LOCUS       NM_001419941           12158 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus talin 2 (Tln2), mRNA.
ACCESSION   NM_001419941 XM_008766404
VERSION     NM_001419941.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 12158)
  AUTHORS   Calderwood,D.A., Campbell,I.D. and Critchley,D.R.
  TITLE     Talins and kindlins: partners in integrin-mediated adhesion
  JOURNAL   Nat Rev Mol Cell Biol 14 (8), 503-517 (2013)
   PUBMED   23860236
  REMARK    Review article
REFERENCE   2  (bases 1 to 12158)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   3  (bases 1 to 12158)
  AUTHORS   Balamuth,F., Brogdon,J.L. and Bottomly,K.
  TITLE     CD4 raft association and signaling regulate molecular clustering at
            the immunological synapse site
  JOURNAL   J Immunol 172 (10), 5887-5892 (2004)
   PUBMED   15128768
REFERENCE   4  (bases 1 to 12158)
  AUTHORS   Di Paolo,G., Pellegrini,L., Letinic,K., Cestra,G., Zoncu,R.,
            Voronov,S., Chang,S., Guo,J., Wenk,M.R. and De Camilli,P.
  TITLE     Recruitment and regulation of phosphatidylinositol phosphate kinase
            type 1 gamma by the FERM domain of talin
  JOURNAL   Nature 420 (6911), 85-89 (2002)
   PUBMED   12422219
REFERENCE   5  (bases 1 to 12158)
  AUTHORS   Zhang,J.Q., Elzey,B., Williams,G., Lu,S., Law,D.J. and Horowits,R.
  TITLE     Ultrastructural and biochemical localization of N-RAP at the
            interface between myofibrils and intercalated disks in the mouse
            heart
  JOURNAL   Biochemistry 40 (49), 14898-14906 (2001)
   PUBMED   11732910
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Apr 21, 2023 this sequence version replaced XM_008766404.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.22235.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               JAXUCZ010000008.1  77133187-77133361   c
            176-265             JAXUCZ010000008.1  77048659-77048748   c
            266-339             JAXUCZ010000008.1  76950017-76950090   c
            340-511             JAXUCZ010000008.1  76887956-76888127   c
            512-609             JAXUCZ010000008.1  76885936-76886033   c
            610-739             JAXUCZ010000008.1  76883978-76884107   c
            740-892             JAXUCZ010000008.1  76882866-76883018   c
            893-1035            JAXUCZ010000008.1  76878989-76879131   c
            1036-1163           JAXUCZ010000008.1  76876974-76877101   c
            1164-1227           JAXUCZ010000008.1  76867096-76867159   c
            1228-1332           JAXUCZ010000008.1  76865994-76866098   c
            1333-1488           JAXUCZ010000008.1  76862647-76862802   c
            1489-1590           JAXUCZ010000008.1  76859092-76859193   c
            1591-1667           JAXUCZ010000008.1  76857829-76857905   c
            1668-1848           JAXUCZ010000008.1  76854619-76854799   c
            1849-1962           JAXUCZ010000008.1  76853321-76853434   c
            1963-2071           JAXUCZ010000008.1  76849017-76849125   c
            2072-2280           JAXUCZ010000008.1  76846892-76847100   c
            2281-2379           JAXUCZ010000008.1  76846309-76846407   c
            2380-2547           JAXUCZ010000008.1  76839605-76839772   c
            2548-2842           JAXUCZ010000008.1  76837807-76838101   c
            2843-3009           JAXUCZ010000008.1  76835179-76835345   c
            3010-3138           JAXUCZ010000008.1  76833082-76833210   c
            3139-3252           JAXUCZ010000008.1  76831396-76831509   c
            3253-3366           JAXUCZ010000008.1  76829389-76829502   c
            3367-3501           JAXUCZ010000008.1  76825353-76825487   c
            3502-3630           JAXUCZ010000008.1  76822631-76822759   c
            3631-3733           JAXUCZ010000008.1  76821441-76821543   c
            3734-3942           JAXUCZ010000008.1  76814300-76814508   c
            3943-4062           JAXUCZ010000008.1  76813061-76813180   c
            4063-4260           JAXUCZ010000008.1  76810939-76811136   c
            4261-4400           JAXUCZ010000008.1  76809811-76809950   c
            4401-4494           JAXUCZ010000008.1  76802312-76802405   c
            4495-4584           JAXUCZ010000008.1  76799634-76799723   c
            4585-4707           JAXUCZ010000008.1  76796955-76797077   c
            4708-4851           JAXUCZ010000008.1  76795503-76795646   c
            4852-5013           JAXUCZ010000008.1  76793203-76793364   c
            5014-5154           JAXUCZ010000008.1  76785563-76785703   c
            5155-5336           JAXUCZ010000008.1  76784888-76785069   c
            5337-5469           JAXUCZ010000008.1  76783170-76783302   c
            5470-5571           JAXUCZ010000008.1  76779694-76779795   c
            5572-5742           JAXUCZ010000008.1  76776401-76776571   c
            5743-5889           JAXUCZ010000008.1  76769590-76769736   c
            5890-5991           JAXUCZ010000008.1  76766975-76767076   c
            5992-6111           JAXUCZ010000008.1  76764413-76764532   c
            6112-6258           JAXUCZ010000008.1  76758613-76758759   c
            6259-6425           JAXUCZ010000008.1  76754355-76754521   c
            6426-6609           JAXUCZ010000008.1  76752778-76752961   c
            6610-6735           JAXUCZ010000008.1  76749654-76749779   c
            6736-6852           JAXUCZ010000008.1  76749359-76749475   c
            6853-7038           JAXUCZ010000008.1  76746408-76746593   c
            7039-7146           JAXUCZ010000008.1  76742384-76742491   c
            7147-7252           JAXUCZ010000008.1  76736904-76737009   c
            7253-7377           JAXUCZ010000008.1  76735417-76735541   c
            7378-7503           JAXUCZ010000008.1  76723926-76724051   c
            7504-7566           JAXUCZ010000008.1  76722036-76722098   c
            7567-7749           JAXUCZ010000008.1  76721762-76721944   c
            7750-7875           JAXUCZ010000008.1  76718773-76718898   c
            7876-12158          JAXUCZ010000008.1  76712112-76716394   c
FEATURES             Location/Qualifiers
     source          1..12158
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..12158
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /note="talin 2"
                     /db_xref="GeneID:315776"
                     /db_xref="RGD:1565416"
     exon            1..175
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            176..265
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            266..339
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            340..511
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     CDS             376..8004
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /codon_start=1
                     /product="talin-2"
                     /protein_id="NP_001406870.1"
                     /db_xref="GeneID:315776"
                     /db_xref="RGD:1565416"
                     /translation="MVALSLKICVRHCNVVKTMQFEPSTAVYDACRVIRERVPEAQTG
                     QASDYGLFLSDEDPRKGIWLEAGRTLDYYMLRNGDILEYKKKQRPQKIRMLDGSVKTV
                     MVDDSKTVGELLVTICSRIGITNYEEYSLIQETIEEKKEEGTGTLRKDRTLLRDERKM
                     EKLKAKLHTDDDLNWLDHSRTFREQGVDENETLLLRRKFFYSDQNVDSRDPVQLNLLY
                     VQARDDILNGSHPVSFEKACEFGGFQAQIQFGPHVEHKHKPGFLDLKEFLPKEYIKQR
                     GAEKRIFQEHKNCGEMSEIEAKVKYVKLARSLRTYGVSFFLVKEKMKGKNKLVPRLLG
                     ITKDSVMRVDEKTKEVLQEWPLTTVKRWAASPKSFTLDFGEYQESYYSVQTTEGEQIS
                     QLIAGYIDIILKKKQSKDRFGLEGDEESTMLEESVSPKKSTILQQQFNRTGKAEHGSV
                     ALPAVMRSGSSGPETFNVGSMPSPQQQVMVGQMHRGHMPPLTSAQQALMGTINTSMHA
                     VQQAQDDLSELDSLPPLGQDMASRVWVQNKVDESKHEIHSQVDAITAGTASVVNLTAG
                     DPADTDYTAVGCAITTISSNLTEMSKGVKLLAALMDDDVGSGEDLLRAARTLAGAVSD
                     LLKAVQPTSGEPRQTVLTAAGSIGQASGDLLRQIGENETDERFQDVLMSLAKAVANAA
                     AMLVLKAKNVAQVAEDTVLQNRVIAAATQCALSTSQLVACAKVVSPTISSPVCQEQLI
                     EAGKLVDRSVENCVRACQAATGDSELLKQVSAAASVVSQALHDLLQHVRQFASRGEPI
                     GRYDQATDTIMCVTESIFSSMGDAGEMVRQARVLAQATSDLVNAMRSDAEAEIDMENS
                     KKLLAAAKLLADSTARMVEAAKGAAANPENEDQQQRLREAAEGLRVATNAAAQNAIKK
                     KIVNRLEVAAKQAAAAATQTIAASQNAAISNKNPSAQQQLVQSCKTVADHIPQLVQGV
                     RGSQAQAEDLSAQLALIISSQNFLQPGSKMVSSAKAAVPTVSDQAAAMQLSQCAKNLA
                     TSLAELRTASQKAHEACGPMEIDSALNTVQTLKSELQDAKMAAAESQLKPLPGETLEK
                     CAQDLGSTSKGVGSSMAQLLTCAAQGNEHYTGVAARETAQALKTLAQAARGVAASTND
                     PEAAHAMLDSARDVMEGSAMLIQEAKQALIAPGDTESQQRLAQVAKAVSHSLNNCVNC
                     LPGQKDVDVALKSIGESSKKLLVDSLPPSTKPFQEAQSELNQAAADLNQSAGEVVHAT
                     RGQSGELAAASGKFSDDFDEFLDAGIEMAGQAQTKEDQMQVIGNLKNISMASSKLLLA
                     AKSLSVDPGAPNAKNLLAAAARAVTESINQLIMLCTQQAPGQKECDNALRELETVKGM
                     LENPNEPVSDLSYFDCIESVMENSKVLGESMAGISQNAKTGDLPAFGECVGIASKALC
                     GLTEAAAQAAYLVGISDPNSQAGHQGLVDPIQFARANQAIQMACQNLVDPGSSPSQVL
                     SAATIVAKHTSALCNACRIASSKTANPVAKRHFVQSAKEVANSTANLVKTIKALDGDF
                     SEDNRNKCRIATTPLIEAVENLTAFASNPEFASIPAQISSEGSQAQEPILVSAKTMLE
                     SSSYLIRTARSLAINPKDPPTWSVLAGHSHTVSDSIKSLITSIRDKAPGQRECDYSID
                     GINRCIRDIEQASLAAVSQSLATRDDISVEALQEQLTSVVQEIGHLIDPIATAARGEA
                     AQLGHKVTQLASYFEPLILAAVGVASKMLDHQQQMTVLDQTKTLAESALQMLYAAKEG
                     GGNPKAQHTHDAITEAAQLMKEAVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEG
                     TPPEPKGTFVDYQTTVVKYSKAIAVTAQEMMTKSVTNPEELGGLASQMTTDYGHLALQ
                     GQMAAATAEPEEIGFQIRTRVQDLGHGCIFLVQKAGALQVCPTDSYTKRELIECARSV
                     TEKVSLVLSALQAGNKGTQACITAATAVSGIIADLDTTIMFATAGTLNAENGETFADH
                     RENILKTAKALVEDTKLLVSGAASTPDKLAQAAQSSAATITQLAEVVKLGAASLGSND
                     PETQVVLINAIKDVAKALSDLIGATKGAASKPADDPSMYQLKGAAKVMVTNVTSLLKT
                     VKAVEDEATRGTRALEATIEYIKQELTVFQSKDIPEKTSSPEESIRMTKGITMATAKA
                     VAAGNSCRQEDVIATANLSRKAVSDMLIACKQASFYPDVSEEVRTRALRYGTECTLGY
                     LDLLEHVLVILQKPTPELKHQLAAFSKRVAGAVTELIQAAEAMKGTEWVDPEDPTVIA
                     ETELLGAAASIEAAAKKLEQLKPRAKPKQADETLDFEEQILEAAKSIAAATSALVKSA
                     SAAQRELVAQGKVGSIPANAADDGQWSQGLISAARMVAAATSSLCEAANASVQGHASE
                     EKLISSAKQVAASTAQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVRAAQKAAF
                     GKADDDDVVVKTKFVGGIAQIIAAQEEMLKKERELEEARKKLAQIRQQQYKFLPTELR
                     EDEG"
     exon            512..609
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            610..739
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            740..892
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1035
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1163
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1227
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1332
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1488
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1590
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1667
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1848
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1962
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2071
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2280
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2379
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..2547
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2842
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..3009
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..3138
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            3139..3252
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            3253..3366
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            3367..3501
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            3502..3630
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            3631..3733
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            3734..3942
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            3943..4062
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            4063..4260
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            4261..4400
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            4401..4494
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            4495..4584
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            4585..4707
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            4708..4851
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            4852..5013
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            5014..5154
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            5155..5336
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            5337..5469
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            5470..5571
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            5572..5742
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            5743..5889
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            5890..5991
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            5992..6111
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            6112..6258
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            6259..6425
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            6426..6609
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            6610..6735
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            6736..6852
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            6853..7038
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            7039..7146
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            7147..7252
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            7253..7377
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            7378..7503
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            7504..7566
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            7567..7749
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            7750..7875
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
     exon            7876..12158
                     /gene="Tln2"
                     /gene_synonym="RGD1565416"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccctcccgg cgctcgcggg ccgtgcgctc gcgctcgccc tcggctccgg ttccgcgccc
       61 ggagccagca gcagcggcgg cggcggcggc agcggcggcg gcggcgcagc gtgagcggag
      121 ctggctgcac tcgggggctg gcgctccgca atgagacagt agctgcatcc ccgcgtgcac
      181 tgctgtaggg taacatctgg actggaattg aggctcctct ggtgcttgga tgtccctaag
      241 ttcctggatc agcttgttga agactgtgct gctgttggaa gcttctcact ccttgggatc
      301 ttttcaggga aaccaaaact gaataaactg agaatttaga tgctctaagt gaaatccatc
      361 aagtcatcca tgaaaatggt ggccctatcc ttaaagatct gtgtccgcca ctgcaatgtg
      421 gtgaagacca tgcagtttga gccgtctaca gctgtgtatg acgcctgtcg agtcattcgg
      481 gagagagtac ctgaagcaca gaccgggcaa gcttctgact atggactgtt tctttctgat
      541 gaagacccca ggaaagggat ttggctagaa gcaggtcgga cactggatta ctacatgttg
      601 cggaatgggg acattctgga gtacaagaag aaacagaggc ctcagaaaat ccgaatgttg
      661 gatggctctg tgaagacggt gatggtggat gactccaaga ccgtggggga gctcctggtc
      721 acaatctgca gcaggatagg aataacaaat tatgaagaat actctttaat ccaagaaacc
      781 attgaagaaa agaaagaaga agggacaggc acactaagaa aagacaggac gttgttacga
      841 gatgagagga agatggagaa gctgaaagcc aagctacaca cggatgatga cctaaattgg
      901 ctagatcaca gccggacatt cagagagcaa ggcgtggatg aaaatgaaac attgctactt
      961 cgacggaagt tcttttactc tgatcagaat gtggactcaa gagacccagt acagttgaac
     1021 ttgctttacg tccaggctcg ggatgacatc ctgaacggct ctcaccctgt ctccttcgag
     1081 aaggcatgtg agtttggtgg gttccaagcc cagatacagt ttggacctca cgtggaacat
     1141 aaacacaagc ctggattctt agatctaaag gaattcctgc ccaaagagta catcaagcag
     1201 agaggagccg agaagcgaat atttcaggaa cataaaaact gtggagagat gagtgaaata
     1261 gaagccaagg tgaagtacgt gaaactcgcc cgatccctcc ggacatatgg agtgtccttt
     1321 tttctggtga aggaaaaaat gaaaggcaag aacaagctgg ttccccgcct cctgggcatc
     1381 accaaggact ctgtcatgcg tgtggatgag aagaccaagg aggtgctgca ggagtggcca
     1441 ctcaccacgg tcaagcgctg ggcagcttca cctaagagct tcacactgga ttttggggag
     1501 taccaagaaa gctactattc agtacagacc acagaggggg agcaaatatc ccagctgatt
     1561 gcaggataca ttgacatcat cctcaagaag aaacaaagca aagatagatt tgggctggaa
     1621 ggggatgagg agtcaactat gttagaagag tcagtttccc caaaaaaatc taccatcttg
     1681 cagcagcagt tcaaccgcac tgggaaggca gagcatggct cggtggcact gccagctgtc
     1741 atgcgctctg gctccagtgg gcccgagact ttcaatgttg gcagcatgcc gtccccccag
     1801 cagcaagtca tggtcggaca gatgcaccga ggacacatgc ctccgctgac ttcggcacag
     1861 caagccctta tggggaccat caacacaagc atgcacgctg tccagcaggc tcaggatgac
     1921 ctcagtgagc tcgactcact gccacctctc ggccaagata tggcatctag ggtatgggtt
     1981 cagaacaaag tggatgaatc caagcatgaa atccactctc aagtcgatgc tatcacagct
     2041 ggcacagcct cggttgtcaa cctcacagct ggtgaccccg cagacactga ctacacagcc
     2101 gtgggctgtg caatcactac aatttcttcc aacctgaccg aaatgtccaa gggggtcaag
     2161 ttgctggcag ccctcatgga cgatgacgtg ggcagtgggg aggaccttct cagagctgcc
     2221 aggaccctcg ccggggctgt gtctgattta ctgaaggctg tgcagcctac ttctggagag
     2281 cctcgacaga ctgttttgac tgctgcggga agcatcggcc aagccagtgg agatctcctg
     2341 agacagatcg gagagaacga gacggacgag agattccaag atgttttaat gagtctcgct
     2401 aaagctgttg ccaacgctgc tgccatgtta gtactcaagg cgaagaatgt ggcccaggtg
     2461 gctgaagaca ccgtcctcca gaacagggtg atcgccgcag ccacccagtg tgccctctcc
     2521 acctcgcagc ttgtggcgtg tgctaaggtg gtgagcccca cgatcagctc ccccgtgtgc
     2581 caggagcagc tgatcgaagc tgggaagctg gtggaccgct ctgtggaaaa ctgtgtccgt
     2641 gcctgccagg cggccaccgg tgacagtgag ctcctgaagc aggtcagcgc ggcggccagc
     2701 gtggtcagcc aggccctgca cgacctcctg cagcacgtgc ggcagttcgc cagccggggc
     2761 gagcccatcg gccgctatga ccaggccacc gacaccatca tgtgtgtcac tgagagcatc
     2821 ttcagttcca tgggggatgc tggtgagatg gtgcgccaag cccgggtgct ggcccaggcc
     2881 acatcagatc tcgtcaatgc catgaggtca gatgcggagg ctgagattga catggagaat
     2941 tccaagaagc tcctggcagc cgcaaagctc ttggccgact ccaccgcccg catggtggaa
     3001 gctgcaaagg gggctgcagc caacccggag aacgaagacc agcagcaaag gctgagagaa
     3061 gctgccgagg gtctccgggt agcaaccaac gccgctgccc agaacgctat taagaaaaaa
     3121 atcgtcaacc ggctggaggt tgcagccaag caggctgcag ctgctgccac acagaccatt
     3181 gcagcctccc agaatgcagc catctccaac aagaacccct cggcccagca gcaactggtg
     3241 cagagctgca agacggtggc tgatcacatc cctcagctag tgcagggggt gagggggagc
     3301 caagctcaag cagaagacct cagcgcccag ctggccctca tcatctccag tcagaacttc
     3361 ctgcagcctg gaagcaagat ggtgtcctct gctaaggcgg ccgtacccac tgtgagtgac
     3421 caggccgcag ccatgcagct gagtcagtgc gccaagaacc tggcgacaag ccttgctgag
     3481 ctgcgcactg cctcacagaa ggcccatgaa gcctgtggtc ccatggaaat cgattctgca
     3541 ctgaacacag tgcagactct caagagtgag cttcaggacg ccaagatggc cgctgcagaa
     3601 agtcaactga aaccacttcc aggagaaaca ctagaaaagt gcgctcagga cctgggaagc
     3661 acctctaagg gagtgggctc ctccatggcg cagctcctca cctgcgctgc tcaaggcaat
     3721 gagcactaca caggcgtggc agctagagaa acagctcaag ctctgaaaac actggcccag
     3781 gctgcccggg gagtggctgc gtctacaaat gaccctgagg ccgctcatgc catgttagac
     3841 tctgctcggg atgtgatgga gggctctgcc atgctcatcc aagaagccaa gcaggcctta
     3901 atcgcacctg gagatacgga aagtcagcag agattagccc aggtggccaa agctgtgtcc
     3961 cactcactga ataactgcgt gaattgcctc cctggtcaga aggatgtgga tgtcgccttg
     4021 aagagcatcg gggagtccag caagaagcta cttgtagatt cgctccctcc gagcacaaag
     4081 cctttccagg aagcccagag tgagctgaac caggctgctg ctgatctgaa ccagtctgcc
     4141 ggggaagtcg tccatgccac aagggggcag agtggagagc tggcggccgc ttctgggaag
     4201 ttcagtgatg actttgacga gttcctggat gcaggcattg agatggctgg ccaggcacag
     4261 acaaaagaag accagatgca agtgatcggg aacctgaaga acatctctat ggcgtccagc
     4321 aagctactgt tagctgccaa gtctctctct gtagatcctg gagctcccaa cgcaaaaaat
     4381 cttttggctg cggctgcaag agctgtgaca gagagcatca atcagctcat catgctgtgc
     4441 actcagcagg cccccgggca gaaggagtgt gacaatgccc ttcgtgagct cgagactgtc
     4501 aaggggatgt tggaaaaccc taatgagcca gtgagcgacc tctcttactt tgactgcatt
     4561 gagagtgtaa tggagaactc caaggttctg ggcgagtcaa tggcagggat ttcacagaat
     4621 gccaaaactg gagacctccc tgccttcgga gaatgcgtgg ggattgcatc caaggctctc
     4681 tgtgggctga cagaggcagc agcccaggct gcgtacctgg ttggcatctc tgatccaaac
     4741 agccaggcag gccaccaagg cctagtggac cccatccagt ttgccagggc caaccaggcg
     4801 atccagatgg catgccagaa cttggtggac cctggcagca gcccatcaca ggttctgtca
     4861 gctgctacca ttgttgccaa gcacacctca gccttatgca atgcctgccg catcgcctcg
     4921 tctaagacag ccaaccctgt ggccaagagg cactttgtcc agtcagccaa ggaggtggcc
     4981 aacagcaccg ccaacctggt caagaccatc aaggccctgg atggggattt ctctgaagac
     5041 aaccgcaata agtgtcgaat tgctaccacg ccgttgatcg aggctgtgga gaacctgaca
     5101 gcatttgcat caaaccccga gtttgccagc attcctgcac agatcagctc tgagggctcc
     5161 caggcacagg aaccaatctt ggtctcagcc aagaccatgc tggagagctc atcgtacctc
     5221 atccgcaccg cacgctctct ggccatcaac cccaaggatc cacccacctg gtctgtgttg
     5281 gctgggcact ctcacactgt gtctgactcc attaagagtc tcatcacgtc tatcagggac
     5341 aaagccccag ggcagaggga atgtgactac tccattgatg gcatcaaccg gtgcatcagg
     5401 gacatcgagc aggcctccct ggcggcagtg agccagagcc tggccacgag ggatgacatc
     5461 tctgtggagg ccctacagga gcagctgacc tcggtggtcc aggaaatagg gcatcttatt
     5521 gatcccattg ccacagcagc acgaggagaa gctgcccaac ttggacataa ggtgacacag
     5581 ctggcaagct actttgagcc attgatctta gctgcagtcg gtgtcgcctc caagatgctg
     5641 gaccatcaac aacagatgac agtgctagac cagaccaaaa ctctcgcaga gtctgccctg
     5701 cagatgctgt atgcagccaa agaaggtgga ggaaacccca aggcacagca cacccacgac
     5761 gccatcacag aggctgcaca gctgatgaag gaagctgtgg atgacattat ggtgacgctg
     5821 aatgaagctg ccagtgaggt ggggctggtg ggaggcatgg tagacgccat cgcagaggcc
     5881 atgagcaagc tggatgaagg cacacctcca gaaccaaagg gaacgtttgt tgactaccag
     5941 acgactgtgg ttaaatactc caaagccatt gccgtcacag ctcaggaaat gatgactaag
     6001 tcggttacta acccggagga gttgggaggc ctggcttcac aaatgaccac tgactatggg
     6061 cacctggctc tccagggcca gatggcagca gccaccgccg aaccagagga gattggattc
     6121 cagattcgca cacgcgtgca ggaccttggc catggctgta tcttcctggt gcagaaggcg
     6181 ggggccctcc aggtttgccc cacagacagc tacaccaaga gggagctgat cgagtgtgcc
     6241 cgttctgtca ccgagaaggt atccttggtg ctgtctgctc tccaggctgg gaacaagggg
     6301 acccaggcat gcatcaccgc tgcaactgca gtttctggga tcattgctga tctggacacc
     6361 accattatgt ttgcaacagc tgggacgctg aatgctgaaa atggcgagac ctttgccgat
     6421 cacagggaga acattctgaa gacagccaag gccttggtgg aagacacaaa gctgcttgtg
     6481 tcgggggccg catccactcc agacaagctg gcccaggcag ctcagtcctc agcagcaacc
     6541 atcacccagc ttgccgaggt ggtcaagctg ggggccgcca gcctgggctc caatgaccct
     6601 gagacccagg tggtactgat aaatgccatc aaagacgtgg ccaaggccct ttccgatctc
     6661 attggtgcta ccaagggagc tgccagcaag ccagctgatg acccctccat gtaccagctc
     6721 aagggagccg ccaaggtgat ggtgaccaat gtcacctccc ttcttaagac tgtgaaggca
     6781 gtggaagacg aggccacccg gggcacaagg gcacttgagg ccaccatcga gtacataaaa
     6841 caggagctca cagtgttcca gtcaaaagac atacctgaga agacatcatc acccgaggaa
     6901 tcaataagaa tgacgaaagg tatcaccatg gcaacagcca aagctgtggc agccgggaac
     6961 tcatgtagac aagaggatgt gattgccacc gccaatctga gcaggaaggc tgtctcagat
     7021 atgttgatag cttgcaagca agcatccttc taccctgatg tcagtgaaga ggtgcgaacc
     7081 agagccttgc ggtatggcac ggagtgcacc ctgggctacc tggacctact agaacacgtc
     7141 ttggtgattc ttcagaagcc aaccccagaa ctcaagcatc agctggctgc tttctccaaa
     7201 agagttgccg gtgctgtgac tgagctcatc caggcagcag aagccatgaa aggaacagag
     7261 tgggtggatc cagaagaccc aaccgtcatt gcagaaaccg agttactggg agctgcagca
     7321 tccattgaag ccgctgccaa gaagttagag caactgaagc cgagagcaaa gccaaagcaa
     7381 gcagacgaga ccctggattt tgaagaacag atcttagaag ctgctaaatc cattgctgct
     7441 gccacaagtg ccctggtcaa gtcggcctca gcggcccaga gggagctggt ggcccaaggc
     7501 aaggtgggct ccatccctgc caatgccgcc gatgatggac agtggtcaca ggggctgatc
     7561 tctgccgccc ggatggtggc agcagcaacc agcagtctct gtgaggcagc caatgcctct
     7621 gttcagggac atgccagtga ggaaaagctc atctcatctg ccaagcaggt cgcagcctca
     7681 accgctcagc tgctggtggc ctgcaaggtg aaggccgacc aggattcaga ggccatgaag
     7741 cggctacagg cggcaggaaa tgctgtgaaa agagcctcag acaatcttgt tcgtgcagcc
     7801 cagaaggcag catttggcaa agctgatgat gacgatgttg tggtgaaaac caagtttgtg
     7861 ggaggcattg ctcagatcat tgcagcccag gaggaaatgc tgaagaaaga acgagagctg
     7921 gaggaagcca ggaagaagct ggcccagatc cgccagcagc agtacaaatt cctacccaca
     7981 gagctgagag aagatgaggg ctagaacccg cccatgttgg cgagccccag gaggtggttc
     8041 ctactccccc aacaagaact ggacataccg gccttcccca gagccaggga ctcctggaaa
     8101 ctgctggccc tccacctgga gtctctctca tctcagtcct gtcaccatca gctgcatgat
     8161 catgatctca cacggtacag tgtcccaccc acagctcctc cagctcccct cacgcctcac
     8221 tatatctcag gacagagggg gcgcacgttt cgtggactgt taccaaaaag aaaagtcagt
     8281 attatgttgt tctcagacac ctttactctt tgtcctccaa gactgctcca gggcctcttt
     8341 gtgaaatccc actaggagaa gaacagtgac agtaatggct cacaggaatc attgatatca
     8401 tggacacaga tattctctct ctagagagaa gaccgagctg gagttggaca ctgttaataa
     8461 agccagaaac actcccaagt ggatctgggg tctggagtca cagaggtcct tgtaagtgtg
     8521 gagcactgat cacccacggg gggagaagat cccccgcccc gtttgcacgc ttttcttgcc
     8581 tcagtgcgta agctccttgt acaactacac ccatcttgta ttctgtggcc cagaaaaaaa
     8641 tggaagttat tttatttttt ttccctccat aatccaaagg gcagagttgt ggaaagtggt
     8701 cagggtcagg tgggcagggg ccggaataaa acactgggct cctttactca gcaaggtggt
     8761 ttcagtttat gcagacgcac acccgagact atgtccctga tggatcccag tgcagcaccg
     8821 cctggaggaa gagtcaggta gcgtttagga aagaggttcc catgtttgag cccggtcatc
     8881 agtttctgtg ctcttaggga gggtccaagt tccagaagga aaattatttg tttagaactt
     8941 tgacctttga tcccaagaag gcatttccca ccatgtatct taatattccc caatctgagt
     9001 gtgccctgtg gtcaaggtgg acctgtgtaa cagtgtactg cttattgtca cagaagtgtt
     9061 ttcacagtgc atcatttggg tgctgcactc tcagccctcc agacgtctcc cccttgtgcc
     9121 ttttctctta gagccctctt ctggcaagga cattatagat ccctgagttt acatttgagc
     9181 tgagcctcta cctaaggtga tgggaggagg gagagcctaa taccaatgcc aagcatgttt
     9241 tcatgaattc atgtagaggt agcgggggcg tgctgggact gtagctcaac tgttggcctg
     9301 gttagcatgc gctgggtccc atcacagaaa ctcgatgtgg tggcacacta gggagacaga
     9361 ggtaggtgga tcagaagttc aagattatct ttggctaaat attaagtcag agacccgcct
     9421 tggctaccaa ggaccttgcc tccaaaggag aaaaaaaaca gctaataatg gaggcctatc
     9481 gtcctcaagg ctaatggctg ctggaggcag gctttctccc ccttaaggat ccactagcac
     9541 actatatact ggactcacca cttagatcca gatttctacc aaagaggaaa tactggaaca
     9601 ctggtcctca gaaagaaaag aaagaatcca ccttcaacgt tgccagatga gtctcctcca
     9661 gcagactcta tcctgttccg caactctaaa atataattaa attctaacac cttcccagat
     9721 gtgtagagac ttataaatgc tgcacaaagg aattcctctg agacaggtag aaggatctaa
     9781 gtgtggtgag aatgaaaagc aaatgtaggg tacacatgga aggagtgagg ccgtgctatc
     9841 atcagatcca acagagcagg gctgctctag cactgggaga gcctaatgct gggagccctc
     9901 aatgctcgtg ggaaagcaag tcgcctggct cacacccttt gagtgtaact cttcatgcct
     9961 ttgctgggta cttcccaaaa cgattaagca aggccccaaa gctcatgatc aagatgtgac
    10021 agtggcctca cacagtagga ccagaggccc tcttgcagct ggctcaccca ctttcctata
    10081 ggatatgctt ctctctgggc atctgcccct caccacccct tccacctgtc ccctgtcaca
    10141 ttggacattc caggggcagt gcaaggacag atactgagtg cccatccctg ccccggggta
    10201 gtttaaaacc ttcgcagaag tgaacacagg agaaaacctc taacaaatga cgggtgaagg
    10261 gctgttctct atggctgtga ggggtgtgcc ctcctgtctg cattgttgtg aactttgggg
    10321 gaagatcgtt cccaggtatc acctgccatg gtcataggcc catttcttgc ctgtccctca
    10381 cttgtccatg ctgtgtccat gtctgtgagt gtcctcatgg ctggctggac ctctcctcat
    10441 ttcacgaaaa ggatgaaatg ctggacggtg ggcattcctt aatcagtgct gctgccgatg
    10501 tccccaaagg cacagagcag actcctggct cctaagggag aaagaacgca gatgtagtga
    10561 attgcatctt ggagtagttt caaggccaag tggcccaagg cctggaacat gaagtccatc
    10621 cctctgtgag agggggactt gcagttgagt gctctcctac ctctgctccc gtgagagagg
    10681 ccgacatttg gtgtttaatc tttacactga tctttttgtc caaaatttcc atttttgatg
    10741 atcaaaagag gtatgtacct ggtggctggg aaattgcatt tggcttgctt ctgtctctca
    10801 gaagcaagac aaggaagcaa aagccatgtt tggtcagaca gccctgggta gcacttccac
    10861 tggccagttg ggactggtct tggaggtcat cacagacaga tacttaggac ctaggcagtc
    10921 ctccggttgt cactggtgat ttccagaggc agctgccctg gctgcagcct gacgcacggg
    10981 ctttcagggc taagccacca cagatcttct ggtatacact cttagtccag aaaacccctc
    11041 taagcctctc ggcacaactc gtctgcttgc tgtctgagtt ctctaccagc tggtgagagt
    11101 atggacagct gaaaccaagt gttaaaaact gtattaaaga ggtgtgacag tgtacaacta
    11161 gaatcccagc actgggaagg tggaggcagg agaattgcaa gtttaaggcc aacctgggct
    11221 aggtagcaag atcctgtctc aaaaaaacaa aggctagtgg gtgtaactta gtgttaaaaa
    11281 tgcttgcctc ataagtgcaa ggaaggccct gggcttgttc ccagcaatgc acacagactt
    11341 tagccaaaat gttcagccac ctaaaagcac gtatttattc ccatctccta agtggcccca
    11401 gaaccagaat ctcatgaagg aagcagggtt ggggcggtaa gacatgctcg ctgcacctcc
    11461 tctttcccct ctggtaggtg gtccccctaa tctccctgag ctttgcagtt ctgggctaag
    11521 gttgggcctc tgggatgtaa ggcttaagat cccagcactg attatatgct ctgctcagat
    11581 gcctagagga acgaactccg tgagtgagcg ctcagacaca tctaagagac tgagcaagtt
    11641 gcaaggaatt ggaaggaaat ggtcgcttac aggctgagag gcagcagtgc ccagaatcct
    11701 aaaagccaaa ggtcttaggg gctatgctgg tggctcaggt cttacctctc cacagagtcc
    11761 ctcccgtagg gtcaacaccc tccgctaagg aaggtgctcc taggaaggca tcctccacaa
    11821 accccgacac cactgctcca ttgtcatgag cttgcgcttg gtgtgttaag gttatggtca
    11881 ttgggactga gcatgaggag agaccttcca gtagcctcac aatactatga aggagggatg
    11941 acacttttct gtgaaatggg ctaggtttta tctggtctcc ctggaaccca gctcgctgcc
    12001 caccaggaag caatagcatg cgagcccctc tgcagccatg tctgacagag acaagaaagg
    12061 gaagctctgc ccttgtcata atgtttaatc acataaatta atttatctaa tcacataaat
    12121 tatttttttt attcatcaga aataaacttt taaaggaa
//
