LOCUS       NM_198791               3388 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Rattus norvegicus toll-like receptor 3 (Tlr3), mRNA.
ACCESSION   NM_198791 XM_344520
VERSION     NM_198791.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3388)
  AUTHORS   Giffin,K.A., Lovelock,D.F. and Besheer,J.
  TITLE     Toll-like receptor 3 neuroimmune signaling and behavior change: A
            strain comparison between Lewis and Wistar rats
  JOURNAL   Behav Brain Res 438, 114200 (2023)
   PUBMED   36334783
  REMARK    GeneRIF: Toll-like receptor 3 neuroimmune signaling and behavior
            change: A strain comparison between Lewis and Wistar rats.
REFERENCE   2  (bases 1 to 3388)
  AUTHORS   Vetreno,R.P., Qin,L., Coleman,L.G. Jr. and Crews,F.T.
  TITLE     Increased Toll-like Receptor-MyD88-NFkappaB-Proinflammatory
            neuroimmune signaling in the orbitofrontal cortex of humans with
            alcohol use disorder
  JOURNAL   Alcohol Clin Exp Res 45 (9), 1747-1761 (2021)
   PUBMED   34415075
REFERENCE   3  (bases 1 to 3388)
  AUTHORS   Schilling,S., Chausse,B., Dikmen,H.O., Almouhanna,F.,
            Hollnagel,J.O., Lewen,A. and Kann,O.
  TITLE     TLR2- and TLR3-activated microglia induce different levels of
            neuronal network dysfunction in a context-dependent manner
  JOURNAL   Brain Behav Immun 96, 80-91 (2021)
   PUBMED   34015428
  REMARK    GeneRIF: TLR2- and TLR3-activated microglia induce different levels
            of neuronal network dysfunction in a context-dependent manner.
REFERENCE   4  (bases 1 to 3388)
  AUTHORS   Felipe,V.L.J., Paula,A. V and Silvio,U.I.
  TITLE     Chikungunya virus infection induces differential inflammatory and
            antiviral responses in human monocytes and monocyte-derived
            macrophages
  JOURNAL   Acta Trop 211, 105619 (2020)
   PUBMED   32634389
REFERENCE   5  (bases 1 to 3388)
  AUTHORS   Ge,L., Chen,D., Chen,W., Cai,C., Tao,Y., Ye,S., Lin,Z., Wang,X.,
            Li,J., Xu,L. and Chen,Y.
  TITLE     Pre-activation of TLR3 enhances the therapeutic effect of BMMSCs
            through regulation the intestinal HIF-2alpha signaling pathway and
            balance of NKB cells in experimental alcoholic liver injury
  JOURNAL   Int Immunopharmacol 70, 477-485 (2019)
   PUBMED   30870678
REFERENCE   6  (bases 1 to 3388)
  AUTHORS   Tabeta,K., Georgel,P., Janssen,E., Du,X., Hoebe,K., Crozat,K.,
            Mudd,S., Shamel,L., Sovath,S., Goode,J., Alexopoulou,L.,
            Flavell,R.A. and Beutler,B.
  TITLE     Toll-like receptors 9 and 3 as essential components of innate
            immune defense against mouse cytomegalovirus infection
  JOURNAL   Proc Natl Acad Sci U S A 101 (10), 3516-3521 (2004)
   PUBMED   14993594
REFERENCE   7  (bases 1 to 3388)
  AUTHORS   Noguchi,E., Nishimura,F., Fukai,H., Kim,J., Ichikawa,K.,
            Shibasaki,M. and Arinami,T.
  TITLE     An association study of asthma and total serum immunoglobin E
            levels for Toll-like receptor polymorphisms in a Japanese
            population
  JOURNAL   Clin Exp Allergy 34 (2), 177-183 (2004)
   PUBMED   14987294
REFERENCE   8  (bases 1 to 3388)
  AUTHORS   Yamamoto,M., Sato,S., Hemmi,H., Hoshino,K., Kaisho,T., Sanjo,H.,
            Takeuchi,O., Sugiyama,M., Okabe,M., Takeda,K. and Akira,S.
  TITLE     Role of adaptor TRIF in the MyD88-independent toll-like receptor
            signaling pathway
  JOURNAL   Science 301 (5633), 640-643 (2003)
   PUBMED   12855817
REFERENCE   9  (bases 1 to 3388)
  AUTHORS   Matsumoto,M., Kikkawa,S., Kohase,M., Miyake,K. and Seya,T.
  TITLE     Establishment of a monoclonal antibody against human Toll-like
            receptor 3 that blocks double-stranded RNA-mediated signaling
  JOURNAL   Biochem Biophys Res Commun 293 (5), 1364-1369 (2002)
   PUBMED   12054664
REFERENCE   10 (bases 1 to 3388)
  AUTHORS   Alexopoulou,L., Holt,A.C., Medzhitov,R. and Flavell,R.A.
  TITLE     Recognition of double-stranded RNA and activation of NF-kappaB by
            Toll-like receptor 3
  JOURNAL   Nature 413 (6857), 732-738 (2001)
   PUBMED   11607032
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 27, 2020 this sequence version replaced NM_198791.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB116229.1, SRR26360186.1377816.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000016.1  53554916-53555017
            103-297             JAXUCZ010000016.1  53555131-53555325
            298-366             JAXUCZ010000016.1  53556763-53556831
            367-819             JAXUCZ010000016.1  53561244-53561696
            820-1011            JAXUCZ010000016.1  53564366-53564557
            1012-2864           JAXUCZ010000016.1  53565784-53567636
            2865-3388           JAXUCZ010000016.1  53567854-53568377
FEATURES             Location/Qualifiers
     source          1..3388
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..3388
                     /gene="Tlr3"
                     /note="toll-like receptor 3"
                     /db_xref="GeneID:364594"
                     /db_xref="RGD:735171"
     exon            1..102
                     /gene="Tlr3"
                     /inference="alignment:Splign:2.1.0"
     exon            103..297
                     /gene="Tlr3"
                     /inference="alignment:Splign:2.1.0"
     exon            298..366
                     /gene="Tlr3"
                     /inference="alignment:Splign:2.1.0"
     exon            367..819
                     /gene="Tlr3"
                     /inference="alignment:Splign:2.1.0"
     CDS             376..3093
                     /gene="Tlr3"
                     /codon_start=1
                     /product="toll-like receptor 3 precursor"
                     /protein_id="NP_942086.2"
                     /db_xref="GeneID:364594"
                     /db_xref="RGD:735171"
                     /translation="MKGRSSYLIYSFGGLLSLWILVVSSTNQCTVRYNVADCSHLKLT
                     HIPDDLPSNITVLNLTHNQLRGLPPANFTRYSQLALLDAGFNSISKLEPELCQILPLL
                     KVLNLQHNELSQISDQTFAFCTNLTELHLMSNSIRKIKSNPFKNQKSLIKLDLSRNGL
                     SSTKLGTGVQLENLQELLLAKNKIFALRSEELDFLGNSSLQKLDLSSNPLKEFSPGCF
                     HAIGKLFVLLLNNAQLNLNLTEKLCWELSNTSIQNLSLANNQLLATSNSTFSGLKQTN
                     LTSLDLSYNSLRYVGNDAFSWLPHLKYLSLEYNNIQSLTPHSFRGLSNLRYLSLKRAF
                     TKQSVALASHPNIDDFSFQWLKCLEHLNMDDNTIPGIKSNTFTGLVSLKYLSLSKTFT
                     GLQTLTNETFVSLTHSPLLTLNLTKNHISKIASGTFSWLGQLRILDLGLNEIEQELTG
                     QEWRGLGNIFEIYLSYNKYLQLTSKSFTLVPSLQRLMLRRVALKSVDISPSPFRPLYN
                     LTILDLSNNNIANLNEDLLEGLENLEILDFQHNNLARLWKHANPGGPVNFLKGLSHLH
                     ILNLESNGLDEIPVKVFKNLFELKSINLGLNNLNTLLPSIFDDQTSLRSLNLQKNLIT
                     SVEKSVFGPAFHNLNSLDMSFNPFDCTCESIAWFVTWLNQTHTNIPELSTHYLCNTPQ
                     RYHGLPVKLFDTSSCKDSAPFQLLFIINTSTLLTFILAVLLIHFEGWRISFYWNVSVH
                     RILGFKEIDAQGEQFEYTAYIIHAQKDRDWVWEHFSPMEEQDQSLKFCLEERDFEAGV
                     LGLEAIVNSIKRSRKIIFVITHHLLKDPLCRRFKVHHAVQQAIEQNLDSIILIFLQNI
                     PDYKLNHALCLRRGMFKSHCILNWPIQKERINAFHHKLQVALGSRNSAH"
     exon            820..1011
                     /gene="Tlr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..2864
                     /gene="Tlr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..3388
                     /gene="Tlr3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttacactt ttctccctaa aggtcagttt atgaattcca ggaggtcctt aaaaagaaac
       61 aagcaaacaa caacaacaac aacaacaaca acaacaaaaa ggtttcactt tcaggatgga
      121 aggaaatgtc tgatttaaaa aaaaaagtct gaatgaaaac tacggcgatg caggatctca
      181 ggctggataa aatcagaatg tgcttggctt ttgaggttaa cacaccagtt ctctatcggg
      241 gaagtaaaac tgcccgagtc acagtcagga aagaaaagaa gacagaagac gctacagctt
      301 tcctgggggg taaatgttat ctaagcaagg agtagactat gatgcagaga ttgtacccat
      361 aatctggaca gaatcatgaa agggcgttca tcttatctaa tatactcctt tgggggactt
      421 ttgtccctat ggattcttgt ggtgtcttcc acaaaccaat gcactgtgag atacaacgta
      481 gctgactgca gccatttgaa gctgacacac atacctgatg accttccctc taatataaca
      541 gtgttgaatc ttactcacaa tcaactcaga ggattaccac ctgccaattt tacgagatac
      601 agccaacttg ctctcttgga tgcaggattc aactccattt caaaactgga gccagaactg
      661 tgccaaattc tccctttgtt gaaggtattg aacctgcaac acaatgagct gtctcagatt
      721 tctgatcaaa cctttgcctt ctgcacgaac ctgacagagc tccatctaat gtccaactca
      781 atacgcaaaa ttaaaagcaa ccctttcaaa aaccagaaga gtctaatcaa actagatttg
      841 tctcgtaatg gcttatcatc tacaaagttg ggaactggag tccaactgga gaacctccaa
      901 gagctgctct tagctaaaaa taaaattttt gcactacgaa gtgaagaact tgattttctt
      961 ggcaattctt ccttacaaaa attggacttg tcatcaaatc cacttaaaga gttttctcca
     1021 gggtgtttcc atgcgattgg caagttattc gtcctcctct tgaacaatgc ccaactgaac
     1081 ctcaacctca cagagaagct ttgttgggaa ctttcaaaca caagcatcca gaatctctct
     1141 ctggctaaca accagctgtt agcaaccagc aacagcactt tctccgggct gaagcagacc
     1201 aacctcacct cgcttgatct ttcctacaac agcctccgat acgtcggtaa cgatgccttc
     1261 tcttggctcc cgcacctgaa gtatctgtcc ctcgagtaca ataatataca gagtttgacc
     1321 cctcactctt ttcgtggact ttccaacctg aggtacctga gtttgaagcg agcatttact
     1381 aagcaaagtg ttgcacttgc ttctcacccc aacattgacg atttttcctt tcagtggcta
     1441 aaatgtttgg aacatctcaa catggacgat aatactatac cgggtataaa aagcaatact
     1501 ttcacaggat tggtgagtct gaagtaccta agtctttcca aaactttcac gggtttgcaa
     1561 acgttaacaa acgaaacgtt tgtgtctctt actcattctc ctttgctcac tctcaattta
     1621 acgaagaatc acatctcgaa gatagcaagt ggtactttct cttggttggg tcaactcagg
     1681 atacttgatc ttggccttaa tgaaattgag caagaactca ccggccagga atggagaggt
     1741 ctgggaaata tatttgagat ctacctgtcc tataataaat acctccaact gactagcaag
     1801 tccttcactt tggttcccag ccttcaacga ctgatgctca ggagggtggc ccttaaaagt
     1861 gtggatatct ccccttcgcc tttccgtccc ctttataacc tgactattct ggacttaagc
     1921 aacaacaaca ttgccaacct gaacgaggac ttgttggagg gtcttgagaa tctagaaatt
     1981 ctggattttc agcacaacaa cttagcaaga ctctggaaac acgcaaaccc aggtggtccc
     2041 gttaatttcc tgaagggtct gtctcacctc cacatcttga acttagaatc caatggctta
     2101 gatgaaatcc cggtcaaggt gttcaagaac ttattcgaac tcaagagcat caatctagga
     2161 ctgaataatt taaacacgct tctaccatcc atttttgatg accagacatc tctaaggtca
     2221 ctgaaccttc agaagaacct catcacatca gttgagaaga gtgttttcgg gccagctttt
     2281 cacaacctga acagcttaga tatgagcttc aatccgttcg actgtacatg tgaaagcatt
     2341 gcctggtttg ttacctggct taaccagacc cacactaata tccctgaact atccactcat
     2401 tacctctgca atacccccca gcgttaccac ggcctcccag tgaagctttt tgacacatca
     2461 tcctgtaaag acagtgcccc cttccaactc ctattcataa ttaacaccag tacgctcctg
     2521 acttttatac ttgcggtact gctcattcac ttcgagggtt ggaggatatc tttttactgg
     2581 aatgtttcag tgcatcgaat tcttggtttc aaggaaatag atgcacaggg tgagcagttc
     2641 gaatacacgg catacataat tcatgcccag aaagacagag actgggtctg ggagcatttc
     2701 tccccaatgg aagaacaaga ccaatctctc aaattttgcc tagaagaaag ggacttcgaa
     2761 gcaggggtcc ttggacttga agcaattgtt aacagcatca aaagaagcag aaaaatcatc
     2821 tttgttataa cgcatcacct actgaaagac ccgctgtgca gaagattcaa ggtgcatcac
     2881 gcggttcagc aagctatcga gcaaaatctg gattcaatta tactgatttt tctccagaat
     2941 attccagatt acaaactaaa ccatgcactc tgcttgcgaa gaggaatgtt taaatctcat
     3001 tgcatcttga actggccaat tcaaaaagaa cggataaacg cctttcatca taaactgcaa
     3061 gtagcacttg ggtctcggaa ttcagcacat taaacttatt tgaagatttg gaattggtga
     3121 agggatagat ccaatttata aaggtctgtc ataagtctga gttttacttg aaagtttgta
     3181 tctgtttatt tatgtatata gatgatgata ttgtatcaca attgaatctc ggttttgaaa
     3241 catttctgtg tctttcaggc ctcttattga cagctggtgt atttgctcca aataaataca
     3301 tgggattcct gaggtgtatc acagctccaa agagtttaaa aatattcttt atacaaataa
     3361 agctaagagt tttatgaatt ttaaaaaa
//
