LOCUS       NM_001414041            4537 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Rattus norvegicus TLE family member 4, transcriptional corepressor
            (Tle4), transcript variant 1, mRNA.
ACCESSION   NM_001414041 XM_006231129
VERSION     NM_001414041.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4537)
  AUTHORS   Aberle,T., Walter,A., Piefke,S., Hillgartner,S., Wust,H.M.,
            Wegner,M. and Kuspert,M.
  TITLE     Sox10 Activity and the Timing of Schwann Cell Differentiation Are
            Controlled by a Tle4-Dependent Negative Feedback Loop
  JOURNAL   Int J Mol Sci 25 (10), 5234 (2024)
   PUBMED   38791273
  REMARK    GeneRIF: Sox10 Activity and the Timing of Schwann Cell
            Differentiation Are Controlled by a Tle4-Dependent Negative
            Feedback Loop.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4537)
  AUTHORS   van Tienen,L.M., Mieszczanek,J., Fiedler,M., Rutherford,T.J. and
            Bienz,M.
  TITLE     Constitutive scaffolding of multiple Wnt enhanceosome components by
            Legless/BCL9
  JOURNAL   Elife 6, e20882 (2017)
   PUBMED   28296634
  REMARK    Erratum:[Elife. 2017 Mar 30;6:e27150. doi: 10.7554/eLife.27150..
            PMID: 28358670]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4537)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (bases 1 to 4537)
  AUTHORS   Slorach,E.M., Chou,J. and Werb,Z.
  TITLE     Zeppo1 is a novel metastasis promoter that represses E-cadherin
            expression and regulates p120-catenin isoform expression and
            localization
  JOURNAL   Genes Dev 25 (5), 471-484 (2011)
   PUBMED   21317240
REFERENCE   5  (bases 1 to 4537)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   6  (bases 1 to 4537)
  AUTHORS   Rave-Harel,N., Miller,N.L., Givens,M.L. and Mellon,P.L.
  TITLE     The Groucho-related gene family regulates the
            gonadotropin-releasing hormone gene through interaction with the
            homeodomain proteins MSX1 and OCT1
  JOURNAL   J Biol Chem 280 (35), 30975-30983 (2005)
   PUBMED   16002402
REFERENCE   7  (bases 1 to 4537)
  AUTHORS   Lang,D., Lu,M.M., Huang,L., Engleka,K.A., Zhang,M., Chu,E.Y.,
            Lipner,S., Skoultchi,A., Millar,S.E. and Epstein,J.A.
  TITLE     Pax3 functions at a nodal point in melanocyte stem cell
            differentiation
  JOURNAL   Nature 433 (7028), 884-887 (2005)
   PUBMED   15729346
REFERENCE   8  (bases 1 to 4537)
  AUTHORS   Puelles,E., Annino,A., Tuorto,F., Usiello,A., Acampora,D.,
            Czerny,T., Brodski,C., Ang,S.L., Wurst,W. and Simeone,A.
  TITLE     Otx2 regulates the extent, identity and fate of neuronal progenitor
            domains in the ventral midbrain
  JOURNAL   Development 131 (9), 2037-2048 (2004)
   PUBMED   15105370
REFERENCE   9  (bases 1 to 4537)
  AUTHORS   Zhu,C.C., Dyer,M.A., Uchikawa,M., Kondoh,H., Lagutin,O.V. and
            Oliver,G.
  TITLE     Six3-mediated auto repression and eye development requires its
            interaction with members of the Groucho-related family of
            co-repressors
  JOURNAL   Development 129 (12), 2835-2849 (2002)
   PUBMED   12050133
REFERENCE   10 (bases 1 to 4537)
  AUTHORS   Schmidt,C.J. and Sladek,T.E.
  TITLE     A rat homolog of the Drosophila enhancer of split (groucho) locus
            lacking WD-40 repeats
  JOURNAL   J Biol Chem 268 (34), 25681-25686 (1993)
   PUBMED   8245004
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 15, 2022 this sequence version replaced XM_006231129.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.5923.1,
                                           SRR26643299.6379.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-681               JAXUCZ010000001.1  221222146-221222826 c
            682-779             JAXUCZ010000001.1  221221542-221221639 c
            780-843             JAXUCZ010000001.1  221220350-221220413 c
            844-888             JAXUCZ010000001.1  221219148-221219192 c
            889-951             JAXUCZ010000001.1  221189731-221189793 c
            952-1026            JAXUCZ010000001.1  221174289-221174363 c
            1027-1228           JAXUCZ010000001.1  221149857-221150058 c
            1229-1245           JAXUCZ010000001.1  221148563-221148579 c
            1246-1365           JAXUCZ010000001.1  221107175-221107294 c
            1366-1419           JAXUCZ010000001.1  221106236-221106289 c
            1420-1572           JAXUCZ010000001.1  221105687-221105839 c
            1573-1705           JAXUCZ010000001.1  221104435-221104567 c
            1706-1899           JAXUCZ010000001.1  221103929-221104122 c
            1900-1976           JAXUCZ010000001.1  221103404-221103480 c
            1977-2226           JAXUCZ010000001.1  221093169-221093418 c
            2227-2474           JAXUCZ010000001.1  221092034-221092281 c
            2475-2622           JAXUCZ010000001.1  221090620-221090767 c
            2623-2773           JAXUCZ010000001.1  221090271-221090421 c
            2774-2850           JAXUCZ010000001.1  221089858-221089934 c
            2851-4537           JAXUCZ010000001.1  221086253-221087939 c
FEATURES             Location/Qualifiers
     source          1..4537
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..4537
                     /gene="Tle4"
                     /gene_synonym="Esp2; Grg-4"
                     /note="TLE family member 4, transcriptional corepressor"
                     /db_xref="GeneID:25565"
                     /db_xref="RGD:3868"
     exon            1..681
                     /gene="Tle4"
                     /gene_synonym="Esp2; Grg-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             637..2958
                     /gene="Tle4"
                     /gene_synonym="Esp2; Grg-4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transducin-like enhancer protein 4; transducin-like
                     enhancer of split 4, E(spl) homolog; transducin-like
                     enhancer of split 4, homolog of Drosophila E(spl);
                     transducin-like enhancer of split 4 (E(sp1) homolog,
                     Drosophila); groucho-related protein 4"
                     /codon_start=1
                     /product="transducin-like enhancer protein 4 isoform 1"
                     /protein_id="NP_001400970.1"
                     /db_xref="GeneID:25565"
                     /db_xref="RGD:3868"
                     /translation="MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQA
                     QYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFL
                     SQEHQQQVVQAVERAKQVTMAELNAIIGQQLQAQHLSHGHGLPVPLTPHPSGLQPPAI
                     PPIGSSAGLLALSSALGGQSHLPIKDEKKHHDNDHQRDRDSIKSSSVSPSASFRGSEK
                     HRNSTDYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEDPSSPRGSPAHSPRE
                     NGLDKTRLLKKDAPISPASVASSSSTPSSKSKELSLNEKSTTPVSKSNTPTPRTDAPT
                     PGSNSTPGLRPVPGKPPGVDPLASSLRTPMAVPCPYPTPFGIVPHAGMNGELTSPGAA
                     YAGLHNISPQMSAAAAAAAAAAAYGRSPVVGFDPHHHMRVPAIPPNLTGIPGGKPAYS
                     FHVSADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKG
                     CVKVWDISHPGNKSPVSQLDCLNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPT
                     PRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASC
                     IDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMENS
                     NVEVLHVTKPDKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASIFQSK
                     ESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY"
     exon            682..779
                     /gene="Tle4"
                     /gene_synonym="Esp2; Grg-4"
                     /inference="alignment:Splign:2.1.0"
     exon            780..843
                     /gene="Tle4"
                     /gene_synonym="Esp2; Grg-4"
                     /inference="alignment:Splign:2.1.0"
     exon            844..888
                     /gene="Tle4"
                     /gene_synonym="Esp2; Grg-4"
                     /inference="alignment:Splign:2.1.0"
     exon            889..951
                     /gene="Tle4"
                     /gene_synonym="Esp2; Grg-4"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1026
                     /gene="Tle4"
                     /gene_synonym="Esp2; Grg-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1228
                     /gene="Tle4"
                     /gene_synonym="Esp2; Grg-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1245
                     /gene="Tle4"
                     /gene_synonym="Esp2; Grg-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1365
                     /gene="Tle4"
                     /gene_synonym="Esp2; Grg-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1419
                     /gene="Tle4"
                     /gene_synonym="Esp2; Grg-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1572
                     /gene="Tle4"
                     /gene_synonym="Esp2; Grg-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1705
                     /gene="Tle4"
                     /gene_synonym="Esp2; Grg-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1899
                     /gene="Tle4"
                     /gene_synonym="Esp2; Grg-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..1976
                     /gene="Tle4"
                     /gene_synonym="Esp2; Grg-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2226
                     /gene="Tle4"
                     /gene_synonym="Esp2; Grg-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2474
                     /gene="Tle4"
                     /gene_synonym="Esp2; Grg-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2622
                     /gene="Tle4"
                     /gene_synonym="Esp2; Grg-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2773
                     /gene="Tle4"
                     /gene_synonym="Esp2; Grg-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2850
                     /gene="Tle4"
                     /gene_synonym="Esp2; Grg-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..4537
                     /gene="Tle4"
                     /gene_synonym="Esp2; Grg-4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcgcgtt gttagagccg ttccgagcgg gcgttcggct gttggctgcc ttcttccccc
       61 tcttacacac tcgtgtatta ttttgaggtg gtgttcgcag agtttgaaag agaattttaa
      121 aaagccgcaa gcgtttcgct cttttatttt tataatcccc ttcaatttgg ggctaaaaaa
      181 acaggaagga agaaaaggaa atgaaatgtg gtaaaagaag ctaaaaggtg ccttttaaaa
      241 gatcgttgct gtgaagtgaa aaatctccag agaaccccca agcgccgcga gacctcttcc
      301 gaaccaaagg agtttgagct agctctcagg gaagaagcga ccattcattc cgaggaatag
      361 cagccaatta aaagacaaat aaaaaaagtt tggagtgggg cgcaagcagg cgggcggcgc
      421 tcggcgggcg cggggctcgg cgggcgcagg acggacggtg cccgccgccc tcagtgacgc
      481 ccgcggggaa tgcggagccg gccgcccgcg ctcagccgcc gcgcctgcct gccgcccgcg
      541 tcacgcgaga cccgcaggcc cgggacgccg ccgcggggcc ctcgaagcgg atgagccgcg
      601 cgcctctgcc tggcgcagcc aactaaagcg gcgtggatga ttcgcgacct gagcaagatg
      661 tacccgcaga cgcgccaccc ggcaccgcat cagcctgctc aacccttcaa atttacaatt
      721 tcagaatcct gtgatcggat taaggaagag tttcagtttt tacaggctca ataccacagt
      781 ctgaagctgg aatgtgagaa gctggccagt gagaagacag agatgcagcg gcattatgtc
      841 atgtattatg aaatgtccta tgggttgaac atagaaatgc acaagcaggc agagattgtt
      901 aaacgactaa atgctatctg tgcacaggtc attcctttcc tgtcccaaga gcaccagcaa
      961 caagtggtgc aggctgtgga acgggccaag caggtgacca tggcagaact gaacgccatc
     1021 attgggcaac aactccaagc tcagcattta tcacatggac atggtctgcc tgtgcctctg
     1081 acaccacacc cttcggggct tcagccccca gccattccac ccatcggcag cagtgcagga
     1141 ctgctggccc tctccagtgc actaggaggt cagtctcacc tcccaattaa ggatgagaaa
     1201 aagcaccatg acaatgatca ccaaagagac agagactcca tcaagagctc ttccgtatcc
     1261 ccatcagcta gtttccgagg ttctgagaaa cacaggaact ctacagacta ttcctcagag
     1321 agcaagaagc agaaaacaga agagaaggaa attgcagctc gctatgacag tgatggtgag
     1381 aagagtgatg acaacttggt agttgatgtg tccaatgagg atccatcttc ccctcgagga
     1441 agcccagcac attccccaag ggagaatggc ctggacaaga cacgcctcct caagaaagat
     1501 gctcccatca gccctgcttc tgttgcatct tccagcagta ctccttcctc caaatccaaa
     1561 gagcttagcc ttaatgaaaa gtctactact cctgtttcaa agtccaatac ccctactcca
     1621 cggactgatg cacctacccc tggcagtaac tctactcccg gactgaggcc tgtacctgga
     1681 aagccaccag gtgtggaccc cttagcatcc agcctgagga ccccaatggc tgtaccttgt
     1741 ccatatccaa ccccttttgg gattgtgccc catgctggga tgaatggaga gctgaccagc
     1801 cctggagccg cctatgctgg gcttcacaac atctccccac agatgagtgc agctgcggca
     1861 gcggcagcgg cagcggcagc ctatggaaga tcacctgtgg tgggatttga tccacaccat
     1921 cacatgcgtg tgccagcaat acctccaaac ttgacaggca ttccaggagg aaaaccagca
     1981 tactcctttc acgttagtgc cgatggtcag atgcagccgg tcccctttcc ccctgatgcg
     2041 ctcattggac cgggaatccc ccgacatgcc cgacagatca acacccttaa ccatggggaa
     2101 gtagtgtgtg cagtgaccat cagcaacccc acaagacacg tgtacacagg tggcaagggc
     2161 tgtgtaaagg tctgggacat cagccatcct ggcaacaaaa gcccagtctc tcagctggac
     2221 tgtctgaaca gggataacta catccgctcc tgcagattgc tccctgatgg ccgcacctta
     2281 attgttggag gggaagccag tacactgtcc atctgggacc tggcagctcc aaccccacgc
     2341 atcaaggcag agctgacgtc ctcagcccct gcctgctatg ctctggccat cagccccgac
     2401 tccaaggtct gcttctcatg ctgcagtgat ggcaacatcg cagtgtggga tctgcacaac
     2461 cagactctgg tgaggcaatt ccaggggcac acagatggag ccagttgtat tgacatttct
     2521 aacgatggca ccaagctctg gacaggtggt ttggacaaca ctgtgaggtc ctgggacctg
     2581 cgtgaagggc ggcaactgca gcaacacgac ttcacctctc agatcttttc tttgggctat
     2641 tgcccaactg gagagtggct tgcagtgggg atggagaata gcaatgtgga agtgttgcat
     2701 gtcaccaagc cagacaaata ccagttgcat cttcatgaga gctgtgttct gtcactcaag
     2761 tttgcccact gtggcaaatg gtttgtaagc actggaaagg acaaccttct gaatgcttgg
     2821 aggacacctt atggggccag catcttccag tccaaagaat cctcatcggt gcttagctgt
     2881 gacatctctg tggatgacaa gtacattgtc actggctctg gggacaagaa agctacggtt
     2941 tatgaagtta tttattaagg acaaatcttc gtgcaaactg gactcctcct catagcactt
     3001 tgcgctgttg tacttttctg ttcacccctc tcccattcta aaaccaagga tttccaatac
     3061 tcattgcagt tgtggagttt aatccccttc catagcccca cgtcctcctt gctattgaat
     3121 tgtgaatact cattaagaac ctgtgatacc aaatcttcag ctattgactt ggaagaacat
     3181 ggaataccta acagtgaatg gaatctttaa ttatgtatta tatctgtaat atatttattt
     3241 tgtttaaaga aggctttcta acaatgactg actaaataaa gctgtccgct cctgcattga
     3301 taatgaaggt gcattgtatt tgatgctcca ccctcccttt tggtaaggga ggggaaagga
     3361 aggtttaaaa taactgattt aaatgtcact aaatgtagac tattgactgt atagagatgt
     3421 gaaatgtata attacacatg gaagcaatat gttgctgtgt tgttatgagg ttgttttgtt
     3481 ttgttttcta cttatattaa aaacatttgg aaatttggct gtttgaacaa gtagaatata
     3541 acaggccaag tactattcct ttgagtctat ttgggcaact ttaaccaata tgtctataac
     3601 tttagattac attcaacaaa aataattgat gtttttcttt tttacttgtt gacaagtatc
     3661 tttgtaatat gtttttaatt ccttttttat tgtattatag acagattaaa aaaaattggg
     3721 cctcaaagag agaacttaat ttcttctaat atttttgcca aatttactgg cagagggagc
     3781 tgtgtgtctc tgggcagttg tgatgctgtg agacatggca ggctgttttg tggcatgctc
     3841 tgtaggagct gcaggtacag gagcactgct tgcctaccgc tgtgcaaagc aagtctttca
     3901 cacacacata cacaaaggcc agcagaggag ggtttgcaga gcccatcctc tgaaagtcac
     3961 aaagaagaga ctctcctggg atgatgactt gctttattta cctctggttc tttccatgtc
     4021 ttagttggat gtccctgaaa tggacacagg ctgtgccatt gtgccagaaa cattgtgtta
     4081 tcttttatgt tgttgttgtt gctgttaaac tataacatgt gactcctttt ttattattat
     4141 ttttttgttt gaatgcttta aaaagatctt ttaagtctgt ggatctgctg atgtacagtg
     4201 cctttgctgc tatggatcaa aatcaagaac tgtgtagata aactttattg tataagtaga
     4261 aaaatcactt aatttcatac tagaattggg tggatgctgc aagttgaaat ggactgtcat
     4321 tgacgttctt tgtgtggtag caaaaaaaaa tggtgtctta agtgcttagt gtttgatgtc
     4381 attaacagtt tcataaaact ctacagtgta gaaagatttt gatactaaac tgtgcattgt
     4441 acatagttct aacgcattgt attggccacc agtacttcta tgatggtaga ttgtttgtgc
     4501 attcagactt ttaagcatta aacataaata acttcta
//
