LOCUS       NM_053785               1575 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus transmembrane 4 L six family member 4 (Tm4sf4),
            mRNA.
ACCESSION   NM_053785
VERSION     NM_053785.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1575)
  AUTHORS   Qiu,J., Liu,Z., Da,L., Li,Y., Xuan,H., Lin,Q., Li,F., Wang,Y.,
            Li,Z. and Zhao,M.
  TITLE     Overexpression of the gene for transmembrane 4 superfamily member 4
            accelerates liver damage in rats treated with CCl4
  JOURNAL   J Hepatol 46 (2), 266-275 (2007)
   PUBMED   17069928
  REMARK    GeneRIF: Rat TM4SF4 is overexpressed in acutely injured liver
            induced by CCl4 and plays a crucial role in accelerating liver
            injury, which may be mediated by the TNF-alpha and HGF/c-met
            signaling pathways.
REFERENCE   2  (bases 1 to 1575)
  AUTHORS   Liu,Z., Zhao,M., Yokoyama,K.K. and Li,T.
  TITLE     Molecular cloning of a cDNA for rat TM4SF4, a homolog of human
            il-TMP (TM4SF4), and enhanced expression of the corresponding gene
            in regenerating rat liver(1)
  JOURNAL   Biochim Biophys Acta 1518 (1-2), 183-189 (2001)
   PUBMED   11267677
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053785.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF205717.1, BC091131.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-507               JAXUCZ010000002.1  143756061-143756567
            508-597             JAXUCZ010000002.1  143757269-143757358
            598-734             JAXUCZ010000002.1  143764342-143764478
            735-924             JAXUCZ010000002.1  143767447-143767636
            925-1575            JAXUCZ010000002.1  143770633-143771283
FEATURES             Location/Qualifiers
     source          1..1575
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..1575
                     /gene="Tm4sf4"
                     /gene_synonym="Lrtm4"
                     /note="transmembrane 4 L six family member 4"
                     /db_xref="GeneID:116467"
                     /db_xref="RGD:621784"
     exon            1..507
                     /gene="Tm4sf4"
                     /gene_synonym="Lrtm4"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..942
                     /gene="Tm4sf4"
                     /gene_synonym="Lrtm4"
                     /note="transmembrane 4 superfamily member 4"
                     /codon_start=1
                     /product="transmembrane 4 L6 family member 4"
                     /protein_id="NP_446237.1"
                     /db_xref="GeneID:116467"
                     /db_xref="RGD:621784"
                     /translation="MCTGGCARCLGGTLIPLAVFAVLANILLFFPGGKVVDDNSHLSD
                     EVWYFGGILGSGVLMIFPALVFLGLQNNDCCGCCGNESCGKRFAMFTSTLFAVVGFLG
                     AAYSFIVSAVSINKGPKCFMTNNTWGYPFHDGDYLNDQALWSKCEEPRDVVPWNLTLF
                     SILLVIGGIQMVLCAIQVINGLLGTLCGDCQCCGCCGGDRPV"
     exon            508..597
                     /gene="Tm4sf4"
                     /gene_synonym="Lrtm4"
                     /inference="alignment:Splign:2.1.0"
     exon            598..734
                     /gene="Tm4sf4"
                     /gene_synonym="Lrtm4"
                     /inference="alignment:Splign:2.1.0"
     exon            735..924
                     /gene="Tm4sf4"
                     /gene_synonym="Lrtm4"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1575
                     /gene="Tm4sf4"
                     /gene_synonym="Lrtm4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcaactcga acatcttgtc tgtgctggtg gattattaac agaggttatt ggtctccatg
       61 gcaaaacaac tgaacgatcg cgcagaacgt aatctcattt atggggtgca aaaaaaaaag
      121 acattgggtc agggatataa atgcccattg ccactgaggg cctgctatag ttcagaagtg
      181 actccacggt tcaaaacgct ctgacatttt ggtcccaaat ttcttactga accaggtaca
      241 gccactgcaa cgcgctgcca aaatccctga ggagtcctgt gaagctggtg gtgaggagcc
      301 tttgatctct gtgctttact gtgccacccc agcatgtgta ctgggggctg tgccaggtgc
      361 ctggggggca ccctcattcc cttggctgtg tttgccgtcc tggcaaatat cctgttgttt
      421 tttcctggag gaaaagtggt ggatgacaac agccaccttt cggatgaggt ctggtacttc
      481 ggaggaatac tgggaagtgg agtcttgatg atcttccctg cgctggtgtt cttgggcctg
      541 cagaacaatg actgctgcgg atgctgtggt aatgagagct gtgggaagcg atttgcgatg
      601 ttcacctcca cgttgtttgc tgtggttggc ttcttgggtg ctgcatactc atttatcgtc
      661 tcagccgttt ccatcaacaa gggtcctaaa tgcttcatga ccaataacac ctggggatac
      721 cccttccacg atggtgatta tcttaatgac caagccttgt ggagcaagtg cgaagaaccc
      781 cgcgatgtgg tcccttggaa tctcaccctt ttctccattc tgctggtcat cggagggatc
      841 cagatggttc tctgtgccat ccaggtgatc aatggcctcc tgggaactct ctgtggagac
      901 tgccagtgct gtggctgctg tgggggtgat agaccagtct aacaggctac gatgatctgc
      961 tccaagtcta cagcaccatg tgtgggaaga catggcccag gcccagcact gcacacatgg
     1021 gctgctaact cctgtccggt tggatcctct ctggcagagc ttgggaggca caggagatcc
     1081 tttactctct ccaaacaact tagctcaacc caggaatttg gtggaatttt tttactttgc
     1141 aaattaggcc ctattttgaa ttccagaaca agtttaaagc acatttttca tgatttccca
     1201 taagaaaagt taaaatagag gaggtcactt gtcctaccac attgtctctt tgtgtataaa
     1261 gatgtccata ctttaggaat atttgcattg aactcaaaga gataaagcat tacaaggaaa
     1321 accggttttt caggatgcat aggtaaggaa tgattgctat attatatata atttttatgt
     1381 gaagcctgtt ttggctaact tgtctggact acttgtaact agttttatga gcctgtcata
     1441 atttgccagg gttcccacat gtatattaag ttaattaaat tcagaattaa aataataaat
     1501 gtggggggag gaagaagaga aagaatgtat cagacctgct tgtctttttt ctttttataa
     1561 atgcattctt tcttt
//
