 1 to 1924)
  AUTHORS   Yamashita,A., Taniwaki,T., Kaikoi,Y. and Yamazaki,T.
  TITLE     Protective role of the endoplasmic reticulum protein mitsugumin23
            against ultraviolet C-induced cell death
  JOURNAL   FEBS Lett 587 (9), 1299-1303 (2013)
   PUBMED   23542032
REFERENCE   3  (bases 1 to 1924)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 1924)
  AUTHORS   Yamazaki,T., Sasaki,N., Nishi,M. and Takeshima,H.
  TITLE     Facilitation of DNA damage-induced apoptosis by endoplasmic
            reticulum protein mitsugumin23
  JOURNAL   Biochem Biophys Res Commun 392 (2), 196-200 (2010)
   PUBMED   20060811
REFERENCE   5  (bases 1 to 1924)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078955.1.
            
            On Nov 29, 2004 this sequence version replaced XM_342025.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078955.1, EV774695.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760475, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1924
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1924
                     /gene="Tmem109"
                     /note="transmembrane protein 109"
                     /db_xref="GeneID:361732"
                     /db_xref="RGD:1359538"
     exon            1..63
                     /gene="Tmem109"
                     /inference="alignment:Splign:2.1.0"
     exon            64..308
                     /gene="Tmem109"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..803
                     /gene="Tmem109"
                     /note="mg23; mitsugumin-23; voltage-gated monoatomic
                     cation channel TMEM109"
                     /codon_start=1
                     /product="voltage-gated monoatomic cation channel TMEM109
                     precursor"
                     /protein_id="NP_001007737.1"
                     /db_xref="GeneID:361732"
                     /db_xref="RGD:1359538"
                     /translation="MAGAHSNPSWSRHLFKAVLMVLGALLLVHSASAQTHREFASPGQ
                     QKRESSADILTEIGRSLKETLDTWLGPETMHVISETLLQVMWAISSAISVACFALSGI
                     AAQLLSALGLDGEQLTQVLKLSPSQVQTLLLWGAAALVIYWLLSLLLGLVLALLGRIL
                     GGLKLVLFVAGFVGLVRSVPDPSTRALLLLALLTVFALLSRLTGSRSSGTHLEAKVRG
                     LERQIEELRGRQRRAAKIPRSMEEE"
     exon            309..411
                     /gene="Tmem109"
                     /inference="alignment:Splign:2.1.0"
     exon            412..1893
                     /gene="Tmem109"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggtttgg tggcgcgttt tctagcgaag tcccacgtga aggatagcgg tggccggagc
       61 aggacacaaa catggcaggc gcacacagca atccatcatg gagcaggcat ctgttcaaag
      121 ctgtcctaat ggtcctaggg gcccttctcc tcgtccactc agcatcagcc cagactcatc
      181 gagagtttgc ctcacctggc caacagaaga gggagtcctc agctgatatt ctgaccgaga
      241 ttggccgatc tctgaaggag acgttggata cctggctggg gccagagacc atgcatgtga
      301 tttcagagac cctgctgcag gtgatgtggg ccatctcatc agccatctct gtggcctgct
      361 ttgccctgtc tgggattgct gcccagttgc tgagtgccct ggggctggat ggtgaacaac
      421 tcacccaggt cttgaagctc agccctagcc aagtccagac ccttctactg tggggagcag
      481 cagcactggt catctactgg ttgctgtccc tgctcctagg cttggtcttg gccttgctag
      541 gacggatcct ggggggtctg aagcttgtcc tcttcgtggc tggctttgtg ggcctggtga
      601 ggtcggtgcc cgacccatcg acccgggcct tgctgctctt ggccttgcta actgtctttg
      661 ccttgctgag tcggctcacc ggctccagga gctcggggac ccacctagaa gccaaggtga
      721 gagggctgga gcgccagata gaagagcttc gagggaggca gaggcgagca gccaagatac
      781 ccaggagcat ggaggaagaa tgacaagggt atcccaaagt gacaccctca ccgtaccaaa
      841 gagctgagct gcctctgggt ctcatggccc tccttgcagc accccccctc tcccttccca
      901 gccctttcct tgcctcgtgt tggaaccctt cacaccctta cccctgcgct agcccctagc
      961 tgagagaaga gaacctgtcc tctgccaggt actcagtcaa ggggtggctc ccagcctgcc
     1021 tcccccaggg cgggttggag agacctcagc cctggcttct gctctcagcc agcaccactg
     1081 ccactgatct cccgtgatga ttaaccttct gctgcctggc ttcctttcaa aaggccttcc
     1141 caggctgacc acaccctcag ctcctttctt cctactcccg gccacactac catccctagt
     1201 cccttgaggc ccttatgtct tcctcactgc ccagcagggg gaaggggaag gagatttgag
     1261 acctgaggat aagggaggag gaaacggtct ggaggcctgt gcacctatgt tctgttacaa
     1321 gtgccttaac aggagtcagt agcaccctcc agttgtccct tgccacactg aatataggaa
     1381 agtgtcctat ggctactttg tgttcagagt gagctgtcct ttgcagaatc cccactccag
     1441 caaacaaagc aaaggctggg gccctgctgt agggactgtt aaatctccct tggggatttc
     1501 agggaccttg aaaaagacag gaggacctgc tgtcttgcag ttttactcct gtccactctg
     1561 ccatccagga gcaacccttg gtcagtgttg tgtcccagtg gctgtgaagg gcaaggtctt
     1621 gccctgatct gttctgcagg gctaggaggg agcctggcac ttacccctct tcaccagggc
     1681 acttgctcac tcctggcctt ggcctttatg gccctggtgg agggaggtgt cctatgccag
     1741 gtccagcaca agatgtgaag aataaatcta ttcttactga taaggtttga tgtggaatca
     1801 cggctgcagt gatatatttt tatcagcgct tggtggtttt aaaaaaagtg catgctattt
     1861 tattatcttc tgaataaaat gtatttactc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1921 aaaa
//
