LOCUS       NM_001039025            8647 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus talin 1 (Tln1), mRNA.
ACCESSION   NM_001039025 XM_242982
VERSION     NM_001039025.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8647)
  AUTHORS   Birukova AA, Shah AS, Tian Y, Moldobaeva N and Birukov KG.
  TITLE     Dual role of vinculin in barrier-disruptive and barrier-enhancing
            endothelial cell responses
  JOURNAL   Cell Signal 28 (6), 541-551 (2016)
   PUBMED   26923917
REFERENCE   2  (bases 1 to 8647)
  AUTHORS   Tan CL, Kwok JC, Heller JP, Zhao R, Eva R and Fawcett JW.
  TITLE     Full length talin stimulates integrin activation and axon
            regeneration
  JOURNAL   Mol Cell Neurosci 68, 1-8 (2015)
   PUBMED   25771432
  REMARK    GeneRIF: This study found that overexpression of the talin head
            activated axonal integrins but inhibited downstream signaling via
            FAK, and did not promote axon growth.
REFERENCE   3  (bases 1 to 8647)
  AUTHORS   Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S and Zaidel-Bar R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8647)
  AUTHORS   Calderwood DA, Campbell ID and Critchley DR.
  TITLE     Talins and kindlins: partners in integrin-mediated adhesion
  JOURNAL   Nat Rev Mol Cell Biol 14 (8), 503-517 (2013)
   PUBMED   23860236
  REMARK    Review article
REFERENCE   5  (bases 1 to 8647)
  AUTHORS   Frobel J, Cadeddu RP, Hartwig S, Bruns I, Wilk CM, Kundgen A,
            Fischer JC, Schroeder T, Steidl UG, Germing U, Lehr S, Haas R and
            Czibere A.
  TITLE     Platelet proteome analysis reveals integrin-dependent aggregation
            defects in patients with myelodysplastic syndromes
  JOURNAL   Mol Cell Proteomics 12 (5), 1272-1280 (2013)
   PUBMED   23382103
REFERENCE   6  (bases 1 to 8647)
  AUTHORS   Izard T and Vonrhein C.
  TITLE     Structural basis for amplifying vinculin activation by talin
  JOURNAL   J Biol Chem 279 (26), 27667-27678 (2004)
   PUBMED   15070891
REFERENCE   7  (bases 1 to 8647)
  AUTHORS   Jiang G, Giannone G, Critchley DR, Fukumoto E and Sheetz MP.
  TITLE     Two-piconewton slip bond between fibronectin and the cytoskeleton
            depends on talin
  JOURNAL   Nature 424 (6946), 334-337 (2003)
   PUBMED   12867986
REFERENCE   8  (bases 1 to 8647)
  AUTHORS   Bouvard D, Vignoud L, Dupe-Manet S, Abed N, Fournier HN,
            Vincent-Monegat C, Retta SF, Fassler R and Block MR.
  TITLE     Disruption of focal adhesions by integrin cytoplasmic
            domain-associated protein-1 alpha
  JOURNAL   J Biol Chem 278 (8), 6567-6574 (2003)
   PUBMED   12473654
REFERENCE   9  (bases 1 to 8647)
  AUTHORS   van der Flier A, Kuikman I, Kramer D, Geerts D, Kreft M, Takafuta
            T, Shapiro SS and Sonnenberg A.
  TITLE     Different splice variants of filamin-B affect myogenesis,
            subcellular distribution, and determine binding to integrin [beta]
            subunits
  JOURNAL   J Cell Biol 156 (2), 361-376 (2002)
   PUBMED   11807098
REFERENCE   10 (bases 1 to 8647)
  AUTHORS   Luo G, Herrera AH and Horowits R.
  TITLE     Molecular interactions of N-RAP, a nebulin-related protein of
            striated muscle myotendon junctions and intercalated disks
  JOURNAL   Biochemistry 38 (19), 6135-6143 (1999)
   PUBMED   10320340
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473962.1.
            
            On May 30, 2008 this sequence version replaced NM_001039025.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..8647
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..8647
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /note="talin 1"
                     /db_xref="GeneID:313494"
                     /db_xref="RGD:1306247"
     exon            1..548
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            549..711
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     CDS             582..8207
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /codon_start=1
                     /product="talin-1"
                     /protein_id="NP_001034114.2"
                     /db_xref="GeneID:313494"
                     /db_xref="RGD:1306247"
                     /translation="MVALSLRISIGNVVKTMQFEPSTMVYDACRMIRERIPEALAGPP
                     SDFGLFLSDDDPKKGIWLEAGKALDYYMLRNGDTMEYRKKQRPLKIRMLDGTVKTIMV
                     DDSKTVTDMLMTICARIGITNHDEYSLVRELMEEKKDEGTGTLRKDKTLLRDEKKMEK
                     LKQKLHTDDELNWLDHGRTLREQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQ
                     ARDDILNGSHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKGE
                     RKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITK
                     ECVMRVDEKTKEVIQEWSLTNIKRWAASPKSFTLDFGDYQDGYYSVQTTEGEQIAQLI
                     AGYIDIILKKKKSKDHFGLEGDEESTMLEDSVSPKKSTVLQQQYNRVGKAEHGSVALP
                     AIMRSGASGPENFQVGSMPPAQQQVTSGQMHRGHMPPLTSAQQALTGTINSSMQAVQA
                     AQAALDDFDALPPLGQDAASKAWRKNKMDESKHEIHSQVDAITAGTASVVNLTAGDPA
                     ETDYTAVGCAVTTISSNLTEMSRGVKLLAALLEDEGGNGRPLLQAAKGLAGAVSELLR
                     SAQPASAEPRQNLLQAAGNVGQASGELLQQIGESDTDPHFQDILMQLAKAVASAAAAL
                     VLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACTKVVAPTISSPVCQEQLVEAG
                     RLVAKAVEGCVSASQAATEDGQLLRGVGAAATAVTQALNELLQHVKAHATGAGPAGRY
                     DQATDTILTVTENIFSSMGDAGEMVRQARILAQATSDLVNAIKADAEGESDLENSRKL
                     LSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGLRMATNAAAQNAIKKKLV
                     QRLEHAAKQAAASATQTIAAAQHAASAPKASAGPQPLLVQSCKAVAEQIPLLVQGVRG
                     SQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASAMQLSQCAKNLGTA
                     LAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEIKAAAREGKLKPLPGETMEKCT
                     QDLGNSTKAVSSAIAKLLGEIAQGNENYAGIAARDVAGGLRSLAQAARGVAALTTDPA
                     VQAIVLDTASDALDKASSLIEEAKKASGHPGDPESQQRLAQVAKAVTQALNRCVSCLP
                     GQRDVDNALRAVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELVQASRG
                     TPQDLARASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAK
                     ALSTDPAAPNLKSQLAAAARAVTDSINQLITMCTQQAPGQKECDNALRQLETVRELLE
                     NPVQPINDMSYFGCLDSVMENSKVLGEAMTGISQNAKNGNLPEFGDAIATASKALCGF
                     TEAAAQAAYLVGVSDPNSQAGQQGLVEPTQFARANQAIQMACQSLGEPGCTQAQVLSA
                     ATIVAKHTSALCNSCRLASARTANPTAKRQFVQSAKEVANSTANLVKTIKALDGAFTE
                     ENRAQCRAATAPLLEAVDNLSAFASNPEFSSVPAQISPEGRAAMEPIVISAKTMLESA
                     GGLIQTARALAVNPRDPPRWSVLAGHSRTVSDSIKKLITSMRDKAPGQLECETAIAAL
                     NSCLRDLDQASLAAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLASAARAEASQ
                     LGHKVSQMAQYFEPLTLAAVGAASKTLSHPQQMALLDQTKTLAESALQLLYTAKEAGG
                     NPKQAAHTQEALEEAVQMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDEGP
                     MGEPEGSFVDYQTTMVRTAKAIAVTVQEMVTKSNTSPEELGPLANQLTSDYGRLASQA
                     KPAAVAAENEEIGAHIKHRVQELGHGCSALVTKAGALQCSPSDVYTKKELIECARRVS
                     EKVSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIMFATAGTLNREGAETFADHR
                     EGILKTAKVLVEDTKVLVQNAAGSQEKLAQAAQSSVATITRLADVVKLGAASLGAEDP
                     ETQVVLINAVKDVAKALGDLISATKAAAGKVGDDPAVWQLKNSAKVMVTNVTSLLKTV
                     KAVEDEATKGTRALEATTEHIRQELAVFCSPEPPAKTSTPEDFIRMTKGITMATAKAV
                     AAGNSCRQEDVIATANLSRRAIADMLRACKEAAFHPEVAPDVRLRALHFGRECANGYL
                     ELLDHVLLTLQKPNPELKQQLTGHSKRVAGSVTELIQAAEAMKGTEWVDPEDPTVIAE
                     NELLGAAAAIEAAAKKLEQLKPRAKPKEADESLNFEEQILEAAKSIAAATSALVKAAS
                     AAQRELVAQGKVGAIPANALDDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQE
                     KLISSAKQVAASTAQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAF
                     EDQENETVVVKEKMVGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQYKFLPSELR
                     DEH"
     exon            712..809
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            810..939
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1092
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1235
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1363
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1424
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1529
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1685
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1787
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1864
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..2045
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2159
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2268
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2477
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2576
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2744
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..3039
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            3040..3206
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            3207..3335
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            3336..3452
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            3453..3566
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            3567..3701
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            3702..3830
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            3831..3933
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            3934..4142
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            4143..4262
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            4263..4460
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            4461..4600
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            4601..4694
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            4695..4784
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            4785..4907
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            4908..5051
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            5052..5213
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            5214..5354
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            5355..5536
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            5537..5669
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            5670..5771
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            5772..5942
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            5943..6092
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            6093..6194
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            6195..6314
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            6315..6461
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            6462..6628
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            6629..6812
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            6813..6938
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            6939..7055
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            7056..7241
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            7242..7349
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            7350..7455
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            7456..7580
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            7581..7706
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            7707..7769
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            7770..7952
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            7953..8081
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
     exon            8082..8647
                     /gene="Tln1"
                     /gene_synonym="Tln"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgttactcta tatgccacac ccgcctctca gcttctattc ccctcagcgt ccaacataac
       61 ggaagtgatg cacatagtcc cgtggaatcc tgggacttgg agttccctcc aactcggaag
      121 tggcttgtgt agtgcgccac gtcccagggg ctatgcaaat tatggggatg tcccttcagc
      181 ttcccacgcc ccagggcggg gattctgagg atccggatcc gccttcgccg cgagctatta
      241 aaaaaaccct aagagtctaa aagggaactc ccgtttagtt cgggcgttct ctccagtgct
      301 ctgcaccctc gcttcctgcc ggggaggggc ggccaggctt cgcgggagcc cgagcatcga
      361 gagctgcggc cagagcagct tcctgcagtc tctgcgacca tagagcggac cgccggcggg
      421 tgggggacgt ttccaggacg gaagtggacg agagtgtgtc gaagggaggg cgaggccgga
      481 gccccaaagc gaccgggaga acgagcgggt agcgggccca gggcggggcg cagagctggg
      541 cagcgcaggt atcgccaggc cgaagagcag aagctgccac catggttgcg ctttcgctga
      601 ggatcagcat tgggaacgtg gtgaagacga tgcagtttga gccgtctacc atggtgtacg
      661 atgcctgccg catgattcgt gagcggatcc cagaggccct ggctggccct cccagcgact
      721 ttgggctatt tctgtcagat gatgacccca aaaaaggtat ctggctcgag gctgggaaag
      781 ctctggacta ctacatgctc cgaaatgggg acaccatgga gtacagaaaa aaacagagac
      841 ccctgaagat ccggatgtta gatggaactg tgaagactat catggtggat gactccaaga
      901 ctgtcacaga catgctcatg actatctgtg cccgaattgg tatcaccaac catgacgaat
      961 attcactggt tcgagagctg atggaagaaa agaaggatga ggggacaggg accctaagaa
     1021 aagacaagac cctgttgcga gatgaaaaga agatggagaa actaaagcag aagttgcaca
     1081 cagacgatga gttgaactgg ctggaccatg ggcggacact gagggaacag ggagtggaag
     1141 agcatgagac gttgctgctg cggagaaagt tcttctactc agaccagaat gtggactccc
     1201 gcgaccctgt acagctgaac cttctttatg tgcaggcacg agatgacatc ctgaacggct
     1261 cccaccctgt ctcctttgac aaggcctgtg agtttgcagg cttccaatgc cagatccagt
     1321 ttggacctca caatgaacag aagcacaagg ctggcttcct tgacctgaag gacttcctgc
     1381 ccaaggagta tgtgaagcag aagggagagc gtaagatctt tcaggcgcac aaaaattgtg
     1441 ggcagatgag tgaaattgag gccaaggtac gctatgtgaa gctggcccgt tccctcaaga
     1501 cttacggtgt ctccttcttc ctagtgaagg aaaagatgaa ggggaagaat aaactagtgc
     1561 ccaggctgtt gggcatcacc aaggaatgtg tgatgcgtgt ggatgagaag accaaggagg
     1621 tgatccagga atggagcctc accaacatca aacgctgggc tgcctctccc aagagcttca
     1681 ctttggactt tggagactac caggatggct actactcagt acagacgact gaaggggagc
     1741 agattgcaca gctcattgct ggctacatcg acatcatcct taagaagaaa aaaagcaagg
     1801 accattttgg gctggaggga gatgaagagt ctactatgtt ggaggactca gtttctccca
     1861 aaaagtcaac agtccttcag cagcaataca accgagtggg gaaagcagag catggctctg
     1921 tggccctacc agccatcatg cgctctggag cctctggccc tgagaatttc caagtgggga
     1981 gcatgccgcc tgcccagcag caggttacca gtggccagat gcaccgcgga cacatgccac
     2041 ctttgacttc agcccagcag gcgctcactg gaaccattaa ctccagcatg caggctgtgc
     2101 aggccgccca agctgctctt gatgactttg atgctctgcc ccctctgggc caggatgctg
     2161 cctccaaagc ttggcgtaag aacaagatgg atgaatcaaa gcatgagatc cactcccagg
     2221 tagatgccat cacagctggc actgcctccg tggtaaacct gacagcagga gaccctgcag
     2281 agacagacta taccgcagtg ggctgtgcag tcaccaccat ctcttccaac ctgacggaga
     2341 tgtcccgtgg agtgaagttg ttggctgccc tgctggagga tgaaggtggc aatggccggc
     2401 cccttctgca agcagcaaag ggccttgcag gggcagtgtc agaactgctt cgcagcgctc
     2461 agcccgccag tgctgagccc cgtcagaacc tgctgcaggc ggctgggaac gtgggccagg
     2521 ccagtgggga gctgttgcag caaattgggg agagtgacac tgacccccac ttccaggata
     2581 ttctgatgca gctagcaaag gcagtggcta gtgctgcagc cgccctggtc ctcaaggcca
     2641 agagtgtggc ccagcgcaca gaggattcag ggcttcagac ccaagttatt gctgcagcta
     2701 cacagtgtgc cctgtccact tcccaactag tggcctgcac caaggtggta gctcctacga
     2761 tcagctcacc tgtctgccag gaacagctgg tagaggcggg acgactggtg gccaaggctg
     2821 tggagggctg tgtgtctgcc tcccaagcag ctacagaaga cggacaactg ttgcgagggg
     2881 taggagcagc agccacagct gtcacccagg ccctcaatga gctgctgcag catgtgaagg
     2941 cccatgccac aggggctggg cctgctggtc gatacgacca agccactgat accatcctca
     3001 ctgtcactga aaatatcttc agctccatgg gtgatgctgg ggagatggtg cgacaggccc
     3061 gcatcctggc ccaagccacc tcagacctgg tcaatgctat caaggccgat gctgaggggg
     3121 agagtgatct ggagaactct aggaagctcc tgagtgctgc caagatcctt gctgatgcca
     3181 ccgccaagat ggtggaggcg gccaagggag cagccgccca ccccgacagt gaggagcagc
     3241 agcagcgact acgtgaagcg gctgaggggc tccgcatggc caccaatgca gctgcacaga
     3301 atgccatcaa gaagaagttg gtgcagcgtc tggagcatgc agccaaacaa gctgcagcct
     3361 ctgctacaca gaccatcgct gcagcacagc atgcagcctc tgcccccaag gcctctgcag
     3421 gcccccagcc actactggta cagagctgta aggctgtggc agagcagatt ccattgctgg
     3481 tgcagggtgt ccgaggaagc caagctcaac ctgacagccc tagtgctcag ctcgccctca
     3541 ttgctgccag ccagagcttc ctgcagccag gtgggaagat ggtggcagca gcaaaggcct
     3601 cagtgccaac aattcaggac caggcttcag cgatgcagct gagtcagtgt gcaaagaacc
     3661 taggcactgc cctggccgag ctccgcactg ctgcccagaa ggctcaggag gcatgtggac
     3721 ctttggagat ggactccgca ctgagcgtcg tacagaatct agagaaggac ctgcaggaga
     3781 taaaagcagc cgctcgcgag ggcaaactta aaccgttacc cggggagacg atggagaagt
     3841 gtacccaaga tcttggcaac agcaccaaag cggtgagctc tgccatcgcc aagctgctgg
     3901 gggagattgc ccagggcaac gagaactatg caggtattgc agctcgggat gtagcaggtg
     3961 gactaaggtc acttgcccag gctgcacggg gtgtagctgc actgacaaca gatcctgcag
     4021 tgcaggccat tgtgcttgac acagccagtg acgctctgga caaggccagc agcctcattg
     4081 aggaggcaaa gaaagcatcc ggccatccag gggacccgga gagccagcaa aggcttgccc
     4141 aggtggctaa agcagtgacg caggccctga accgctgtgt cagctgcctg cctggccaga
     4201 gagatgtgga taacgcccta agagctgttg gagatgccag caagcgactc ctgagtgact
     4261 cgcttcctcc aagcaccggg acgtttcagg aagcacagag ccgactgaat gaagctgctg
     4321 ctgggttaaa tcaggcggcc acagagctgg tgcaggcctc ccgaggaacc ccacaggacc
     4381 tggctcgggc ctcaggtcga ttcggacagg acttcagcac cttcctggaa gctggtgtgg
     4441 agatggctgg acaggccccg agccaggagg accgagccca ggtggtgtcc aacttgaagg
     4501 gcatatccat gtcttcgagc aaacttcttc tggctgctaa ggccttgtcc acagaccctg
     4561 ctgctcccaa cctcaagagt cagctggctg cagctgcccg ggcagtgaca gacagcatca
     4621 accagctcat caccatgtgc acccagcaag cccctggcca gaaggagtgt gacaacgcac
     4681 ttcggcagct agagacggtc cgagagctcc tggagaaccc agtgcagccc atcaacgaca
     4741 tgtcctactt cggttgcttg gacagtgtca tggagaactc taaggtccta ggtgaagcca
     4801 tgactggcat ctcccagaat gccaagaatg gaaatctgcc agagtttgga gatgccattg
     4861 ccacagcctc caaggctctc tgcggcttca ctgaggcagc cgcacaggca gcatatctgg
     4921 ttggtgtctc tgaccccaat agccaagctg gacagcaagg actggtggaa cccacacagt
     4981 ttgcccgcgc aaaccaggca attcagatgg cctgtcagag tctgggggag cctggctgta
     5041 cccaggccca ggtgttgtct gcagccacta ttgtggccaa gcacacttct gccctgtgta
     5101 acagctgtcg cctggcttcc gctcggactg ccaatcccac tgccaagcgc cagtttgtac
     5161 agtcagccaa ggaggtggcc aacagtacag ccaatcttgt caagaccatc aaggcactag
     5221 atggggcctt cacagaagag aaccgggccc agtgccgagc ggccacagcc cctctgctgg
     5281 aagctgtgga taacctgagt gcctttgcat ccaaccctga gttctctagc gttcctgccc
     5341 agatcagccc tgagggccga gctgccatgg agcccattgt aatctctgct aagacaatgt
     5401 tagagagtgc tggagggctc atccagacag ctcgggcatt agcagtcaat ccacgggatc
     5461 ctccacgttg gtcggtgcta gctggccact ctcggactgt ctcagattcc atcaagaaac
     5521 ttattacaag catgagagac aaagccccgg gacagttgga gtgtgagaca gccattgcag
     5581 ctctgaacag ctgcttgcgg gacctggacc aggcttctct tgctgctgtc agccaacagc
     5641 tggctccccg tgaaggaatc tcccaagagg ctctgcacac ccagatgctc actgcagtgc
     5701 aggaaatttc ccatctcatt gagccactgg ccagtgctgc tcgagctgaa gcctcccagc
     5761 tgggacacaa ggtgtcccaa atggcccagt actttgagcc actcaccctg gccgcagtgg
     5821 gtgctgcatc taagaccctg agccacccac agcagatggc acttctggac cagacgaaaa
     5881 cattggcaga gtctgccttg cagttgctat acactgccaa ggaggccggt ggtaacccta
     5941 agcaagcagc acacacccag gaagccctgg aggaagctgt gcagatgatg acagaagctg
     6001 tagaagacct gacaacaacc ctcaacgaag cagctagtgc tgcaggggtc gttggtggca
     6061 tggtggactc catcacccag gctatcaacc agctagatga aggacctatg ggtgaaccag
     6121 aaggttcgtt cgtagattat cagacaacca tggtgaggac agccaaggcc atagctgtca
     6181 ctgttcaaga aatggtaacc aagtcgaaca ccagccctga agagctgggc cctcttgcca
     6241 accagctgac cagtgactat ggccgactgg cctcacaagc caagcctgca gctgtggctg
     6301 ctgagaatga ggagataggt gcgcatatca agcaccgagt acaggagctg ggccatggct
     6361 gttctgctct ggtcaccaag gcaggcgcct tgcagtgtag ccccagtgat gtctacacca
     6421 agaaggagct catagagtgc gcccgcagag tatcagagaa ggtctcccat gttctggctg
     6481 cactccaggc tgggaatcgt ggtacccagg cctgcatcac agcagccagt gctgtgtctg
     6541 gtatcattgc tgaccttgac accaccatca tgtttgctac tgctggcaca cttaaccgtg
     6601 agggtgccga aacttttgca gaccaccggg agggtatctt aaagacagca aaggttcttg
     6661 tggaggacac caaggtcctg gtacaaaatg cagctgggag ccaggagaag ttggcacaag
     6721 ctgcccagtc ctcagtggcc accattaccc gcctcgctga tgtagtcaag cttggtgcag
     6781 ccagcctagg agctgaggac cccgaaactc aggtggtgct gatcaatgca gtaaaggacg
     6841 tagccaaggc cctgggagac ctcatcagtg caacgaaggc tgcagcgggc aaagttgggg
     6901 atgaccctgc agtgtggcag ctcaagaact ctgctaaggt gatggtgact aatgtgacat
     6961 cgttgctcaa gactgtgaag gctgtggaag atgaggccac caaaggcacc cgggccctag
     7021 aggcaaccac agagcacata cgtcaggaac tggcggtctt ctgttcccca gagccccctg
     7081 ccaagacctc cacccctgaa gatttcatcc gaatgaccaa gggtattact atggcaacag
     7141 ccaaagctgt tgctgctggc aattcctgtc ggcaggaaga tgtcattgcc acagccaatc
     7201 tgagccgacg tgctattgca gacatgcttc gggcttgcaa ggaagcagct ttccacccag
     7261 aagtggcacc tgatgtgcgg cttcgagccc tacactttgg ccgggagtgt gccaatggct
     7321 acctggagct gctggaccac gtgctgctga ccctccagaa gccaaaccca gaactaaagc
     7381 agcagctgac aggacactca aagcgagttg ctggctcggt gactgagctt atccaagctg
     7441 ctgaagccat gaaaggaaca gagtgggtgg accccgagga ccctactgtt attgccgaga
     7501 acgagcttct gggagccgca gctgccattg aggctgcggc caaaaagcta gagcaactga
     7561 agccccgggc caagcccaag gaggcagatg agtccttgaa ctttgaggag caaatcctgg
     7621 aagctgccaa gtccatcgcc gcagccacca gtgcactagt aaaggcggcc tcagcagccc
     7681 agagggagct ggtggctcag ggaaaggtgg gcgccattcc agccaatgca ctggacgatg
     7741 ggcagtggtc gcagggcctc atttccgctg cccgtatggt ggctgcggcc accaacaatc
     7801 tgtgtgaagc agccaatgca gctgtccagg gccatgctag ccaggagaaa ctcatttctt
     7861 cagccaagca agtagctgcc tccacagccc agctcctggt cgcttgcaag gtcaaagcag
     7921 atcaggactc agaggcaatg aagaggcttc aggctgctgg caatgcagtg aagagggctt
     7981 cagataacct ggtaaaggcg gcccagaaag ctgcagcctt cgaagaccag gagaatgaga
     8041 cggtggtggt gaaggagaaa atggttgggg gcattgccca gattatcgca gcacaggaag
     8101 agatgcttcg gaaggaacga gagctggaag aggctcggaa aaagcttgcc cagatccggc
     8161 agcagcagta caagttcttg ccttcagagc ttcgagacga gcactgagga aacccctgta
     8221 tttaatgcag acccagccca gagactgtgc ctgccactac caaagccttc tgggctgctc
     8281 agggcccaag ctgccaaccc cagcactccc caaagtgcct gccaaacccc gggcctggtc
     8341 ctgcccagtc ccactgcaag ccgtgtcctc tccctgactc caagtgcctt cgcaccctag
     8401 ggccccaagt gcctgtcccc tccagagtat taacgctcca agagtattat taacgctgcc
     8461 atacctcagt tttaccctgc cagggctcca gctgctccaa cctgccagca gcttccagcc
     8521 aatccccaca gccacagcag ctcaactcat ccctttttga tactctatcc ctgccccagc
     8581 tacctgtgga gcctgagggt tacaaaccca acaggtcaag ctccaataaa ggtgactcta
     8641 tggctac
//
