LOCUS       NP_001091051            1050 aa            linear   ROD 28-JAN-2025
DEFINITION  toll-like receptor 7 precursor [Rattus norvegicus].
ACCESSION   NP_001091051 XP_001066039 XP_228909
VERSION     NP_001091051.1
DBSOURCE    REFSEQ: accession NM_001097582.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1050)
  AUTHORS   Kim,J., Ha,S., Son,M., Kim,D., Kim,M.J., Kim,B., Kim,D., Chung,H.Y.
            and Chung,K.W.
  TITLE     TLR7 activation by miR-21 promotes renal fibrosis by activating the
            pro-inflammatory signaling pathway in tubule epithelial cells
  JOURNAL   Cell Commun Signal 21 (1), 215 (2023)
   PUBMED   37596656
  REMARK    GeneRIF: TLR7 activation by miR-21 promotes renal fibrosis by
            activating the pro-inflammatory signaling pathway in tubule
            epithelial cells.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1050)
  AUTHORS   Estevez,J. and Martinez,V.
  TITLE     The Local Activation of Toll-like Receptor 7 (TLR7) Modulates
            Colonic Epithelial Barrier Function in Rats
  JOURNAL   Int J Mol Sci 24 (2), 1254 (2023)
   PUBMED   36674770
  REMARK    GeneRIF: The Local Activation of Toll-like Receptor 7 (TLR7)
            Modulates Colonic Epithelial Barrier Function in Rats.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1050)
  AUTHORS   Vetreno,R.P., Qin,L., Coleman,L.G. Jr. and Crews,F.T.
  TITLE     Increased Toll-like Receptor-MyD88-NFkappaB-Proinflammatory
            neuroimmune signaling in the orbitofrontal cortex of humans with
            alcohol use disorder
  JOURNAL   Alcohol Clin Exp Res 45 (9), 1747-1761 (2021)
   PUBMED   34415075
REFERENCE   4  (residues 1 to 1050)
  AUTHORS   Fallerini,C., Daga,S., Mantovani,S., Benetti,E., Picchiotti,N.,
            Francisci,D., Paciosi,F., Schiaroli,E., Baldassarri,M., Fava,F.,
            Palmieri,M., Ludovisi,S., Castelli,F., Quiros-Roldan,E., Vaghi,M.,
            Rusconi,S., Siano,M., Bandini,M., Spiga,O., Capitani,K., Furini,S.,
            Mari,F., Renieri,A., Mondelli,M.U. and Frullanti,E.
  CONSRTM   GEN-COVID Multicenter Study
  TITLE     Association of Toll-like receptor 7 variants with life-threatening
            COVID-19 disease in males: findings from a nested case-control
            study
  JOURNAL   Elife 10, e67569 (2021)
   PUBMED   33650967
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1050)
  AUTHORS   Wu,W., Liu,J., Yang,C., Xu,Z., Huang,J. and Lin,J.
  TITLE     Astrocyte-derived exosome-transported microRNA-34c is
            neuroprotective against cerebral ischemia/reperfusion injury via
            TLR7 and the NF-kappaB/MAPK pathways
  JOURNAL   Brain Res Bull 163, 84-94 (2020)
   PUBMED   32682816
  REMARK    GeneRIF: Astrocyte-derived exosome-transported microRNA-34c is
            neuroprotective against cerebral ischemia/reperfusion injury via
            TLR7 and the NF-kappaB/MAPK pathways.
REFERENCE   6  (residues 1 to 1050)
  AUTHORS   Kariko,K., Buckstein,M., Ni,H. and Weissman,D.
  TITLE     Suppression of RNA recognition by Toll-like receptors: the impact
            of nucleoside modification and the evolutionary origin of RNA
  JOURNAL   Immunity 23 (2), 165-175 (2005)
   PUBMED   16111635
REFERENCE   7  (residues 1 to 1050)
  AUTHORS   Hornung,V., Guenthner-Biller,M., Bourquin,C., Ablasser,A.,
            Schlee,M., Uematsu,S., Noronha,A., Manoharan,M., Akira,S., de
            Fougerolles,A., Endres,S. and Hartmann,G.
  TITLE     Sequence-specific potent induction of IFN-alpha by short
            interfering RNA in plasmacytoid dendritic cells through TLR7
  JOURNAL   Nat Med 11 (3), 263-270 (2005)
   PUBMED   15723075
REFERENCE   8  (residues 1 to 1050)
  AUTHORS   Heil,F., Hemmi,H., Hochrein,H., Ampenberger,F., Kirschning,C.,
            Akira,S., Lipford,G., Wagner,H. and Bauer,S.
  TITLE     Species-specific recognition of single-stranded RNA via toll-like
            receptor 7 and 8
  JOURNAL   Science 303 (5663), 1526-1529 (2004)
   PUBMED   14976262
REFERENCE   9  (residues 1 to 1050)
  AUTHORS   Diebold,S.S., Kaisho,T., Hemmi,H., Akira,S. and Reis e Sousa,C.
  TITLE     Innate antiviral responses by means of TLR7-mediated recognition of
            single-stranded RNA
  JOURNAL   Science 303 (5663), 1529-1531 (2004)
   PUBMED   14976261
REFERENCE   10 (residues 1 to 1050)
  AUTHORS   Bottcher,T., von Mering,M., Ebert,S., Meyding-Lamade,U., Kuhnt,U.,
            Gerber,J. and Nau,R.
  TITLE     Differential regulation of Toll-like receptor mRNAs in experimental
            murine central nervous system infections
  JOURNAL   Neurosci Lett 344 (1), 17-20 (2003)
   PUBMED   12781911
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from EF032637.1.
            
            On or before May 23, 2007 this sequence version replaced
            XP_228909.3, XP_001066039.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF032637.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1050
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq13"
     Protein         1..1050
                     /product="toll-like receptor 7 precursor"
                     /calculated_mol_wt=118190
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3128
     Region          48..69
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          75..139
                     /region_name="LRR_8"
                     /note="Leucine rich repeat; pfam13855"
                     /db_xref="CDD:404697"
     Region          91..128
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          124..>434
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          129..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          174..205
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          190..>734
                     /region_name="PLN00113"
                     /note="leucine-rich repeat receptor-like protein kinase;
                     Provisional"
                     /db_xref="CDD:215061"
     Region          206..226
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          227..250
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          251..291
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          292..315
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          316..341
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          352..371
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          372..398
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          399..422
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          497..519
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          520..544
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          545..568
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          569..598
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          599..621
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          622..652
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          653..677
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          678..701
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          702..725
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          725..>768
                     /region_name="LRR_8"
                     /note="Leucine rich repeat; pfam13855"
                     /db_xref="CDD:404697"
     Region          750..768
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          891..1036
                     /region_name="TIR"
                     /note="Toll - interleukin 1 - resistance; smart00255"
                     /db_xref="CDD:214587"
     CDS             1..1050
                     /gene="Tlr7"
                     /gene_synonym="RGD1563357"
                     /coded_by="NM_001097582.1:155..3307"
                     /db_xref="GeneID:317468"
                     /db_xref="RGD:1563357"
ORIGIN      
        1 mvfpmwtlkr qsfiflnmil vsrvlgfrwy pktlpcdvsl dstnthvivd ctdkhlteip
       61 egiptnttnl tltinhipsi spdsfhrlkh leeldlrcnc vpillgskan vctkrlqirp
      121 gsfsglsdlk slyldgnqll eipqdlpssl qllsleanni fsitkenlse lvnieslylg
      181 qncyyrnpcn vsysiekdaf lvmknlkvls lkdnnvtavp tilppnllel ylynniikri
      241 qehdfnklsq lqvldlsgnc prcynvpypc tpcennsplq ihdnafdslt elkvlrlhsn
      301 slqhvpaewf knmsnlqeld lsqnylarei eeakflnslp nlvqldlsfn yelqvyhasi
      361 tlphslsslt klknlyikgy vfkelkdssl svlhnlsnle vldlgtnfik iadlnifqqf
      421 enlkfidlsv nkispseesr evglcpnaqt svdwhgpqvl ealhyfryde yarscrfknk
      481 epptflplna dchtygktld lsrnniffik psdfkhlsfl kclnlsgnai gqtlngselq
      541 plrelryldf snnrldllys tafeelqnle ildlssnshy fqaegithml nftkklrhle
      601 klmmndndis tsasrtmese slrvlefrgn hldvlwrdgd nryldffknl lnleeldisr
      661 nslnsvppgv fegmppnltt lslaknglrs fswgrlqllk hlknldlshn qlttvparla
      721 ncsksltkli lnhnqirqlt kyfledalql ryldissnki qviqktsfpe nvlnnlnmll
      781 lhhnrflcnc davwfvwwvn htdvtipyla tdvtcagpga hkgqsvisld lytceldltn
      841 lilfsvsiss vlflmivmtt shlffwdmwy iyyfwkakik gyqhlqsmes cydafivydt
      901 knsavtewvl qelvvkledp rekhfnlcle erdwlpgqpv lenlsqsiql srktvfvmtq
      961 kyaktesfkm afylshqrlm dekvdviili flekplqksk flqlrkrlcs ssvlewptnp
     1021 qahpyfwqcl knalttdnhv aysqmfketv
//
