LOCUS       NM_019220               1356 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Rattus norvegicus TLE family member 5, transcriptional modulator
            (Tle5), mRNA.
ACCESSION   NM_019220
VERSION     NM_019220.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1356)
  AUTHORS   Wang,Z., Zhou,L., Wang,Y., Peng,Q., Li,H., Zhang,X., Su,Z.,
            Song,J., Sun,Q., Sayed,S., Liu,S. and Lu,D.
  TITLE     The CK1delta/epsilon-AES axis regulates tumorigenesis and
            metastasis in colorectal cancer
  JOURNAL   Theranostics 11 (9), 4421-4435 (2021)
   PUBMED   33754069
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1356)
  AUTHORS   Okada,Y., Sonoshita,M., Kakizaki,F., Aoyama,N., Itatani,Y.,
            Uegaki,M., Sakamoto,H., Kobayashi,T., Inoue,T., Kamba,T.,
            Suzuki,A., Ogawa,O. and Taketo,M.M.
  TITLE     Amino-terminal enhancer of split gene AES encodes a tumor and
            metastasis suppressor of prostate cancer
  JOURNAL   Cancer Sci 108 (4), 744-752 (2017)
   PUBMED   28178391
REFERENCE   3  (bases 1 to 1356)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1356)
  AUTHORS   Brunquell,C., Biliran,H., Jennings,S., Ireland,S.K., Chen,R. and
            Ruoslahti,E.
  TITLE     TLE1 is an anoikis regulator and is downregulated by Bit1 in breast
            cancer cells
  JOURNAL   Mol Cancer Res 10 (11), 1482-1495 (2012)
   PUBMED   22952044
REFERENCE   5  (bases 1 to 1356)
  AUTHORS   Nishiyama,A., Xin,L., Sharov,A.A., Thomas,M., Mowrer,G., Meyers,E.,
            Piao,Y., Mehta,S., Yee,S., Nakatake,Y., Stagg,C., Sharova,L.,
            Correa-Cerro,L.S., Bassey,U., Hoang,H., Kim,E., Tapnio,R., Qian,Y.,
            Dudekula,D., Zalzman,M., Li,M., Falco,G., Yang,H.T., Lee,S.L.,
            Monti,M., Stanghellini,I., Islam,M.N., Nagaraja,R., Goldberg,I.,
            Wang,W., Longo,D.L., Schlessinger,D. and Ko,M.S.
  TITLE     Uncovering early response of gene regulatory networks in ESCs by
            systematic induction of transcription factors
  JOURNAL   Cell Stem Cell 5 (4), 420-433 (2009)
   PUBMED   19796622
REFERENCE   6  (bases 1 to 1356)
  AUTHORS   Zhu,C.C., Dyer,M.A., Uchikawa,M., Kondoh,H., Lagutin,O.V. and
            Oliver,G.
  TITLE     Six3-mediated auto repression and eye development requires its
            interaction with members of the Groucho-related family of
            co-repressors
  JOURNAL   Development 129 (12), 2835-2849 (2002)
   PUBMED   12050133
REFERENCE   7  (bases 1 to 1356)
  AUTHORS   Wang,W.F., Wang,Y.G., Reginato,A.M., Plotkina,S., Gridley,T. and
            Olsen,B.R.
  TITLE     Growth defect in Grg5 null mice is associated with reduced Ihh
            signaling in growth plates
  JOURNAL   Dev Dyn 224 (1), 79-89 (2002)
   PUBMED   11984876
REFERENCE   8  (bases 1 to 1356)
  AUTHORS   Tetsuka,T., Uranishi,H., Imai,H., Ono,T., Sonta,S., Takahashi,N.,
            Asamitsu,K. and Okamoto,T.
  TITLE     Inhibition of nuclear factor-kappaB-mediated transcription by
            association with the amino-terminal enhancer of split, a
            Groucho-related protein lacking WD40 repeats
  JOURNAL   J Biol Chem 275 (6), 4383-4390 (2000)
   PUBMED   10660609
REFERENCE   9  (bases 1 to 1356)
  AUTHORS   Leimeister,C., Bach,A., Woolf,A.S. and Gessler,M.
  TITLE     Screen for genes regulated during early kidney morphogenesis
  JOURNAL   Dev Genet 24 (3-4), 273-283 (1999)
   PUBMED   10322635
REFERENCE   10 (bases 1 to 1356)
  AUTHORS   Schmidt,C.J. and Sladek,T.E.
  TITLE     A rat homolog of the Drosophila enhancer of split (groucho) locus
            lacking WD-40 repeats
  JOURNAL   J Biol Chem 268 (34), 25681-25686 (1993)
   PUBMED   8245004
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L14462.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L14462.1, DY312974.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1356
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1356
                     /gene="Tle5"
                     /gene_synonym="Aes; Grg; Grg-5"
                     /note="TLE family member 5, transcriptional modulator"
                     /db_xref="GeneID:29466"
                     /db_xref="RGD:2731"
     exon            1..110
                     /gene="Tle5"
                     /gene_synonym="Aes; Grg; Grg-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..677
                     /gene="Tle5"
                     /gene_synonym="Aes; Grg; Grg-5"
                     /note="R-esp1; amino enhancer of split; related to
                     Drosophila groucho; amino-terminal enhancer of split;
                     groucho-related protein 5"
                     /codon_start=1
                     /product="TLE family member 5"
                     /protein_id="NP_062093.1"
                     /db_xref="GeneID:29466"
                     /db_xref="RGD:2731"
                     /translation="MMFPQSRHSGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLK
                     LECDKLASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQ
                     QVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAG
                     TGLLSLSALGSQTHLSKEDKNGHDGDTHQEDDGEKSD"
     exon            111..208
                     /gene="Tle5"
                     /gene_synonym="Aes; Grg; Grg-5"
                     /inference="alignment:Splign:2.1.0"
     exon            209..272
                     /gene="Tle5"
                     /gene_synonym="Aes; Grg; Grg-5"
                     /inference="alignment:Splign:2.1.0"
     exon            273..317
                     /gene="Tle5"
                     /gene_synonym="Aes; Grg; Grg-5"
                     /inference="alignment:Splign:2.1.0"
     exon            318..380
                     /gene="Tle5"
                     /gene_synonym="Aes; Grg; Grg-5"
                     /inference="alignment:Splign:2.1.0"
     exon            381..455
                     /gene="Tle5"
                     /gene_synonym="Aes; Grg; Grg-5"
                     /inference="alignment:Splign:2.1.0"
     exon            456..1348
                     /gene="Tle5"
                     /gene_synonym="Aes; Grg; Grg-5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccggagctg tcgatcgggg acaaagcgcg gccgcccgcg ccccccgagc cgcccgagcc
       61 ggggccagcc ccccgcgact gacatgatgt ttccgcaaag ccggcactcg ggctcctccc
      121 acctccccca gcagctcaag ttcaccacct ccgactcctg cgaccgcatc aaggatgagt
      181 tccagctgct acaagcgcag taccacagcc tgaagctgga gtgtgacaag ctggccagcg
      241 agaagtcaga gatgcaaagg cattacgtca tgtactatga gatgtcttac ggattgaaca
      301 tcgagatgca caaacaggct gaaattgtga agaggctgaa tgggatttgc gcccaggttc
      361 taccctattt gtcccaggag catcagcagc aggtcctggg agctatcgag agagccaagc
      421 aggtcacggc tcccgagctg aactccatca tccgacagca gctccaggct caccagctgt
      481 cccagctcca ggcgctggcc ctgcccctga caccgctgcc tgtcgggctc cagccgccat
      541 ccctccctgc ggtcagcgca ggcacaggcc tgctgtcact ctctgctctg ggctctcaga
      601 cccacctctc caaggaggac aagaacggac acgatgggga cacccaccag gaggatgatg
      661 gagagaagtc cgattagctc ctggggagag ggagggggag gggggatacc aggggagaca
      721 ggcacagaga gcacagtgtt ctgagggcca cactgcacac agctcggtcc ctacccaagc
      781 ttccacctcc agtcctggtt ccagctgtgc accctgggcc taggagacgc cagagggaca
      841 gcccaggcta cagggaaaat tccccacctt caacatttcc ccgggctaca gccaccaatc
      901 tcggcccaga atgtacacaa cgctagccgc ccctttccac cctgtgcacc ccgaatttgc
      961 cccctttccc cttctctgct tcctgcactg cacacctgct aggcccagac ccctcccccc
     1021 agctcaccca gctctggttc cctcaaccgc ggaaagaaag cattggctcg ggactgcagt
     1081 gggggtgggc accccacaaa cttccctctc cccttcccca aataaacgtg agggttaaaa
     1141 gtcggtttgt ttattatttc tttttcgtcc cagtactcta tagctaccat ctaagagaga
     1201 aaaagaagga agccctggag cgagcgaggg tctgtctgtg catatagtta gatttttctg
     1261 gtcgcctcgc tttgcaccga gaggtggagg gccgctgtac tgagggtggg gtctagctgt
     1321 gccttcaaaa taaaaacatg aaaaggtcaa aaaaaa
//
