LOCUS       NM_198131               3326 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Rattus norvegicus toll-like receptor 9 (Tlr9), mRNA.
ACCESSION   NM_198131
VERSION     NM_198131.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3326)
  AUTHORS   Shao,W., Huang,Y., Wang,L., Li,P., Jia,Y. and Zhang,J.
  TITLE     Expression of fibrinogen-like protein 2 (Fgl2) on Toll-like
            receptor 9 (TLR9) expression in autoimmune myelitis
  JOURNAL   Int Immunopharmacol 114, 109539 (2023)
   PUBMED   36508913
  REMARK    GeneRIF: Expression of fibrinogen-like protein 2 (Fgl2) on
            Toll-like receptor 9 (TLR9) expression in autoimmune myelitis.
REFERENCE   2  (bases 1 to 3326)
  AUTHORS   Niu,Z., Bao,L. and Chen,J.
  TITLE     Upregulation of TLR9 may contribute to activation of microglia and
            painful diabetic neuropathy via the p38 MAPK pathway in rats
  JOURNAL   Histol Histopathol 37 (1), 81-91 (2022)
   PUBMED   34889455
  REMARK    GeneRIF: Upregulation of TLR9 may contribute to activation of
            microglia and painful diabetic neuropathy via the p38 MAPK pathway
            in rats.
REFERENCE   3  (bases 1 to 3326)
  AUTHORS   Vetreno,R.P., Qin,L., Coleman,L.G. Jr. and Crews,F.T.
  TITLE     Increased Toll-like Receptor-MyD88-NFkappaB-Proinflammatory
            neuroimmune signaling in the orbitofrontal cortex of humans with
            alcohol use disorder
  JOURNAL   Alcohol Clin Exp Res 45 (9), 1747-1761 (2021)
   PUBMED   34415075
REFERENCE   4  (bases 1 to 3326)
  AUTHORS   Niemczyk,G., Fus,L., Czarzasta,K., Jesion,A., Radziszewski,P.,
            Gornicka,B. and Cudnoch-Jedrzejewska,A.
  TITLE     Expression of Toll-Like Receptors in the Animal Model of Bladder
            Outlet Obstruction
  JOURNAL   Biomed Res Int 2020, 6632359 (2020)
   PUBMED   33381567
  REMARK    GeneRIF: Expression of Toll-Like Receptors in the Animal Model of
            Bladder Outlet Obstruction.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3326)
  AUTHORS   Guo,H.Y. and Cui,Z.J.
  TITLE     Extracellular Histones Activate Plasma Membrane Toll-Like Receptor
            9 to Trigger Calcium Oscillations in Rat Pancreatic Acinar Tumor
            Cell AR4-2J
  JOURNAL   Cells 8 (1), 3 (2018)
   PUBMED   30577532
  REMARK    GeneRIF: These data together suggest that extracellular histones
            activate plasma membrane TLR9 to trigger calcium oscillations in
            AR4-2J cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3326)
  AUTHORS   Cornelie,S., Hoebeke,J., Schacht,A.M., Bertin,B., Vicogne,J.,
            Capron,M. and Riveau,G.
  TITLE     Direct evidence that toll-like receptor 9 (TLR9) functionally binds
            plasmid DNA by specific cytosine-phosphate-guanine motif
            recognition
  JOURNAL   J Biol Chem 279 (15), 15124-15129 (2004)
   PUBMED   14736866
REFERENCE   7  (bases 1 to 3326)
  AUTHORS   Tabeta,K., Georgel,P., Janssen,E., Du,X., Hoebe,K., Crozat,K.,
            Mudd,S., Shamel,L., Sovath,S., Goode,J., Alexopoulou,L.,
            Flavell,R.A. and Beutler,B.
  TITLE     Toll-like receptors 9 and 3 as essential components of innate
            immune defense against mouse cytomegalovirus infection
  JOURNAL   Proc Natl Acad Sci U S A 101 (10), 3516-3521 (2004)
   PUBMED   14993594
REFERENCE   8  (bases 1 to 3326)
  AUTHORS   Wald,D., Qin,J., Zhao,Z., Qian,Y., Naramura,M., Tian,L., Towne,J.,
            Sims,J.E., Stark,G.R. and Li,X.
  TITLE     SIGIRR, a negative regulator of Toll-like receptor-interleukin 1
            receptor signaling
  JOURNAL   Nat Immunol 4 (9), 920-927 (2003)
   PUBMED   12925853
REFERENCE   9  (bases 1 to 3326)
  AUTHORS   Bottcher,T., von Mering,M., Ebert,S., Meyding-Lamade,U., Kuhnt,U.,
            Gerber,J. and Nau,R.
  TITLE     Differential regulation of Toll-like receptor mRNAs in experimental
            murine central nervous system infections
  JOURNAL   Neurosci Lett 344 (1), 17-20 (2003)
   PUBMED   12781911
REFERENCE   10 (bases 1 to 3326)
  AUTHORS   Hemmi,H., Takeuchi,O., Kawai,T., Kaisho,T., Sato,S., Sanjo,H.,
            Matsumoto,M., Hoshino,K., Wagner,H., Takeda,K. and Akira,S.
  TITLE     A Toll-like receptor recognizes bacterial DNA
  JOURNAL   Nature 408 (6813), 740-745 (2000)
   PUBMED   11130078
  REMARK    Erratum:[Nature 2001 Feb 1;409(6820):646]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY191271.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY191271.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3326
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..3326
                     /gene="Tlr9"
                     /note="toll-like receptor 9"
                     /db_xref="GeneID:338457"
                     /db_xref="RGD:631352"
     exon            1..99
                     /gene="Tlr9"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..3195
                     /gene="Tlr9"
                     /codon_start=1
                     /product="toll-like receptor 9 precursor"
                     /protein_id="NP_937764.1"
                     /db_xref="GeneID:338457"
                     /db_xref="RGD:631352"
                     /translation="MVLCSRTLHPLSLLVQAAVLAEALALGTLPAFLPCELKPHGLVD
                     CNWLFLKSVPHFSAAEPRSNITSLSLIANRIHHLHNLDFVHLPNVRQLNLKWNCPPPG
                     LSPLHFSCRMTIEPKTFLAMRMLEELNLSYNGITTVPRLPSSLTNLSLSHTNILVLDA
                     SSLAGLHSLRVLFMDGNCYYKNPCNGAVNVTPDAFLGLSNLTHLSLKYNNLTEVPRQL
                     PPSLEYLLLSYNLIVKLGPEDLANLTSLRVLDVGGNCRRCDHAPDLCTECRQKSLDLH
                     PQTFHHLSHLEGLVLKDSSLHSLNSKWFQGLVNLSVLDLSENFLYESINKTSAFQNLT
                     RLRKLDLSFNYCKKVSFARLHLASSFKSLVSLQELNMNGIFFRLLNKNTLRWLAGLPK
                     LHTLHLQMNFINQAQLSVFSTFRALRFVDLSNNRISGPPTLSRVAPEKADEAEKGVPW
                     PASLTPALPSTPVSKNFMVRCKNLRFTMDLSRNNLVTIKPEMFVNLSHLQCLSLSHNC
                     IAQAVNGSQFLPLTNLKVLDLSYNKLDLYHSKSFSELPQLQALDLSYNSQPFSMQGIG
                     HNFSFLANLSRLQNLSLAHNDIHSRVSSRLYSTSVEYLDFSGNGVGRMWDEEDLYLYF
                     FQDLRSLIHLDLSQNKLHILRPQNLNYLPKSLTKLSFRDNHLSFFNWSSLAFLPNLRD
                     LDLAGNLLKALTNGTLPNGTLLQKLDVSSNSIVFVVPAFFALAVELKEVNLSHNILKT
                     VDRSWFGPIVMNLTVLDVSSNPLHCACGAPFVDLLLEVQTKVPGLANGVKCGSPRQLQ
                     GRSIFAQDLRLCLDDVLSRDCFGLSLLAVAVGTVLPLLQHLCGWDVWYCFHLCLAWLP
                     LLTRGRRSAQALPYDAFVVFDKAQSAVADWVYNELRVRLEERRGRRALRLCLEDRDWL
                     PGQTLFENLWASIYGSRKTLFVLAHTDKVSGLLRTSFLLAQQRLLEDRKDVVVLVILR
                     PDAHRSRYVRLRQRLCRQSVLFWPHQPNGQGSFWAQLSTALTRDNHHFYNRNFCRGPT
                     AE"
     exon            100..3313
                     /gene="Tlr9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgcttcct caattctctg agggaccctg gtgcggatca ttctctgctg cccagtttgt
       61 cagagggagc ctctggagaa tcttccattt tccatcatgg ttctctgtag caggaccctg
      121 caccccttgt ctctcctggt acaggctgca gtgctggctg aggctctggc cctgggtacc
      181 ctgcctgcct tcctaccctg tgaactgaag cctcatggcc tggtagactg caactggctg
      241 ttcctgaagt ctgtgcctca cttctctgcc gcagaacccc gttccaacat caccagcctt
      301 tccttgatcg ccaaccgcat ccaccacctg cacaacctcg actttgtcca cctgcccaac
      361 gtgcgacagc tgaacctcaa gtggaactgt ccgccccctg gtctcagccc cttgcacttc
      421 tcctgccgca tgaccattga gcccaaaacc ttcctggcta tgcgcatgct ggaagagctg
      481 aacctgagct ataacggtat caccactgtg ccccgcctgc ccagctccct gacgaatctg
      541 agcctaagcc acaccaacat cctggtactc gatgccagca gccttgctgg cctgcacagc
      601 ctgcgagttc tcttcatgga cgggaactgc tactacaaga acccctgcaa cggggcggtg
      661 aacgtgaccc cggacgcctt cctgggcttg agcaacctca cccacttgtc ccttaagtat
      721 aacaacctca cagaggtgcc ccgccaactg ccccccagcc tggagtacct cctgctgtcc
      781 tataacctca tcgtcaagct ggggcccgaa gacctagcca acctgacctc ccttcgagtg
      841 cttgatgtgg gtgggaattg ccgtcgctgt gatcacgccc ccgacctctg tacagaatgc
      901 cggcagaagt cccttgatct gcaccctcag actttccatc acctgagcca ccttgaaggc
      961 ctggtgctga aggacagttc tctccactcg ctgaactcca agtggttcca gggtctggtg
     1021 aacctctcgg tgctggacct aagcgagaac tttctctacg agagcatcaa caaaaccagc
     1081 gcctttcaga acctgacccg tctgcgcaag ctcgacctgt ccttcaatta ctgcaagaag
     1141 gtatcgttcg cccgcctcca cctggcaagt tccttcaaga gcctggtgtc gctgcaggag
     1201 ctgaacatga acggcatctt cttccgcttg ctcaacaaga acacgctcag gtggctggct
     1261 ggtctgccca agctccacac gctgcacctt caaatgaatt tcatcaacca ggcgcagctc
     1321 agcgtcttta gtaccttccg agcccttcgc tttgtggacc tgtccaataa tcgcatcagc
     1381 gggcctccaa cgctgtccag agtcgccccc gaaaaggcag acgaggcgga gaagggggtt
     1441 ccatggcctg caagtctcac cccagctctc ccgagcactc ccgtctcaaa gaacttcatg
     1501 gtcaggtgta agaacctcag attcaccatg gacctgtctc ggaacaacct ggtgactatc
     1561 aagccagaga tgttcgtcaa cctctcccat ctccagtgtc tgagcctgag ccacaactgc
     1621 atcgcgcagg ctgtcaatgg ctctcagttc ctgccgctga ccaacctgaa ggtgctggac
     1681 ctgtcctata acaagctgga cctgtaccat tcgaaatcgt tcagtgagct cccacagttg
     1741 caggccctgg acctgagcta caacagccag cccttcagca tgcaggggat aggccacaac
     1801 ttcagttttc tggccaatct gtccaggtta cagaacctta gcctggcaca caatgacatt
     1861 cacagccgcg tgtcctcacg cctctacagc acctcagtgg agtatctgga cttcagcggc
     1921 aacggtgtgg gccgcatgtg ggacgaggag gacctttacc tctatttctt ccaagacctg
     1981 agaagcctga ttcatctgga cctatctcag aataagctgc acatcctccg gccccagaac
     2041 ctcaactacc tccccaagag cctgacgaag ctgagtttcc gtgacaatca cctctctttc
     2101 tttaactgga gcagtctggc cttcctgccc aatctgcgag acctggacct ggcaggcaat
     2161 ctactaaagg ccctgaccaa cggcaccctg cctaatggca cgctcctcca gaaactggat
     2221 gtcagtagca acagtatcgt ctttgtggtc ccagccttct ttgctctggc ggtagagcta
     2281 aaagaggtca acctcagcca taacatcctc aagactgtgg atcgctcctg gtttgggccc
     2341 attgtgatga acctgacggt tctagacgtg agcagcaacc ctctgcattg tgcctgcggt
     2401 gcaccctttg tagacttact gctggaagtg cagaccaagg tgcctggcct ggctaacggt
     2461 gtgaagtgtg gcagtccccg ccagctgcag ggccgcagca tctttgcgca agacctgcgg
     2521 ctgtgcctgg atgacgtcct ttctcgggac tgctttggcc tttcactcct ggctgtggcc
     2581 gtgggcacgg tgttgccttt actgcagcat ctctgcggct gggacgtctg gtactgtttc
     2641 catctgtgcc tggcatggct acctttgctg acccgtggcc ggcgcagcgc ccaagctctc
     2701 ccttatgatg ccttcgtggt gttcgataag gcgcagagcg cggttgctga ctgggtgtat
     2761 aacgagcttc gagtgcggct agaggagcgg cgcggtcgcc gagccctacg cttgtgtctg
     2821 gaggaccgag attggctgcc tggccagaca ctcttcgaga acctctgggc ctccatctat
     2881 ggcagccgca agactctgtt tgtgctggcc cacacggaca aggtcagtgg cctcctgcgc
     2941 accagcttcc tgctggctca gcagcgcctg ctggaggacc gcaaggacgt ggtggtgttg
     3001 gtgatcctgc gccctgatgc ccaccgctcc cgctacgtgc gactgcgcca gcgcctctgc
     3061 cgccagagtg tgctcttctg gccccatcag cccaacgggc agggcagctt ctgggcccag
     3121 ctgagtacag ccctgactag ggacaaccac cacttctata accggaactt ctgccgggga
     3181 cctacagcag aatagctcag agcgagcgac agctgcatct tcacgcctgg tcaccgggtt
     3241 gctctgcctg ccttgctctg tcttatattg tcatatgtgg caagtgtgca atatatgcta
     3301 ctaagccacc aggaaaaaaa aaaaaa
//
