LOCUS       NM_001172120            2565 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus toll-like receptor 1 (Tlr1), mRNA.
ACCESSION   NM_001172120
VERSION     NM_001172120.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2565)
  AUTHORS   Wang,J.G., Zhao,X.G., Wang,X.L., Liu,M.X. and Wan,W.
  TITLE     Low expression of miR-1 promotes osteogenic repair of bone marrow
            mesenchymal stem cells by targeting TLR1
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (7), 3492-3500 (2020)
   PUBMED   32329822
  REMARK    GeneRIF: Low expression of miR-1 promotes osteogenic repair of bone
            marrow mesenchymal stem cells by targeting TLR1.
REFERENCE   2  (bases 1 to 2565)
  AUTHORS   Ohno,K., Kuno,A., Murase,H., Muratsubaki,S., Miki,T., Tanno,M.,
            Yano,T., Ishikawa,S., Yamashita,T. and Miura,T.
  TITLE     Diabetes increases the susceptibility to acute kidney injury after
            myocardial infarction through augmented activation of renal
            Toll-like receptors in rats
  JOURNAL   Am J Physiol Heart Circ Physiol 313 (6), H1130-H1142 (2017)
   PUBMED   28822965
  REMARK    GeneRIF: Diabetes mellitus increases the susceptibility to acute
            kidney injury after acute myocardial infarction by augmented
            activation of renal TLR1/TLR2-mediated signaling.
REFERENCE   3  (bases 1 to 2565)
  AUTHORS   Aplin,A.C., Ligresti,G., Fogel,E., Zorzi,P., Smith,K. and
            Nicosia,R.F.
  TITLE     Regulation of angiogenesis, mural cell recruitment and adventitial
            macrophage behavior by Toll-like receptors
  JOURNAL   Angiogenesis 17 (1), 147-161 (2014)
   PUBMED   24091496
  REMARK    GeneRIF: aortic angiogenesis is preceded by an immune reaction with
            overexpression of Toll-like receptors (TLRs) and TLR-inducible
            genes.
REFERENCE   4  (bases 1 to 2565)
  AUTHORS   Liu,S., Liu,Y., Hao,W., Wolf,L., Kiliaan,A.J., Penke,B., Rube,C.E.,
            Walter,J., Heneka,M.T., Hartmann,T., Menger,M.D. and Fassbender,K.
  TITLE     TLR2 is a primary receptor for Alzheimer's amyloid beta peptide to
            trigger neuroinflammatory activation
  JOURNAL   J Immunol 188 (3), 1098-1107 (2012)
   PUBMED   22198949
REFERENCE   5  (bases 1 to 2565)
  AUTHORS   Godfroy,J.I. 3rd, Roostan,M., Moroz,Y.S., Korendovych,I.V. and
            Yin,H.
  TITLE     Isolated Toll-like receptor transmembrane domains are capable of
            oligomerization
  JOURNAL   PLoS One 7 (11), e48875 (2012)
   PUBMED   23155421
REFERENCE   6  (bases 1 to 2565)
  AUTHORS   Kesh,S., Mensah,N.Y., Peterlongo,P., Jaffe,D., Hsu,K., VAN DEN
            Brink,M., O'reilly,R., Pamer,E., Satagopan,J. and Papanicolaou,G.A.
  TITLE     TLR1 and TLR6 polymorphisms are associated with susceptibility to
            invasive aspergillosis after allogeneic stem cell transplantation
  JOURNAL   Ann N Y Acad Sci 1062, 95-103 (2005)
   PUBMED   16461792
REFERENCE   7  (bases 1 to 2565)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   8  (bases 1 to 2565)
  AUTHORS   Schroder,N.W., Heine,H., Alexander,C., Manukyan,M., Eckert,J.,
            Hamann,L., Gobel,U.B. and Schumann,R.R.
  TITLE     Lipopolysaccharide binding protein binds to triacylated and
            diacylated lipopeptides and mediates innate immune responses
  JOURNAL   J Immunol 173 (4), 2683-2691 (2004)
   PUBMED   15294986
REFERENCE   9  (bases 1 to 2565)
  AUTHORS   Alexopoulou,L., Thomas,V., Schnare,M., Lobet,Y., Anguita,J.,
            Schoen,R.T., Medzhitov,R., Fikrig,E. and Flavell,R.A.
  TITLE     Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in
            humans and in TLR1- and TLR2-deficient mice
  JOURNAL   Nat Med 8 (8), 878-884 (2002)
   PUBMED   12091878
REFERENCE   10 (bases 1 to 2565)
  AUTHORS   Takeuchi,O., Sato,S., Horiuchi,T., Hoshino,K., Takeda,K., Dong,Z.,
            Modlin,R.L. and Akira,S.
  TITLE     Cutting edge: role of Toll-like receptor 1 in mediating immune
            response to microbial lipoproteins
  JOURNAL   J Immunol 169 (1), 10-14 (2002)
   PUBMED   12077222
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Feb 16, 2013 this sequence version replaced NM_001172120.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2565              JAXUCZ010000014.1  43747821-43750385
FEATURES             Location/Qualifiers
     source          1..2565
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..2565
                     /gene="Tlr1"
                     /note="toll-like receptor 1"
                     /db_xref="GeneID:305354"
                     /db_xref="RGD:1309975"
     exon            1..2565
                     /gene="Tlr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1..2388
                     /gene="Tlr1"
                     /EC_number="3.2.2.6"
                     /note="rCG56938-like"
                     /codon_start=1
                     /product="toll-like receptor 1 precursor"
                     /protein_id="NP_001165591.1"
                     /db_xref="GeneID:305354"
                     /db_xref="RGD:1309975"
                     /translation="MTKTQSTIFYCIVVLGLILIKIQLSEESELIIKRPNANLTRVPK
                     DLPLQTTTLDVSQNNISELQTSDILLLSKLRVFIMSYNRLQYLNISVFKFNTELEYLD
                     LSHNELRLISCHATADLKHLDLSFNAFDALPICKEFGNLSQLQFLGLSGSQIQNSSVQ
                     LIAHLNISKVLLVLGDTYGEKEDPKCLQHISTETLHIVFPSKREFHFLLDMSVSTAIS
                     LELSNIKCVLEDKNCSYFLGTLERLRKTQRLSNLTLNNVDTTWNSFINILQLVWHTPV
                     KSFSISNVKLKGHFNFRRFHYSDTSLRALSIHQVVTDVFSFPQSNIYSIFSNMNIQSF
                     TVSGTRMVHMLCPDQISPFLYLDFTDNLLTDIVFEDCRNLIRLKTLSLQKNQLKTLEN
                     IILMSMEMTSLQKLDISQNSLRYSDAGSPCSWTQSLLVLNLSSNMLTDSVFRCLPPKV
                     KVLDLHNNRIVSISKDVTHLQALQELNVASNFLTDLPGCGAFSSLSVLVIDHNSVSHP
                     SSDFFQSCQNIRSITAGNNPFRCTCELREFVKNIGQASREVVEGWPDSYRCDYPDSIK
                     GTPLQDFHMSPLSCDTILLTVTIGATLLLLAAIGASLCLYFDLPWYLRMLWQWTQTRH
                     RARNIPLEELQRNLQFHAFVSYSGHDSAWVKNELLPNLEKDDIRVCLHERNFVPGKSI
                     VENIIHFIEKSYKSIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLILILLEPIPQY
                     SIPTNYHKLKTLMARRTYLEWPTEKSKHGLFWANLRASINVKLVNQAEATCYTQQ"
ORIGIN      
        1 atgactaaaa cacagtccac catcttctat tgtattgttg tcttagggct gatacttatc
       61 aaaatccagt tatctgagga aagtgagttg atcattaaga ggccaaatgc aaaccttacc
      121 agagtgccca aggacctacc cttgcaaaca actactttag atgtatcaca aaacaatata
      181 tctgagcttc agacttctga catactcttg ttgtccaaac tgagggtctt cattatgtcc
      241 tacaacagac tccagtatct taatatcagt gttttcaaat tcaacacgga actggaatat
      301 ttggatttgt cccacaatga gttaaggctg atctcttgcc acgcaacagc cgacctcaaa
      361 catttagacc tctcctttaa tgcatttgat gccctgccca tatgcaaaga gtttggcaac
      421 ctgtcccaac tacagtttct gggattgagc ggttctcaga tacaaaattc aagtgtgcag
      481 ctgattgctc atctgaacat cagtaaggtt ttgctggtgt taggagacac ttatggggaa
      541 aaagaagatc ccaagtgtct tcagcacatt agcactgaga ctctgcatat cgttttccct
      601 tccaaaagag aattccattt tcttctggac atgtctgtca gcacggccat cagtttggaa
      661 ctgtctaaca tcaagtgtgt gcttgaggac aagaactgct cttacttcct aggtacctta
      721 gaaagactta gaaagactca gaggctctca aatcttaccc tgaacaacgt ggacacaaca
      781 tggaattcct tcattaacat ccttcagctg gtttggcata caccagtcaa gtctttctca
      841 atttcaaacg tgaaactaaa aggtcatttt aacttcagaa gattccatta ttctgacact
      901 tctctgaggg ctttgtcgat acatcaagtt gtcactgatg tgttcagctt cccccaaagt
      961 aacatataca gcatcttctc caatatgaac atccaaagtt ttacagtatc tggaacacgc
     1021 atggtccaca tgctttgccc agaccaaatt agcccatttc tgtatttgga ctttacagat
     1081 aaccttttaa cagacatagt ttttgaagac tgtagaaatt taattagatt gaaaacactt
     1141 agtttacaaa agaatcagtt aaaaacactt gaaaatataa ttcttatgtc tatggagatg
     1201 acatccctac aaaaactaga cattagccag aattctctaa ggtacagtga tgcgggaagc
     1261 ccatgctcct ggacccagag tttgttagtt ttaaatttgt cttcaaacat gcttacggac
     1321 tctgtcttca ggtgcttacc tcccaaggtc aaggtccttg accttcacaa caacaggata
     1381 gtgagcatct ctaaagatgt cacccacctg caagctttgc aggaactcaa tgtcgcatcc
     1441 aattttttaa ctgaccttcc tggatgtgga gccttcagta gcctttctgt gctggtcatc
     1501 gaccataact cagtttccca cccctcctct gatttcttcc agagctgtca gaatatcagg
     1561 tccataacag cggggaacaa cccattccga tgcacatgtg agctgaggga gtttgtcaaa
     1621 aacataggtc aggcatcaag agaagtggtg gagggctggc ctgactctta caggtgtgat
     1681 tacccagaca gcattaaggg aaccccactg caggacttcc acatgtctcc actgtcctgc
     1741 gatacaattc tactgactgt caccattggg gccactctgc tgctgctggc tgccattggg
     1801 gcttccctct gtctctactt tgatctgccc tggtatctca ggatgctatg gcagtggaca
     1861 cagaccaggc acagggcccg gaacatcccc ttagaggaac tgcagaggaa cctccagttc
     1921 catgcttttg tctcatacag tgggcatgat tctgcctggg tgaagaatga attactacca
     1981 aacctagaga aagatgacat tcgggtttgc ctccatgaga gaaactttgt ccctggcaag
     2041 agcattgtgg agaacatcat acacttcatt gagaagagtt acaagtccat ctttgtgctg
     2101 tctccccact tcatccagag tgagtggtgc cattatgaac tctactttgc ccatcacaat
     2161 ctcttccacg aagggtctga taacttaatc ctgatcttgc tggaaccaat tccacagtac
     2221 tccatcccta ccaattacca caagctcaaa actctcatgg cacggaggac ctatttggaa
     2281 tggcccacag aaaagagcaa gcatggactc ttttgggcaa atctaagagc atccattaat
     2341 gttaagctgg tcaaccaggc agaagcaaca tgttacacac agcaataaga atacccacct
     2401 catcaggaag ctgctttggg gagcaacaac actggggagt tctggtaatg gtaccattca
     2461 catcagcaag aagcaaaaga tgtttctgtc tttatgatgt gggaattcgt gctttttagc
     2521 ccgactgtgc cactagtgtt tgctaataaa aagtagcggg gtact
//
