LOCUS       NM_001191898            6666 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus tolloid-like 2 (Tll2), mRNA.
ACCESSION   NM_001191898 XM_345031
VERSION     NM_001191898.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6666)
  AUTHORS   Lee SJ.
  TITLE     Genetic analysis of the role of proteolysis in the activation of
            latent myostatin
  JOURNAL   PLoS One 3 (2), e1628 (2008)
   PUBMED   18286185
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000054.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001191898.3.
            
            On Oct 14, 2022 this sequence version replaced NM_001191898.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132263, SAMD00155328
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-427               JACYVU010000054.1  1121783-1122209     c
            428-538             JACYVU010000054.1  1098046-1098156     c
            539-613             JACYVU010000054.1  1073223-1073297     c
            614-769             JACYVU010000054.1  1060284-1060439     c
            770-887             JACYVU010000054.1  1056811-1056928     c
            888-1066            JACYVU010000054.1  1053325-1053503     c
            1067-1172           JACYVU010000054.1  1051945-1052050     c
            1173-1297           JACYVU010000054.1  1044690-1044814     c
            1298-1413           JACYVU010000054.1  1041866-1041981     c
            1414-1516           JACYVU010000054.1  1037366-1037468     c
            1517-1633           JACYVU010000054.1  1030212-1030328     c
            1634-1779           JACYVU010000054.1  1029459-1029604     c
            1780-1975           JACYVU010000054.1  1028199-1028394     c
            1976-2101           JACYVU010000054.1  1023417-1023542     c
            2102-2262           JACYVU010000054.1  1022584-1022744     c
            2263-2443           JACYVU010000054.1  1020645-1020825     c
            2444-2569           JACYVU010000054.1  1018265-1018390     c
            2570-2697           JACYVU010000054.1  1016855-1016982     c
            2698-2911           JACYVU010000054.1  1014373-1014586     c
            2912-3162           JACYVU010000054.1  1011703-1011953     c
            3163-6666           JACYVU010000054.1  1006689-1010192     c
FEATURES             Location/Qualifiers
     source          1..6666
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..6666
                     /gene="Tll2"
                     /gene_synonym="RGD1559756; Tll2b"
                     /note="tolloid-like 2"
                     /db_xref="GeneID:365460"
                     /db_xref="RGD:1559756"
     exon            1..427
                     /gene="Tll2"
                     /gene_synonym="RGD1559756; Tll2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..3297
                     /gene="Tll2"
                     /gene_synonym="RGD1559756; Tll2b"
                     /note="tolloid-like protein 2; tolloid-like 2b"
                     /codon_start=1
                     /product="tolloid-like protein 2 precursor"
                     /protein_id="NP_001178827.1"
                     /db_xref="GeneID:365460"
                     /db_xref="RGD:1559756"
                     /translation="MPQATALGTLVLLLLLPLLLRAEVTGDHSDVALDYGALEGEEGT
                     EQEQQLQYHDPCKAAVFWGDIALDEDDLKLFHIDKAEDWTKPSMERMGHDTGGLEETS
                     ARWPNDTASNSSIQALRKDGKDSTTLLPGPGTSNTTAKTFSARVRRATTSRTERIWPG
                     GVIPYVIGGNFTGTQRAIFKQAMRHWEKHTCVTFIERTDEESFIVFSYRTCGCCSYVG
                     RRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYN
                     FLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRRDDNGVRPTIGQRVRLS
                     QGDIAQARKLYKCPACGETLQDTSGNFSAPGFPNGYPSYSHCVWRISVTPGEKIILNF
                     TSMDLFKSRLCWYDYVEIRDGYWRKAPLLGRFCGDKVPEPLVSSDSRLWVEFRSSSSI
                     LGKGFFAVYEAMCGGDITKDAGQIQSPNYPDDYRPSKECVWRITVADGFHVGLTFQSF
                     EIERHDSCAYDYLEIRDGPTEESALIGHFCGYEKPEAVKSSANRLWVKFVSDGSINKA
                     GFAASFFKEVDECSWPDHGGCEQRCVNTLGSYTCACDPGYELAANKKTCEVACGGFIT
                     KLNGTITSPGWPKEYPTNKNCVWQVVAPMQYRISLQFEAFELEGNDVCKYDFVEVRSG
                     LSPDAKLHGKFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNG
                     GCQQECVNTFGSYLCRCRNGYRLHENGHDCKEAGCAYKISSAEGTLMSPNWPDKYPSR
                     KECTWNISSTAGHRVKITFSEFEVEQHQECAYDHLELYDGTDSSAPILGRFCGSKKPD
                     PVVATGSSLFLRFYSDASVQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPS
                     QAHCDWVIVAEDGYGVELVFRTFEVEEEADCGYDYLEAYDGYDSSAPRLGRFCGSGPL
                     EEIYSAGDSLMIHFHTDDTINKKGFHARYTSTKFQDALHMRK"
     exon            428..538
                     /gene="Tll2"
                     /gene_synonym="RGD1559756; Tll2b"
                     /inference="alignment:Splign:2.1.0"
     exon            539..613
                     /gene="Tll2"
                     /gene_synonym="RGD1559756; Tll2b"
                     /inference="alignment:Splign:2.1.0"
     exon            614..769
                     /gene="Tll2"
                     /gene_synonym="RGD1559756; Tll2b"
                     /inference="alignment:Splign:2.1.0"
     exon            770..887
                     /gene="Tll2"
                     /gene_synonym="RGD1559756; Tll2b"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1066
                     /gene="Tll2"
                     /gene_synonym="RGD1559756; Tll2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1172
                     /gene="Tll2"
                     /gene_synonym="RGD1559756; Tll2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1297
                     /gene="Tll2"
                     /gene_synonym="RGD1559756; Tll2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1413
                     /gene="Tll2"
                     /gene_synonym="RGD1559756; Tll2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1516
                     /gene="Tll2"
                     /gene_synonym="RGD1559756; Tll2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1633
                     /gene="Tll2"
                     /gene_synonym="RGD1559756; Tll2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1779
                     /gene="Tll2"
                     /gene_synonym="RGD1559756; Tll2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1975
                     /gene="Tll2"
                     /gene_synonym="RGD1559756; Tll2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2101
                     /gene="Tll2"
                     /gene_synonym="RGD1559756; Tll2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2262
                     /gene="Tll2"
                     /gene_synonym="RGD1559756; Tll2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2443
                     /gene="Tll2"
                     /gene_synonym="RGD1559756; Tll2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2569
                     /gene="Tll2"
                     /gene_synonym="RGD1559756; Tll2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2697
                     /gene="Tll2"
                     /gene_synonym="RGD1559756; Tll2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..2911
                     /gene="Tll2"
                     /gene_synonym="RGD1559756; Tll2b"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3162
                     /gene="Tll2"
                     /gene_synonym="RGD1559756; Tll2b"
                     /inference="alignment:Splign:2.1.0"
     exon            3163..6666
                     /gene="Tll2"
                     /gene_synonym="RGD1559756; Tll2b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgttccta ccgctaccgc cgccaacaca atcacagcca ccgcagcctt ggcctctggg
       61 caagtcgtgt tgagcagcgg cttctccggt gtccagacca gacaggaacg ccttactggg
      121 cttgctccgt accctaccgg tgcctggcag ccaagcagca accaccacaa ccgaccctga
      181 acgtggtgtc tcgctggatc tgagctttct gtgcacgtta agtccctcgg gccccagcga
      241 ccccttgtca ctatgcctca ggcgaccgct cttggcaccc tggtgctact gttgctgcta
      301 ccgctactcc tccgtgctga agtgactggg gaccactcgg atgtcgcgtt ggattacggg
      361 gccttggaag gcgaggaggg cacggagcag gagcagcagc tgcaatacca cgacccctgc
      421 aaagctgctg tcttctgggg agatatcgcc ttggatgaag atgatctcaa gttatttcac
      481 attgacaagg ctgaagactg gaccaagcca tccatggaaa gaatgggaca cgacactggt
      541 ggccttgagg aaacatctgc aaggtggcca aatgatacag cctctaacag cagcatccag
      601 gcactaagaa aggatggcaa ggatagcacc acacttctgc ctggccctgg gacctcaaac
      661 accaccgcta agaccttctc tgctcgggtc cgaagagcta caacctcaag gacagagcgg
      721 atatggcctg gaggggtcat tccttatgtc atcggaggga actttactgg cacccagagg
      781 gccattttca aacaggccat gaggcactgg gagaagcaca cctgtgtgac cttcatagag
      841 aggacagacg aggagagctt cattgttttc agttacagga cctgtggctg ttgttcctac
      901 gtgggacgcc gaggaggtgg ccctcaggcc atatccattg ggaaaaactg tgacaagttc
      961 ggcatcgtgg ctcacgagct gggccacgtg gttgggttct ggcacgaaca cactcggcca
     1021 gaccgagacc agcatgtcac catcatcaga gaaaacatcc agccaggtca ggagtataat
     1081 ttcttaaaaa tggaagccgg cgaggtgagc tctctgggag agacctacga cttcgacagc
     1141 atcatgcact atgcccggaa caccttctca agaggagttt tcttagacac catcctcccc
     1201 cgtcgagacg acaatggcgt caggccaacc attggccaac gcgtgcggct cagtcaggga
     1261 gatatagctc aagccaggaa gctgtacaaa tgcccagcgt gtggggaaac actacaggac
     1321 acatcaggaa acttctctgc acctggtttc ccaaatggct acccctctta ttcccactgc
     1381 gtctggagga tctccgtcac cccaggggaa aagatcatcc taaatttcac ctccatggat
     1441 ttgtttaaga gccgcttgtg ctggtacgat tacgtggaga tccgggatgg ttactggaga
     1501 aaggcccccc tgttggggag gttttgcggc gataaggttc ctgagcccct cgtctcctcg
     1561 gacagccggc tgtgggtgga attccgtagt agcagcagca tcctgggcaa gggcttcttc
     1621 gctgtctatg aagccatgtg tgggggagac ataactaaag atgcgggcca gattcaatct
     1681 cccaactacc ctgacgacta caggccttcc aaggaatgtg tgtggagaat cacagtagca
     1741 gacgggtttc atgtggggct taccttccag tcctttgaga ttgaaagaca tgacagttgt
     1801 gcatatgact atctggaaat ccgagacggt cccacagagg agagcgccct gattggccat
     1861 ttctgtggct acgagaagcc agaggctgtg aaatccagtg ccaaccgact atgggtgaag
     1921 tttgtgtcgg acggctccat caataaagca ggctttgcag ccagtttctt caaggaggtg
     1981 gatgagtgct cctggccaga ccatggtggg tgtgagcagc gctgtgtaaa cacactcggc
     2041 agctacacgt gtgcctgtga ccctggctac gagctagctg ctaacaagaa gacatgtgaa
     2101 gtggcctgtg gtggatttat taccaagcta aacggcacca tcaccagccc tggatggccg
     2161 aaggagtacc ccacaaacaa gaactgtgtc tggcaggtgg tggcccccat gcagtaccgc
     2221 atctccctgc agttcgaagc attcgagttg gaaggcaatg acgtttgtaa gtatgacttc
     2281 gtagaggtgc gcagtggcct gtccccagat gccaagcttc atggcaagtt ctgtggctcc
     2341 gagaccccgg aggtcatcac atctcagagc aacaacatgc gcgtggagtt caagtccgac
     2401 aacaccgtct ccaagcgagg cttcagggct cacttcttct cagacaaaga cgagtgtgcc
     2461 aaagacaatg gcggctgcca gcaggagtgt gtcaacacat ttgggagcta cctgtgccga
     2521 tgcaggaatg ggtaccggct gcacgagaac ggacatgact gcaaagaggc tggctgtgca
     2581 tacaagatca gcagtgcaga gggaaccctg atgagcccca actggcctga caaatacccc
     2641 agccggaagg aatgtacctg gaacatttca tcaactgcag gccacagggt gaaaattaca
     2701 ttcagtgagt ttgaggttga gcagcatcag gaatgcgcct acgaccacct ggaactgtat
     2761 gacgggacgg acagctcggc ccccatcctc ggccgcttct gtggcagcaa gaagccggat
     2821 cccgtggtgg ctacaggcag cagcctgttc ctcaggtttt actcagatgc ctcggtgcag
     2881 aggaaaggtt tccaggctgt gcacagcaca gaatgtggag gcagactgaa ggctgaagtg
     2941 cagaccaaag agctctactc tcatgcccag tttggggaca acaactaccc gagccaggcc
     3001 cactgtgact gggtgatagt cgcggaagac ggttatggcg tggagctggt attccggacc
     3061 tttgaagtgg aggaggaagc tgactgtggc tatgactact tggaggccta tgatgggtac
     3121 gacagctcag cacccaggct tggccgcttc tgtggctcag ggccgttaga ggaaatctac
     3181 tctgcaggag actcactgat gattcacttc cacacggacg acaccatcaa caagaaaggc
     3241 tttcacgccc gatacaccag caccaagttc caagatgcct tgcacatgag gaagtagcac
     3301 ctcagttctg gagagacggg gagactaagg atgttttaaa cactcgcgaa tgagcagccc
     3361 tcagtgtaca gtacttttct tcactacgaa aactcacact acaatcttga aactgtctat
     3421 ctggatgaca gtacatgcct ctggccaatg cgggggagga agaggggccc attggttccg
     3481 ttggttctgg ctgtggcgct atcaattcca gcttttggag gagggcgaag tttggagtta
     3541 gggatccaca agacgggact cttcacattt gttttcaagc tttgctccta tggggcaaaa
     3601 ggccagcctg gggcaaaggg ccagcctgag gcaaaaggct gcctctttct caactgcaga
     3661 ctggcttccc taggtgacat gagctcgcgc tggtgacttg gctgccttct gacagtactg
     3721 ggcatggagg attaaagctt ggcaagggct acgtcggtac ctacaggagt tgctgaacac
     3781 ttttatgaag ctctatcaga gtcagacaat caggaaacct gagaatgtgg acacaagagt
     3841 taagtagcat cccagggcac agagaggagg ctcaacctgg gaaccaccta atggcgttgg
     3901 aagaccttga gcattttcct ctgtcactgc ctgtccttat ctcctcgggg gcacccctta
     3961 tcatcagccc ccattcagaa aggagaattc acggttggcc ctaggaggac actcgccagt
     4021 tagcccctcc aggttgctga gatggcacat ggctttgccc agtactcctc ctctcagagg
     4081 cttagaagat gtcacccgtg atggggttcc cactggcttc caggacctcc atctgtgaag
     4141 gtgcctggtc tagggagcct cagcccctgg acggccagtt caaacagcat ctgtgagacg
     4201 gagacgcgcc aagtcacctc aggaccaatc caggtctcac tacgagaaaa ctagtaattc
     4261 catgttacgt gagagccatc acctctggaa caagtcggtc ttgtggcaca catggaacca
     4321 ggcaggttag agtgcattgg taaccctgct ggggttaact gggacccagc catccacttg
     4381 cactcggaac tctcaacacc ctggcacttg ctctagagaa gtgttgaggg tgacgtttac
     4441 ataacttgag cacctcaagg tataactgaa acagtgaggt agttttgaat ggcatttcat
     4501 taaggcatct ctgggcatta tgagctaaac gctgtggtat gttagctttc taagagcatg
     4561 tatgtcggag aacttttaaa acaatgttta cacaaccgca ggtcctgttg ggttggtggt
     4621 gaacccaggg aggcacagga gactgttaca gttagagtag cttccgagca ccagaatcct
     4681 atgggatgga ctgtcacttt aaaccaagca cgtgtggggg ttggggattt agctcagtgg
     4741 tagagcgctt gcctaggaag cgcaaggccc tgggttcgaa ccccagctcc ggaaaaaaaa
     4801 aaaaaaacaa aaaaaaaaaa aaaaaaaaaa cccaaaaaca aaacaacaac agcaacaaag
     4861 aaaaaaacaa gcacgtgtga aggctaaagg ttctacttaa aaaataaaaa aaccgcaata
     4921 taccaatcgc aggatgacgt ccgactggaa tgagtgttgg gagcgaaaaa tagaatgaga
     4981 caaaagggag agaaatgcat gggaggtctt tgttcttaaa acagaagcaa atacaagtat
     5041 tattattatt aatatatatc tgtatatatg tatgtatcta tgtatgtatg taaggatcag
     5101 ctatcaacgc cttaatcagg gcatcgagac agtgccaacc cactgactgt ggcttatcgt
     5161 cagactctgg tgctggcccc acaccttatg ccgctccctt caaaaccgag acctcttctc
     5221 tcttctctgg gctctgaact gaaaggctca gcttccatcc tgtcctgatt gctggcacac
     5281 ccactcggag agcttcatgt ggcaaaagag acagcttggg ccgtggttct tatcccatca
     5341 gcacactgtg atagattcca cttctctggt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     5401 gtgtgtgtgt atgtgtgtgt gtgagtgtgt gtgtgagtgt gtgtgtgtgt gagtgtgtgt
     5461 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgatt agcttttatt ttttgcctca
     5521 tcttgtctgt caaggtcgga atggaaacca ggaggcgtaa ggtatctgtc acccatccca
     5581 ctttatctcc tcagagataa agaaaattct gtatttttaa cccttagaag tgtaaacaag
     5641 attggcaaat tccatggaaa ataggacctg gggagagtca gggttggttt cagcatttgt
     5701 caccctggta aataattctt tttagtgtga atgttttcag aagcgcacag ctttagtgga
     5761 ggccagctta caacaatagg gctgtcatga aagctctcat ttaggcctgt gagtgacata
     5821 ttcccagaag acaggctcca attcaacaag ggctgttaga gggcccctcc tctggaagcc
     5881 aacacccaca gggattgcac atgacacagg ccctgcaaaa gaactacaga ctggcttcca
     5941 tgaatagtcc actccacaga aagacccagg tgcccactct ggtccttcca attgcttggt
     6001 ggcctttctg aaaatgtccg atgtggctgg agagaggggc ttgaggatag ccctttggct
     6061 taccatccct tttctatggg accaggcctg ggggtgtcat ggagctctaa gacccaagaa
     6121 ctgcctctgg gacaagtgac gtaaggaagt atttgtagct tgggactcca ggatgagcta
     6181 attctagtat actccaagtt agcagaaact acaccccagg gtggaaaact tctccaaaca
     6241 gctggagcca ggccgtgtat tgattcacta ctttctctaa aatatctttc tcagtatttc
     6301 cctctccaca gtcatggtta accagcaaat ctacataaga atgtgctgtc agtttggccc
     6361 catagctctt cagtgtcctt ggtattgttc atgcagtttg ggaagagatg gtcccttaac
     6421 atctgcagtc gttttttaaa gtttgcttca cagattgtga tcggcgttcc aatcagaaaa
     6481 ccccaaatat ctaaaatgtc tctctttttt taaagtagaa aagtgttaat ctataaatat
     6541 aaaggtattt tttatttcca gtaactttac atttcatgta aaaatgtcag ttggcaagaa
     6601 catggggaga tggtaactct tgttaaaaat gatgatttca ttaaagaatg tggatttagt
     6661 gctgtg
//
