LOCUS       NM_001172125            1382 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus T-cell leukemia homeobox 2 (Tlx2), mRNA.
ACCESSION   NM_001172125 XM_001054552 XM_001072343
VERSION     NM_001172125.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1382)
  AUTHORS   Parisi,M.A., Lipman,N.S., Clarke,C.M., Taylor,B. and Kapur,R.P.
  TITLE     Evaluation of Hox11L1 in the fmc/fmc rat model of chronic
            intestinal pseudo-obstruction
  JOURNAL   J Pediatr Surg 40 (11), 1760-1765 (2005)
   PUBMED   16291166
  REMARK    GeneRIF: Despite the phenotypic similarities between fmc/fmc rats
            and Hox11L1-/- mice, fmc does not appear to be a mutant allele of
            the Hox11L1 gene
REFERENCE   2  (bases 1 to 1382)
  AUTHORS   Shimizu,H., Kang,M., Iitsuka,Y., Ichinose,M., Tokuhisa,T. and
            Hatano,M.
  TITLE     Identification of an optimal Ncx binding sequence required for
            transcriptional activation
  JOURNAL   FEBS Lett 475 (3), 170-174 (2000)
   PUBMED   10869550
REFERENCE   3  (bases 1 to 1382)
  AUTHORS   Tang,S.J., Suen,T.C., McInnes,R.R. and Buchwald,M.
  TITLE     Association of the TLX-2 homeodomain and 14-3-3eta signaling
            proteins
  JOURNAL   J Biol Chem 273 (39), 25356-25363 (1998)
   PUBMED   9738002
REFERENCE   4  (bases 1 to 1382)
  AUTHORS   Tang,S.J., Hoodless,P.A., Lu,Z., Breitman,M.L., McInnes,R.R.,
            Wrana,J.L. and Buchwald,M.
  TITLE     The Tlx-2 homeobox gene is a downstream target of BMP signalling
            and is required for mouse mesoderm development
  JOURNAL   Development 125 (10), 1877-1887 (1998)
   PUBMED   9550720
REFERENCE   5  (bases 1 to 1382)
  AUTHORS   Hatano,M., Aoki,T., Dezawa,M., Yusa,S., Iitsuka,Y., Koseki,H.,
            Taniguchi,M. and Tokuhisa,T.
  TITLE     A novel pathogenesis of megacolon in Ncx/Hox11L.1 deficient mice
  JOURNAL   J Clin Invest 100 (4), 795-801 (1997)
   PUBMED   9259577
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Feb 5, 2010 this sequence version replaced
            XM_001054552.1, XM_001072343.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AW533294.1, AI575156.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN17050745, SAMN17050746
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-614               JAXUCZ010000004.1  117132746-117133359 c
            615-852             JAXUCZ010000004.1  117132125-117132362 c
            853-1382            JAXUCZ010000004.1  117131516-117132045 c
FEATURES             Location/Qualifiers
     source          1..1382
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..1382
                     /gene="Tlx2"
                     /gene_synonym="Hox11L.1"
                     /note="T-cell leukemia homeobox 2"
                     /db_xref="GeneID:680117"
                     /db_xref="RGD:1595506"
     exon            1..614
                     /gene="Tlx2"
                     /gene_synonym="Hox11L.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1069
                     /gene="Tlx2"
                     /gene_synonym="Hox11L.1"
                     /codon_start=1
                     /product="T-cell leukemia homeobox protein 2"
                     /protein_id="NP_001165596.1"
                     /db_xref="GeneID:680117"
                     /db_xref="RGD:1595506"
                     /translation="MEPAVLAPHHLPHHEPISFGIDQILSGPEPPGGGLGPGQVGQSQ
                     GESAAFSSGFHGTSGYAPAGSLASLPRGSGVGPGGVIRVPAHRPVPVPPPSGAAPAVA
                     GPSGLGGPGGLAGLTFPWMDSGRRFAKDRLTAALSPFSGTRRIGHPYQNRTPPKRKKP
                     RTSFSRSQVLELERRFLRQKYLASAERAALAKALRMTDAQVKTWFQNRRTKWRRQTAE
                     EREAERHRAGRLLLHLQQDALPRPLRPPLPPDPLCLHNSSLFALQNLQPWAEDNKVAS
                     VSGLASVV"
     exon            615..852
                     /gene="Tlx2"
                     /gene_synonym="Hox11L.1"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1382
                     /gene="Tlx2"
                     /gene_synonym="Hox11L.1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggatgcga gtccctgagc ggactcccgg gaggggcggg cacacgcgcg gcttctcccg
       61 gtgcacaggg atgttgctgt cccgggggcc ccggcgcgtg gccgaggcca gccccgcggg
      121 cccctgaagc tgctgccccg agcgcgccgc cgccgggctc ccgcagccgt cagagacacc
      181 gtttccagtc atccaacctc tcaggcttgg acccatggag cccgcagtgt tggctccgca
      241 ccaccttccg caccacgaac ccattagctt cggcatcgat cagatactga gcggccccga
      301 gcccccgggg ggcggtctgg gtccgggtca ggttggccag agccaagggg agagtgcggc
      361 gttctccagt ggattccacg gaacctcagg ctacgctcca gccggctcgc tggcctcgtt
      421 gcctaggggc tcgggagtgg gccccggcgg cgtgatccga gtccccgcgc accgcccggt
      481 gcctgtgccg ccgccctcgg gtgcggcccc cgccgtggcc ggaccgtctg gtttgggtgg
      541 ccctgggggc ctagcgggac tcactttccc ctggatggac agcggccgcc gctttgcaaa
      601 ggacaggctc accgctgcgc tctcgccctt ctctgggaca cgtcgcatag gccaccccta
      661 tcaaaaccgg acccccccga agcgcaagaa gccgcgcacc tccttttccc gctcacaggt
      721 gctggagctg gagcgccgct tcttgcgcca gaagtacctg gcctcggcag agagggcggc
      781 gctggccaag gccctgcgca tgacggacgc acaggtcaag acctggttcc agaaccgacg
      841 cacgaagtgg cggcgccaga cagcggagga gcgcgaggcc gagcggcatc gcgcgggtcg
      901 cctgctgctg cacctgcagc aagacgcgct gccccggccg ctgcgaccac cgctgccacc
      961 ggacccgctc tgcctgcaca actcgtcact cttcgcgctg cagaatctac agccttgggc
     1021 cgaggacaac aaggtggctt cagtgtcggg gctcgcctcg gtggtgtgag ctacgcctgc
     1081 ccgatgagcg aacgccatcg tgactgggtg ccgtgccacc agcgaagcgt gaggagcgga
     1141 aagcctgcag ctgtcctcta aggctccttg gccaccagtg gcccctggcc cgcactttga
     1201 cttcgccctt catggctttt ttttttagac ccgctgagac atgggtttgc aagggcaacc
     1261 tgcaggattg tgaatgaaga agggaccctg caaggcactg cgactctgcc ctgccctgag
     1321 tgagctcaga gctcaggtcc tgctgggaag gggccaccga actggtacga aagcggacat
     1381 ca
//
