LOCUS       NM_001395018            4742 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus tousled-like kinase 1 (Tlk1), transcript variant
            1, mRNA.
ACCESSION   NM_001395018 XM_008761896
VERSION     NM_001395018.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4742)
  AUTHORS   Groth,A., Lukas,J., Nigg,E.A., Sillje,H.H., Wernstedt,C., Bartek,J.
            and Hansen,K.
  TITLE     Human Tousled like kinases are targeted by an ATM- and
            Chk1-dependent DNA damage checkpoint
  JOURNAL   EMBO J 22 (7), 1676-1687 (2003)
   PUBMED   12660173
REFERENCE   2  (bases 1 to 4742)
  AUTHORS   Cabaniols,J.P., Ravichandran,V. and Roche,P.A.
  TITLE     Phosphorylation of SNAP-23 by the novel kinase SNAK regulates
            t-SNARE complex assembly
  JOURNAL   Mol Biol Cell 10 (12), 4033-4041 (1999)
   PUBMED   10588641
REFERENCE   3  (bases 1 to 4742)
  AUTHORS   Sillje,H.H., Takahashi,K., Tanaka,K., Van Houwe,G. and Nigg,E.A.
  TITLE     Mammalian homologues of the plant Tousled gene code for
            cell-cycle-regulated kinases with maximal activities linked to
            ongoing DNA replication
  JOURNAL   EMBO J 18 (20), 5691-5702 (1999)
   PUBMED   10523312
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On May 26, 2021 this sequence version replaced XM_008761896.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.14132.1,
                                           SRR26643297.11481.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-326               JAXUCZ010000003.1  76034734-76035059   c
            327-445             JAXUCZ010000003.1  75999968-76000086   c
            446-517             JAXUCZ010000003.1  75986450-75986521   c
            518-593             JAXUCZ010000003.1  75974048-75974123   c
            594-640             JAXUCZ010000003.1  75970946-75970992   c
            641-736             JAXUCZ010000003.1  75969194-75969289   c
            737-826             JAXUCZ010000003.1  75967454-75967543   c
            827-919             JAXUCZ010000003.1  75966027-75966119   c
            920-1030            JAXUCZ010000003.1  75962278-75962388   c
            1031-1167           JAXUCZ010000003.1  75961840-75961976   c
            1168-1356           JAXUCZ010000003.1  75957668-75957856   c
            1357-1423           JAXUCZ010000003.1  75953374-75953440   c
            1424-1521           JAXUCZ010000003.1  75941226-75941323   c
            1522-1603           JAXUCZ010000003.1  75939930-75940011   c
            1604-1785           JAXUCZ010000003.1  75937737-75937918   c
            1786-1955           JAXUCZ010000003.1  75937379-75937548   c
            1956-2091           JAXUCZ010000003.1  75936814-75936949   c
            2092-2203           JAXUCZ010000003.1  75934296-75934407   c
            2204-2311           JAXUCZ010000003.1  75933088-75933195   c
            2312-4742           JAXUCZ010000003.1  75928303-75930733   c
FEATURES             Location/Qualifiers
     source          1..4742
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q22"
     gene            1..4742
                     /gene="Tlk1"
                     /note="tousled-like kinase 1"
                     /db_xref="GeneID:311118"
                     /db_xref="RGD:1310370"
     exon            1..326
                     /gene="Tlk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..2488
                     /gene="Tlk1"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine-protein kinase tousled-like 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase tousled-like 1
                     isoform 1"
                     /protein_id="NP_001381947.1"
                     /db_xref="GeneID:311118"
                     /db_xref="RGD:1310370"
                     /translation="MSVQSSSGSLEGPPSWSRLSTSPTPGSAAAARSLLNHTPPSGRP
                     REGAMDELHSLDPRRQELLEARFTGVATGSTGSTGSCSVGAKASTNNESSNHSFGSLG
                     SLSDKESETPEKKQSESSRGRKRKAESQNESSQGKSIGGRGHKISDYFEYQGGNGSSP
                     VRGIPPAIRSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPVVQPKQLSFKITQTDLTM
                     LKLAALESTKNQDLEKKEGRIDDLLRANCDLRRQIDDQQKLLEKYKERLNKCISMSKK
                     LLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQ
                     QREDIERQRKLLAKRKPPTANNSQAPATNSEPKQRKNKAVNGAENDPFVRPNLPQLLT
                     LAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHP
                     TLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACRE
                     YRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVM
                     QIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGM
                     DLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQD
                     ILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRR
                     SNSSGNLHMSGLTATPTPPSSSIITY"
     exon            327..445
                     /gene="Tlk1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..517
                     /gene="Tlk1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..593
                     /gene="Tlk1"
                     /inference="alignment:Splign:2.1.0"
     exon            594..640
                     /gene="Tlk1"
                     /inference="alignment:Splign:2.1.0"
     exon            641..736
                     /gene="Tlk1"
                     /inference="alignment:Splign:2.1.0"
     exon            737..826
                     /gene="Tlk1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..919
                     /gene="Tlk1"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1030
                     /gene="Tlk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1167
                     /gene="Tlk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1356
                     /gene="Tlk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1423
                     /gene="Tlk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1521
                     /gene="Tlk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1603
                     /gene="Tlk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1785
                     /gene="Tlk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1955
                     /gene="Tlk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2091
                     /gene="Tlk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2203
                     /gene="Tlk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2311
                     /gene="Tlk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..4742
                     /gene="Tlk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttgcctcc cctcagcgct gccctccccg cctgccctcc gcccggcgcg ctccctcggc
       61 ggcgcggcgc tcccctccca gccctcgcgc ccgcgctcgc cctcagcgcg gcccccgcca
      121 tgacggaggc gggtgccggt gccgccgccg tcgcaggggg ggagtcgggc tcccagaaag
      181 tagcttgatg agtgtccaaa gtagcagtgg aagtttggag gggccgccat cttggtcccg
      241 gctctccacg tctccaaccc caggctcggc ggcagcggcc aggtccctgc tgaatcacac
      301 gccgccatcc gggaggccca gggaaggtgc aatggatgaa cttcacagtc tggatccaag
      361 aaggcaagaa ttattggaag cgagatttac tggagttgct actgggagca ctgggagtac
      421 tgggagttgc agtgttggag cgaaagcttc aacaaataat gaaagttcta atcacagttt
      481 tggaagctta ggatctctaa gtgacaaaga atcagagaca ccagagaaga aacaatctga
      541 gtcatccagg ggaagaaaga gaaaagcaga aagtcagaat gaaagtagtc agggaaaaag
      601 tattgggggg cgtggccaca agattagcga ctattttgaa taccaaggtg gaaatggctc
      661 cagtcccgta agaggcatac ctccagcaat ccgttctccg caaaactcac actctcattc
      721 cactccctcc tcatctgttc gaccgaatag tccttctcct actgcattag ctttcgggga
      781 ccaccctgtt gtacaaccaa agcagttatc ctttaagatc actcaaactg atcttacaat
      841 gctgaaattg gcagcattag aaagtactaa aaatcaggac ctggaaaaga aggaaggtcg
      901 gatagatgat ttgctcaggg ccaactgtga tctcaggcgg caaatagatg atcaacagaa
      961 attacttgaa aaatacaaag aacgattaaa taagtgcata tctatgagca agaaactgct
     1021 tattgaaaag agtacacaag aaaaattgtc aagcagagag aagagtatgc aagatcggtt
     1081 gcgccttggg cactttacaa cagttagaca tggcgcttct tttacagaac aatggacaga
     1141 tggttttgca tttcaaaatc ttgtgaagca acaagagtgg gtgaatcaac aaagggaaga
     1201 tattgaacgg caaagaaaac ttctagccaa acgcaaacct cccacagcta ataattctca
     1261 ggcacctgca accaattctg aaccaaaaca aagaaaaaac aaggcagtca acggagcaga
     1321 aaatgatccc tttgttagac caaatttacc acaactgctg actctggcag aatatcatga
     1381 acaagaggaa atttttaaac ttagactagg acatctcaaa aaggaagagg ctgaaatcca
     1441 ggcggaacta gagcgtttgg aaagggtcag gaatcttcac atccgagagc tgaagagaat
     1501 aaacaatgag gataattcac agttcaaaga tcatccaaca ttaaatgaaa gatatttatt
     1561 actccatctg cttggaagag gtggctttag tgaggtgtat aaggcttttg acttgtatga
     1621 gcaaagatat gctgctgtga agatccacca gcttaataaa agctggagag atgagaaaaa
     1681 agaaaactac cataaacacg cttgcagaga gtatcgaata cacaaagagc tggaccaccc
     1741 cagaatagtt aaactctatg attacttctc cttggacaca gatacgtttt gtacagtgct
     1801 agagtactgt gaaggcaatg acttggactt ctacctgaaa caacacaagt tgatgtctga
     1861 gaaagaagca cggtccattg tgatgcagat tgtgaatgcc ttacgatatc ttaatgaaat
     1921 caaacctcct attatacatt atgaccttaa gccaggaaat atccttctag tagatggaac
     1981 ggcgtgtgga gaaatcaaaa tcactgattt tggtctgtct aagattatgg acgatgacag
     2041 ttatggtgtt gatgggatgg atctgacttc ccagggggca ggcacttact ggtatttacc
     2101 tcccgagtgc tttgtagttg gaaaagagcc accgaagatc tccaacaagg ttgacgtgtg
     2161 gtcagttggg gtcatcttct tccagtgcct ctatggtaga aaaccctttg gtcacaatca
     2221 atctcaacaa gacattctac aggaaaacac aatactaaaa gccacagaag tccagttccc
     2281 tgtaaaacca gttgtaagca gtgaagccaa ggccttcata agacgctgtt tggcttaccg
     2341 aaaagaagat cgatttgatg tgcaccagct ggcaaatgac ccataccttc tgccacacat
     2401 gagaagatca aattcttcag gcaacctaca tatgtctggg ctgacagcaa ctcccacgcc
     2461 tccttcttca agcataatta cttactgact cctccaagat gggcatgatc tcttctcttt
     2521 gattggcttc cagatgcata cttgaatttg agtgcatttg agtgtttgtg attttttttt
     2581 ttaacatggg acatggttaa gaagtgtttg tgaactaaag ctctccatgg agtcctttgt
     2641 gtgagagtgg atcatggaca gtgactaagt acacactcct cactgccctg gagcagcaca
     2701 aaacaggaac accatgttac agtagaacaa ggggactctg taaataacgt ttataatgct
     2761 taaatatatt tgattgttac cagagagttc taataagaag ggtagttttt cattatttaa
     2821 gaacacatgg aaaaatgatg ggacatttgt gacacgggag ctacagtgcc tggtacagcg
     2881 tcagcactcg gcagctgatc tacagaaacc aaagcaagag ccgagtggca gccgctgtgt
     2941 ttgcagcaga acgtgagagc tggggtcttt ggacagttgt ggactttgtc atttgccgat
     3001 tctggctttt accaagttgt acctcgaaat cacatgtcag tggtccacca ccctaccccc
     3061 aacccctctt aactggtttt gttaaaggcg agctgtcatt tctggatact ttatactttt
     3121 aacacaaaga gctgcctatt tcaaatcagt tgaagttact aaatcatagt atttccaggg
     3181 ctttcagtgt tttagaatta acaggcattt ttcttttgtt tctaggcctc gttcattaaa
     3241 acaggagaca gtgtgtaacc aaaagcaggc cagtcgtgtg caagataatg atgaatcccc
     3301 ttctggctct attgtaaact actgtacaga tgtcgattac aattactgag tttcagcagc
     3361 ttattcttgt acaaatgttt aaaaatactg cttttctaat tggatattgt atttttttta
     3421 agtcttcttg aaggcgcttt aattgctgct aaatgatact gcttttttgc tataaaaatt
     3481 tgaatgacct tgaaggcaca agttgactgt acatcataga gagatattaa aagcaggcat
     3541 tcattaacaa tcaaggcatg taaatgatct acatcgggca tattgagttc ttcaaatcag
     3601 tttttaggtt ctagagctgt ggaacaatag aaactagatt tataaattgt tcatggttat
     3661 tctacatttc tagaaagttc ttagcatcga gatgggatga tagtcccata gaatgtttct
     3721 tgtggtttgt acagatttgt taaaatgtga acattttcta actgccttgt gtggtagaaa
     3781 ccaatatttt tgggggatgc tatatttcat tcttgtaagg attttttttt attgtcacac
     3841 tcataatgct gagacttaca tgtaagttgt ccatggtgca gaaaacagac tatccctgcc
     3901 agatgcccca taccatgtac agttaaactg tggctcttag ctggtgttgc aagccatttt
     3961 gtttgtttgt tttcattgta catagacaca ctgtctgttt aagaagctgc tggaattata
     4021 gagaatgtag ccaaacagta ataaacaacg acagcaaaat gtaaagatgt ggaagattac
     4081 gttcaaagag cccgaaggtt taggttacta actgagcttc ataaaggcag atgaagatgt
     4141 ccttaagaca agcatgaagt gtttcaggct taaaagcagt gtttggaaaa aaatataaat
     4201 aagagtatca gaaacaactt acccatgttt tccacagttt ttccaaatgt agatttaaat
     4261 agcctactag tgcttgggct cagtgaacca gtatcagctt cgtgtagaac tggtgcttgt
     4321 tgctgaataa tttccatgtt tccacccatc tgttttgagt attagttgtt ttcttgtctt
     4381 gtggagtctg cactgactgc aggtaaagtg cacagttctc atccttgaaa gcagctgtac
     4441 cgatgggttg tagtccattg ggaggggaga gtgctgcact gagctcgtgg aagttcagtc
     4501 cccagcacac tgctccccca aaaccagtaa gtacaggcac ttcggtaaac acttggatgt
     4561 tgaaaggatg cagaagctgc cgtggtgatg gggcgggggg cgggagacat gcggttggct
     4621 ttccttgtgg ccacccactt tccctacttg agtttaaatg tgaacaaact caccaggtcc
     4681 ttctctagtt tgactgtaaa tttccatgtt tttaaagaag tttttcctct gagtacatga
     4741 aa
//
