LOCUS       NM_198769               2614 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Rattus norvegicus toll-like receptor 2 (Tlr2), mRNA.
ACCESSION   NM_198769 XM_227315
VERSION     NM_198769.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2614)
  AUTHORS   Tagoe,H., Hassan,S., Bliss,E., Youssef,G., Heywood,W., Mills,K.,
            Harper,J.I. and O'Shaughnessy,R.F.L.
  TITLE     Chronic activation of Toll-like receptor 2 induces an ichthyotic
            skin phenotype
  JOURNAL   Br J Dermatol 189 (1), 91-102 (2023)
   PUBMED   36972303
  REMARK    GeneRIF: Chronic activation of Toll-like receptor 2 induces an
            ichthyotic skin phenotype.
REFERENCE   2  (bases 1 to 2614)
  AUTHORS   Maccioni,L., Kasavuli,J., Leclercq,S., Pirlot,B., Laloux,G.,
            Horsmans,Y., Leclercq,I., Schnabl,B. and Starkel,P.
  TITLE     Toll-like receptor 2 activation in monocytes contributes to
            systemic inflammation and alcohol-associated liver disease in
            humans
  JOURNAL   Hepatol Commun 7 (5), e0107 (2023)
   PUBMED   37058088
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2614)
  AUTHORS   Wigger,G.W., Khani,D., Ahmed,M., Sayegh,L., Auld,S.C., Fan,X.,
            Guidot,D.M. and Staitieh,B.S.
  TITLE     Alcohol impairs recognition and uptake of Mycobacterium
            tuberculosis by suppressing toll-like receptor 2 expression
  JOURNAL   Alcohol Clin Exp Res 46 (12), 2214-2224 (2022)
   PUBMED   36281822
REFERENCE   4  (bases 1 to 2614)
  AUTHORS   Dou,X., Yan,D., Ma,Z., Gao,N. and Shan,A.
  TITLE     Sodium butyrate alleviates LPS-induced kidney injury via inhibiting
            TLR2/4 to regulate rBD2 expression
  JOURNAL   J Food Biochem 46 (7), e14126 (2022)
   PUBMED   35322444
  REMARK    GeneRIF: Sodium butyrate alleviates LPS-induced kidney injury via
            inhibiting TLR2/4 to regulate rBD2 expression.
REFERENCE   5  (bases 1 to 2614)
  AUTHORS   Vetreno,R.P., Qin,L., Coleman,L.G. Jr. and Crews,F.T.
  TITLE     Increased Toll-like Receptor-MyD88-NFkappaB-Proinflammatory
            neuroimmune signaling in the orbitofrontal cortex of humans with
            alcohol use disorder
  JOURNAL   Alcohol Clin Exp Res 45 (9), 1747-1761 (2021)
   PUBMED   34415075
REFERENCE   6  (bases 1 to 2614)
  AUTHORS   da Silva Correia,J., Soldau,K., Christen,U., Tobias,P.S. and
            Ulevitch,R.J.
  TITLE     Lipopolysaccharide is in close proximity to each of the proteins in
            its membrane receptor complex. transfer from CD14 to TLR4 and MD-2
  JOURNAL   J Biol Chem 276 (24), 21129-21135 (2001)
   PUBMED   11274165
REFERENCE   7  (bases 1 to 2614)
  AUTHORS   Takeuchi,O., Hoshino,K. and Akira,S.
  TITLE     Cutting edge: TLR2-deficient and MyD88-deficient mice are highly
            susceptible to Staphylococcus aureus infection
  JOURNAL   J Immunol 165 (10), 5392-5396 (2000)
   PUBMED   11067888
REFERENCE   8  (bases 1 to 2614)
  AUTHORS   Liu,S., Salyapongse,A.N., Geller,D.A., Vodovotz,Y. and Billiar,T.R.
  TITLE     Hepatocyte toll-like receptor 2 expression in vivo and in vitro:
            role of cytokines in induction of rat TLR2 gene expression by
            lipopolysaccharide
  JOURNAL   Shock 14 (3), 361-365 (2000)
   PUBMED   11028557
REFERENCE   9  (bases 1 to 2614)
  AUTHORS   Takeuchi,O., Hoshino,K., Kawai,T., Sanjo,H., Takada,H., Ogawa,T.,
            Takeda,K. and Akira,S.
  TITLE     Differential roles of TLR2 and TLR4 in recognition of gram-negative
            and gram-positive bacterial cell wall components
  JOURNAL   Immunity 11 (4), 443-451 (1999)
   PUBMED   10549626
REFERENCE   10 (bases 1 to 2614)
  AUTHORS   Yoshimura,A., Lien,E., Ingalls,R.R., Tuomanen,E., Dziarski,R. and
            Golenbock,D.
  TITLE     Cutting edge: recognition of Gram-positive bacterial cell wall
            components by the innate immune system occurs via Toll-like
            receptor 2
  JOURNAL   J Immunol 163 (1), 1-5 (1999)
   PUBMED   10384090
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY151255.1.
            
            On Feb 9, 2004 this sequence version replaced NM_198769.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY151255.1, EF127848.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2614
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2614
                     /gene="Tlr2"
                     /note="toll-like receptor 2"
                     /db_xref="GeneID:310553"
                     /db_xref="RGD:735138"
     exon            1..46
                     /gene="Tlr2"
                     /inference="alignment:Splign:2.1.0"
     exon            47..2594
                     /gene="Tlr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..2416
                     /gene="Tlr2"
                     /EC_number="3.2.2.6"
                     /codon_start=1
                     /product="toll-like receptor 2 precursor"
                     /protein_id="NP_942064.1"
                     /db_xref="GeneID:310553"
                     /db_xref="RGD:735138"
                     /translation="MLQALWLFWILMAVIGLSREGHSAQASLSCDAAGVCDGSSRSFT
                     SIPSGLTANTKKLDLSFNKITYIGHGDLRACVNLRVLTLESSGINTIEGDAFYSLGSL
                     EHLDLSNNHLSSLSSSWFRPLSSLKYLNLMGNPYRTLGETSLFSNLTNLQTLRVGNVD
                     TFSEIRRIDFAGLTSLNELEIQVLSLGNYESRSLQSIRDIYHLTLHLSESAFLLGIFA
                     DILSSVRYLELRDTNLARFQFSELSVDEINSPMKKLAFRNADLTDKSFNELLKLLRYI
                     LELMEVEFDHCTLNGVGNFNPSESDVVRELGKVETVTIRSLHIPQFYLFYDLSTVYSL
                     LEKVKRITVENSKVFLVPCSFSQHLKSLEFLDLSENLMVEEYLKNSACEGGWPSLQSL
                     VLSQNHLRSIRKTAEILLTLKNLTALDISKNSFQPMPDSCQWPGKMRFLNLSSTGIQA
                     VKTCIPQTLEVLDVSNNNLDSFSLFLPRLQELYISRNKLKTLPEASLFPVLQVMKIRE
                     NAISTFSKDQLGSFPKLETLEAGDNHFICSCELLSFILERPALVHVLVDWPDSYLCDS
                     PPRLHGQRLQDARPSVLECHQAALVSGVCCALLLLILLLGALCYHFHGLWYLRMMWAW
                     LRAKRKPKKAPCRDLCYDAFVSYSEQDSYWVENLMVQQLENSDPPFKLCLHKRDFVPG
                     KWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELDFSHFRLFDENNDAAILVLLEPI
                     EKKAIPQRFCKLRKIMNTKTYLEWPLDEGQREVFWANLRTAIKS"
ORIGIN      
        1 gcccagatgg ccacaggact caagagcatc ggctggaggt ctccaggtca aatctcagag
       61 gatgctgcaa gctctttggc tcttctggat cttgatggct gtgataggcc tctcaaggga
      121 aggccattct gcccaggcat ctctgtcatg tgatgctgct ggtgtgtgtg atggcagctc
      181 caggtctttc acctctattc cctcgggact cacagcaaac acaaagaagc ttgacctgtc
      241 tttcaacaag atcacctaca ttggccatgg tgacttgcga gcctgtgtga acctccgggt
      301 tctgacattg gagtccagcg gaatcaacac aatagaggga gatgcctttt attctctggg
      361 cagtcttgaa cacttggact tgtctaataa tcacctatct agtttatctt cctcctggtt
      421 caggcccctt tcctctttga aatacttaaa cttaatggga aatccttaca ggacactggg
      481 ggaaacatca ctgttctcca atctcacaaa tttacaaacc cttagggtag gaaatgttga
      541 cactttcagt gagataagga gaatagattt tgctgggctg acctctctca acgaacttga
      601 aattcaggta ttaagtctcg gcaactatga gtcccgaagt ctacagtcaa ttagagacat
      661 ctatcacctg accctgcact tgagcgagtc tgctttcctg ctggggattt ttgcagatat
      721 tctgagttcc gtgagatatt tagaactaag agatactaac ttggctaggt tccaattttc
      781 tgaactgtct gtagacgaaa tcaattcgcc aatgaagaag ctggcattcc ggaatgcaga
      841 tctcaccgat aaaagtttta atgaactcct gaagctgttg cgttacatct tggaactgat
      901 ggaggtggag tttgatcact gcaccctcaa tggggttggt aatttcaacc cctcagagtc
      961 agacgtagtg agggagctag gtaaagtaga aacggtaaca atacggagcc tgcacatccc
     1021 ccagttctat ttgttctatg atctgagcac tgtgtattcc ctcctggaga aagtgaagcg
     1081 aatcacagta gagaacagta aggtctttct ggttccctgc tctttctcac agcatttaaa
     1141 atcattagag ttcttagacc tcagcgaaaa tctgatggtt gaagagtatt tgaaaaactc
     1201 agcctgtgag ggtggctggc cttctctaca aagcttggtt ttgagtcaga atcatttgag
     1261 atcaatacga aaaactgctg agattttgct gactctgaaa aacctgacag cccttgacat
     1321 cagcaagaac agttttcagc ctatgcccga cagttgtcag tggccaggaa agatgcgctt
     1381 cctgaacttg tccagtacag ggatacaggc cgtcaagaca tgcattcctc agaccctgga
     1441 ggtgttggat gttagtaaca acaatctcga ttcattttct ttgtttttgc ctcggctcca
     1501 agagctgtat atttccagaa ataaactgaa gacactccca gaagcttcat tgttccctgt
     1561 gttacaggtc atgaagatca gagagaacgc aataagtact ttctctaaag accagcttgg
     1621 ttcttttccc aaactggaga ctctggaagc aggtgacaac catttcatct gctcctgtga
     1681 actcctgtcc ttcattctgg agaggccagc cctggtccat gtcctggttg actggccaga
     1741 cagctacctg tgtgattctc cgcctcgcct gcatggccag aggcttcagg atgcccggcc
     1801 ctcagtcttg gagtgtcacc aggccgcact ggtctctgga gtctgctgtg cccttctcct
     1861 gttgatcctg ctcttaggcg ccctgtgtta ccatttccat gggctgtggt atctgagaat
     1921 gatgtgggcg tggctccggg ccaagaggaa gcccaagaaa gctccttgca gggacctttg
     1981 ctatgatgcc tttgtttcct acagcgagca ggattcctat tgggtggaga acctcatggt
     2041 ccagcagctg gagaactctg acccaccctt caagctgtgt ctccacaagc gggactttgt
     2101 tccgggcaaa tggatcattg acaacatcat tgattccatc gaaaagagcc acaaaactgt
     2161 gttcgtgctt tctgagaact tcgtacgcag tgagtggtgc aagtatgaac tggacttctc
     2221 ccacttcagg ctctttgacg agaacaatga cgcggccatc cttgttttgc tggaacccat
     2281 tgagaagaaa gccattcccc agcgcttctg caaactgcgc aagataatga acactaagac
     2341 atacctggag tggcccttgg atgaaggcca gcgggaagtg ttttgggcaa atctgagaac
     2401 tgcaataaaa tcctaggttc tccaccctgt ttctgtcttg ccttaactaa aggtctttgt
     2461 gacaggaact gtaacaaagt ttattctgac ataattatat aagtatcata gaattgtact
     2521 actgaggatt tggtaagtat aactagtaac tatgagcttt atcttgaata ctgttatata
     2581 aatatttgac atcaaaaaaa aaaaaaaaaa aaaa
//
