LOCUS       NM_001394330            2977 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus transmembrane protein with EGF-like and two
            follistatin-like domains 2 (Tmeff2), mRNA.
ACCESSION   NM_001394330 XM_017596515
VERSION     NM_001394330.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2977)
  AUTHORS   Chen,X., Corbin,J.M., Tipton,G.J., Yang,L.V., Asch,A.S. and
            Ruiz-Echevarria,M.J.
  TITLE     The TMEFF2 tumor suppressor modulates integrin expression, RhoA
            activation and migration of prostate cancer cells
  JOURNAL   Biochim Biophys Acta 1843 (6), 1216-1224 (2014)
   PUBMED   24632071
REFERENCE   2  (bases 1 to 2977)
  AUTHORS   Kumarasamy,S., Gopalakrishnan,K., Toland,E.J., Yerga-Woolwine,S.,
            Farms,P., Morgan,E.E. and Joe,B.
  TITLE     Refined mapping of blood pressure quantitative trait loci using
            congenic strains developed from two genetically hypertensive rat
            models
  JOURNAL   Hypertens Res 34 (12), 1263-1270 (2011)
   PUBMED   21814219
  REMARK    GeneRIF: Tmeff2 can be prioritized as a candidate gene for
            hypertension and associated cardiac hypertrophy in both rats and in
            humans
REFERENCE   3  (bases 1 to 2977)
  AUTHORS   Chen,Q., Watson,J.T., Marengo,S.R., Decker,K.S., Coleman,I.,
            Nelson,P.S. and Sikes,R.A.
  TITLE     Gene expression in the LNCaP human prostate cancer progression
            model: progression associated expression in vitro corresponds to
            expression changes associated with prostate cancer progression in
            vivo
  JOURNAL   Cancer Lett 244 (2), 274-288 (2006)
   PUBMED   16500022
REFERENCE   4  (bases 1 to 2977)
  AUTHORS   Afar,D.E., Bhaskar,V., Ibsen,E., Breinberg,D., Henshall,S.M.,
            Kench,J.G., Drobnjak,M., Powers,R., Wong,M., Evangelista,F.,
            O'Hara,C., Powers,D., DuBridge,R.B., Caras,I., Winter,R.,
            Anderson,T., Solvason,N., Stricker,P.D., Cordon-Cardo,C.,
            Scher,H.I., Grygiel,J.J., Sutherland,R.L., Murray,R.,
            Ramakrishnan,V. and Law,D.A.
  TITLE     Preclinical validation of anti-TMEFF2-auristatin E-conjugated
            antibodies in the treatment of prostate cancer
  JOURNAL   Mol Cancer Ther 3 (8), 921-932 (2004)
   PUBMED   15299075
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Apr 13, 2021 this sequence version replaced XM_017596515.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.35298.1,
                                           SRR26643285.34431.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-600               JAXUCZ010000009.1  58224773-58225372   c
            601-710             JAXUCZ010000009.1  58222244-58222353   c
            711-840             JAXUCZ010000009.1  58214130-58214259   c
            841-867             JAXUCZ010000009.1  58209285-58209311   c
            868-964             JAXUCZ010000009.1  58073226-58073322   c
            965-1113            JAXUCZ010000009.1  57994870-57995018   c
            1114-1173           JAXUCZ010000009.1  57994143-57994202   c
            1174-1297           JAXUCZ010000009.1  57944082-57944205   c
            1298-1456           JAXUCZ010000009.1  57942831-57942989   c
            1457-2977           JAXUCZ010000009.1  57937873-57939393   c
FEATURES             Location/Qualifiers
     source          1..2977
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q22"
     gene            1..2977
                     /gene="Tmeff2"
                     /note="transmembrane protein with EGF-like and two
                     follistatin-like domains 2"
                     /db_xref="GeneID:363228"
                     /db_xref="RGD:1308839"
     exon            1..600
                     /gene="Tmeff2"
                     /inference="alignment:Splign:2.1.0"
     CDS             429..1553
                     /gene="Tmeff2"
                     /codon_start=1
                     /product="tomoregulin-2"
                     /protein_id="NP_001381259.1"
                     /db_xref="GeneID:363228"
                     /db_xref="RGD:1308839"
                     /translation="MVLWESPRQCSSWTLCEGFCWLLLLPVTLLIIARPVKLAAFPTS
                     LSDCQTPTGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNSDYVPV
                     CGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETS
                     TCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEK
                     IEVMSLGRCQDNTTTTTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHG
                     KCEHSINMQEPSCRCDAGYTGQHCEKKDYSVLYVVPGPVRFQYVLIAAVIGTIQIAVI
                     CVVVLCITRKCPRSNRIHRQKQNTGHYSSDNTTRASTRLI"
     exon            601..710
                     /gene="Tmeff2"
                     /inference="alignment:Splign:2.1.0"
     exon            711..840
                     /gene="Tmeff2"
                     /inference="alignment:Splign:2.1.0"
     exon            841..867
                     /gene="Tmeff2"
                     /inference="alignment:Splign:2.1.0"
     exon            868..964
                     /gene="Tmeff2"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1113
                     /gene="Tmeff2"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1173
                     /gene="Tmeff2"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1297
                     /gene="Tmeff2"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1456
                     /gene="Tmeff2"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..2977
                     /gene="Tmeff2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagggatgc gggcggcaga gcgcgagagg cggcggctgg gctgcggggc gctgtgactg
       61 tccctccacc cagtctggtc gcgctcctct cttcggccgg ttgcccgcct cctctctgca
      121 ccctggtttc tgtctcctgc tcctcctttg ccccgaccct gttcctatgg cagcagctcc
      181 ctgcgtctgg ggcgcagctt ctcagcggac tatcccctcg ctccgcaggc tgagcccagt
      241 cactggatgt tgctgaaact ccggagatca tgcgctcctt tggccgcagc ctcaccgccg
      301 gctgtctctg ctgccgcccc ctcctctgct gccgaggtcc gcgggatgct cagtagcccg
      361 ctgcgtggcc cccgcgatcc cgtgttcttc agaagccgtt ggttgctgca gagttgcgcg
      421 aagtagtcat ggtgctgtgg gagtccccgc ggcagtgcag cagctggaca ctttgcgagg
      481 gcttctgctg gctgctgctg ctgccggtga cgctgcttat catagcccgc ccggtgaaac
      541 tcgctgcttt ccctacctcc ttaagtgact gccaaacgcc caccggctgg aactgctccg
      601 gttacgatga cagagaaaat gatctcttcc tgtgtgatac caacacctgt aaatttgacg
      661 gggaatgtct aaggattgga gacactgtga cttgcgtctg tcagttcaag tgtaacagtg
      721 actacgtgcc tgtgtgtggc tccaatggag agagctacca gaatgaatgc tacctgaggc
      781 aagctgcctg caagcaacag agtgagatac ttgtggtctc agaaggatcc tgtgctacag
      841 atgcaggatc gggatctgga gacggagtcc atgaaggctc tggagagacc agtcagaagg
      901 agacatctac ctgtgacatt tgccagtttg gtgcggaatg cgatgaagat gctgaggatg
      961 tctggtgtgt gtgcaacatt gactgttctc aaaccaactt taatcccctc tgtgcttctg
     1021 atgggaaatc ttatgataat gcatgtcaaa tcaaagaagc gtcatgtcag aaacaggaga
     1081 aaattgaagt catgtctctg ggtcgatgtc aagataacac aactacaacc actaaatctg
     1141 aagatgggca ttatgcaaga acagattatg cagagaatgc taacaaatta gaagaaagtg
     1201 ccagagaaca ccacatacct tgtccagaac actacaacgg tttctgcatg catggcaagt
     1261 gtgaacactc catcaatatg caggagccat cttgcagatg tgatgctggt tatactggtc
     1321 aacactgtga aaagaaggac tacagtgttc tctacgttgt tcctggtcct gtaagattcc
     1381 agtacgtctt gattgcagct gtgattggaa caattcagat tgctgtcatc tgtgtggtgg
     1441 tcctctgtat cacaaggaaa tgtcccagaa gcaacagaat tcacagacag aagcaaaata
     1501 cagggcacta cagttcagac aacacaacaa gagcatccac acggttaatc tagagggagc
     1561 atgtttccca gtggccggac aaccgacagc ttggactaca caatacagta ttagagacaa
     1621 aagaataaga cgagatctac acatgttgcc ttgcgtttgt ggtaatctac gccaatgaaa
     1681 acatgtacta caactatatt tgattatgta tggatatatt tgaaatagta tacattgtct
     1741 tgatgttttt ctgtaatgta aataaactat ttatatcaca caatatagtt ttttctttcc
     1801 catgtatttg ttatatataa taaatactca gtgatgagaa aaaaatggct ttcttaaact
     1861 tgcagtaatt catagctgta gacacagttt aactgtcaca ggctatgcag acagcaatat
     1921 ttcatccctc tgtgcatctt cagacaatac attagtttgc acaggaatct gtagctagct
     1981 tttgagtgat tccgagatca aaggatatac tggttattgg caaagaggaa aaaataattt
     2041 agtttattga ggaagcataa gatatgtcat tgccttggat catctctgtt tcatctactt
     2101 tcctccctgt ctttcactgc cattcccagg acagaaaact ctctggcata aaagctacag
     2161 aagagaagaa gggaaggagg gaatgaggga agaagggaag tgttttgtag ctcaaaataa
     2221 aatgcaaaaa ggatacttgt ctttactgaa aagcaacata actatcttag ttaaatacat
     2281 ctaccctggg tgttctgaga aagctatctg ttaggtgtat aaacagtggt caaacctatt
     2341 ttgtatttgt ttctgcaagc aggaataaga gctaagagaa cattgtaact gtgtcaataa
     2401 gtatgagtcc aaactgtggc ttcttagaag acccttgctg tgtttatatc ttatttgaaa
     2461 agaagttaga ctagcaaaca aatgccccaa gaacagtttt atggcccaaa gagtactgtt
     2521 attcgaaact gaaatacaaa aagacaatgt ttttatgaca atggagaaat acgttttaag
     2581 catatttaca gaaggaagaa aatccctgag aatctaaggg actttcatga gcgctgttgt
     2641 taactcctat gggatctgag cagacaggta tgaatggtca atttgcttcg ggaaagtaaa
     2701 ttgggaaaat tctcaaggaa taagatgaaa taccaaatta agtaatttat tatagtttac
     2761 ctttgagtag ttcctgtggc acatatgggt gatttaaata aagctttatt tgtcttcctc
     2821 aaatgacttc ttcatggact aaaagaaatg gcatcccctc ctttgttacg aaccaaaaaa
     2881 acacatagca aatcaaaatg ttctggatat aaaatattct atgaaaaaat aagagtctga
     2941 ggtgaaattt aaactacctg ttaatgtata ataaagc
//
