LOCUS       NM_001191652            3711 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus tousled-like kinase 2 (Tlk2), mRNA.
ACCESSION   NM_001191652 XM_221023
VERSION     NM_001191652.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3711)
  AUTHORS   Yeh,C.H., Yang,H.J., Lee,I.J. and Wu,Y.C.
  TITLE     Caenorhabditis elegans TLK-1 controls cytokinesis by localizing
            AIR-2/Aurora B to midzone microtubules
  JOURNAL   Biochem Biophys Res Commun 400 (2), 187-193 (2010)
   PUBMED   20705056
REFERENCE   2  (bases 1 to 3711)
  AUTHORS   Pilyugin,M., Demmers,J., Verrijzer,C.P., Karch,F. and Moshkin,Y.M.
  TITLE     Phosphorylation-mediated control of histone chaperone ASF1 levels
            by Tousled-like kinases
  JOURNAL   PLoS One 4 (12), e8328 (2009)
   PUBMED   20016786
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3711)
  AUTHORS   Groth,A., Lukas,J., Nigg,E.A., Sillje,H.H., Wernstedt,C., Bartek,J.
            and Hansen,K.
  TITLE     Human Tousled like kinases are targeted by an ATM- and
            Chk1-dependent DNA damage checkpoint
  JOURNAL   EMBO J 22 (7), 1676-1687 (2003)
   PUBMED   12660173
REFERENCE   4  (bases 1 to 3711)
  AUTHORS   Sillje,H.H., Takahashi,K., Tanaka,K., Van Houwe,G. and Nigg,E.A.
  TITLE     Mammalian homologues of the plant Tousled gene code for
            cell-cycle-regulated kinases with maximal activities linked to
            ongoing DNA replication
  JOURNAL   EMBO J 18 (20), 5691-5702 (1999)
   PUBMED   10523312
REFERENCE   5  (bases 1 to 3711)
  AUTHORS   Zhang,S., Xing,H. and Muslin,A.J.
  TITLE     Nuclear localization of protein kinase U-alpha is regulated by
            14-3-3
  JOURNAL   J Biol Chem 274 (35), 24865-24872 (1999)
   PUBMED   10455159
REFERENCE   6  (bases 1 to 3711)
  AUTHORS   Shalom,S. and Don,J.
  TITLE     Tlk, a novel evolutionarily conserved murine serine threonine
            kinase, encodes multiple testis transcripts
  JOURNAL   Mol Reprod Dev 52 (4), 392-405 (1999)
   PUBMED   10092119
REFERENCE   7  (bases 1 to 3711)
  AUTHORS   Yamakawa,A., Kameoka,Y., Hashimoto,K., Yoshitake,Y., Nishikawa,K.,
            Tanihara,K. and Date,T.
  TITLE     cDNA cloning and chromosomal mapping of genes encoding novel
            protein kinases termed PKU-alpha and PKU-beta, which have nuclear
            localization signal
  JOURNAL   Gene 202 (1-2), 193-201 (1997)
   PUBMED   9427565
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1, FN804032.1, FM091827.1, FM098672.1, FM082999.1
            and BC086544.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_001191652.3.
            
            On Aug 5, 2017 this sequence version replaced NM_001191652.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.39357.1,
                                           SRR26643293.66706.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-522               JAXUCZ010000010.1  90656689-90657210
            523-605             JAXUCZ010000010.1  90659105-90659187
            606-677             JAXUCZ010000010.1  90679937-90680008
            678-747             JAXUCZ010000010.1  90680951-90681020
            748-791             JAXUCZ010000010.1  90681871-90681914
            792-887             JAXUCZ010000010.1  90682642-90682737
            888-1490            FN804032.1         136-738
            1491-1798           FM091827.1         207-514
            1799-2277           FM098672.1         34-512
            2278-107716085      JAXUCZ010000010.1  1-107713808
            107716086-107716199 FM098672.1         514-627
            107716200-107716742 FM082999.1         46-588
            107716743-107717518 BC086544.1         1544-2319
FEATURES             Location/Qualifiers
     source          1..3711
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..3711
                     /gene="Tlk2"
                     /note="tousled-like kinase 2"
                     /db_xref="GeneID:303592"
                     /db_xref="RGD:1310907"
     exon            1..522
                     /gene="Tlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            523..605
                     /gene="Tlk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             525..2777
                     /gene="Tlk2"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase tousled-like 2"
                     /protein_id="NP_001178581.1"
                     /db_xref="GeneID:303592"
                     /db_xref="RGD:1310907"
                     /translation="MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGS
                     LSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSGPGTSPGR
                     SVPPVARSSPQHSLSNPLPRRVEQPLYGLDGSTAKEASEEQSALPTLMSVMLAKPRLD
                     TEQLAPRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKIS
                     ALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIE
                     KSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREE
                     IERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLG
                     HLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGG
                     FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLY
                     DYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPI
                     IHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPP
                     ECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQF
                     PPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIAST
                     SGASNNSSSN"
     exon            606..677
                     /gene="Tlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            678..747
                     /gene="Tlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            748..791
                     /gene="Tlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            792..887
                     /gene="Tlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1055
                     /gene="Tlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1151
                     /gene="Tlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1244
                     /gene="Tlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1355
                     /gene="Tlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1492
                     /gene="Tlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1645
                     /gene="Tlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1712
                     /gene="Tlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1810
                     /gene="Tlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1892
                     /gene="Tlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..1984
                     /gene="Tlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2074
                     /gene="Tlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2244
                     /gene="Tlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2383
                     /gene="Tlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2495
                     /gene="Tlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2603
                     /gene="Tlk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..3686
                     /gene="Tlk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtgcaaatc tcgcgaggaa acacgaggtt tcactagtgt gtttacaccg atcactacta
       61 atccggaccg aaccgatccg gattaagggg ccggaggcgg gtcctgggca ctagcggttc
      121 cgaccccccc caccccgccc tctgcgccgc acccgagtgg cccccccaac cgagccggcc
      181 cccacttctc ggcccgaccc ggacccttct gcgcctccct tggcctttgt ccggcgccag
      241 gaggccggcc ccgcgccccc cggcggccgc ccgggcccgg gcccgcgtca ggcgcctggc
      301 tctgtacgcg agctcgggga tctgcggcct ccgtggcccc cctcccccgc ccgccctctc
      361 gtggagcccg gcgccggcgg cggctgcccg ggcggggggt tgcggcgctc aggagaggcc
      421 ccggctccgc cccgggcctg cccaggggga gagcagaacg atcggcaacc gggtcgggtc
      481 ggggcccctc ccgagaggag cgtggagcgg cagcggcggc agaaatgatg gaagaactgc
      541 acagcctgga cccacggagg caggagttac tggaggccag gttcactggg gttggcgtaa
      601 gtaaggggcc actcaacagt gagtcttcca accagagttt gtgcagtgtg gggtccttga
      661 gtgataaaga agtagagact cctgagaaaa agcagaatga ccagcgaaat cggaaaagaa
      721 aagctgaacc atatgaaact agccaaggga aaggcactcc taggggacat aaaattagtg
      781 attactttga gtttgctggg ggaagcgggc caggaaccag ccctggcaga agtgttccac
      841 cagttgcacg atcctcaccg caacattcct tatccaatcc cttaccgcgt cgagtagaac
      901 agcctctcta tggtttagat ggcagtactg caaaggaggc ctcagaagag cagtctgccc
      961 tgccaaccct catgtcagtg atgttagcaa aacctcgact tgacacagag cagttagcgc
     1021 caaggggagc tggcctctgc ttcactttcg tctctgctca acaaaacagc ccttcgtcca
     1081 cggggtctgg caatacagaa cattcttgca gctcccagaa acagatctcc atccagcaca
     1141 ggcagaccca gtctgacctc acaatagaaa aaatatctgc actagaaaac agtaagaact
     1201 ctgacttaga gaagaaggaa ggaagaatag atgatttatt aagagccaac tgtgatttga
     1261 gacgacagat agatgaacag caaaagatgc tagagaaata caaggaacga ttaaatagat
     1321 gtgtcaccat gagcaagaag ctccttatag aaaagtcaaa acaagagaag atggcatgca
     1381 gggacaagag catgcaggac cgattgcgat taggtcactt tacaactgtc cggcatggag
     1441 cctcttttac tgaacagtgg acagatggtt atgctttcca aaacctcatc aagcaacagg
     1501 aaaggataaa ttcacagaga gaagagatag aaaggcaacg gaaaatgtta gcaaaacgga
     1561 aaccccctgc catgggtcag gcccctcccg caaccaatga gcagaaacaa cggaaaagca
     1621 agaccaatgg agctgaaaat gaaacgttaa ccttagctga ataccatgaa caagaagaaa
     1681 tcttcaaact tagattaggt catcttaaga aagaggaagc agaaatccag gcagaactgg
     1741 aaaggctaga aagggttagg aatctacaca tcagggaatt aaaaaggata cataatgaag
     1801 ataattcaca gtttaaagac cacccaacac taaatgacag atatttgttg ttacatcttt
     1861 tgggtagagg aggtttcagt gaagtttaca aggcgtttga tctaacggag caaagatatg
     1921 tagctgtgaa aattcaccag ttaaataaaa actggagaga tgagaaaaag gagaattacc
     1981 acaagcatgc gtgtagggaa taccggattc acaaagaact ggatcacccc agaatagtga
     2041 agctgtatga ttacttttca ctggacactg actcgttttg tacagtatta gaatactgtg
     2101 aaggaaatga tctggacttc tacctaaagc agcacaaatt aatgtcggag aaagaagccc
     2161 gatccattat tatgcagatt gtgaatgctt taaagtactt aaatgaaata aaacctccca
     2221 tcatacacta tgacctcaaa ccaggtaata tccttttagt aaatggtaca gcgtgtggag
     2281 agataaaaat tacagatttt ggtctttcca agatcatgga tgacgatagc tacaattcag
     2341 tggacggcat ggagctaacg tcacaaggtg ctggtactta ttggtatttg ccaccagagt
     2401 gttttgtggt tgggaaagag ccaccaaaga tctcaaataa agtcgatgtc tggtcagtgg
     2461 gtgtgatctt ctaccagtgt ctgtatggga ggaagccttt tggtcataac cagtcccagc
     2521 aagatattct acaagagaat actattctta aagctactga agtacagttc ccgcccaagc
     2581 cagtagtaac acctgaagca aaggcgttta tcaggcgatg tttggcctat cgaaaggaag
     2641 accgcattga tgtgcagcag ctggcctgtg acccctactt gttgcctcac atccgaaagt
     2701 cagtctccac aagtagtcct gcaggagctg ccattgcatc aacctcgggg gcatccaata
     2761 acagttcttc gaattgagac caactcccaa ggccactaac tgttcagcac acgaagtgga
     2821 cacatggcat tcagcagtgg gtttggaaca tagtgaatcc gaatggatct catgaaacct
     2881 gtaccaggtg cttttatttt cttgcttttt ttcccatcca tagagcatga cagcatcgat
     2941 tctcattgag gagaagcctt gggcagctct ggccaggcct cataggaaaa ggcccctccc
     3001 gaggttccag cgtcaacggt caccatgggt ggctgctctg agtgaggaaa aaaattaaaa
     3061 agaaaaaact ggttccatgt actgtgaact tgaaaacatg cagactcagg gggttccctg
     3121 acgcagtgct tcagatgaag aatgtggact tgaaaataca gactgggcta gtccagtgtc
     3181 tatatttaaa cttgctcttt tcttttaata aagtttaggt aacatctcct aaaaagctgg
     3241 tagcacaagg cttgactggg gatggcgttt gacttcggag gacaaagttg ctactgccat
     3301 taaaggcact agagttagtg tgctagcccc gagtaagctc agtctctaaa acgtgcagct
     3361 ccctcgcccc ttcttatttt taaagaatac atttggtcat aaagtgaaac ccgtattagc
     3421 gagtacgtgg caatgttcat tccagtcaga tgcagctttc tcctccatct gggctccgct
     3481 tgtgaatgct tctctcacct cagtagggag aaacggggtt ctgagatgcg tgggttttgc
     3541 catcggacaa agaatgaggt tagaagaccg cagtttggag tctctaggtt ttcagatatt
     3601 tcttcacaat ttgaacactt gacggttgtc ccttttaatt tatttgaagt gctatttttt
     3661 taaataaagg ttcatctgtc catgcaaaaa aaaaaaaaaa aaaaaaaaaa a
//
