LOCUS       NM_001004267            1879 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus transmembrane protein 106B (Tmem106b), mRNA.
ACCESSION   NM_001004267 XM_231500
VERSION     NM_001004267.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1879)
  AUTHORS   Zhou,X., Sun,L., Bastos de Oliveira,F., Qi,X., Brown,W.J.,
            Smolka,M.B., Sun,Y. and Hu,F.
  TITLE     Prosaposin facilitates sortilin-independent lysosomal trafficking
            of progranulin
  JOURNAL   J Cell Biol 210 (6), 991-1002 (2015)
   PUBMED   26370502
REFERENCE   2  (bases 1 to 1879)
  AUTHORS   Stagi,M., Klein,Z.A., Gould,T.J., Bewersdorf,J. and
            Strittmatter,S.M.
  TITLE     Lysosome size, motility and stress response regulated by
            fronto-temporal dementia modifier TMEM106B
  JOURNAL   Mol Cell Neurosci 61, 226-240 (2014)
   PUBMED   25066864
REFERENCE   3  (bases 1 to 1879)
  AUTHORS   Schwenk,B.M., Lang,C.M., Hogl,S., Tahirovic,S., Orozco,D.,
            Rentzsch,K., Lichtenthaler,S.F., Hoogenraad,C.C., Capell,A.,
            Haass,C. and Edbauer,D.
  TITLE     The FTLD risk factor TMEM106B and MAP6 control dendritic
            trafficking of lysosomes
  JOURNAL   EMBO J 33 (5), 450-467 (2014)
   PUBMED   24357581
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079127.1.
            
            On Sep 10, 2004 this sequence version replaced XM_231500.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079127.1, EV769119.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1879
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q21"
     gene            1..1879
                     /gene="Tmem106b"
                     /gene_synonym="LRRGT00101"
                     /note="transmembrane protein 106B"
                     /db_xref="GeneID:312132"
                     /db_xref="RGD:1303037"
     exon            1..19
                     /gene="Tmem106b"
                     /gene_synonym="LRRGT00101"
                     /inference="alignment:Splign:2.1.0"
     exon            20..119
                     /gene="Tmem106b"
                     /gene_synonym="LRRGT00101"
                     /inference="alignment:Splign:2.1.0"
     exon            120..341
                     /gene="Tmem106b"
                     /gene_synonym="LRRGT00101"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..949
                     /gene="Tmem106b"
                     /gene_synonym="LRRGT00101"
                     /codon_start=1
                     /product="transmembrane protein 106B"
                     /protein_id="NP_001004267.1"
                     /db_xref="GeneID:312132"
                     /db_xref="RGD:1303037"
                     /translation="MGKSLSHLPLHSNKEDGYDGVTSTDNMRNGLVSSEVRNEDGRSG
                     DVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMAS
                     VFVCLLLSGLAVFFLFPRSIDVKYIGVKSAYVSYDSQKRMIYLNITNTLNITNNNYYS
                     VEVENITAQVQFSKTVIGKARLSNITNIGPLDMKQIDYTVPTVIAEEMSYMYDFCTLP
                     SIKVHNIVLMMQVTVTTAYFGHSEQISQERYQYVDCGRNTTYQLAQSEYLNVLQPQQ"
     exon            342..405
                     /gene="Tmem106b"
                     /gene_synonym="LRRGT00101"
                     /inference="alignment:Splign:2.1.0"
     exon            406..565
                     /gene="Tmem106b"
                     /gene_synonym="LRRGT00101"
                     /inference="alignment:Splign:2.1.0"
     exon            566..706
                     /gene="Tmem106b"
                     /gene_synonym="LRRGT00101"
                     /inference="alignment:Splign:2.1.0"
     exon            707..756
                     /gene="Tmem106b"
                     /gene_synonym="LRRGT00101"
                     /inference="alignment:Splign:2.1.0"
     exon            757..810
                     /gene="Tmem106b"
                     /gene_synonym="LRRGT00101"
                     /inference="alignment:Splign:2.1.0"
     exon            811..1854
                     /gene="Tmem106b"
                     /gene_synonym="LRRGT00101"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcagcactc cgcgtgcgga gcatctgaga accgtgttga gttcacagga ccgcgacata
       61 aacattgaga gcctggggag gaaacgaagg ggatctagca ttccttttaa aaacctcaaa
      121 catgggaaag tctctttctc atttaccttt gcattccaat aaagaagatg gctatgatgg
      181 ggtcacatca acagacaata tgaggaatgg attggttagc agtgaggtgc gtaacgaaga
      241 cggaagaagt ggagacgtct ctcagtttcc atacgtggag tttactggaa gagatagtgt
      301 cacttgtccc acttgtcaag ggacaggaag aatccctagg gggcaagaaa accaactggt
      361 ggcattgatt ccatatagtg atcaacggtt acgaccaaga agaacaaagc tgtatgtgat
      421 ggcatctgtg tttgtctgcc tgctcctgtc tggattggct gtgttttttc ttttccctcg
      481 atctattgac gtgaagtaca ttggtgtaaa atcagcctat gttagttacg actctcaaaa
      541 gcgaatgata tatttaaaca tcacgaacac actaaatata acaaataata actattattc
      601 tgttgaagtt gaaaacatca ctgctcaagt tcagttttca aaaacagtga ttgggaaggc
      661 acggttaagc aacataacta acattggccc acttgatatg aagcagattg attatacggt
      721 acccacagtt attgccgagg aaatgagcta catgtatgat ttctgtacac tgccctccat
      781 caaagtacac aacatagtac tcatgatgca agttactgta acaacagcat actttggaca
      841 ctctgagcag atatctcagg agaggtacca gtatgttgac tgtggaagga acacgactta
      901 ccagttggcc cagtctgagt atctaaatgt ccttcagcca caacaataaa ctctaaagga
      961 gatgtggtta gacccagcac cacacctgag acatggtcag agctgtcagt gaggaggtac
     1021 tgcctctaag gacatcttta attgagcatg tctaaagttt acactgggat gttggcgatc
     1081 cagctaacag aatttggtcc ttatgcagtt cctggactct gttttctgtg ttgacgattt
     1141 gctcccacca cgagcttttc ctccatccaa tgttaactga ttggctttct tctcaccttt
     1201 gttcccaagg tgaaaaattg agacttcctt agaatacaat aaatgattat ataaaagtca
     1261 tagatttaat ctatatatct attgataata tagttcaatc ctgaacataa tttgaaaaat
     1321 aacttctgaa gatttttata tattactgaa agcctattat tcatggagaa cttttaaaaa
     1381 ctgacctgtt ttataaattc ccattcttac atagtaaact ttcaactata tgaataactt
     1441 agctattagc taaatgtttt tagcctttaa tttcttcaaa ttctacaggt ttgcatgttt
     1501 cgtcttattt ctagctaatg gttgcataat attcaccaac cataacagtc tgccaaattc
     1561 tgtcctacat tttataagaa cctctcagta tgtgtttcat gtatagcttt gtgaacttcc
     1621 tgtgtgatct tcaaacactt taatgtacaa tattgtaaat aaactgcatg gcttttatac
     1681 agctttgata aatgtcaaat gaagtggtac agattaagaa gtaaagcaag ttgctcataa
     1741 aaaataaagt aggaaaatga aattcagaaa cctatgaagt atcagtaggt tccagctaca
     1801 tgttggatct ggcataaaat agatgcacaa taaaacactt tgctgctctc tctaaaaaaa
     1861 aaaaaaaaaa aaaaaaaaa
//
