LOCUS       NM_001106183             867 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus transmembrane p24 trafficking protein 6 (Tmed6),
            mRNA.
ACCESSION   NM_001106183 XM_001076527 XM_214683
VERSION     NM_001106183.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 867)
  AUTHORS   Wang X, Yang R, Jadhao SB, Yu D, Hu H, Glynn-Cunningham N, Sztalryd
            C, Silver KD and Gong DW.
  TITLE     Transmembrane emp24 protein transport domain 6 is selectively
            expressed in pancreatic islets and implicated in insulin secretion
            and diabetes
  JOURNAL   Pancreas 41 (1), 10-14 (2012)
   PUBMED   22129529
  REMARK    GeneRIF: Data suggest that TMED6 may play a functional role in
            islet biology, particularly in hormone production or secretion, and
            its dysregulation may be implicated in the development of diabetes.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473972.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001076527.1, XM_214683.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680414
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..867
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..867
                     /gene="Tmed6"
                     /gene_synonym="RGD1305260"
                     /note="transmembrane p24 trafficking protein 6"
                     /db_xref="GeneID:291991"
                     /db_xref="RGD:1305260"
     exon            1..248
                     /gene="Tmed6"
                     /gene_synonym="RGD1305260"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..752
                     /gene="Tmed6"
                     /gene_synonym="RGD1305260"
                     /note="transmembrane emp24 domain-containing protein 6;
                     transmembrane emp24 protein transport domain containing 6"
                     /codon_start=1
                     /product="transmembrane emp24 domain-containing protein 6
                     precursor"
                     /protein_id="NP_001099653.1"
                     /db_xref="GeneID:291991"
                     /db_xref="RGD:1305260"
                     /translation="MFALLLEAGLVVLSLVTSAKSQRTDPLHGSKDQPLLRGADRHDF
                     AIVVHPGNTECFWQFADQMGYLYFSYEVQRTLGMSHDRHIVATAHTPQGFLIDTSQDV
                     RGQINFATQETGFYQLCLKNEQNRFSSIQVYLNFGVFYEGPEMDHKQSQRKQLNDTLD
                     AIEDSTRRVQNHVFHMWRFYNSARMRKVADFFLLQSNYSYVNWWSTAQSLAIVLSGVL
                     QLYFLKRLFTISTDTKKPRC"
     exon            249..375
                     /gene="Tmed6"
                     /gene_synonym="RGD1305260"
                     /inference="alignment:Splign:2.1.0"
     exon            376..524
                     /gene="Tmed6"
                     /gene_synonym="RGD1305260"
                     /inference="alignment:Splign:2.1.0"
     exon            525..867
                     /gene="Tmed6"
                     /gene_synonym="RGD1305260"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaactcacc tgcagaagaa tccacagaag gcagcatgtt cgctttgctt cttgaggctg
       61 ggctggtggt tctgagccta gtgacttctg ctaagagcca gaggacagat cccctacatg
      121 gctccaagga ccagcccctc ctccgtggag ctgaccgaca tgactttgcc atcgtggtcc
      181 atccgggaaa cacagaatgt ttctggcaat ttgctgacca gatgggatac ctgtacttca
      241 gctatgaggt tcagcgcact cttggaatgt cacatgaccg ccacattgtt gccacggcac
      301 ataccccaca gggtttcctt attgacacct cccaggatgt tcggggccag attaactttg
      361 ctacacaaga gacaggtttc tatcagcttt gtctaaaaaa tgagcagaat cgcttcagtt
      421 ctatacaagt gtatctcaac ttcggagtct tctatgaggg gcccgagatg gatcataaac
      481 agagtcaaag aaaacagctg aacgatactc tggacgccat agaggacagt acccggaggg
      541 tgcagaacca cgttttccac atgtggcgct tctacaactc tgccaggatg aggaaggtgg
      601 ctgacttttt cctcctgcag tctaactaca gctatgtgaa ctggtggtcc acagctcaga
      661 gccttgctat tgttctttcc ggggtcctcc agctctattt cctgaaacgg cttttcacca
      721 tctcaactga cacaaagaag ccaagatgct aacatagagc attatatgtc aaagatttga
      781 tcaaatcagc tttgttaagt tattggggtg gaaaaagtca atttaaatcc cgtctctgag
      841 tccatcaata aaggcaatgg cagtaat
//
