LOCUS       NM_207604               2820 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Rattus norvegicus toll-like receptor 6 (Tlr6), mRNA.
ACCESSION   NM_207604 XM_223420
VERSION     NM_207604.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2820)
  AUTHORS   Vetreno,R.P., Qin,L., Coleman,L.G. Jr. and Crews,F.T.
  TITLE     Increased Toll-like Receptor-MyD88-NFkappaB-Proinflammatory
            neuroimmune signaling in the orbitofrontal cortex of humans with
            alcohol use disorder
  JOURNAL   Alcohol Clin Exp Res 45 (9), 1747-1761 (2021)
   PUBMED   34415075
REFERENCE   2  (bases 1 to 2820)
  AUTHORS   Freire,D., Reyes,R.E., Baghram,A., Davies,D.L. and Asatryan,L.
  TITLE     P2X7 Receptor Antagonist A804598 Inhibits Inflammation in Brain and
            Liver in C57BL/6J Mice Exposed to Chronic Ethanol and High Fat Diet
  JOURNAL   J Neuroimmune Pharmacol 14 (2), 263-277 (2019)
   PUBMED   30353422
REFERENCE   3  (bases 1 to 2820)
  AUTHORS   Wang,H.F., Li,Y., Wang,Y.Q., Li,H.J. and Dou,L.
  TITLE     MicroRNA-494-3p alleviates inflammatory response in sepsis by
            targeting TLR6
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (7), 2971-2977 (2019)
   PUBMED   31002148
REFERENCE   4  (bases 1 to 2820)
  AUTHORS   Golovkin,A.S., Ponasenko,A.V., Yuzhalin,A.E., Salakhov,R.R.,
            Khutornaya,M.V., Kutikhin,A.G., Rutkovskaya,N.V., Savostyanova,Y.Y.
            and Barbarash,L.S.
  TITLE     An association between single nucleotide polymorphisms within TLR
            and TREM-1 genes and infective endocarditis
  JOURNAL   Cytokine 71 (1), 16-21 (2015)
   PUBMED   25213166
REFERENCE   5  (bases 1 to 2820)
  AUTHORS   Jang,T.H. and Park,H.H.
  TITLE     Crystal structure of TIR domain of TLR6 reveals novel dimeric
            interface of TIR-TIR interaction for toll-like receptor signaling
            pathway
  JOURNAL   J Mol Biol 426 (19), 3305-3313 (2014)
   PUBMED   25088687
REFERENCE   6  (bases 1 to 2820)
  AUTHORS   Krishnegowda,G., Hajjar,A.M., Zhu,J., Douglass,E.J., Uematsu,S.,
            Akira,S., Woods,A.S. and Gowda,D.C.
  TITLE     Induction of proinflammatory responses in macrophages by the
            glycosylphosphatidylinositols of Plasmodium falciparum: cell
            signaling receptors, glycosylphosphatidylinositol (GPI) structural
            requirement, and regulation of GPI activity
  JOURNAL   J Biol Chem 280 (9), 8606-8616 (2005)
   PUBMED   15623512
REFERENCE   7  (bases 1 to 2820)
  AUTHORS   Schroder,N.W., Heine,H., Alexander,C., Manukyan,M., Eckert,J.,
            Hamann,L., Gobel,U.B. and Schumann,R.R.
  TITLE     Lipopolysaccharide binding protein binds to triacylated and
            diacylated lipopeptides and mediates innate immune responses
  JOURNAL   J Immunol 173 (4), 2683-2691 (2004)
   PUBMED   15294986
REFERENCE   8  (bases 1 to 2820)
  AUTHORS   Tantisira,K., Klimecki,W.T., Lazarus,R., Palmer,L.J., Raby,B.A.,
            Kwiatkowski,D.J., Silverman,E., Vercelli,D., Martinez,F.D. and
            Weiss,S.T.
  TITLE     Toll-like receptor 6 gene (TLR6): single-nucleotide polymorphism
            frequencies and preliminary association with the diagnosis of
            asthma
  JOURNAL   Genes Immun 5 (5), 343-346 (2004)
   PUBMED   15266299
REFERENCE   9  (bases 1 to 2820)
  AUTHORS   Takeuchi,O., Kawai,T., Muhlradt,P.F., Morr,M., Radolf,J.D.,
            Zychlinsky,A., Takeda,K. and Akira,S.
  TITLE     Discrimination of bacterial lipoproteins by Toll-like receptor 6
  JOURNAL   Int Immunol 13 (7), 933-940 (2001)
   PUBMED   11431423
REFERENCE   10 (bases 1 to 2820)
  AUTHORS   Takeuchi,O., Kawai,T., Sanjo,H., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Takeda,K. and Akira,S.
  TITLE     TLR6: A novel member of an expanding toll-like receptor family
  JOURNAL   Gene 231 (1-2), 59-65 (1999)
   PUBMED   10231569
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC062390.1.
            
            On Aug 30, 2004 this sequence version replaced XM_223420.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062390.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2820
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..2820
                     /gene="Tlr6"
                     /note="toll-like receptor 6"
                     /db_xref="GeneID:305353"
                     /db_xref="RGD:1303030"
     exon            1..211
                     /gene="Tlr6"
                     /inference="alignment:Splign:2.1.0"
     exon            212..2700
                     /gene="Tlr6"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..2663
                     /gene="Tlr6"
                     /EC_number="3.2.2.6"
                     /codon_start=1
                     /product="toll-like receptor 6"
                     /protein_id="NP_997487.1"
                     /db_xref="GeneID:305353"
                     /db_xref="RGD:1303030"
                     /translation="MVKSLWDSLCNMSQDREPIVESFHFVCTLALIVGSMTQFSDELE
                     SVVDYSNKNLTHVPKDLSPSTKSLSLSQNSISDLQMSDISFLSELRVLRLSHNRIRRL
                     DFGVFLLNRDLEYLDVSHNQLQNISCCPMVNLKHLDLSFNDFEVLPVYKEFGNLRKLS
                     FLGLSAAKFRQLDLLPISHLHLSCVLLDLVNYQIKDGETESLQVPNTNVLHLVFHPNS
                     LFSVQVNISVNALGCLQLSNIKLNDENCQSLIIFLSELTRGPTLLNLTLQHIETNWKC
                     FVRLLQFLWPRPVEYLNIYNLTITESISRETFIYVETVLKSLKIEHVTNQVFLFVKDA
                     LYSVFAEMNIRMLTLSDTPFIHMVCPEFPSTFAFLNFTQNVFTDSIFQGCSTLKRLET
                     LILQRNGLKNLFKVALMTKTMSSLETLDVSLNSLNSHVYDRTCAWAESIRVLNLSSNV
                     LSDSVFRCLPPKVKVLDLHNNRIVSIPKDVTHLQALQELNVASNFLTDLPGCGAFSSL
                     SVLVIDHNSVSHPSSDFFQSCQNIRSITAGNNPFRCTCELREFVKNIGQASREVVEGW
                     PDSYRCDYPDSIKGTPLQDFHMSPLSCDTILLTVTIGATLLLLAAIGASLCLYFDLPW
                     YLRMLWQWTQTRHRARNIPLEELQRNLQFHAFVSYSEHDSAWVKNELLPNLEKDDIRV
                     CLHERNFVPGKSIVENIIHFIEKSYKSIFVLSPHFIQSEWCHYELYFAHHNLFHEGSD
                     NLILILLEPIQQNNIPSRYHKLRALMAQRTYLEWPIEKGKRGLFWANLRASFIMKLAL
                     VNENDVKT"
ORIGIN      
        1 gtgggcctgt gttttgagtt caccaggcag ctttcttgca gcagaaaagt tggtcttacc
       61 tgtggtcccg aggctcaagt tcgctcgtgg ggtgctgccc acgggctctc tgcggcggca
      121 gcaaccagga atacctgtgc cgcctcttcc gggagcttca gtgcaccagg gttccagatg
      181 gcctttggtg ttttcctctg gcgtccgaga tatcttgaag acaagtaaaa atgctgtgaa
      241 gaatggtaaa atccctctgg gatagcctct gcaacatgtc ccaagacaga gaacccatcg
      301 tggagagttt ccattttgtt tgcaccctgg ccttaatagt cggaagcatg acccagttct
      361 ctgatgaact tgagtctgta gtagactatt caaacaagaa ccttactcat gtcccaaaag
      421 acctgtcacc aagcacaaaa tccttgagtc tgtctcaaaa ctccatatct gatcttcaga
      481 tgtctgatat cagctttctg tcagagctga gagttctgag actctcccac aacagaatac
      541 ggagacttga ctttggtgtg ttcttgctca atcgggactt agaatacctg gatgtctctc
      601 acaatcagtt acaaaacatc tcttgctgtc ctatggtgaa cttgaaacat ctagacctct
      661 cattcaatga ttttgaagtg ctgcccgtgt ataaggaatt tggcaacttg aggaagctga
      721 gtttcttggg attaagtgct gcaaagttcc gacaactgga tctgctccca atttctcact
      781 tgcacctgag ctgtgttctt ctggacttgg tgaattatca gataaaagat ggtgaaacag
      841 aaagtcttca ggttccaaat accaacgttc tccatttggt ctttcatccg aatagcctgt
      901 tctctgtgca agtgaacata tctgtaaatg ctttaggatg cttacaactg agtaatatta
      961 aattgaatga tgaaaactgt caaagcttaa ttatattttt atcagaactc accagaggtc
     1021 caaccttatt gaatctgacc ctccagcaca tagaaacaaa ctggaagtgc tttgttagac
     1081 ttttacaatt cctttggccc agacctgtgg agtatctcaa tatttacaac ttaacgataa
     1141 ctgagagcat aagcagggag acatttattt acgtggagac agtgttgaag tcactgaaga
     1201 tagagcatgt cacaaaccaa gtgttcctct ttgtgaagga tgcactatat tctgtgtttg
     1261 cagaaatgaa catcaggatg ctcacactgt cagacacgcc attcatccac atggtgtgcc
     1321 ctgagttccc aagcacattt gcatttctga actttaccca gaacgttttt actgacagca
     1381 tttttcaagg ctgttccacc ttgaagagac tggagacact tatcttgcaa aggaatggtt
     1441 taaagaacct ttttaaggta gctctcatga ccaagactat gtcctctctg gaaacattgg
     1501 atgtcagttt gaattctttg aactctcatg tgtatgacag aacatgtgct tgggccgaga
     1561 gcatacgggt gttgaatttg tcttcgaatg tactttcgga ctctgtcttc aggtgcttac
     1621 ctcccaaggt caaggtcctt gaccttcaca acaacaggat agtgagcatc cctaaagatg
     1681 tcacccacct gcaagctttg caggaactca atgtcgcatc caatttttta actgaccttc
     1741 ctggatgtgg agccttcagt agcctttctg tgctggtcat cgaccataac tcagtttccc
     1801 acccctcctc tgatttcttc cagagctgtc agaatatcag gtccataaca gcggggaaca
     1861 acccattccg atgcacatgt gagctgaggg agtttgtcaa aaacataggt caggcatcaa
     1921 gagaagtggt ggagggctgg cctgactctt acagatgtga ttacccagac agcattaagg
     1981 gaaccccact gcaggacttc cacatgtctc cactgtcctg cgatacaatt ctactgactg
     2041 tcaccattgg ggccactctg ctgctactgg ctgccattgg ggcttccctc tgtctctact
     2101 ttgatctgcc ctggtatctc aggatgctat ggcagtggac acagaccagg cacagggcca
     2161 ggaacatccc cttagaggaa ctgcagagga acctccagtt ccatgctttt gtctcataca
     2221 gtgagcatga ttctgcctgg gtgaagaatg aattactacc aaacctagag aaagatgaca
     2281 ttcgggtttg cctccatgag agaaactttg tccctggcaa gagcattgtg gagaacatca
     2341 tacacttcat tgagaagagt tacaagtcca tctttgtgct gtctccccac ttcatccaga
     2401 gtgagtggtg ccattatgaa ctctactttg cccatcacaa tctcttccac gaagggtctg
     2461 ataacttaat cctgatcttg ctggaaccca tccaacagaa caacattccc agtagatacc
     2521 acaagctgag ggctctcatg gcacagcgga cttacttgga atggcctatt gagaagggta
     2581 aacgtgggct gttttgggcc aaccttagag cttcttttat tatgaagcta gccttagtta
     2641 atgagaatga tgtgaaaact tgaagcttgg ctttccaaca taataaactg tcaatctgga
     2701 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2761 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
