LOCUS       NP_001165591             795 aa            linear   ROD 31-MAR-2024
DEFINITION  toll-like receptor 1 precursor [Rattus norvegicus].
ACCESSION   NP_001165591
VERSION     NP_001165591.1
DBSOURCE    REFSEQ: accession NM_001172120.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 795)
  AUTHORS   Wang,J.G., Zhao,X.G., Wang,X.L., Liu,M.X. and Wan,W.
  TITLE     Low expression of miR-1 promotes osteogenic repair of bone marrow
            mesenchymal stem cells by targeting TLR1
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (7), 3492-3500 (2020)
   PUBMED   32329822
  REMARK    GeneRIF: Low expression of miR-1 promotes osteogenic repair of bone
            marrow mesenchymal stem cells by targeting TLR1.
REFERENCE   2  (residues 1 to 795)
  AUTHORS   Ohno,K., Kuno,A., Murase,H., Muratsubaki,S., Miki,T., Tanno,M.,
            Yano,T., Ishikawa,S., Yamashita,T. and Miura,T.
  TITLE     Diabetes increases the susceptibility to acute kidney injury after
            myocardial infarction through augmented activation of renal
            Toll-like receptors in rats
  JOURNAL   Am J Physiol Heart Circ Physiol 313 (6), H1130-H1142 (2017)
   PUBMED   28822965
  REMARK    GeneRIF: Diabetes mellitus increases the susceptibility to acute
            kidney injury after acute myocardial infarction by augmented
            activation of renal TLR1/TLR2-mediated signaling.
REFERENCE   3  (residues 1 to 795)
  AUTHORS   Aplin,A.C., Ligresti,G., Fogel,E., Zorzi,P., Smith,K. and
            Nicosia,R.F.
  TITLE     Regulation of angiogenesis, mural cell recruitment and adventitial
            macrophage behavior by Toll-like receptors
  JOURNAL   Angiogenesis 17 (1), 147-161 (2014)
   PUBMED   24091496
  REMARK    GeneRIF: aortic angiogenesis is preceded by an immune reaction with
            overexpression of Toll-like receptors (TLRs) and TLR-inducible
            genes.
REFERENCE   4  (residues 1 to 795)
  AUTHORS   Liu,S., Liu,Y., Hao,W., Wolf,L., Kiliaan,A.J., Penke,B., Rube,C.E.,
            Walter,J., Heneka,M.T., Hartmann,T., Menger,M.D. and Fassbender,K.
  TITLE     TLR2 is a primary receptor for Alzheimer's amyloid beta peptide to
            trigger neuroinflammatory activation
  JOURNAL   J Immunol 188 (3), 1098-1107 (2012)
   PUBMED   22198949
REFERENCE   5  (residues 1 to 795)
  AUTHORS   Godfroy,J.I. 3rd, Roostan,M., Moroz,Y.S., Korendovych,I.V. and
            Yin,H.
  TITLE     Isolated Toll-like receptor transmembrane domains are capable of
            oligomerization
  JOURNAL   PLoS One 7 (11), e48875 (2012)
   PUBMED   23155421
REFERENCE   6  (residues 1 to 795)
  AUTHORS   Kesh,S., Mensah,N.Y., Peterlongo,P., Jaffe,D., Hsu,K., VAN DEN
            Brink,M., O'reilly,R., Pamer,E., Satagopan,J. and Papanicolaou,G.A.
  TITLE     TLR1 and TLR6 polymorphisms are associated with susceptibility to
            invasive aspergillosis after allogeneic stem cell transplantation
  JOURNAL   Ann N Y Acad Sci 1062, 95-103 (2005)
   PUBMED   16461792
REFERENCE   7  (residues 1 to 795)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   8  (residues 1 to 795)
  AUTHORS   Schroder,N.W., Heine,H., Alexander,C., Manukyan,M., Eckert,J.,
            Hamann,L., Gobel,U.B. and Schumann,R.R.
  TITLE     Lipopolysaccharide binding protein binds to triacylated and
            diacylated lipopeptides and mediates innate immune responses
  JOURNAL   J Immunol 173 (4), 2683-2691 (2004)
   PUBMED   15294986
REFERENCE   9  (residues 1 to 795)
  AUTHORS   Alexopoulou,L., Thomas,V., Schnare,M., Lobet,Y., Anguita,J.,
            Schoen,R.T., Medzhitov,R., Fikrig,E. and Flavell,R.A.
  TITLE     Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in
            humans and in TLR1- and TLR2-deficient mice
  JOURNAL   Nat Med 8 (8), 878-884 (2002)
   PUBMED   12091878
REFERENCE   10 (residues 1 to 795)
  AUTHORS   Takeuchi,O., Sato,S., Horiuchi,T., Hoshino,K., Takeda,K., Dong,Z.,
            Modlin,R.L. and Akira,S.
  TITLE     Cutting edge: role of Toll-like receptor 1 in mediating immune
            response to microbial lipoproteins
  JOURNAL   J Immunol 169 (1), 10-14 (2002)
   PUBMED   12077222
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..795
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     Protein         1..795
                     /product="toll-like receptor 1 precursor"
                     /EC_number="3.2.2.6"
                     /note="rCG56938-like"
                     /calculated_mol_wt=88319
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2827
     Region          50..73
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          <51..>156
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          74..97
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          98..112
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          119..143
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          144..156
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          <355..>529
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          355..376
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          377..402
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          403..427
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          428..449
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          450..472
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          473..494
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          495..518
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          527..581
                     /region_name="LRRCT"
                     /note="Leucine rich repeat C-terminal domain; smart00082"
                     /db_xref="CDD:214507"
     Region          639..782
                     /region_name="TIR"
                     /note="Toll - interleukin 1 - resistance; smart00255"
                     /db_xref="CDD:214587"
     CDS             1..795
                     /gene="Tlr1"
                     /coded_by="NM_001172120.2:1..2388"
                     /db_xref="GeneID:305354"
                     /db_xref="RGD:1309975"
ORIGIN      
        1 mtktqstify civvlglili kiqlseesel iikrpnanlt rvpkdlplqt ttldvsqnni
       61 selqtsdill lsklrvfims ynrlqylnis vfkfnteley ldlshnelrl ischatadlk
      121 hldlsfnafd alpickefgn lsqlqflgls gsqiqnssvq liahlniskv llvlgdtyge
      181 kedpkclqhi stetlhivfp skrefhflld msvstaisle lsnikcvled kncsyflgtl
      241 erlrktqrls nltlnnvdtt wnsfinilql vwhtpvksfs isnvklkghf nfrrfhysdt
      301 slralsihqv vtdvfsfpqs niysifsnmn iqsftvsgtr mvhmlcpdqi spflyldftd
      361 nlltdivfed crnlirlktl slqknqlktl eniilmsmem tslqkldisq nslrysdags
      421 pcswtqsllv lnlssnmltd svfrclppkv kvldlhnnri vsiskdvthl qalqelnvas
      481 nfltdlpgcg afsslsvlvi dhnsvshpss dffqscqnir sitagnnpfr ctcelrefvk
      541 nigqasrevv egwpdsyrcd ypdsikgtpl qdfhmsplsc dtilltvtig atllllaaig
      601 aslclyfdlp wylrmlwqwt qtrhrarnip leelqrnlqf hafvsysghd sawvknellp
      661 nlekddirvc lhernfvpgk siveniihfi eksyksifvl sphfiqsewc hyelyfahhn
      721 lfhegsdnli lillepipqy siptnyhklk tlmarrtyle wptekskhgl fwanlrasin
      781 vklvnqaeat cytqq
//
