LOCUS       NM_001126301            2684 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus transmembrane channel-like 8 (Tmc8), mRNA.
ACCESSION   NM_001126301 XM_001081759
VERSION     NM_001126301.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2684)
  AUTHORS   Gaud,G., Guillemot,D., Jacob,Y., Favre,M. and Vuillier,F.
  TITLE     EVER2 protein binds TRADD to promote TNF-alpha-induced apoptosis
  JOURNAL   Cell Death Dis 4 (2), e499 (2013)
   PUBMED   23429285
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2684)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   3  (bases 1 to 2684)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 2684)
  AUTHORS   Lazarczyk,M., Pons,C., Mendoza,J.A., Cassonnet,P., Jacob,Y. and
            Favre,M.
  TITLE     Regulation of cellular zinc balance as a potential mechanism of
            EVER-mediated protection against pathogenesis by cutaneous
            oncogenic human papillomaviruses
  JOURNAL   J Exp Med 205 (1), 35-42 (2008)
   PUBMED   18158319
REFERENCE   5  (bases 1 to 2684)
  AUTHORS   Ramoz,N., Rueda,L.A., Bouadjar,B., Montoya,L.S., Orth,G. and
            Favre,M.
  TITLE     Mutations in two adjacent novel genes are associated with
            epidermodysplasia verruciformis
  JOURNAL   Nat Genet 32 (4), 579-581 (2002)
   PUBMED   12426567
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC160873.1.
            
            On May 7, 2008 this sequence version replaced XM_001081759.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC160873.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2684
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.2"
     gene            1..2684
                     /gene="Tmc8"
                     /note="transmembrane channel-like 8"
                     /db_xref="GeneID:688276"
                     /db_xref="RGD:1591150"
     exon            1..100
                     /gene="Tmc8"
                     /inference="alignment:Splign:2.1.0"
     exon            101..338
                     /gene="Tmc8"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..2349
                     /gene="Tmc8"
                     /codon_start=1
                     /product="transmembrane channel-like protein 8"
                     /protein_id="NP_001119773.1"
                     /db_xref="GeneID:688276"
                     /db_xref="RGD:1591150"
                     /translation="MFRQWSVQSGPAPRRSESQASSEDLWKQEVERLCASRTPVRMLP
                     YAMADKRFIRELREPEGVKNSCWQRWHRPRQVARQQLGEAAKRLGRGFGLWEGALYEI
                     GGLFGTGIQSYFTFLRFLLLLNLLTMLLTACFVLLPLLWLRSPEPGPALKLTGLQCSG
                     SPLPQSDIPRFHNPLWNVLTGRAFNNTYLFYGAYRAGPESSSAYSIRLAYLLSPLACL
                     LLCFCVILQRMAEGLSQQTLVGQRYRTPLSAKVFSSWDFCIRVWEAATIKKHEISNEL
                     KVELEEGHRLELAQQQTRAQKACRLLTYLRTNVLIVLLVIGAISAIFWATKYSQDNKE
                     ESLFLVLQYLPPGVIALVNFLGPQLFTVLIQVENYPPSTEVNLTLFWCVVLKLVSLGM
                     FSFSLGQTVLCIGRNKTSCETYGYNACDYQCWENSVGEELYKLIIFNFLLTVAFAFLV
                     SLPRRLLVERFSGWFWTWLDREEFLVPKNVLDIVAAQTVTWMGLFYCPLLSLLNSVFF
                     FLTFYIKKYTLLRNSKASPRLFRASSSIFFFHLVLLLGLLLAAVPLAYVISSTHSSWD
                     CGLFTNYSAPWQVVPELVALQLPLPGQYALHYLSSHAFSFPLLFLLSLVLTVCISQSR
                     ANARAIHELRKQLVWQVQEKWHLVDDLSRLLPELSPEPESPHFRASRPRSFCPGFPCP
                     GSPGPRTPWLGSSTRLSSSSLGTPSASVPASRFHFPSLTEL"
     exon            339..487
                     /gene="Tmc8"
                     /inference="alignment:Splign:2.1.0"
     exon            488..637
                     /gene="Tmc8"
                     /inference="alignment:Splign:2.1.0"
     exon            638..723
                     /gene="Tmc8"
                     /inference="alignment:Splign:2.1.0"
     exon            724..860
                     /gene="Tmc8"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1008
                     /gene="Tmc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1179
                     /gene="Tmc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1319
                     /gene="Tmc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1443
                     /gene="Tmc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1541
                     /gene="Tmc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1725
                     /gene="Tmc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1856
                     /gene="Tmc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..2015
                     /gene="Tmc8"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2094
                     /gene="Tmc8"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2659
                     /gene="Tmc8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctgtttgg tgtgttgaga gctggtcata gcagggggct cctcggggag tttagtccct
       61 tgcccctttg tgaactgctt gccccgggac gataaggacg ggccaaggtg gagctcggct
      121 cccctcgtta ctcctgcgag caaggatctt gcctgtctgt cccgcgcgcc cactgggatg
      181 tttcgccagt ggtcggtgca gtcaggacca gccccacgaa gatctgaatc ccaggcgtcc
      241 tcggaggatc tgtggaagca agaagtggag cggctatgcg cctcccggac gcctgtgcgg
      301 atgctgccct acgccatggc agataagcgc ttcatccggg aactgcggga gcccgagggc
      361 gtgaagaact cctgctggca gcggtggcat cgcccgaggc aggtggcacg acagcagctg
      421 ggggaggcag caaaacggct aggccgcggt ttcgggctct gggagggagc tctctacgag
      481 attggaggcc tcttcgggac cgggatccag tcctacttca ctttccttcg cttcctgctg
      541 ctgctcaacc tgctgaccat gctgctgact gcctgctttg tgctgctgcc cctgctctgg
      601 ctccgctccc ctgagccagg ccctgccctg aaactgacag gtctccagtg ctccggcagc
      661 cccctgcccc agagtgacat tccaaggttc cacaacccac tttggaatgt tttaactggc
      721 agggccttca acaacaccta tctcttctac ggtgcctacc gagcagggcc agagagcagc
      781 tcagcgtaca gcatccgcct ggcctacctc cttagcccgt tggcctgcct gctcctatgc
      841 ttctgtgtga tactgcagag gatggcagaa ggcctctcac agcagacact cgtgggccag
      901 cgctacagga cgcccctcag cgccaaagtg ttctcatcct gggacttctg catccgggtg
      961 tgggaagccg ccaccatcaa gaagcacgag atcagcaatg aactgaaggt ggagctggaa
     1021 gagggccacc gcttggagct ggctcaacag cagacccggg cccagaaggc ctgccgcctt
     1081 ctcacctacc tgcgtaccaa cgtcctcatt gtactcctag tgatcggagc catcagcgcc
     1141 atcttctggg ccaccaagta ctcacaggac aacaaggagg agtccctttt tttggtgctc
     1201 cagtacctgc ctcctggagt catcgccctg gtcaacttcc tgggtcccca actgttcaca
     1261 gtcttgatcc aggtggagaa ctaccctccc agcaccgaag tcaatctcac cctgttctgg
     1321 tgcgtggtac tgaagctagt cagcttgggg atgttctcct tctccctggg tcagacggtg
     1381 ctgtgcatcg gcagaaacaa gaccagctgt gagacctacg gctacaacgc ttgcgactac
     1441 cagtgctggg agaactcggt gggtgaagaa ttatataaat taatcatctt caacttcctg
     1501 ctcaccgtgg ccttcgcctt cctggtcagc ctgcctcgga ggctgttagt agagcgcttc
     1561 tcaggctggt tctggacttg gctggaccgg gaggagttcc tggtgcccaa aaacgtgctg
     1621 gacatcgtgg ctgcacagac tgtcacctgg atgggtctct tctactgccc cctgctgtca
     1681 ctactcaaca gtgtcttctt ctttctcacc ttctacatca agaagtacac cctcctgagg
     1741 aactccaagg catccccacg gcttttccga gcctccagct ccatcttctt cttccatctg
     1801 gtgctgctcc ttggcttgct tttggctgca gtgcctctgg cctacgtgat cagcagcacc
     1861 cactcctcct gggactgtgg cctcttcaca aactactcgg ccccctggca ggtggtacca
     1921 gagctggtgg ccctccagct cccacttcct ggccagtatg ccctccatta cctcagctcc
     1981 catgccttca gcttcccact cctctttctg ctcagcctcg tcctgaccgt ttgcatctcc
     2041 cagtcccggg cgaatgccag agccatccat gagctgagga agcaactggt gtggcaagtc
     2101 caggagaagt ggcacctggt ggatgacctg tcgcggctgc tgccggagct gagcccagag
     2161 cccgagtccc ctcactttcg agcttcgcgt ccacgatcct tctgcccggg attcccatgc
     2221 ccaggttcac ctggtcccag gacaccctgg ctgggatcct ccaccaggct gagctcttcg
     2281 agcctcggaa cccccagtgc ctcggttccc gcctccagat ttcacttccc cagcctcaca
     2341 gagctgtagc accgacccca cgtccctcgg ctctacctca gcttcctcca gcgcctccac
     2401 tcccgccctt ccacctcctt ttgcccatgc tctctgcccc acccccaccc caccccgaac
     2461 cacggcctac agatggctcc tggccctctg gcaaggttct ccaaagtgag ccacaccctc
     2521 aggtcaccaa gaagaacagg agaatttcta cctcttttat ctcattcctt caatttttat
     2581 tgagtgttgt acagtgtaca aaacagtatg aatataaact cacgggtgca atttataaat
     2641 atatatatat tttttgaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
