LOCUS       NP_001020820             643 aa            linear   ROD 03-APR-2024
DEFINITION  transmembrane 9 superfamily member 4 precursor [Rattus norvegicus].
ACCESSION   NP_001020820 XP_215889
VERSION     NP_001020820.1
DBSOURCE    REFSEQ: accession NM_001025649.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 643)
  AUTHORS   Lozupone,F., Borghi,M., Marzoli,F., Azzarito,T., Matarrese,P.,
            Iessi,E., Venturi,G., Meschini,S., Canitano,A., Bona,R., Cara,A.
            and Fais,S.
  TITLE     TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor
            pH alterations associated with drug resistance and invasiveness of
            colon cancer cells
  JOURNAL   Oncogene 34 (40), 5163-5174 (2015)
   PUBMED   25659576
REFERENCE   2  (residues 1 to 643)
  AUTHORS   Perrin,J., Le Coadic,M., Vernay,A., Dias,M., Gopaldass,N.,
            Ouertatani-Sakouhi,H. and Cosson,P.
  TITLE     TM9 family proteins control surface targeting of glycine-rich
            transmembrane domains
  JOURNAL   J Cell Sci 128 (13), 2269-2277 (2015)
   PUBMED   25999474
REFERENCE   3  (residues 1 to 643)
  AUTHORS   Paolillo,R., Spinello,I., Quaranta,M.T., Pasquini,L., Pelosi,E., Lo
            Coco,F., Testa,U. and Labbaye,C.
  TITLE     Human TM9SF4 Is a New Gene Down-Regulated by Hypoxia and Involved
            in Cell Adhesion of Leukemic Cells
  JOURNAL   PLoS One 10 (5), e0126968 (2015)
   PUBMED   25961573
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 643)
  AUTHORS   Lozupone,F., Perdicchio,M., Brambilla,D., Borghi,M., Meschini,S.,
            Barca,S., Marino,M.L., Logozzi,M., Federici,C., Iessi,E., de
            Milito,A. and Fais,S.
  TITLE     The human homologue of Dictyostelium discoideum phg1A is expressed
            by human metastatic melanoma cells
  JOURNAL   EMBO Rep 10 (12), 1348-1354 (2009)
   PUBMED   19893578
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099133.1.
            
            On Jul 22, 2005 this sequence version replaced XP_215889.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099133.1, SRR8487226.33707.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..643
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     Protein         1..643
                     /product="transmembrane 9 superfamily member 4 precursor"
                     /note="transmembrane 9 superfamily protein member 4"
                     /calculated_mol_wt=72067
     sig_peptide     1..23
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q4KLL4.1)"
                     /calculated_mol_wt=2626
     mat_peptide     24..643
                     /product="Transmembrane 9 superfamily member 4.
                     /id=PRO_0000311812"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4KLL4.1)"
                     /calculated_mol_wt=72067
     Region          55..600
                     /region_name="EMP70"
                     /note="Endomembrane protein 70; pfam02990"
                     /db_xref="CDD:460774"
     Site            283..303
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4KLL4.1)"
     Site            313
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q92544; propagated from
                     UniProtKB/Swiss-Prot (Q4KLL4.1)"
     Site            348..368
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4KLL4.1)"
     Site            378..398
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4KLL4.1)"
     Site            418..438
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4KLL4.1)"
     Site            451..471
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4KLL4.1)"
     Site            503..523
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4KLL4.1)"
     Site            537..557
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4KLL4.1)"
     Site            572..592
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4KLL4.1)"
     Site            600..620
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4KLL4.1)"
     CDS             1..643
                     /gene="Tm9sf4"
                     /coded_by="NM_001025649.1:212..2143"
                     /db_xref="GeneID:296279"
                     /db_xref="RGD:1307768"
ORIGIN      
        1 maaamiwwpr fllllcltck gstfyvpgva pinfhqndpv eikavkltss rtqlpyeyys
       61 lpfcqpnkit ykaenlgevl rgdrivntpf qvlmnsekkc evlcgqsnkp viltveqsrl
      121 vaeriteeyy vhliadnlpv atrlelyssn rdsddkkkek dvqfehgyrl gftdvnkiyl
      181 hnhlsfilyy hredteedqe htyrvvrfev ipqsirledl kidekssctl peganslpqe
      241 idptkenqly ftysvhwees dikwasrwdt yltmsdvqih wfsiinsvvv vfflsgilsm
      301 iiirtlrkdi anynkeddie dtmeesgwkl vhgdvfrppq ypmilssllg sgiqlfcmil
      361 ivifvamlgm lspssrgalm ttacflfmfm gvfggfsagr lyrtlkghrw kkgafctatl
      421 ypgvvfgicf vlncfiwgkh ssgavpfptm vallcmwfgi slplvylgyy fgfrkqpydn
      481 pvrtnqiprq ipeqrwymnr fvgilmagil pfgamfielf fifsaiwenq fyylfgflfl
      541 vfiilvvscs qisivmvyfq lcaedyrwww rnflvsggsa fyvlvyaify fvnkldivef
      601 ipsllyfgyt tlmvlsfwll tgtigfyaay mfvrkiyaav kid
//
