LOCUS       NM_001101009            3381 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Rattus norvegicus toll-like receptor 8 (Tlr8), mRNA.
ACCESSION   NM_001101009 XM_001070405
VERSION     NM_001101009.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3381)
  AUTHORS   Peng,C., Zhu,J., Guo,H., Zhao,L., Wu,F. and Liu,B.
  TITLE     Long non-coding RNA TLR8-AS1 induces preeclampsia through
            increasing TLR8/STAT1 axis
  JOURNAL   J Hypertens 41 (8), 1245-1257 (2023)
   PUBMED   37199563
  REMARK    GeneRIF: Long non-coding RNA TLR8-AS1 induces preeclampsia through
            increasing TLR8/STAT1 axis.
REFERENCE   2  (bases 1 to 3381)
  AUTHORS   Vetreno,R.P., Qin,L., Coleman,L.G. Jr. and Crews,F.T.
  TITLE     Increased Toll-like Receptor-MyD88-NFkappaB-Proinflammatory
            neuroimmune signaling in the orbitofrontal cortex of humans with
            alcohol use disorder
  JOURNAL   Alcohol Clin Exp Res 45 (9), 1747-1761 (2021)
   PUBMED   34415075
REFERENCE   3  (bases 1 to 3381)
  AUTHORS   Lu,Y.Y., Ma,X.J. and Yang,Y.N.
  TITLE     MicroRNA-18a-5p mitigates
            oxygen-glucose-deprivation/reoxygenation-induced injury through
            suppression of TLRs/NF-kappaB signaling by targeting TLR8 in PC12
            cells
  JOURNAL   Biosci Biotechnol Biochem 84 (12), 2476-2483 (2020)
   PUBMED   32815784
  REMARK    GeneRIF: MicroRNA-18a-5p mitigates
            oxygen-glucose-deprivation/reoxygenation-induced injury through
            suppression of TLRs/NF-kappaB signaling by targeting TLR8 in PC12
            cells.
REFERENCE   4  (bases 1 to 3381)
  AUTHORS   Tanji,H., Ohto,U., Shibata,T., Taoka,M., Yamauchi,Y., Isobe,T.,
            Miyake,K. and Shimizu,T.
  TITLE     Toll-like receptor 8 senses degradation products of single-stranded
            RNA
  JOURNAL   Nat Struct Mol Biol 22 (2), 109-115 (2015)
   PUBMED   25599397
REFERENCE   5  (bases 1 to 3381)
  AUTHORS   Zhen,A., Krutzik,S.R., Levin,B.R., Kasparian,S., Zack,J.A. and
            Kitchen,S.G.
  TITLE     CD4 ligation on human blood monocytes triggers macrophage
            differentiation and enhances HIV infection
  JOURNAL   J Virol 88 (17), 9934-9946 (2014)
   PUBMED   24942581
REFERENCE   6  (bases 1 to 3381)
  AUTHORS   Melchjorsen,J., Jensen,S.B., Malmgaard,L., Rasmussen,S.B.,
            Weber,F., Bowie,A.G., Matikainen,S. and Paludan,S.R.
  TITLE     Activation of innate defense against a paramyxovirus is mediated by
            RIG-I and TLR7 and TLR8 in a cell-type-specific manner
  JOURNAL   J Virol 79 (20), 12944-12951 (2005)
   PUBMED   16188996
REFERENCE   7  (bases 1 to 3381)
  AUTHORS   Peng,G., Guo,Z., Kiniwa,Y., Voo,K.S., Peng,W., Fu,T., Wang,D.Y.,
            Li,Y., Wang,H.Y. and Wang,R.F.
  TITLE     Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell
            function
  JOURNAL   Science 309 (5739), 1380-1384 (2005)
   PUBMED   16123302
REFERENCE   8  (bases 1 to 3381)
  AUTHORS   Kariko,K., Buckstein,M., Ni,H. and Weissman,D.
  TITLE     Suppression of RNA recognition by Toll-like receptors: the impact
            of nucleoside modification and the evolutionary origin of RNA
  JOURNAL   Immunity 23 (2), 165-175 (2005)
   PUBMED   16111635
REFERENCE   9  (bases 1 to 3381)
  AUTHORS   Heil,F., Hemmi,H., Hochrein,H., Ampenberger,F., Kirschning,C.,
            Akira,S., Lipford,G., Wagner,H. and Bauer,S.
  TITLE     Species-specific recognition of single-stranded RNA via toll-like
            receptor 7 and 8
  JOURNAL   Science 303 (5663), 1526-1529 (2004)
   PUBMED   14976262
REFERENCE   10 (bases 1 to 3381)
  AUTHORS   Jurk,M., Heil,F., Vollmer,J., Schetter,C., Krieg,A.M., Wagner,H.,
            Lipford,G. and Bauer,S.
  TITLE     Human TLR7 or TLR8 independently confer responsiveness to the
            antiviral compound R-848
  JOURNAL   Nat Immunol 3 (6), 499 (2002)
   PUBMED   12032557
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from EF032638.1.
            
            On Aug 13, 2007 this sequence version replaced XM_001070405.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF032638.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3381
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq13"
     gene            1..3381
                     /gene="Tlr8"
                     /note="toll-like receptor 8"
                     /db_xref="GeneID:684440"
                     /db_xref="RGD:1590327"
     exon            1..135
                     /gene="Tlr8"
                     /inference="alignment:Splign:2.1.0"
     exon            136..3381
                     /gene="Tlr8"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..3231
                     /gene="Tlr8"
                     /codon_start=1
                     /product="toll-like receptor 8 precursor"
                     /protein_id="NP_001094479.1"
                     /db_xref="GeneID:684440"
                     /db_xref="RGD:1590327"
                     /translation="MSPQSWILTCFCLLSSGTSAVFLKGNFSRSYPCDEKRHNALVTA
                     ECNHRQLHEVPQTIGKYVTDVDLSDNTIMHITNESFQKFRNLTKINLNHNAKQQHPNE
                     NKNGMNITEGAFLSLRNLTELLLEDNQLYTIPAGLPESLKELSLIQNNIFQVTKNNTF
                     GLRNLERLYLGWNCYFKCNQIFKVEDGAFNNLINLKLLSLSFNNLFSVPPKLPSSLSK
                     LFLSNAKISTITQEDFKGLEHLILLDLSGNCPRCFNAPFPCESCNLSASIRIHPLAFQ
                     NLTQLRFLNLSSTSLRTIPSTWFDNLTNLKELHLEFNYLVQEIASGAFLTKLPSLQTL
                     DLSFNFIHKEYLQYITISPNFSMLRSLRKLHLKGYVFRELKKEHFKPLQNLPNLTTIN
                     LGINFIEKIDFKAFQDFPNLKVIYLSGNRIASVIDGTDHSSWRNRLRKPLSTDYDEFD
                     PHMNFYHSTEPLIKPQCTTYGKALDLSLNNIFVIGKSQFEGFQDIACLNLSFNANGQV
                     LNGTEFSSMPHIKYLDLTNNRLDFDDNQTFSDLHDLEVLDLSHNAHYFSIAGVTHRLG
                     FIQNLIKLKVLNLSHNGIYTLTDEYKLQSKSLKELVFSGNRLDRLWNANDGKYWSIFT
                     SLETLTRLDLSYNNLQQIPNEAFLNLPQSLQELHINDNRLRFFNWTLLQYFPHLHVLD
                     LGRNELYFLTNCLSKFTHSLKTLLLNHNHFSHLPAGFLSEARNLVYLDLSFNTIKMIN
                     KSSLQTETKTNLSVLDLQGNHFDCTCDISDFRSWLEENPHVRIPRLVDVICSNPGDQR
                     WKSVMSLDLTTCVSDTTAAILFFFTFLTTSTVLLAALVHHLFYWDVWFIYHMCSAKLR
                     GYRSSSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESEDKSVLLCLEERDWDPGL
                     PIIDNLMQSINQSKKTIFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVL
                     QYSQYLRLRQRICKSSILQWPNNPKAENLFWQSLKNVVLTENDSRYDNLYIDSIRQY"
ORIGIN      
        1 tgatgctaaa acaaccagat ttcagaagtt tgccaaaatc tgctctctgc acaactcctg
       61 tacacagagg accacactgc actgctactg caagctattg aaagagaacc ttccagggat
      121 ctcagccgga aaggggaaaa catgtcccct cagtcgtgga ttctgacctg cttttgcctg
      181 ctctcctctg gaaccagtgc agtcttcctc aaagggaact tttccagaag ctatccctgt
      241 gatgagaaaa ggcacaatgc ccttgtgact gcagaatgca atcatcgtca actgcatgaa
      301 gttccccaaa ctatcggcaa atatgtgaca gatgtagact tgtcagacaa tactattatg
      361 cacataacaa atgagtcctt tcagaagttt cgaaacctca ctaaaatcaa tctgaaccac
      421 aatgccaaac aacagcaccc aaatgaaaat aaaaatggta tgaatattac agaaggggct
      481 ttcctcagcc taagaaatct aactgaatta ctgttggaag acaaccagtt atatactata
      541 cctgctgggt tgcctgagtc tttgaaagaa cttagcctaa ttcaaaacaa tatatttcag
      601 gtaactaaaa acaacacttt cgggctcagg aacttggaaa gactctattt gggctggaac
      661 tgctatttta agtgtaatca aatctttaaa gtagaagatg gggcatttaa caatcttata
      721 aacttgaagc ttctctcatt atctttcaat aaccttttct ccgtgcctcc caaactacca
      781 agctctctaa gcaaactttt tctgagcaat gccaagatct caaccatcac tcaggaagac
      841 ttcaaaggac tggaacattt aatattacta gatttgagtg gaaactgccc aaggtgtttc
      901 aatgccccat ttccttgtga atcttgcaac ttaagtgcgt ccatcagaat acatcctctt
      961 gcttttcaaa atctcactca acttcgcttt cttaacctct ctagcacttc cctcaggacg
     1021 attccttcta cctggttcga caatctgaca aatttgaagg aactccatct tgaattcaat
     1081 tatttagttc aagaaattgc ctcaggagca tttttaacca agctacccag tttacaaacc
     1141 cttgacctgt ccttcaactt tatacataaa gaatatttac aatatattac tatctccccg
     1201 aacttctcta tgcttcgttc tctcaggaag ttgcacttaa aaggttatgt gttccgagaa
     1261 cttaaaaagg aacatttcaa gcccctccag aatcttccaa acttaacaac cattaacttg
     1321 ggcattaact ttattgagaa aattgatttc aaagctttcc aggattttcc caacctcaaa
     1381 gttatttact tatcgggaaa tcgcatagca tccgtaatag atggtacaga ccactcctct
     1441 tggcgaaacc gtcttaggaa gcctctctca acagactatg acgagtttga tccacacatg
     1501 aatttttacc atagcactga acctttaata aagccacagt gtactactta tggcaaggcc
     1561 ttggatttaa gtttgaacaa tattttcgtt attgggaaaa gtcaatttga aggttttcag
     1621 gatatcgcct gcttaaatct gtctttcaat gccaatggtc aagtgttgaa tggcacagaa
     1681 ttctcatcca tgccccacat taaatacttg gatttaacca acaacagact agactttgat
     1741 gataaccaga ccttcagtga ccttcatgat ctagaagtgt tggacctgag ccacaatgca
     1801 cactatttca gtatagcagg ggtaacacac cgtctaggat ttatccagaa cttaataaag
     1861 ctcaaggtgt taaacctgag ccacaatggc atttacacgc tcacagatga atacaagctg
     1921 caaagcaaat ctctgaaaga gttggttttt agtggaaatc gccttgaccg tctgtggaat
     1981 gcaaatgatg gcaaatactg gtccattttt acaagtctcg agactctgac acgcttggac
     2041 ttatcgtaca ataaccttca acaaatccca aatgaagcat tcctcaactt gcctcagagc
     2101 ctccaagagc tacatatcaa tgataacaga ttacgtttct ttaattggac attactccag
     2161 tattttcctc accttcatgt gctggacttg gggagaaatg agctgtattt tctaaccaat
     2221 tgcctatcga agtttacaca ttccctgaag acactgctgc tgaaccacaa tcatttctct
     2281 cacctacctg ctggcttcct ctccgaagcc aggaatctgg tgtacctgga tctaagtttc
     2341 aacacaataa agatgatcaa taaatcctcc ctgcaaactg agacaaaaac aaacttgtct
     2401 gttctggatc tacaagggaa ccattttgac tgcacgtgtg acataagtga tttccgaagc
     2461 tggctagaag aaaatccgca tgtcagaatt cctagattgg tagatgtcat ttgttccaat
     2521 cctggggatc agagatggaa gagtgtcatg agcctagatc tcacgacttg tgtgtcagat
     2581 accactgcag ctatcctgtt cttcttcaca ttccttacca cctccacagt gctgttggct
     2641 gctctggttc atcatctgtt ttactgggat gtttggttta tctatcacat gtgctctgct
     2701 aagttaagag gctacaggtc ttcatccaca tcccaaactt tctatgatgc ttacatttct
     2761 tatgacacca aagacgcatc cgtcactgac tgggtgatca atgagctgcg ctaccacctt
     2821 gaagagagtg aggacaaaag tgtcctcctt tgcttagagg agagggattg ggatccggga
     2881 ttacctatca ttgataacct catgcagagc ataaaccaga gcaagaagac aatctttgtt
     2941 ttaaccaaga aatatgccaa gagctggaac tttaaaaccg ctttctactt ggccttgcag
     3001 aggctaatgg atgagaacat ggatgtgatt atcttcatcc tcctggaacc agtgttacag
     3061 tattcacagt acctgaggct tcggcagagg atctgtaaga gctccatcct ccagtggccc
     3121 aacaacccca aagcggaaaa cttgttttgg caaagtctta aaaatgtggt cttgaccgaa
     3181 aatgattcac ggtatgacaa tttgtacatc gattccatta ggcaatacta atgctgggaa
     3241 gttatggctc tgtgccatca aaaaaaccac acagcttctc tttataatga actgtggcaa
     3301 gtgaatgggc acatggctgc gcgaggtgct gaaaataagg gacaattggg tgttcagccc
     3361 taaagaggac acttatacca g
//
