LOCUS       NM_001415991            4089 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus transmembrane channel-like 1 (Tmc1), mRNA.
ACCESSION   NM_001415991
VERSION     NM_001415991.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4089)
  AUTHORS   Beurg,M., Kim,K.X. and Fettiplace,R.
  TITLE     Conductance and block of hair-cell mechanotransducer channels in
            transmembrane channel-like protein mutants
  JOURNAL   J Gen Physiol 144 (1), 55-69 (2014)
   PUBMED   24981230
REFERENCE   2  (bases 1 to 4089)
  AUTHORS   Pan,B., Geleoc,G.S., Asai,Y., Horwitz,G.C., Kurima,K., Ishikawa,K.,
            Kawashima,Y., Griffith,A.J. and Holt,J.R.
  TITLE     TMC1 and TMC2 are components of the mechanotransduction channel in
            hair cells of the mammalian inner ear
  JOURNAL   Neuron 79 (3), 504-515 (2013)
   PUBMED   23871232
REFERENCE   3  (bases 1 to 4089)
  AUTHORS   Kawashima,Y., Geleoc,G.S., Kurima,K., Labay,V., Lelli,A., Asai,Y.,
            Makishima,T., Wu,D.K., Della Santina,C.C., Holt,J.R. and
            Griffith,A.J.
  TITLE     Mechanotransduction in mouse inner ear hair cells requires
            transmembrane channel-like genes
  JOURNAL   J Clin Invest 121 (12), 4796-4809 (2011)
   PUBMED   22105175
REFERENCE   4  (bases 1 to 4089)
  AUTHORS   Takayanagi,S., Hiroyama,T., Yamazaki,S., Nakajima,T., Morita,Y.,
            Usui,J., Eto,K., Motohashi,T., Shiomi,K., Keino-Masu,K., Masu,M.,
            Oike,Y., Mori,S., Yoshida,N., Iwama,A. and Nakauchi,H.
  TITLE     Genetic marking of hematopoietic stem and endothelial cells:
            identification of the Tmtsp gene encoding a novel cell surface
            protein with the thrombospondin-1 domain
  JOURNAL   Blood 107 (11), 4317-4325 (2006)
   PUBMED   16455951
REFERENCE   5  (bases 1 to 4089)
  AUTHORS   Kurima,K., Peters,L.M., Yang,Y., Riazuddin,S., Ahmed,Z.M., Naz,S.,
            Arnaud,D., Drury,S., Mo,J., Makishima,T., Ghosh,M., Menon,P.S.,
            Deshmukh,D., Oddoux,C., Ostrer,H., Khan,S., Riazuddin,S.,
            Deininger,P.L., Hampton,L.L., Sullivan,S.L., Battey,J.F. Jr.,
            Keats,B.J., Wilcox,E.R., Friedman,T.B. and Griffith,A.J.
  TITLE     Dominant and recessive deafness caused by mutations of a novel
            gene, TMC1, required for cochlear hair-cell function
  JOURNAL   Nat Genet 30 (3), 277-284 (2002)
   PUBMED   11850618
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN09345331, SAMN11044071
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               JAXUCZ010000001.1  227872418-227872534 c
            118-225             JAXUCZ010000001.1  227859394-227859501 c
            226-273             JAXUCZ010000001.1  227825342-227825389 c
            274-433             JAXUCZ010000001.1  227819041-227819200 c
            434-562             JAXUCZ010000001.1  227812947-227813075 c
            563-653             JAXUCZ010000001.1  227790828-227790918 c
            654-735             JAXUCZ010000001.1  227788976-227789057 c
            736-842             JAXUCZ010000001.1  227779036-227779142 c
            843-941             JAXUCZ010000001.1  227776368-227776466 c
            942-1084            JAXUCZ010000001.1  227747637-227747779 c
            1085-1229           JAXUCZ010000001.1  227742626-227742770 c
            1230-1424           JAXUCZ010000001.1  227741560-227741754 c
            1425-1604           JAXUCZ010000001.1  227739401-227739580 c
            1605-1766           JAXUCZ010000001.1  227739108-227739269 c
            1767-1895           JAXUCZ010000001.1  227731203-227731331 c
            1896-1963           JAXUCZ010000001.1  227721341-227721408 c
            1964-2203           JAXUCZ010000001.1  227715359-227715598 c
            2204-2329           JAXUCZ010000001.1  227712112-227712237 c
            2330-2408           JAXUCZ010000001.1  227708544-227708622 c
            2409-2460           JAXUCZ010000001.1  227708401-227708452 c
            2461-4089           JAXUCZ010000001.1  227701781-227703409 c
FEATURES             Location/Qualifiers
     source          1..4089
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q51"
     gene            1..4089
                     /gene="Tmc1"
                     /note="transmembrane channel-like 1"
                     /db_xref="GeneID:361739"
                     /db_xref="RGD:1308682"
     exon            1..117
                     /gene="Tmc1"
                     /inference="alignment:Splign:2.1.0"
     exon            118..225
                     /gene="Tmc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..2483
                     /gene="Tmc1"
                     /note="transmembrane channel-like gene family 1"
                     /codon_start=1
                     /product="transmembrane channel-like protein 1"
                     /protein_id="NP_001402920.1"
                     /db_xref="GeneID:361739"
                     /db_xref="RGD:1308682"
                     /translation="MLQIQVEGKEDDTDASSKEEEDKLPRRESLRPKRKRTRDVINED
                     DPEPEPEDEETRKAREKERRRRLRRGAEEEEEIDEEELERLKALLDENRQMIATVKCK
                     PWKMEKKIEVLKEAKKFVSENEGALGKGKGKKWFAFKMMMAKKWAKFLRDFENFKAAC
                     VPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFILTFSLIMLPEYLWGLPYGSLP
                     RKTVPRAEEASAANFGVLYDFNGLAQYSVLFYGYYDNKRTIGWLNFRLPLSYFLVGIM
                     CIGYSFLVVLKAMTKNIGDDGGGDDNTFNFSWKVFCSWDYLIGNPETADNKFNSITMN
                     FKEAIIEERAAQVEENIHLIRFLRFLANFFVFLTLGASGYLIFWAVKRSQEFAQQDPD
                     TLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALLLGNLYVF
                     ILALMDEINNKIEEEKLVKANITLWEANMIKAYNESLSGNTTGPPFFVHPADVPRGPC
                     WETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYPSYTEFDI
                     SGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVFKASR
                     SNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLEHDFPSWM
                     AKILRQLSNPGLVIAVILVMVLTIYYLNATAKGQKAANLDLKKKMKQQALENKMRNKK
                     MAAARAAAAAGGQ"
     exon            226..273
                     /gene="Tmc1"
                     /inference="alignment:Splign:2.1.0"
     exon            274..433
                     /gene="Tmc1"
                     /inference="alignment:Splign:2.1.0"
     exon            434..562
                     /gene="Tmc1"
                     /inference="alignment:Splign:2.1.0"
     exon            563..653
                     /gene="Tmc1"
                     /inference="alignment:Splign:2.1.0"
     exon            654..735
                     /gene="Tmc1"
                     /inference="alignment:Splign:2.1.0"
     exon            736..842
                     /gene="Tmc1"
                     /inference="alignment:Splign:2.1.0"
     exon            843..941
                     /gene="Tmc1"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1084
                     /gene="Tmc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1229
                     /gene="Tmc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1424
                     /gene="Tmc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1604
                     /gene="Tmc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1766
                     /gene="Tmc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1895
                     /gene="Tmc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..1963
                     /gene="Tmc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2203
                     /gene="Tmc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2329
                     /gene="Tmc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2408
                     /gene="Tmc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2460
                     /gene="Tmc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..4089
                     /gene="Tmc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcagtagg cagtgtgtgg atgttctata tcaaacctgc aggttttgtc ccttcaactt
       61 gcaatccccg attggagaca ttctgacagg ataccgccag gatgcccccc aaaaaaggtg
      121 tgcctggcca tttctgatgt aaggtcacct attttcttct tagcttctgt cctggacatt
      181 aattattaag gtgcaaaatt acatttctcc tcaactcttt tatgttgcaa atccaagtgg
      241 aggggaaaga agatgataca gatgcaagct caaaggaaga ggaagacaaa ctacctagaa
      301 gagagagctt gagaccaaag aggaaacgga ccagagacgt catcaatgag gatgatccag
      361 aaccagagcc agaggatgaa gaaacaagaa aggcgagaga aaaagaaagg cggaggaggc
      421 tgaggagagg agcggaagaa gaagaagaaa ttgatgaaga ggaattagaa cgattaaaag
      481 cactgctaga tgagaacaga caaatgatcg ctactgtcaa atgtaaacct tggaaaatgg
      541 agaagaaaat tgaagttctc aaggaagcaa agaaatttgt gagtgaaaat gaaggagctc
      601 ttgggaaagg aaaaggaaag aagtggtttg catttaagat gatgatggcc aagaaatggg
      661 caaaattcct ccgtgatttt gagaacttca aagctgcttg tgtcccatgg gaaaacaaga
      721 tcaaggcaat tgaaagtcag tttggttcct cagtggcctc atacttcctg ttcctgaggt
      781 ggatgtatgg cgtcaacatg gttctcttta tattgacctt cagcctcatc atgttaccag
      841 agtacctctg gggtttacca tatggcagct tacctaggaa aacagtccca agagctgaag
      901 aggcatctgc agcaaacttt ggtgtgctgt acgacttcaa cggcctggca cagtactctg
      961 tcctctttta tggctattac gacaataaac gcacaatcgg atggctgaat ttccggctac
     1021 ctctttccta cttcctggtg gggattatgt gcattggata cagctttctg gttgtcctca
     1081 aagcgatgac caaaaacatc ggtgatgatg gaggtggcga tgacaacact ttcaacttca
     1141 gctggaaggt gttctgtagc tgggactatc tgattggtaa ccctgaaaca gctgacaaca
     1201 aattcaattc tatcacgatg aactttaagg aagccatcat tgaagagaga gcagcccagg
     1261 tggaggagaa catccacctc atcagattcc tgaggtttct tgctaacttc ttcgtgttcc
     1321 taacacttgg tgcaagtgga tacctcatct tttgggctgt gaagcgatcc caggaatttg
     1381 cccagcaaga tcctgacacc cttgggtggt gggaaaagaa tgaaatgaac atggttatgt
     1441 ccctcctggg gatgttctgt cctacgctgt ttgacttatt tgctgaactg gaagattacc
     1501 atcctctcat cgctctgaag tggctcctgg gacgcatttt tgctcttctt ctaggcaact
     1561 tgtatgtatt cattctcgcc ttgatggatg agattaacaa caagattgaa gaggagaagc
     1621 ttgtgaaggc caatattacc ctgtgggaag ccaacatgat taaggcttac aatgaatctc
     1681 tctctgggaa cacgacaggg ccaccctttt tcgttcatcc tgcagatgta ccccgaggtc
     1741 cctgctggga aacaatggtg gggcaggaat tcgtgcgtct cacagtttct gatgtcctga
     1801 ccacttatgt cacgatcctc attggtgact tcctcagagc atgcttcgtg aggttctgca
     1861 actactgctg gtgctgggat ttagaatatg gctatccttc atatacagaa ttcgacatca
     1921 gtggcaacgt cctcgctctg atcttcaacc aaggcatgat ctggatgggc tccttctttg
     1981 ctcctagcct cccaggcatc aacatcctcc gactccacac atccatgtat ttccagtgtt
     2041 gggctgtgat gtgctgcaat gttcccgagg ccagggtctt caaagcttcc agatccaaca
     2101 acttctacct tgggatgctg ctcctcatcc tcttcctgtc caccatgccc gttctgtaca
     2161 tgattgtctc cctcccaccg tcttttgatt gtgggccttt cagtggtaaa aacagaatgt
     2221 ttgaagtcat tggtgagacc ctggaacacg atttcccaag ctggatggcg aagatcctga
     2281 ggcagctttc taaccccggc cttgtcattg ctgtcattct ggtgatggtt ctgaccatct
     2341 actatctcaa tgctactgcc aagggacaga aagcagcaaa cctggatctc aaaaagaaga
     2401 tgaaacagca agctttggag aacaaaatgc gaaacaagaa gatggcggcc gctcgagcag
     2461 ctgcagctgc tggtggccag taactttatc aaatgtcctg gagtgcccag aagtactctt
     2521 catgtccatc tttttgtgtg ctgagctagg gtcaatggac gagtgccagg gaaccgttgc
     2581 tccatgttct accatgcgtc agcaaggcca tgaccatcta tcaaggaatc atcagccctt
     2641 tttgagtgag aagagtctca ccatgttatg tatttctcca gattctgaca ctttctcact
     2701 tccctgacac attctcaaac aaatggagtt taaatgtggg tgagacatag tgatacgaat
     2761 tactgggtct aattgacagg atatttttaa aaagtcaaca tttccttata tagacttttt
     2821 cttacacact ggtttaattt cttaaattgg gaggagggct attaggacat cttctcccct
     2881 ctgaatttgg aactatctgt gtgcagcatt tgttgtggtc gttcactact gtttcatgtg
     2941 cactgtcttt cttcttaatt catcaggatg gtagagttga ctttgttctc acctacataa
     3001 aagtcacatt cacaaaatat gaattttaag agaattgcct cacttttaaa atacaatatt
     3061 ctcactcaca tctttttttt cttctgtctt cctacccaat gagcccagtg agcccaactc
     3121 atatatttgc acctggattc agtatgaaaa gaaggaggct tttcaggaga aatcccacat
     3181 atgatttgag agtctctgca gtgcccactt aacaatcagt ttatcacagt gaggacacat
     3241 gcagttcttg gactaactgg atcatgatga ctgtaaggaa agaaggactc ataaacaact
     3301 gatggccggt cagtgtctcc tcatcgaacc ctcaatgata atttttcctg aacaacattg
     3361 ttgttgtcta catttgtttt tgcttttttt tgttgagatt aggcctttaa ttgaagcttt
     3421 agattatagc agtgtttaat catgtttatc taaagtgtaa gttcactgaa tggtagcaca
     3481 cagcaccctc cctgtcttgt gctgtgacct cagtagtatc ttataactca cagcatctcc
     3541 ttctggagct gagccaaact caattccctg aagttaatgt cctgagtttt gttgcttttt
     3601 aactgacccc ttcctcttta atcttttctg gaccatggaa tgatcccact gttgtcttgt
     3661 caattcctta ctccattcct ccaattactt tgtacagatt ggcacctagt tccaatcact
     3721 ctcctaacag gattcctgag aatcttgtat ctgtatcttc agggtagcat ctgtatattt
     3781 tctgtaaaat ttcatggttg taattgattc ttacatgcat ggataatctt tcctatctag
     3841 actgtagctc tgtatgaaga tagattgtat cttctcatcc tttatatgtc tcatacagtg
     3901 ctaggcacag ttgggcactg cataaatgct tcttaattaa attgaatcaa tttgacttat
     3961 agcagttgag acaaaacttg tgttcgatgc gtggaaaatg ttctgtgatg tacgaaatgg
     4021 attaactgct gcctggcttt tgttatcatt agactgtaat gcagatgagt aaataaaaga
     4081 gcattgatt
//
