LOCUS       NM_001013071            1510 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus transmembrane 7 superfamily member 2 (Tm7sf2),
            mRNA.
ACCESSION   NM_001013071 XM_215199
VERSION     NM_001013071.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1510)
  AUTHORS   Lei N, Wang P and Meng Q.
  TITLE     Tm7sf2 may participate in the healing of burn wounds
  JOURNAL   Mol Med Rep 14 (1), 1002-1006 (2016)
   PUBMED   27220550
  REMARK    GeneRIF: burn serum extracted from an electrical burn rat model
            increased the expression of Tm7sf2. In addition, Tm7sf2 may
            participate in the wound healing process by interacting with LC3II
            and Beclin1 a
REFERENCE   2  (bases 1 to 1510)
  AUTHORS   Ghai R, Bugarcic A, Liu H, Norwood SJ, Skeldal S, Coulson EJ, Li
            SS, Teasdale RD and Collins BM.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   3  (bases 1 to 1510)
  AUTHORS   Bennati AM, Schiavoni G, Franken S, Piobbico D, Della Fazia MA,
            Caruso D, De Fabiani E, Benedetti L, Cusella De Angelis MG,
            Gieselmann V, Servillo G, Beccari T and Roberti R.
  TITLE     Disruption of the gene encoding 3beta-hydroxysterol Delta-reductase
            (Tm7sf2) in mice does not impair cholesterol biosynthesis
  JOURNAL   FEBS J 275 (20), 5034-5047 (2008)
   PUBMED   18785926
REFERENCE   4  (bases 1 to 1510)
  AUTHORS   Bennati AM, Castelli M, Della Fazia MA, Beccari T, Caruso D,
            Servillo G and Roberti R.
  TITLE     Sterol dependent regulation of human TM7SF2 gene expression: role
            of the encoded 3beta-hydroxysterol Delta14-reductase in human
            cholesterol biosynthesis
  JOURNAL   Biochim Biophys Acta 1761 (7), 677-685 (2006)
   PUBMED   16784888
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091237.1.
            
            On Apr 20, 2005 this sequence version replaced XM_215199.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091237.1, FQ218409.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1510
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1510
                     /gene="Tm7sf2"
                     /note="transmembrane 7 superfamily member 2"
                     /db_xref="GeneID:293688"
                     /db_xref="RGD:1311205"
     exon            1..140
                     /gene="Tm7sf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1345
                     /gene="Tm7sf2"
                     /EC_number="1.3.1.70"
                     /note="delta(14)-sterol reductase"
                     /codon_start=1
                     /product="delta(14)-sterol reductase TM7SF2"
                     /protein_id="NP_001013089.1"
                     /db_xref="GeneID:293688"
                     /db_xref="RGD:1311205"
                     /translation="MASREASQAPLEFGGPLGVTAMLILLPATMFHLLLAARSGPARL
                     LALPAYLPGLEELWSPRALLLLFIWLGLQVALYLLPARKVAEGLELKDKSRLRYPING
                     FQALVLTALLVGLGVSVGLPLGALPGMLLPLAFATTLTSFIFSLLLYAKALVAPASAL
                     APGGNSGNSVYDFFLGRELNPRLGSFDFKYFCELRPGLIGWVFINLALLMQEAELRGS
                     PSLAMWLVNGFQLLYVGDALWYEESVLTTMDIIHDGFGFMLVFGDLAWVPFTYSLQAQ
                     FLLYHPQPLGLPMALLICLIKAVGYYIFRGANSQKNTFRKNPSDPSVAGLETIPTATG
                     RQLLVSGWWGMVRHPNYLGDLIMALAWSLPCGLSHLLPYFYLLYFTALLVHREARDEQ
                     QCLRKYGRAWQEYCKRVPYRIIPYVY"
     exon            141..337
                     /gene="Tm7sf2"
                     /inference="alignment:Splign:2.1.0"
     exon            338..392
                     /gene="Tm7sf2"
                     /inference="alignment:Splign:2.1.0"
     exon            393..587
                     /gene="Tm7sf2"
                     /inference="alignment:Splign:2.1.0"
     exon            588..691
                     /gene="Tm7sf2"
                     /inference="alignment:Splign:2.1.0"
     exon            692..811
                     /gene="Tm7sf2"
                     /inference="alignment:Splign:2.1.0"
     exon            812..980
                     /gene="Tm7sf2"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1061
                     /gene="Tm7sf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1184
                     /gene="Tm7sf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1467
                     /gene="Tm7sf2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagaggcgta gccaggccat tgggatgggg tgggctgtgt ttccctgatc gactttgtga
       61 accattgttt cccggcaaag gagagatcat ggcttctcgt gaggcctccc aggccccact
      121 ggaattcggg gggccgttgg gcgtcacggc gatgctgatc ctgctgcctg ccaccatgtt
      181 ccacctgctt ctggcggccc gctcgggtcc ggcgcgcctc ctggccctac cagcctatct
      241 gcctgggctg gaggagctgt ggagcccacg ggctctgctg ctgttgttca tctggctcgg
      301 cctgcaggtg gcgctctatt tgctgcctgc acgcaaggtg gccgaggggc tggaactgaa
      361 ggacaagagt cgcctgcgct accctattaa tggtttccag gctctggtgc taacagccct
      421 gttggtgggg ctaggggtgt cagttgggct gcccctgggg gcactccctg gaatgctcct
      481 gcccctggcc tttgcgacca ctctcaccag ctttatcttc agcctccttc tctatgcaaa
      541 ggctttggta gctcctgcct cagccctggc tcctggggga aactcaggaa attctgtgta
      601 tgacttcttt ctcggacggg agctgaaccc tcgcctcggt tcctttgact tcaaatattt
      661 ctgtgagctg cgacctggcc tcatcggctg ggtcttcatt aacctggccc tgctgatgca
      721 ggaggcggag cttcggggga gtccttcact ggctatgtgg ctggtcaatg gcttccagtt
      781 gctgtatgtg ggtgatgccc tctggtatga ggagtctgtt ctcaccacca tggacataat
      841 acatgatggt tttggcttca tgctggtctt tggagacctg gcctgggtac cattcaccta
      901 cagcctgcag gcccagttcc tgttgtacca tccacagcct ctgggattgc ccatggcctt
      961 gctcatctgc ctcattaagg ctgttggtta ctacatcttc cgaggggcca attcccagaa
     1021 aaatacattc agaaagaatc cttctgaccc cagtgtggct ggtcttgaga ccatccctac
     1081 tgccacgggg aggcagctgt tggtgtctgg gtggtggggt atggttcgac accccaacta
     1141 cctgggagac ctcatcatgg ctctggcttg gtccttgccc tgtgggctgt cccacctgct
     1201 gccctacttc tacctgctct acttcactgc actgctggtg caccgcgagg cccgagatga
     1261 gcagcagtgc ctgcgaaagt atggccgtgc ctggcaggaa tactgcaagc gcgtgcctta
     1321 ccgaatcata ccgtatgtct actgaagcag aaccagttct actcggcagg gatgctcagc
     1381 acgttgaaaa caagaacgtt gaaagcaaga gggagccact gctcccagaa ggaaattttt
     1441 ccctgttgaa taaatgtttt caaccttaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1501 aaaaaaaaaa
//
