LOCUS       NM_001106510            3103 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus transmembrane channel-like 2 (Tmc2), mRNA.
ACCESSION   NM_001106510 XM_001081150 XM_230602
VERSION     NM_001106510.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3103)
  AUTHORS   Beurg M, Kim KX and Fettiplace R.
  TITLE     Conductance and block of hair-cell mechanotransducer channels in
            transmembrane channel-like protein mutants
  JOURNAL   J Gen Physiol 144 (1), 55-69 (2014)
   PUBMED   24981230
REFERENCE   2  (bases 1 to 3103)
  AUTHORS   Pan B, Geleoc GS, Asai Y, Horwitz GC, Kurima K, Ishikawa K,
            Kawashima Y, Griffith AJ and Holt JR.
  TITLE     TMC1 and TMC2 are components of the mechanotransduction channel in
            hair cells of the mammalian inner ear
  JOURNAL   Neuron 79 (3), 504-515 (2013)
   PUBMED   23871232
REFERENCE   3  (bases 1 to 3103)
  AUTHORS   Kawashima Y, Geleoc GS, Kurima K, Labay V, Lelli A, Asai Y,
            Makishima T, Wu DK, Della Santina CC, Holt JR and Griffith AJ.
  TITLE     Mechanotransduction in mouse inner ear hair cells requires
            transmembrane channel-like genes
  JOURNAL   J Clin Invest 121 (12), 4796-4809 (2011)
   PUBMED   22105175
REFERENCE   4  (bases 1 to 3103)
  AUTHORS   Kurima K, Peters LM, Yang Y, Riazuddin S, Ahmed ZM, Naz S, Arnaud
            D, Drury S, Mo J, Makishima T, Ghosh M, Menon PS, Deshmukh D,
            Oddoux C, Ostrer H, Khan S, Riazuddin S, Deininger PL, Hampton LL,
            Sullivan SL, Battey JF Jr, Keats BJ, Wilcox ER, Friedman TB and
            Griffith AJ.
  TITLE     Dominant and recessive deafness caused by mutations of a novel
            gene, TMC1, required for cochlear hair-cell function
  JOURNAL   Nat Genet 30 (3), 277-284 (2002)
   PUBMED   11850618
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001081150.1, XM_230602.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760389
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3103
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..3103
                     /gene="Tmc2"
                     /note="transmembrane channel-like 2"
                     /db_xref="GeneID:296153"
                     /db_xref="RGD:1310073"
     exon            1..153
                     /gene="Tmc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..2786
                     /gene="Tmc2"
                     /note="transmembrane channel-like gene family 2"
                     /codon_start=1
                     /product="transmembrane channel-like protein 2"
                     /protein_id="NP_001099980.1"
                     /db_xref="GeneID:296153"
                     /db_xref="RGD:1310073"
                     /translation="MSPQLKSLDGEDDKSARRPTRKQTSIAACPQDGHRAQSSRKDPA
                     KGSPRPGSSRKKQMEHGSYQKGLRGQKPCKVERPSQGRKKDRRTPLTERRTPPRKERE
                     VLRKETGKHLRKPRTTSLASSVSTRESLSEEELAQILEQVEEKKKLITTMRNKPWPMA
                     KKLRELREAQAFVEKYEGALGKGKGKHLYAYRMMMAKKWAKFKRDFDNFKTQCIPWEM
                     KIKDIESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIPEVLMGMPYGSIPRKTVP
                     RAEEERAMDFSVLWDFEGYIKYSALFYGYYNNQRTIGWLRYRLPMAYFMVGVSVFGYS
                     LMIVIRSMASNTQGSTSEGDSDSFTFSFKMFTSWDYLIGNSETADNKYVSITTSFKES
                     IVDEQESSKEGNIHLTRFLRVLANFLILCCLCGSGYLIYFVVKRSQEFSKMQNVSWYE
                     RNEVEIVMSLLGMFCPPLFETIAALENYHPRTGLKWQLGRIFALFLGNLYTFLLALMD
                     DVHLKLSNEEKIKNITHWTLFNYYNSSGGNESVPRPPPHPADVPRGSCWETAVGIEFM
                     RLTVSDMLVTYLTILVGDFLRACFVRFMNHCWCWDLEAGFPSYAEFDISGNVLGLIFN
                     QGMIWMGSFYAPGLVGINVLRLLTSMYFQCWAVMSSNVPHERVFKASRSNNFYMGLLL
                     LVLFLSLLPVAYTVMSLPPSFDCGPFSGKNRMYDVLHETIENDFPKFLGKIFAFLANP
                     GLIIPAILLMFLAIYYLNSVSKSLSRANTQLRKKIQALREVEKNHKSIKGKATVTYSE
                     DTNKNSSKNATQPHLTNEEPTSYSPSQIQTLDKKARGSSTSRTDGGASQSTSWHHVGS
                     QPPRVRQDSGQPQSQTYTGRSPSGKRTQRPHN"
     exon            154..466
                     /gene="Tmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            467..619
                     /gene="Tmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            620..710
                     /gene="Tmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            711..792
                     /gene="Tmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            793..899
                     /gene="Tmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            900..998
                     /gene="Tmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1141
                     /gene="Tmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1289
                     /gene="Tmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1478
                     /gene="Tmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1658
                     /gene="Tmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1808
                     /gene="Tmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1937
                     /gene="Tmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2005
                     /gene="Tmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2245
                     /gene="Tmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2371
                     /gene="Tmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2450
                     /gene="Tmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2568
                     /gene="Tmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..3103
                     /gene="Tmc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaccccagct gctgtcaggt ccgaggaaga ggccagtgac catgacagca tgaaattacc
       61 ccaggcgggc agtatatgaa gacgtcagcc agtgtgagga ccttgaaatt ctggtgacca
      121 tgagccccca gttaaagagc ctggatgggg aagatgacaa gtcagcaagg agacccacaa
      181 ggaaacaaac ctccatagct gcatgtcccc aagatgggca ccgagcccag tctagccgga
      241 aggatcctgc taagggtagc cccagaccag ggtcttcccg gaagaaacag atggagcatg
      301 gaagctatca aaagggactg cggggacaga aaccatgcaa agtggagagg ccttcccagg
      361 ggaggaagaa ggaccggaga actcccctca cggagcggag aacacctcca aggaaggaaa
      421 gggaggttct gaggaaggag acaggcaagc atctgagaaa gcccaggact acttccttgg
      481 cctccagtgt ctccactaga gagtccctgt cagaagagga gttggctcag atcctggaac
      541 aggtggaaga gaaaaagaag ctcatcacta ccatgaggaa caaaccctgg cccatggcga
      601 agaagctgag ggaactcagg gaagcccaag cctttgtgga gaagtatgaa ggagccttgg
      661 gaaaaggcaa gggcaaacac ctctatgcct acaggatgat gatggctaag aaatgggcca
      721 agtttaagag ggactttgat aatttcaaga cgcaatgtat tccctgggaa atgaagatca
      781 aggacattga aagtcacttt ggttcttccg tggcgtctta cttcatcttc ctccgatgga
      841 tgtacggagt aaacctcgtc ctttttggct taatatttgg tctagtcatc atcccagagg
      901 tgctgatggg catgccctac ggaagcatac ccagaaagac ggtgcctcgg gctgaggaag
      961 aaagagccat ggacttctct gtcctttggg attttgaggg ctacatcaaa tattctgctc
     1021 tcttctatgg ctactataac aaccagagga ccatcggatg gctgaggtac agactgccca
     1081 tggcttactt tatggtgggg gtcagcgtgt ttggctacag cttgatgatc gtcattaggt
     1141 cgatggccag caatacccag ggtagcacca gcgaggggga cagtgacagc ttcacgttca
     1201 gcttcaagat gttcaccagt tgggactacc tcatcgggaa ttcagagaca gcagacaaca
     1261 aatatgtctc catcaccacc agcttcaagg aatctatagt ggatgaacaa gagagtagca
     1321 aagaggggaa tattcacctg acaagattcc tccgtgtcct ggccaacttt ctcattctct
     1381 gctgtctgtg tggaagcggg tacctcattt actttgtggt gaaacggtcc caggagttct
     1441 ccaaaatgca gaatgtcagc tggtatgaaa ggaatgaggt ggagatcgtg atgtctctgc
     1501 tagggatgtt ttgtcctcct ctgtttgaaa ccatcgccgc cctggagaat tatcacccgc
     1561 gcaccgggct gaagtggcag ctgggccgca tctttgcgct cttcctggga aacctctaca
     1621 cgtttctcct ggccctcatg gacgatgtcc accttaagct ttctaatgag gagaaaatca
     1681 agaacatcac tcactggacc ctgtttaact attacaattc ctcgggtggg aatgaaagtg
     1741 tgccccggcc accaccacac cctgcagacg tgcccagagg ttcttgctgg gagacagctg
     1801 tgggcattga gtttatgagg ctgactgtgt ctgacatgct ggtaacgtac ctcaccatct
     1861 tggttgggga tttcctccga gcttgttttg tccggttcat gaatcactgc tggtgttggg
     1921 acctcgaggc tggttttccc tcatatgccg agtttgatat tagtggaaat gtactgggtt
     1981 tgatcttcaa ccaaggaatg atctggatgg gctccttcta tgctccagga ctcgtgggca
     2041 tcaatgtcct gcgtctgttg acctccatgt acttccagtg ctgggcagtg atgagcagca
     2101 acgttcccca cgagcgcgtg tttaaagcct cccgatccaa caacttctac atgggcttgc
     2161 tgctgctggt gctcttcctc agcctcctac cggtggccta caccgtcatg tctctcccac
     2221 cctcgtttga ctgtggcccc ttcagtggga aaaacagaat gtatgatgtc cttcatgaga
     2281 ccattgaaaa tgatttccct aaattcctgg gcaagatctt cgcattcctc gccaatccgg
     2341 gccttatcat tccagccatc ctactgatgt ttctggccat ctactacctg aactcagttt
     2401 caaaaagtct ttcgagagct aatacccagc ttcgaaagaa aatccaagcg ctccgtgaag
     2461 ttgagaagaa ccacaaatcc atcaagggaa aagccacagt cacatattca gaggacacaa
     2521 ataagaacag ctccaaaaat gccacccagc cacatcttac taatgaagag cccacatctt
     2581 actctcccag ccaaatccag actctggaca agaaagcgcg gggctccagc acctccagga
     2641 ctgatggtgg ggcctcacag tctacctcct ggcaccatgt tgggtctcag ccaccaagag
     2701 tcagacaaga ttctggccaa ccccagtctc agacttacac aggcaggtca ccttctggaa
     2761 agagaaccca gaggcctcac aactgatggc tggcattcat gggtgtccca gtcctggcct
     2821 tgatcctcag gctcttctgt tttacatatc tcttcccttc ttgtctcaca tacatacgtg
     2881 tttccttatg gcacatgtaa catatgaact ttaatccttg gttccaaacc ttgattgcta
     2941 accaaagggg atagcagtgg cttcccctga tttggggagt ggcaggagct gaaaccttgt
     3001 ttgaactaac tggccctctc aatatcttgc tgaggaaact ctggacctca cacgctagta
     3061 gtttcctttg catccagact tgggaaggca gggatgaggc cat
//
