LOCUS       NM_001106081            4728 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus tolloid-like 1 (Tll1), mRNA.
ACCESSION   NM_001106081 XM_001073797
VERSION     NM_001106081.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4728)
  AUTHORS   LaHaye S, Corsmeier D, Basu M, Bowman JL, Fitzgerald-Butt S, Zender
            G, Bosse K, McBride KL, White P and Garg V.
  TITLE     Utilization of Whole Exome Sequencing to Identify Causative
            Mutations in Familial Congenital Heart Disease
  JOURNAL   Circ Cardiovasc Genet 9 (4), 320-329 (2016)
   PUBMED   27418595
REFERENCE   2  (bases 1 to 4728)
  AUTHORS   Li J, Ding JD, Fang X, Zhang H, Zheng RL, Cui JY, Gao CH, Wang D
            and Ma GS.
  TITLE     [Metalloproteinase Tolloid-like 1 gene mutation in Chinese patients
            with sporadic congenital heart diseases]
  JOURNAL   Zhonghua Xin Xue Guan Bing Za Zhi 40 (5), 402-405 (2012)
   PUBMED   22883091
REFERENCE   3  (bases 1 to 4728)
  AUTHORS   Cresci S, Wu J, Province MA, Spertus JA, Steffes M, McGill JB,
            Alderman EL, Brooks MM, Kelsey SF, Frye RL and Bach RG.
  CONSRTM   BARI 2D Study Group
  TITLE     Peroxisome proliferator-activated receptor pathway gene
            polymorphism associated with extent of coronary artery disease in
            patients with type 2 diabetes in the bypass angioplasty
            revascularization investigation 2 diabetes trial
  JOURNAL   Circulation 124 (13), 1426-1434 (2011)
   PUBMED   21911782
REFERENCE   4  (bases 1 to 4728)
  AUTHORS   Stanczak P, Witecka J, Szydlo A, Gutmajster E, Lisik M,
            Augusciak-Duma A, Tarnowski M, Czekaj T, Czekaj H and Sieron AL.
  TITLE     Mutations in mammalian tolloid-like 1 gene detected in adult
            patients with ASD
  JOURNAL   Eur J Hum Genet 17 (3), 344-351 (2009)
   PUBMED   18830233
REFERENCE   5  (bases 1 to 4728)
  AUTHORS   Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M,
            Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail
            S, Li P and Sutton G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   6  (bases 1 to 4728)
  AUTHORS   Steiglitz BM, Keene DR and Greenspan DS.
  TITLE     PCOLCE2 encodes a functional procollagen C-proteinase enhancer
            (PCPE2) that is a collagen-binding protein differing in
            distribution of expression and post-translational modification from
            the previously described PCPE1
  JOURNAL   J Biol Chem 277 (51), 49820-49830 (2002)
   PUBMED   12393877
REFERENCE   7  (bases 1 to 4728)
  AUTHORS   Clark TG, Conway SJ, Scott IC, Labosky PA, Winnier G, Bundy J,
            Hogan BL and Greenspan DS.
  TITLE     The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal
            septation and positioning of the heart
  JOURNAL   Development 126 (12), 2631-2642 (1999)
   PUBMED   10331975
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000279.1.
            
            [WARNING] On Mar 28, 2024 this sequence was replaced by
            NM_001106081.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001106081.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760384,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-788               JACYVU010000279.1  5413311-5414098
            789-899             JACYVU010000279.1  5500277-5500387
            900-980             JACYVU010000279.1  5503755-5503835
            981-1133            JACYVU010000279.1  5505708-5505860
            1134-1251           JACYVU010000279.1  5506345-5506462
            1252-1430           JACYVU010000279.1  5519743-5519921
            1431-1536           JACYVU010000279.1  5522782-5522887
            1537-1661           JACYVU010000279.1  5527222-5527346
            1662-1777           JACYVU010000279.1  5533853-5533968
            1778-1880           JACYVU010000279.1  5548097-5548199
            1881-1997           JACYVU010000279.1  5550815-5550931
            1998-2143           JACYVU010000279.1  5551971-5552116
            2144-2339           JACYVU010000279.1  5569088-5569283
            2340-2465           JACYVU010000279.1  5570843-5570968
            2466-2626           JACYVU010000279.1  5574046-5574206
            2627-2807           JACYVU010000279.1  5578233-5578413
            2808-2933           JACYVU010000279.1  5584260-5584385
            2934-3061           JACYVU010000279.1  5586840-5586967
            3062-3275           JACYVU010000279.1  5596247-5596460
            3276-3526           JACYVU010000279.1  5610890-5611140
            3527-4728           JACYVU010000279.1  5612507-5613708
FEATURES             Location/Qualifiers
     source          1..4728
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p13"
     gene            1..4728
                     /gene="Tll1"
                     /gene_synonym="Tll"
                     /note="tolloid-like 1"
                     /db_xref="GeneID:678743"
                     /db_xref="RGD:1306120"
     exon            1..788
                     /gene="Tll1"
                     /gene_synonym="Tll"
                     /inference="alignment:Splign:2.1.0"
     CDS             620..3661
                     /gene="Tll1"
                     /gene_synonym="Tll"
                     /EC_number="3.4.24.-"
                     /note="tolloid-like protein 1"
                     /codon_start=1
                     /product="tolloid-like protein 1 precursor"
                     /protein_id="NP_001099551.1"
                     /db_xref="GeneID:678743"
                     /db_xref="RGD:1306120"
                     /translation="MGLQALSPRMLLWLVVSGIVFSRELWVCTGLDYDYTFDGNEEDK
                     TEPIDYKDPCKAAVFWGDIALDDEDLNIFQIDRTIDLTQGPFGKLGHITGGFGDHGMP
                     KKRGALYQLIDRIRRIGSGLEQNNTTKGKAPPKLSEQNEKNRVPRAATSRTERIWPGG
                     VIPYVIGGNFTGSQRAMFKQAMRHWEKHTCVTFTERSDEESYIVFTYRPCGCCSYVGR
                     RGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQEYNF
                     LKMEPGEVNSLGERYDFDSIMHYARNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLSK
                     GDIAQARKLYRCPACGETLQESSGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFT
                     TMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKVAGVLTSTDSRMWIEFRSSSNWV
                     GKGFAAVYEAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKIMVSEGYHVGLTFQAFE
                     IERHDSCAYDHLEVRDGNSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAG
                     FAANFFKEEDECAKADRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTK
                     LNGTITTPGWPKEYPPNKNCVWQVIAPSQYRISVKFEFFELEGNEVCKYDYVEIWSGL
                     SSESKLHGKFCGADVPEVITSHFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGG
                     CQHECVNTMGSYTCQCRNGFVLHENKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRK
                     ECTWAISAIPGHRIKLAFNEFEVEQHQECAYDHLEIFDGQTEKSPILGRLCGSKIPDP
                     LMATGNEMFIRFISDASVQRKGFQATHSTECGGRLKAERKPKDLYSHAQFGDNNYPGQ
                     LDCEWLLVSEQGSRLELSFQTFEVEEEADCGYDYVEVFDGLNSKAVGLGRFCGSGPPE
                     EIYSIGDVALIHFHTDDTINKKGFYIRYKSIRYPETMHAEN"
     exon            789..899
                     /gene="Tll1"
                     /gene_synonym="Tll"
                     /inference="alignment:Splign:2.1.0"
     exon            900..980
                     /gene="Tll1"
                     /gene_synonym="Tll"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1133
                     /gene="Tll1"
                     /gene_synonym="Tll"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1251
                     /gene="Tll1"
                     /gene_synonym="Tll"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1430
                     /gene="Tll1"
                     /gene_synonym="Tll"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1536
                     /gene="Tll1"
                     /gene_synonym="Tll"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1661
                     /gene="Tll1"
                     /gene_synonym="Tll"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1777
                     /gene="Tll1"
                     /gene_synonym="Tll"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1880
                     /gene="Tll1"
                     /gene_synonym="Tll"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1997
                     /gene="Tll1"
                     /gene_synonym="Tll"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2143
                     /gene="Tll1"
                     /gene_synonym="Tll"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2339
                     /gene="Tll1"
                     /gene_synonym="Tll"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2465
                     /gene="Tll1"
                     /gene_synonym="Tll"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2626
                     /gene="Tll1"
                     /gene_synonym="Tll"
                     /inference="alignment:Splign:2.1.0"
     exon            2627..2807
                     /gene="Tll1"
                     /gene_synonym="Tll"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..2933
                     /gene="Tll1"
                     /gene_synonym="Tll"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..3061
                     /gene="Tll1"
                     /gene_synonym="Tll"
                     /inference="alignment:Splign:2.1.0"
     exon            3062..3275
                     /gene="Tll1"
                     /gene_synonym="Tll"
                     /inference="alignment:Splign:2.1.0"
     exon            3276..3526
                     /gene="Tll1"
                     /gene_synonym="Tll"
                     /inference="alignment:Splign:2.1.0"
     exon            3527..4728
                     /gene="Tll1"
                     /gene_synonym="Tll"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacacccctt tgctctccgg gcagtcgaga gcttccctag cttctgcagg cttttaaggt
       61 ctggcggcgt agaaatgcct ggctcccacc cccttcctcg gtctcccctt tcagttcaga
      121 tgtgctgatg tgcagaccgg attcatcttc ccggagcggc ggcggcggca gcggcagcgg
      181 cgggcgcagg cggctgcagc tcgcgctcgg ccgcggggtc ctgacagcgg cgggggcgcg
      241 gcgcaggagc cggagctccg gtggcagctg agcccgccgt gcgcctctcg ccgcggccgg
      301 tcgcgatcgc gatcgcggga agttcggccg ctggaaggac gacctggacc gtgccgggtt
      361 ggctgcggct gccctgggcc gagctcctca cctgccttcc gcccacccgc gggtccctgg
      421 ccaagttccc cagcatccgg gggagccagg cagcgtttgc cctctctagg gtccggaaga
      481 cacccgcatg tctccggaca cctgaacact caggtctttc cgaggatcct cccagtgggg
      541 agaagagcac tgtccctaga gccccgcata tccacgcggc cctcggggtc tggtcccctc
      601 cttcctctag gggaggagga tgggtttgca agcgctctcc cctaggatgc ttctgtggtt
      661 ggtggtctcg ggtattgttt tctcccggga gctgtgggtc tgcactggcc tcgattatga
      721 ttacactttt gatgggaacg aagaggacaa aacggagcct atagattaca aggacccgtg
      781 caaagctgct gtgttttggg gtgacatcgc cttagacgat gaagacttaa atatcttcca
      841 aatagacagg acaattgacc tgactcaggg cccctttgga aaacttggac atatcacagg
      901 tggctttgga gaccatggca tgccaaagaa acgaggggca ctctaccaac ttatagacag
      961 gatcagaaga attggctctg gcttggagca aaataacacc acgaagggaa aggcacctcc
     1021 aaaactgtca gagcaaaatg agaaaaatcg agttcccagg gctgctacat caagaacgga
     1081 aaggatatgg cctgggggtg tcatccctta tgtcatagga ggaaacttta ctggcagcca
     1141 gagagccatg ttcaagcagg ccatgagaca ctgggaaaag cacacctgcg tgacttttac
     1201 ggagagaagc gatgaagaaa gttacattgt gttcacctac aggccttgtg gatgctgctc
     1261 ctatgttggt cggcggggga atggccctca ggccatctct attggcaaga actgtgacaa
     1321 gtttggaatt gttgttcatg aactgggcca cgtgataggc ttctggcatg agcatacccg
     1381 cccagaccga gataaccacg tcaccatcat aagagagaac atccagccag gtcaagagta
     1441 caattttcta aagatggagc ctggagaagt aaactctctt ggggaaagat acgattttga
     1501 cagtatcatg cactacgcca ggaacacctt ctcaaggggg atgtttttag acacaatact
     1561 cccatcccgt gatgataatg gcatccgtcc tgcaattggt caacggaccc ggttaagcaa
     1621 aggagacatt gcacaagcaa gaaagctgta tcgatgtcca gcatgtggag aaaccctaca
     1681 agaatccagt ggcaaccttt cttccccagg attcccaaat ggctatcctt cctatacaca
     1741 ctgcatctgg agagtgtctg tgaccccggg agaaaagatt gtcttgaatt ttaccacgat
     1801 ggacctatac aagagtagtt tgtgctggta tgattacatt gaagtaagag atggctactg
     1861 gagaaagtca cctctccttg gtagattctg tggggacaaa gtggctggag ttctcacatc
     1921 aacagacagc agaatgtgga ttgagtttcg tagcagcagt aactgggtag ggaaagggtt
     1981 tgcagccgtc tatgaagcga tttgtggagg ggagataagg aaaaatgaag gacagattca
     2041 gtctcccaat taccccgacg actatcgacc aatgaaggag tgtgtatgga aaataatggt
     2101 gtccgagggc taccatgttg gactgacctt tcaggccttt gagattgaaa gacacgacag
     2161 ctgtgcctat gaccacctag aagttcgaga cggcaacagt gagaatagtc ctttgatagg
     2221 acggttctgt ggttatgaca aacctgaaga tattagatct acttccaaca ccctgtggat
     2281 gaagttcgtc tctgatggga ctgtgaacaa ggcaggattt gctgccaact tttttaaaga
     2341 agaagatgag tgtgccaaag ctgaccgggg aggctgtgag cagaggtgtc tcaacacgct
     2401 aggcagctac cagtgtgcct gtgagcctgg ctacgagctg gggccagaca gaaggagctg
     2461 cgaagctgct tgcggaggac ttcttacaaa gctcaatggc acaataacca cccccggctg
     2521 gcccaaagag taccctccaa acaaaaactg tgtgtggcaa gtgattgcgc caagccagta
     2581 cagaatctct gtgaagtttg agttttttga attggaaggc aatgaagttt gcaagtatga
     2641 ttacgtggag atctggagcg gtctgtcctc tgaatctaaa ctgcatggca agttctgtgg
     2701 cgctgatgtc cctgaggtga tcacttccca tttcaacaac atgaggattg aattcaaatc
     2761 ggacaacact gtttccaaga agggcttcaa agcacatttc ttctcagata aggatgagtg
     2821 ttcaaaggat aacggtggct gccagcatga gtgtgtcaac acaatgggaa gctacacgtg
     2881 tcagtgcagg aatggatttg tgttgcatga gaacaaacat gattgtaagg aagcggagtg
     2941 tgaacagaag atccacagcc caagtggcct catcaccagt cccaactggc cagacaagta
     3001 tccaagcagg aaagagtgca cgtgggccat cagtgccatt cctggccacc gcatcaaatt
     3061 agccttcaat gagttcgagg ttgagcagca tcaagaatgt gcatatgatc acttggaaat
     3121 tttcgacgga caaacggaga agtcaccaat ccttggccgg ctgtgtggca gcaagatacc
     3181 agatcccctc atggctaccg ggaatgaaat gtttattcga ttcatttctg atgcctctgt
     3241 tcaaaggaaa gggtttcaag ccacccactc cacagaatgt ggaggtcgat tgaaagcaga
     3301 gcggaagccc aaagatctgt actctcatgc tcagtttggt gataataatt acccaggaca
     3361 actggattgt gaatggttgc tggtgtcaga acaaggctct cggcttgaat tgtccttcca
     3421 gactttcgaa gtagaagaag aagccgactg tggctatgac tatgttgaag tctttgatgg
     3481 tctcaattcc aaagctgtgg gtcttggtag attctgtggc tcagggccac cagaagaaat
     3541 ctattccatt ggagatgtgg ctttaattca ttttcacaca gatgacacta tcaacaagaa
     3601 aggattttat ataagatata aaagtataag atacccagaa accatgcatg ccgagaacta
     3661 acgccaaccc tccctcagaa cagaaaggaa tgtgcatatg gaaagaagac atttttaaaa
     3721 tcgacaatat tagtacaatt gttttatata atgaatctga acaagagaaa cctgcaagat
     3781 taaagatatc tccaaagtca aagagaattt tccagaaaac ctgattggca ttgcaaggat
     3841 gtttgaaagt catgcttgtt caaggaagat taacagcttg aaatagatgc ctcacacttt
     3901 ggacaattca cttcatgggc tgtgaatctc tggagtgatt tcttgactac tttttcaaga
     3961 tctggggata aaaaatgatc ggacagatca tagtttggaa acccacttct tgggtctcag
     4021 catgtttgct tagactttgt aggtcagaca gtgtaaacca aattcttgaa gggtaatgtg
     4081 gaatagtggt ctttggaagg tgattcgtca tttaaaagta gatgtgtgtt tgtgtatgtt
     4141 catttgtgtg tatgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtttg
     4201 gaaactggaa tatttcatct tcattatttt caagtgcagg ccagcttaac ctgttcacac
     4261 aaatgatttc gtgaccactt cattgtatct atatcttgag aagtttgaac tatgtatagt
     4321 gtctacaatg cagttaatcc ctagatatca tatttaatta ctggataata cccagttcat
     4381 tagtaaactc atttttctct ggggaagtgc tgaatagtca caccaaatcc gagaaactca
     4441 ctatgtctta taaactttaa gataaaattt caacgaggtg tgtgcagcca tcttccaaat
     4501 gactgcctgg atgtttctta ttccagttac tactgctgct gctatggtct ttcttttatt
     4561 gttaatgtgt tgatatgtta ttattttgga tattgttatt gatgttgtta ctatatttaa
     4621 aaatgatgag atggagtgaa agtagagttt gggagaaatt aaatctatct cttttatttt
     4681 ttgttctctt cttgaaattc agtttcaaaa atacaatatt gggtggaa
//
