LOCUS       NM_031722               2005 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus transmembrane p24 trafficking protein 2 (Tmed2),
            transcript variant 2, mRNA.
ACCESSION   NM_031722
VERSION     NM_031722.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2005)
  AUTHORS   Hou,W., Gupta,S., Beauchamp,M.C., Yuan,L. and Jerome-Majewska,L.A.
  TITLE     Non-alcoholic fatty liver disease in mice with heterozygous
            mutation in TMED2
  JOURNAL   PLoS One 12 (8), e0182995 (2017)
   PUBMED   28797121
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2005)
  AUTHORS   Bonnon,C., Wendeler,M.W., Paccaud,J.P. and Hauri,H.P.
  TITLE     Selective export of human GPI-anchored proteins from the
            endoplasmic reticulum
  JOURNAL   J Cell Sci 123 (Pt 10), 1705-1715 (2010)
   PUBMED   20427317
REFERENCE   3  (bases 1 to 2005)
  AUTHORS   Jerome-Majewska,L.A., Achkar,T., Luo,L., Lupu,F. and Lacy,E.
  TITLE     The trafficking protein Tmed2/p24beta(1) is required for
            morphogenesis of the mouse embryo and placenta
  JOURNAL   Dev Biol 341 (1), 154-166 (2010)
   PUBMED   20178780
REFERENCE   4  (bases 1 to 2005)
  AUTHORS   Stepanchick,A. and Breitwieser,G.E.
  TITLE     The cargo receptor p24A facilitates calcium sensing receptor
            maturation and stabilization in the early secretory pathway
  JOURNAL   Biochem Biophys Res Commun 395 (1), 136-140 (2010)
   PUBMED   20361938
REFERENCE   5  (bases 1 to 2005)
  AUTHORS   Luo,W., Wang,Y. and Reiser,G.
  TITLE     p24A, a type I transmembrane protein, controls ARF1-dependent
            resensitization of protease-activated receptor-2 by influence on
            receptor trafficking
  JOURNAL   J Biol Chem 282 (41), 30246-30255 (2007)
   PUBMED   17693410
  REMARK    GeneRIF: p24A is a regulator of signal-dependent trafficking that
            controls ARF1-dependent resensitization of PAR-2
REFERENCE   6  (bases 1 to 2005)
  AUTHORS   Lanoix,J., Ouwendijk,J., Stark,A., Szafer,E., Cassel,D.,
            Dejgaard,K., Weiss,M. and Nilsson,T.
  TITLE     Sorting of Golgi resident proteins into different subpopulations of
            COPI vesicles: a role for ArfGAP1
  JOURNAL   J Cell Biol 155 (7), 1199-1212 (2001)
   PUBMED   11748249
REFERENCE   7  (bases 1 to 2005)
  AUTHORS   Barr,F.A., Preisinger,C., Kopajtich,R. and Korner,R.
  TITLE     Golgi matrix proteins interact with p24 cargo receptors and aid
            their efficient retention in the Golgi apparatus
  JOURNAL   J Cell Biol 155 (6), 885-891 (2001)
   PUBMED   11739402
REFERENCE   8  (bases 1 to 2005)
  AUTHORS   Goldberg,J.
  TITLE     Decoding of sorting signals by coatomer through a GTPase switch in
            the COPI coat complex
  JOURNAL   Cell 100 (6), 671-679 (2000)
   PUBMED   10761932
REFERENCE   9  (bases 1 to 2005)
  AUTHORS   Gommel,D., Orci,L., Emig,E.M., Hannah,M.J., Ravazzola,M.,
            Nickel,W., Helms,J.B., Wieland,F.T. and Sohn,K.
  TITLE     p24 and p23, the major transmembrane proteins of COPI-coated
            transport vesicles, form hetero-oligomeric complexes and cycle
            between the organelles of the early secretory pathway
  JOURNAL   FEBS Lett 447 (2-3), 179-185 (1999)
   PUBMED   10214941
REFERENCE   10 (bases 1 to 2005)
  AUTHORS   Blum,R., Feick,P., Puype,M., Vandekerckhove,J., Klengel,R.,
            Nastainczyk,W. and Schulz,I.
  TITLE     Tmp21 and p24A, two type I proteins enriched in pancreatic
            microsomal membranes, are members of a protein family involved in
            vesicular trafficking
  JOURNAL   J Biol Chem 271 (29), 17183-17189 (1996)
   PUBMED   8663407
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Mar 15, 2021 this sequence version replaced NM_031722.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062036.1, SRR22582416.1634999.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840111
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-278               JAXUCZ010000012.1  37722329-37722606   c
            279-471             JAXUCZ010000012.1  37720392-37720584   c
            472-579             JAXUCZ010000012.1  37717100-37717207   c
            580-2005            JAXUCZ010000012.1  37713522-37714947   c
FEATURES             Location/Qualifiers
     source          1..2005
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q15"
     gene            1..2005
                     /gene="Tmed2"
                     /gene_synonym="Rnp24"
                     /note="transmembrane p24 trafficking protein 2"
                     /db_xref="GeneID:65165"
                     /db_xref="RGD:69243"
     exon            1..278
                     /gene="Tmed2"
                     /gene_synonym="Rnp24"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..704
                     /gene="Tmed2"
                     /gene_synonym="Rnp24"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; transmembrane emp24 domain-containing protein
                     2; RNP21.4; membrane protein p24A; coated vesicle membrane
                     protein; p24beta1; p24 family protein beta-1; COPI-coated
                     vesicle membrane protein p24; transmembrane emp24 domain
                     trafficking protein 2"
                     /codon_start=1
                     /product="transmembrane emp24 domain-containing protein 2
                     isoform 2 precursor"
                     /protein_id="NP_113910.1"
                     /db_xref="GeneID:65165"
                     /db_xref="RGD:69243"
                     /translation="MVTLAELLVLLAALLATASGYFVSIDAHAEECFFERVTSGTKMG
                     LIFEVAEGGFLDIDVEITGPDNKGIYKGDRESSGKYTFAAHMDGTYKFCFSNRMSTMT
                     PKIVMFTIDIGEAPKGQDMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRA
                     INDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV"
     exon            279..471
                     /gene="Tmed2"
                     /gene_synonym="Rnp24"
                     /inference="alignment:Splign:2.1.0"
     exon            472..579
                     /gene="Tmed2"
                     /gene_synonym="Rnp24"
                     /inference="alignment:Splign:2.1.0"
     exon            580..2005
                     /gene="Tmed2"
                     /gene_synonym="Rnp24"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaaggggcg gagctgaggc ggcggcggct gaggcggcag cggtggcggc ggctccggag
       61 gccgcagtcc gcgtcccggc ttcggcccgt gccgcaccat ggtgacgctc gcagaactgc
      121 tggtgctgct ggccgcgctg ctggccacgg cctcgggcta cttcgtcagc atcgacgcgc
      181 acgccgagga gtgcttcttc gagcgggtca cctcgggcac caagatgggc ctcatcttcg
      241 aggtggcgga gggcggcttc ctggacatcg acgtggagat cacaggacca gataataaag
      301 gaatctataa aggagaccgg gagtccagcg ggaagtacac gtttgcagcc cacatggatg
      361 ggacatacaa gttctgcttt agtaatagga tgtccactat gactccaaag atagtgatgt
      421 tcaccattga cattggggag gctcctaaag gacaagacat ggagacagaa gctcatcaaa
      481 acaagctaga agaaatgatt aatgagctgg cagtggccat gacagccgta aagcacgaac
      541 aggagtacat ggaagtccgg gagagaatac acagagccat caatgacaac acaaacagca
      601 gagtggtcct ttggtccttc ttcgaagctc ttgttcttgt tgccatgaca ttgggacaga
      661 tctactacct gaagagattt tttgaagtcc ggagggttgt ttaaaaggcc ttttcctatt
      721 gatcccaaat tcatgattta cttgtttacc aaacaccttg gtcataataa tgtcattagt
      781 ttatacattt ttattttctg aacgttcatg acttatgttt ctttgtgatt attaggtgtt
      841 ggggaaaacc tgtttaggaa agttagagtg aaaatttgac atttggttgg cctgtaattc
      901 ttacttgaaa gcagcccatg atacaggtcc tttcaagagt tcagaggctg ttgatgctgt
      961 atgggactat ggtctttatt atgtttttac ctttggtttt catagtagaa tgcagttttt
     1021 ccaggaagtg cccacagcct gacatacttg ttaactaact gcattctagt agttccttgg
     1081 ctgtgcttca tcatcagagg ctccttttgt ttctccagca acagcgatct gaatcttgac
     1141 ccttgtggcc cctcctcagg gccaggagac ctgatggggc atgttaccag ggcgggcact
     1201 catactttct cttgagtttg atttaaagac tcatcgcaca cttcccccta aagttttata
     1261 ttgaacctta gaactgaatc acctctaatt gaattgacac aagcagccaa taacttagcc
     1321 gtctgtcgag tccagttccc cgggtgtcag acagacagac tgctgtccct gtgtgctgca
     1381 tatctgtctg ttgttggcac tcaggaagat ggagttcctc acgtggaagc ctgcacttct
     1441 caagctaaag ggttaaacct ctgggattgc ttgcagtgat ggcagccact gttgtccttt
     1501 tagtcagtgg ccttcgtgcc ctggtcttca gtgtcagcaa tagggtttat ttgtcctctg
     1561 gggtctttct tttttggcac atgtcagttt tgtttataaa agatgaagag actgtctctc
     1621 tgatgatggg cttaatgaaa ggcactctgc tttgggtgtg ggcggtccag gattatgtgg
     1681 tgactaatgt ctgttagtta cctggatatt ttatttttat ttttggatct tgcaagggga
     1741 aaactacaag taacaagttt tataaattta atttaaattt gttacaggtt ttcatgttca
     1801 ggacaaataa tttttcaacc ttcgatgata tcttgcaaca gttggttggt gactctgtca
     1861 ccctagggca gctgttgcat gccaattttt ttgtgtgtgt atgtgtgaaa acacttcaga
     1921 attgaattaa aagatgtaaa tttaaaatcg gttgtgtatc taatatgccc caagttcagt
     1981 aaataaacaa ttctttttaa aaaca
//
