LOCUS       NM_001305128            3516 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus transmembrane and coiled-coil domain family 2
            (Tmcc2), mRNA.
ACCESSION   NM_001305128 XM_001059693 XM_223107
VERSION     NM_001305128.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3516)
  AUTHORS   Hopkins,P.C., Sainz-Fuertes,R. and Lovestone,S.
  TITLE     The impact of a novel apolipoprotein E and amyloid-beta protein
            precursor-interacting protein on the production of amyloid-beta
  JOURNAL   J Alzheimers Dis 26 (2), 239-253 (2011)
   PUBMED   21593558
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On or before Feb 25, 2015 this sequence version replaced
            XM_223107.8, XM_001059693.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211467.1, SRR22582424.75609.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840109,
                                           SAMN12840111 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-406               JAXUCZ010000013.1  46383457-46383862   c
            407-931             JAXUCZ010000013.1  46373165-46373689   c
            932-1872            JAXUCZ010000013.1  46350046-46350986   c
            1873-2008           JAXUCZ010000013.1  46348632-46348767   c
            2009-3516           JAXUCZ010000013.1  46346177-46347684   c
FEATURES             Location/Qualifiers
     source          1..3516
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..3516
                     /gene="Tmcc2"
                     /gene_synonym="RGD1311960"
                     /note="transmembrane and coiled-coil domain family 2"
                     /db_xref="GeneID:305095"
                     /db_xref="RGD:1311960"
     exon            1..406
                     /gene="Tmcc2"
                     /gene_synonym="RGD1311960"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..2320
                     /gene="Tmcc2"
                     /gene_synonym="RGD1311960"
                     /note="transmembrane and coiled-coil domains 2"
                     /codon_start=1
                     /product="transmembrane and coiled-coil domains protein 2"
                     /protein_id="NP_001292057.1"
                     /db_xref="GeneID:305095"
                     /db_xref="RGD:1311960"
                     /translation="MKRCKSDELQQQQGEEDGAGMEDAACLLPGADLRHGEASSANSA
                     GGPTSDAGAAVAPNPGPRSKPPDLKKIQQLSEGSMFGHGLKHLFHSRRRSREREHQAS
                     QEAQQQQQHQGLSDQDSPDEKERSPEMHRVSYAVSLHDLPARPTAFNRVLQQIRSRPS
                     IKRGASLHSSGGSGGRRAKSSSLEPQRGSPHLLRKAPQDSSLTAILHQHQGRPRSSST
                     TDTALLLADGSNAYLLAEEAESTGDKGDKGDLVALSLPSGPGHGDTDGPISLDVPDGA
                     PDPQRTKAAIDHLHQKILKITEQIKIEQEARDDNVAEYLKLANNADKQQVSRIKQVFE
                     KKNQKSAQTIAQLHKKLEQYRRRLKEIEQNGPSRQPKDVLRDMQQGLKDVGANMRAGI
                     SGFGGGVVEGVKGSLSGLSQATHTAVVSKPREFASLIRNKFGSADNIAHLKDPMEDGP
                     PEEAARALSGSATLVSSPKYGSDDECSSASASSAGAGSNSGAGPAGALGSPRSNTLYG
                     APGNLDTLLEELREIKDGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQL
                     NDLTELHQNEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQQ
                     VVQLEGVENANARALLGKFINVILALMAVLLVFVSTIANFITPLMKTRLRITSTALLL
                     LVLFLLWKHWDSLTYLLEHVLLPS"
     exon            407..931
                     /gene="Tmcc2"
                     /gene_synonym="RGD1311960"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1872
                     /gene="Tmcc2"
                     /gene_synonym="RGD1311960"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2008
                     /gene="Tmcc2"
                     /gene_synonym="RGD1311960"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..3516
                     /gene="Tmcc2"
                     /gene_synonym="RGD1311960"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tatcccaagg ctccccctct ccgcccctcc gtcatcctcc tttaaaaaag ataatttctt
       61 aaattcaaga actcgtgatc tgcctactcc cctcgtccat aatttaaacc ctaggtcttt
      121 tgagtgcaag agggagtgcg gtctctcccc aagatagcac gctagaagga cagattcccc
      181 ttgccgaccc acttacacca tgaagaggtg caaatcggat gagctgcagc aacagcaagg
      241 cgaggaggat ggggctggga tggaagacgc cgcttgcctt ctgccaggcg cggacctccg
      301 gcatggggag gcctcgagtg ctaactccgc tggcgggcca acttcagatg ctggcgctgc
      361 ggtggcaccc aacccgggtc cccgaagcaa gcctcctgat ttaaagaaaa tccagcagct
      421 ctcagagggc tccatgtttg gccacggcct gaagcacctg tttcacagcc gccgcaggtc
      481 acgggagagg gagcaccagg cgtctcagga ggcccagcaa cagcagcaac atcagggcct
      541 atcggatcag gactccccag atgagaagga gcgctccccg gagatgcacc gcgtctccta
      601 tgctgtgtcc ctgcacgacc tgcccgcgcg acctactgct ttcaaccggg tgttacagca
      661 aatccgttcc aggccctcca tcaagcgggg cgccagcctg cacagcagtg gcgggagcgg
      721 tggccgccgt gccaagagca gctccctgga gccgcagcgt ggcagccctc acctgcttcg
      781 taaggccccc caggacagca gcctgaccgc catcctgcac cagcaccagg gccgaccccg
      841 gtcctcctct accaccgata ccgccttgct cctggctgac ggcagcaatg cgtacctcct
      901 ggctgaggag gcagagagca ctggggacaa gggtgacaag ggagatcttg tggccctgag
      961 cctcccctct ggccctggcc atggtgacac tgatggaccc atcagcctgg atgtgccaga
     1021 tggagcgcca gacccccagc ggactaaggc tgccattgac cacctgcacc aaaagatcct
     1081 gaagatcact gagcagatca agatcgagca ggaggcgcgg gatgataacg tggctgagta
     1141 cctgaagctg gccaacaatg cggacaagca gcaggtgtcg cgcatcaagc aggtgtttga
     1201 aaagaagaac cagaagtcag cccagaccat cgcccagctg cacaagaaac tggagcagta
     1261 ccgtcggcgc ctgaaggaga tcgagcagaa tgggccctcg aggcagccca aggatgtgct
     1321 acgtgatatg cagcaagggc tgaaggatgt aggcgccaac atgcgtgccg gcatcagtgg
     1381 cttcgggggt ggcgtggtgg agggcgtcaa gggcagtctc tctggcctct cgcaagccac
     1441 ccacactgca gtggtgtcca agccccggga gttcgccagc ctcattcgca acaagttcgg
     1501 cagtgcggac aacatcgccc acctcaagga ccctatggaa gatggacccc ctgaagaggc
     1561 agcccgggcg ctgagtggca gtgccacatt ggtttccagc cccaagtacg gcagtgacga
     1621 tgaatgctcg agtgccagtg ccagctcagc tggagcaggc agcaactccg gggctgggcc
     1681 agcaggcgca ctggggagcc ctagatccaa cactctttat ggtgcccctg gaaatctgga
     1741 cactctgctg gaggagctta gggagataaa ggatggccag tcacacctgg aggactccat
     1801 ggaggacttg aagactcagc tgcagaggga ctacacttac atgacccagt gcctgcaaga
     1861 agagcgctac aggtatgaga ggctggagga gcagctgaac gacctgactg agcttcacca
     1921 gaatgagatg accaacctaa agcaggagct tgccagcatg gaggagaagg tggcctacca
     1981 gtcctacgag agggcccggg atattcagga ggccgtggag tcttgcctga cccgtgtcac
     2041 caagctggag ctgcagcagc agcagcagca ggtggtgcag ttagaaggtg tagagaacgc
     2101 caacgcgcgc gctctgctgg gcaagttcat caacgtgatc ctggcactca tggcagtgct
     2161 gctggtgttt gtgtccacca ttgccaactt catcacgccc ctcatgaaga cgcgcctccg
     2221 tatcaccagc accgccctcc tgctcctcgt cctcttccta ctctggaagc actgggactc
     2281 gctcacctac ctcctggagc atgtgctgct gcccagctga gcggctgctg tccaccctgt
     2341 gctctctgga ttccactggc cacacgcatc tccaggaggg cccaggcctc ctgagtccct
     2401 cggggtctgt catgtgacct ctttggcccc taactgtccc ttctctgcac tgcttctgtc
     2461 tggcaccatc tccctttcag cctgaaggtt gcagagaggg tgctctgggc tggagggagc
     2521 agggacactc acagccaaat ggagcagccg ggagacaccg gggctgaatt atttgaatta
     2581 tttgcagtca catgggactt ttctgggctg accggaggat gctctagtca tgaaagccac
     2641 taagatagaa ggccagtctc gatttcccta gggaagagcc catcctagag gcagcccagt
     2701 ttcctcccat ggcaacagtc tggatataag ccagtgggcg gcagtgttga gcccaaaggg
     2761 tgcagaaagg ggagggtccc caggcttggg gccagacagc aggcttggca cagccactgg
     2821 gagctcagcc tcccctcccc ctgcttctct tcccacttga actggtttgg gactggtttc
     2881 tggaggctgg gtggggtgtg gctttgggtt tgtgttttct ctgctcatct ttctgcctgt
     2941 cactgggtgt gctgtttttc tgaaaaaaac aggccccaag gggccctgag cctccagccc
     3001 aaacccttag acctctggga tcacattgag ttctatttat ttatttattt atttacttat
     3061 ttatttattt gttcctatcc tttccacgct tctgcccggc tgggctccag ggagaggacc
     3121 ctacccgtcc tccctctgaa gcccgggctt attcttggtt catcacaccc cagaccacgt
     3181 ctccggtgtt cctggctgga agaaggggcg tgtggccatg cagcccgctc tcccaagcca
     3241 ccccagcaga agggttggag ggggcatggc ctcttttata tatatctatt tattttacgt
     3301 gtgtgtcttt gtgaggaaga ggatgtttgt catttcctta cgctctggag tgtgtgttcc
     3361 aattctgcac agcccagcct ccccaggagc ccttccaagc acagtgggga tttctcagaa
     3421 taggggagag gaacccatga agcaggagaa gcagtgcctg ccagccatgg tggaccttcc
     3481 taagaaataa atatcctcta tgttttcaaa ccatca
//
