LOCUS       NM_019178               3341 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Rattus norvegicus toll-like receptor 4 (Tlr4), mRNA.
ACCESSION   NM_019178
VERSION     NM_019178.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3341)
  AUTHORS   Tao,X., Hu,Y., Mao,N., Shen,M., Fang,M., Zhang,M., Lou,J., Fang,Y.,
            Guo,X. and Lin,Z.
  TITLE     Echinatin alleviates inflammation and pyroptosis in
            hypoxic-ischemic brain damage by inhibiting TLR4/ NF-kappaB pathway
  JOURNAL   Int Immunopharmacol 136, 112372 (2024)
   PUBMED   38850784
  REMARK    GeneRIF: Echinatin alleviates inflammation and pyroptosis in
            hypoxic-ischemic brain damage by inhibiting TLR4/ NF-kappaB
            pathway.
REFERENCE   2  (bases 1 to 3341)
  AUTHORS   Xu,L., Zhang,Y., Yu,J., Huo,W., Xu,J., Yang,H., Zhang,M., Yu,S.,
            Wu,Y. and Wang,M.
  TITLE     miR-708-5p deficiency involves the degeneration of mandibular
            condylar chondrocytes via the TLR4/NF-kappaB pathway
  JOURNAL   Osteoarthritis Cartilage 32 (6), 666-679 (2024)
   PUBMED   38403153
  REMARK    GeneRIF: miR-708-5p deficiency involves the degeneration of
            mandibular condylar chondrocytes via the TLR4/NF-kappaB pathway.
REFERENCE   3  (bases 1 to 3341)
  AUTHORS   Cao,W., Zeng,Y., Su,Y., Gong,H., He,J., Liu,Y. and Li,C.
  TITLE     The involvement of oxidative stress and the TLR4/NF-kappaB/NLRP3
            pathway in acute lung injury induced by high-altitude hypoxia
  JOURNAL   Immunobiology 229 (3), 152809 (2024)
   PUBMED   38788361
  REMARK    GeneRIF: The involvement of oxidative stress and the
            TLR4/NF-kappaB/NLRP3 pathway in acute lung injury induced by
            high-altitude hypoxia.
REFERENCE   4  (bases 1 to 3341)
  AUTHORS   de Oliveira,A.A., Elder,E., Spaans,F., Graton,M.E., Quon,A.,
            Kirschenman,R., Wooldridge,A.L., Cooke,C.M. and Davidge,S.T.
  TITLE     Excessive hypercholesterolemia in pregnancy impairs rat uterine
            artery function via activation of Toll-like receptor 4
  JOURNAL   Clin Sci (Lond) 138 (4), 137-151 (2024)
   PUBMED   38299431
  REMARK    GeneRIF: Excessive hypercholesterolemia in pregnancy impairs rat
            uterine artery function via activation of Toll-like receptor 4.
REFERENCE   5  (bases 1 to 3341)
  AUTHORS   Khomula,E.V., Araldi,D., Green,P.G. and Levine,J.D.
  TITLE     Sensitization of human and rat nociceptors by low dose morphine is
            toll-like receptor 4-dependent
  JOURNAL   Mol Pain 20, 17448069241227922 (2024)
   PUBMED   38195088
  REMARK    GeneRIF: Sensitization of human and rat nociceptors by low dose
            morphine is toll-like receptor 4-dependent.
REFERENCE   6  (bases 1 to 3341)
  AUTHORS   Ohashi,K., Burkart,V., Flohe,S. and Kolb,H.
  TITLE     Cutting edge: heat shock protein 60 is a putative endogenous ligand
            of the toll-like receptor-4 complex
  JOURNAL   J Immunol 164 (2), 558-561 (2000)
   PUBMED   10623794
REFERENCE   7  (bases 1 to 3341)
  AUTHORS   Takeuchi,O., Takeda,K., Hoshino,K., Adachi,O., Ogawa,T. and
            Akira,S.
  TITLE     Cellular responses to bacterial cell wall components are mediated
            through MyD88-dependent signaling cascades
  JOURNAL   Int Immunol 12 (1), 113-117 (2000)
   PUBMED   10607756
REFERENCE   8  (bases 1 to 3341)
  AUTHORS   Takeuchi,O., Hoshino,K., Kawai,T., Sanjo,H., Takada,H., Ogawa,T.,
            Takeda,K. and Akira,S.
  TITLE     Differential roles of TLR2 and TLR4 in recognition of gram-negative
            and gram-positive bacterial cell wall components
  JOURNAL   Immunity 11 (4), 443-451 (1999)
   PUBMED   10549626
REFERENCE   9  (bases 1 to 3341)
  AUTHORS   Frantz,S., Kobzik,L., Kim,Y.D., Fukazawa,R., Medzhitov,R., Lee,R.T.
            and Kelly,R.A.
  TITLE     Toll4 (TLR4) expression in cardiac myocytes in normal and failing
            myocardium
  JOURNAL   J Clin Invest 104 (3), 271-280 (1999)
   PUBMED   10430608
REFERENCE   10 (bases 1 to 3341)
  AUTHORS   Vogel,S.N., Johnson,D., Perera,P.Y., Medvedev,A., Lariviere,L.,
            Qureshi,S.T. and Malo,D.
  TITLE     Cutting edge: functional characterization of the effect of the
            C3H/HeJ defect in mice that lack an Lpsn gene: in vivo evidence for
            a dominant negative mutation
  JOURNAL   J Immunol 162 (10), 5666-5670 (1999)
   PUBMED   10229796
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 27, 2020 this sequence version replaced NM_019178.1.
            
            Sequence Note: This sequence has been modified as follows: removed
            22 bp suspected to be vector contamination from the 5' end.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ175880.1, AF057025.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-327               JAXUCZ010000005.1  85161247-85161573
            328-494             JAXUCZ010000005.1  85166812-85166978
            495-3341            JAXUCZ010000005.1  85172036-85174882
FEATURES             Location/Qualifiers
     source          1..3341
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..3341
                     /gene="Tlr4"
                     /note="toll-like receptor 4"
                     /db_xref="GeneID:29260"
                     /db_xref="RGD:3870"
     exon            1..327
                     /gene="Tlr4"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..2745
                     /gene="Tlr4"
                     /EC_number="3.2.2.6"
                     /note="toll4"
                     /codon_start=1
                     /product="toll-like receptor 4 precursor"
                     /protein_id="NP_062051.2"
                     /db_xref="GeneID:29260"
                     /db_xref="RGD:3870"
                     /translation="MMPLLHLAGTLIMALFLSCLRPGSLNPCIEVLPNITYQCMDQNL
                     SKIPHDIPYSTKNLDLSFNPLKILRSYSFSNFSQLQWLDLSRCEIETIEDKAWHGLNQ
                     LSTLVLTGNPIKSFSPGSFSGLTNLENLVAVETKMTSLEGFHIGQLISLKKLNVAHNL
                     IHSFKLPEYFSNLTNLEHVDLSYNYIQTISVKDLQFLRENPQVNLSLDLSLNPIDSIQ
                     AQAFQGIRLHELTLRSNFNSSNVLKMCLQNMTGLHVHRLILGEFKNERNLESFDRSVM
                     EGLCNVSIDEFRLTYINHFSDDIYNLNCLANISAMSFTGVHIKHIADVPRHFKWQSLS
                     IIRCHLKPFPKLSLPFLKSWTLTTNREDISFGQLALPSLRYLDLSRNAMSFRGCCSYS
                     DFGTNNLKYLDLSFNGVILMSANFMGLEELEYLDFQHSTLKKVTEFSVFLSLEKLLYL
                     DISYTNTKIDFDGIFLGLISLNTLKMAGNSFKDNTLSNVFTNTTNLTFLDLSKCQLEQ
                     ISRGVFDTLYRLQLLNMSHNNLLFLDPSHYKQLYSLRTLDCSFNRIETSKGILQHFPK
                     SLAVFNLTNNSVACICEYQNFLQWVKDQKMFLVNVEQMKCASPIDMKASLVLDFTNST
                     CYIYKTIISVSVVSVLVVATVAFLIYHFYFHLILIAGCKKYSRGESIYDAFVIYSSQN
                     EDWVRNELVKNLEEGVPRFQLCLHYRDFIPGVAIAANIIQEGFHKSRKVIVVVSRHFI
                     QSRWCIFEYEIAQTWQFLSSRSGIIFIVLEKVEKSLLRQQVELYRLLSRNTYLEWEDN
                     ALGRHIFWRRLKKALLDGKALNPDETSEEEQEATTLT"
     exon            328..494
                     /gene="Tlr4"
                     /inference="alignment:Splign:2.1.0"
     exon            495..3341
                     /gene="Tlr4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttctaacttc cctcctgaga tgggcttatt aattctagaa caaaaccaaa agtgagaatg
       61 ctaaggttgg cactctcact tcctcttgct ctctagccag tatacctttg aatacaatat
      121 ttacagaggg gcaaccgctg ggagagaagg ggcaggggcc ccagggactc tgccctgcca
      181 ccatttacag ttcgtcatgc tttctcacgg cctccgctgg ttgcagaaaa tgccaggatg
      241 atgcctctct tgcatctggc tgggactctg atcatggcat tgttcctttc ctgcctgaga
      301 ccaggaagct tgaatccctg catagaggta cttcctaata ttacctacca atgcatggat
      361 cagaatctca gcaaaatccc tcatgacatc ccttattcaa ccaagaacct agatctgagc
      421 ttcaaccccc tgaagatctt aagaagctat agcttctcca atttctcaca acttcagtgg
      481 ctggatttat ccaggtgtga aattgagaca attgaagaca aggcatggca tggcttaaac
      541 cagctctcaa ccttggtact gacaggaaac cctatcaaga gtttttcccc aggaagtttt
      601 tctggactaa caaatttaga gaatctggtg gctgtggaga caaaaatgac ctctctagag
      661 ggtttccata ttggacagct tatatcctta aagaaactaa atgtggctca taatcttata
      721 cattccttta agttacctga atatttttct aatctgacaa acctagaaca tgtggatctt
      781 tcttataact atattcaaac tatttctgtc aaagacttac agtttctacg tgaaaatccc
      841 caagtcaatc tctctttaga cctgtcttta aacccaattg actccattca agcccaagcc
      901 tttcagggaa ttaggctcca tgaattgact ctaagaagta attttaatag ctcaaatgta
      961 ctgaaaatgt gccttcaaaa catgactggt ttacatgtcc atcggttgat cttgggagaa
     1021 tttaaaaatg aaaggaatct ggaaagtttt gaccgttctg tcatggaagg actatgcaat
     1081 gtgagcattg atgagttcag gttaacatat ataaatcatt tttcagatga tatttataat
     1141 ctcaattgct tggcaaatat ttctgcaatg tctttcacag gtgtacatat aaaacacata
     1201 gcagatgttc ctagacattt caaatggcaa tccttatcaa tcattagatg tcatcttaag
     1261 ccttttccaa agctgagtct accttttctt aaaagttgga ctttaactac caacagagag
     1321 gatatcagct ttggtcagtt ggctctgcca agtctcagat atctagatct tagtagaaat
     1381 gccatgagct ttagaggttg ctgttcttat tctgattttg gaacaaacaa cctgaagtac
     1441 ttagacctca gcttcaatgg tgtcatcctg atgagtgcca acttcatggg tctagaagag
     1501 ctggaatacc tggactttca gcactccact ttaaaaaagg tcacagaatt ctcagtgttc
     1561 ttatctcttg aaaaacttct ttaccttgac atctcttaca ctaataccaa aattgacttt
     1621 gatggcatat ttcttggctt gatcagtctc aacactttaa aaatggctgg caattctttc
     1681 aaagacaaca ccctttcaaa tgtctttaca aacacaacaa acttaacatt cctggatctt
     1741 tctaaatgcc aactggaaca gatatctagg ggggtatttg acacactcta cagactccag
     1801 ttattaaaca tgagtcacaa caacctactg tttctggatc catcccatta taaacagctg
     1861 tactccctca ggactcttga ttgcagtttc aatcgcatag agacatccaa aggaatactg
     1921 caacattttc caaagagtct agccgtcttc aatctgacta ataattctgt tgcttgtata
     1981 tgtgaatatc agaatttctt gcagtgggtc aaggaccaga aaatgttctt ggtgaatgtt
     2041 gaacaaatga aatgtgcatc acctatagac atgaaggcct ccctggtgtt ggattttacg
     2101 aattccacct gttatatata caagactatc atcagtgtat cggtggtcag tgtgcttgtg
     2161 gtagccactg tagcatttct gatataccac ttctattttc acctgatact tattgctggc
     2221 tgtaaaaagt acagcagagg agaaagcatc tatgatgcat ttgtgatcta ctcgagccag
     2281 aatgaggact gggtgagaaa cgagctggta aagaatttag aagaaggagt gccccgcttt
     2341 cagctttgcc ttcattacag ggactttatt cctggtgtag ccattgctgc caacatcatc
     2401 caggaaggct tccacaagag ccggaaagtt attgtggtgg tgtctagaca ctttatccag
     2461 agccgttggt gtatctttga atatgagatt gctcagacat ggcagtttct gagtagccgc
     2521 tctggcatca tcttcattgt ccttgagaaa gtggagaagt ccttgctgag gcagcaggtc
     2581 gaattgtatc gccttcttag cagaaacacc tacctcgagt gggaggacaa tgctctgggg
     2641 aggcacatct tctggagaag actcaaaaaa gccctgttgg atggaaaagc cttgaatcca
     2701 gatgaaacat cagaggaaga acaagaagca acaactttga cctgaggagt acaaaactct
     2761 gcgcctaaaa cccattatgt ttacaatttc cgaatgctac agttcatctg ggtttctgct
     2821 gtggacaggg agtccaggga gcacgaggct tctaacctca acgacctcac agggcacaag
     2881 gaagtagcaa tgtgatgaaa ccccatactt tccatgtgta tcaggtgtat gaattaagca
     2941 actcaggcaa agaatcataa tcagcaaagt ttactcttat aaaacctaag gagaggaggc
     3001 taaggcccag tgagaacaga aaggaacatc attcttctct ggatctttga atataagcac
     3061 aacatgtagt gtgctgcagt taccttagaa gagttttgat catttaaact gaagtgaatg
     3121 tttccttcct ttcccttttt ctattgaata taatttaaat ggcactgact ctttttgaga
     3181 gaccctcatt caaatttctt cttccatttt ctgtcagttt ctttttttaa atctagttct
     3241 acaagaaata tgactgatac atgctcaaag atatcctggt caatccttag aatgctatat
     3301 ttataaaata aaaaatttta gtgtactttt attttttaaa a
//
