LOCUS       NP_001178581             750 aa            linear   ROD 23-APR-2024
DEFINITION  serine/threonine-protein kinase tousled-like 2 [Rattus norvegicus].
ACCESSION   NP_001178581 XP_221023
VERSION     NP_001178581.1
DBSOURCE    REFSEQ: accession NM_001191652.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 750)
  AUTHORS   Yeh,C.H., Yang,H.J., Lee,I.J. and Wu,Y.C.
  TITLE     Caenorhabditis elegans TLK-1 controls cytokinesis by localizing
            AIR-2/Aurora B to midzone microtubules
  JOURNAL   Biochem Biophys Res Commun 400 (2), 187-193 (2010)
   PUBMED   20705056
REFERENCE   2  (residues 1 to 750)
  AUTHORS   Pilyugin,M., Demmers,J., Verrijzer,C.P., Karch,F. and Moshkin,Y.M.
  TITLE     Phosphorylation-mediated control of histone chaperone ASF1 levels
            by Tousled-like kinases
  JOURNAL   PLoS One 4 (12), e8328 (2009)
   PUBMED   20016786
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 750)
  AUTHORS   Groth,A., Lukas,J., Nigg,E.A., Sillje,H.H., Wernstedt,C., Bartek,J.
            and Hansen,K.
  TITLE     Human Tousled like kinases are targeted by an ATM- and
            Chk1-dependent DNA damage checkpoint
  JOURNAL   EMBO J 22 (7), 1676-1687 (2003)
   PUBMED   12660173
REFERENCE   4  (residues 1 to 750)
  AUTHORS   Sillje,H.H., Takahashi,K., Tanaka,K., Van Houwe,G. and Nigg,E.A.
  TITLE     Mammalian homologues of the plant Tousled gene code for
            cell-cycle-regulated kinases with maximal activities linked to
            ongoing DNA replication
  JOURNAL   EMBO J 18 (20), 5691-5702 (1999)
   PUBMED   10523312
REFERENCE   5  (residues 1 to 750)
  AUTHORS   Zhang,S., Xing,H. and Muslin,A.J.
  TITLE     Nuclear localization of protein kinase U-alpha is regulated by
            14-3-3
  JOURNAL   J Biol Chem 274 (35), 24865-24872 (1999)
   PUBMED   10455159
REFERENCE   6  (residues 1 to 750)
  AUTHORS   Shalom,S. and Don,J.
  TITLE     Tlk, a novel evolutionarily conserved murine serine threonine
            kinase, encodes multiple testis transcripts
  JOURNAL   Mol Reprod Dev 52 (4), 392-405 (1999)
   PUBMED   10092119
REFERENCE   7  (residues 1 to 750)
  AUTHORS   Yamakawa,A., Kameoka,Y., Hashimoto,K., Yoshitake,Y., Nishikawa,K.,
            Tanihara,K. and Date,T.
  TITLE     cDNA cloning and chromosomal mapping of genes encoding novel
            protein kinases termed PKU-alpha and PKU-beta, which have nuclear
            localization signal
  JOURNAL   Gene 202 (1-2), 193-201 (1997)
   PUBMED   9427565
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Jul 17, 2010 this sequence version replaced XP_221023.3.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.39357.1,
                                           SRR26643293.66706.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..750
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     Protein         1..750
                     /product="serine/threonine-protein kinase tousled-like 2"
                     /EC_number="2.7.11.1"
                     /calculated_mol_wt=85284
     Region          171..>410
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     Region          433..741
                     /region_name="STKc_TLK2"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Tousled-Like Kinase 2; cd14041"
                     /db_xref="CDD:270943"
     Site            order(446..450,454,467,469,505,522..525,529,531,570,572,
                     574..575,577,591,594,617..620)
                     /site_type="active"
                     /db_xref="CDD:270943"
     Site            order(446..450,454,467,469,505,522..525,529,570,572,
                     574..575,577,591)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270943"
     Site            order(450,529,531,570,572,574,594,617..620)
                     /site_type="other"
                     /note="polypeptide substrate binding site"
                     /db_xref="CDD:270943"
     Site            order(590..596,617..620)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270943"
     CDS             1..750
                     /gene="Tlk2"
                     /coded_by="NM_001191652.3:499..2751"
                     /db_xref="GeneID:303592"
                     /db_xref="RGD:1310907"
ORIGIN      
        1 mmeelhsldp rrqellearf tgvgvskgpl nsessnqslc svgslsdkev etpekkqndq
       61 rnrkrkaepy etsqgkgtpr ghkisdyfef aggsgpgtsp grsvppvars spqhslsnpl
      121 prrveqplyg ldgstakeas eeqsalptlm svmlakprld teqlaprgag lcftfvsaqq
      181 nspsstgsgn tehscssqkq isiqhrqtqs dltiekisal ensknsdlek kegriddllr
      241 ancdlrrqid eqqkmlekyk erlnrcvtms kklliekskq ekmacrdksm qdrlrlghft
      301 tvrhgasfte qwtdgyafqn likqqerins qreeierqrk mlakrkppam gqappatneq
      361 kqrksktnga enetltlaey heqeeifklr lghlkkeeae iqaelerler vrnlhirelk
      421 rihnednsqf kdhptlndry lllhllgrgg fsevykafdl teqryvavki hqlnknwrde
      481 kkenyhkhac reyrihkeld hprivklydy fsldtdsfct vleycegndl dfylkqhklm
      541 sekearsiim qivnalkyln eikppiihyd lkpgnillvn gtacgeikit dfglskimdd
      601 dsynsvdgme ltsqgagtyw ylppecfvvg keppkisnkv dvwsvgvify qclygrkpfg
      661 hnqsqqdilq entilkatev qfppkpvvtp eakafirrcl ayrkedridv qqlacdpyll
      721 phirksvsts spagaaiast sgasnnsssn
//
