LOCUS       NM_053400               4769 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus TLE family member 3, transcriptional corepressor
            (Tle3), mRNA.
ACCESSION   NM_053400
VERSION     NM_053400.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4769)
  AUTHORS   van Tienen,L.M., Mieszczanek,J., Fiedler,M., Rutherford,T.J. and
            Bienz,M.
  TITLE     Constitutive scaffolding of multiple Wnt enhanceosome components by
            Legless/BCL9
  JOURNAL   Elife 6, e20882 (2017)
   PUBMED   28296634
  REMARK    Erratum:[Elife. 2017 Mar 30;6:e27150. doi: 10.7554/eLife.27150..
            PMID: 28358670]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4769)
  AUTHORS   Villanueva,C.J., Vergnes,L., Wang,J., Drew,B.G., Hong,C., Tu,Y.,
            Hu,Y., Peng,X., Xu,F., Saez,E., Wroblewski,K., Hevener,A.L.,
            Reue,K., Fong,L.G., Young,S.G. and Tontonoz,P.
  TITLE     Adipose subtype-selective recruitment of TLE3 or Prdm16 by
            PPARgamma specifies lipid storage versus thermogenic gene programs
  JOURNAL   Cell Metab 17 (3), 423-435 (2013)
   PUBMED   23473036
REFERENCE   3  (bases 1 to 4769)
  AUTHORS   Wang,J.C., Waltner-Law,M., Yamada,K., Osawa,H., Stifani,S. and
            Granner,D.K.
  TITLE     Transducin-like enhancer of split proteins, the human homologs of
            Drosophila groucho, interact with hepatic nuclear factor 3beta
  JOURNAL   J Biol Chem 275 (24), 18418-18423 (2000)
   PUBMED   10748198
REFERENCE   4  (bases 1 to 4769)
  AUTHORS   Feldman,J.D., Vician,L., Crispino,M., Hoe,W., Baudry,M. and
            Herschman,H.R.
  TITLE     rTLE3, a newly identified transducin-like enhancer of split, is
            induced by depolarization in brain
  JOURNAL   J Neurochem 74 (5), 1838-1847 (2000)
   PUBMED   10800926
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            [WARNING] On Mar 11, 2025 this sequence was replaced by
            NM_053400.3.
            
            On Nov 26, 2020 this sequence version replaced NM_053400.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF186092.1, SRR26643299.35512.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-758               JAXUCZ010000008.1  70753777-70754534
            759-859             JAXUCZ010000008.1  70755028-70755128
            860-923             JAXUCZ010000008.1  70755588-70755651
            924-968             JAXUCZ010000008.1  70756612-70756656
            969-1031            JAXUCZ010000008.1  70774229-70774291
            1032-1106           JAXUCZ010000008.1  70775659-70775733
            1107-1311           JAXUCZ010000008.1  70782797-70783001
            1312-1328           JAXUCZ010000008.1  70784419-70784435
            1329-1448           JAXUCZ010000008.1  70788295-70788414
            1449-1499           JAXUCZ010000008.1  70789262-70789312
            1500-1652           JAXUCZ010000008.1  70789717-70789869
            1653-1785           JAXUCZ010000008.1  70790230-70790362
            1786-1970           JAXUCZ010000008.1  70790810-70790994
            1971-2047           JAXUCZ010000008.1  70792121-70792197
            2048-2297           JAXUCZ010000008.1  70793078-70793327
            2298-2545           JAXUCZ010000008.1  70793690-70793937
            2546-2693           JAXUCZ010000008.1  70794731-70794878
            2694-2844           JAXUCZ010000008.1  70795421-70795571
            2845-2921           JAXUCZ010000008.1  70796240-70796316
            2922-4769           JAXUCZ010000008.1  70797223-70799070
FEATURES             Location/Qualifiers
     source          1..4769
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..4769
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="TLE family member 3, transcriptional corepressor"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
     exon            1..758
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             735..3029
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /note="rTLE3; transducin-like enhancer of split 3, E(spl)
                     homolog; transducin-like enhancer of split 3, homolog of
                     Drosophila E(spl); transducin-like enhancer of split 3
                     homolog of Drosophila; transducin-like enhancer of split 3
                     (E(sp1) homolog, Drosophila)"
                     /codon_start=1
                     /product="transducin-like enhancer protein 3"
                     /protein_id="NP_445852.1"
                     /db_xref="GeneID:84424"
                     /db_xref="RGD:620292"
                     /translation="MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLK
                     VEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQ
                     QVAQAVERAKQVTMTELNAIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVT
                     GSSSGLLALGALGSQAHLAVKDEKNHHELDHRERESSTNNSVSPSESLRASEKHRGSA
                     DYSMEAKKRKAEEKDSLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKA
                     RGLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTT
                     PGLRSMPGKPPGMDPIASALRTPISLTSSYAAPFAMMSHHEMNGSLTSPSAYAGLHNI
                     PSQMSAAAAAAAAAYGRSPMVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQM
                     QPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQ
                     PGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTS
                     SAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTK
                     LWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTK
                     PDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCD
                     ISADDKYIVTGSGDKKATVYEVIY"
     exon            759..859
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            860..923
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            924..968
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1031
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1106
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1311
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1328
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1448
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1499
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1652
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1785
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1970
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2047
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2297
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2545
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2693
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2694..2844
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..2921
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2922..4769
                     /gene="Tle3"
                     /gene_synonym="Esp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgaggctt cctatgccgg ctggagttag gatgccacgg cccattattt gcaccgacta
       61 acccggagtt cctcctcggc cctgggaagg actggcggcg gcggctggag cagacagagc
      121 agcaggctct cttctccgag gggagggggg ggcgtcgaag cgccctcgct gggctctagc
      181 cctcacccac ggtcctcaag ccgtcacctc ggtggcctgc ttcctttttc ttctccccgc
      241 gactccgggc ccgaccgcct ctgggatttg acccgcgcgc cccggatgct ccgagctgcc
      301 cagacgcgcc cccccccctc cagcctcatc gtgctgattg acccgtgagg ggacaagaga
      361 aacccacccc ccaacctccg ggcctcggga tcctgctctg gagctgccag ggagccgatg
      421 atgtccacgc agacccggct tctgacactg tccacgcagc cgggggaagg tggccggccg
      481 cagccggccg agccttaggc gcacaaagcg cgagcccgcc gacgactttg ccgctcgctc
      541 cgccgctctt tgtctgcact tggggcgcac gcccgactct gggatttcgc tgcgagagcg
      601 ggctgggggg gccgggggcg agctctcggt tccccggccg ccccccgctc gggctcgcct
      661 cccccctccc ccgcacgtcc ccggctcggg ctctcagcgc ttccaagctc tcggaatcgc
      721 gacccctccc tgccatgtat ccgcaaggca gacatccggc accccatcaa cccgggcagc
      781 caggatttaa attcactgtg gccgagtcct gtgacaggat caaagacgaa ttccagttcc
      841 tgcaagctca gtatcacagc ctcaaagtgg agtacgacaa gctggcgaac gagaagacag
      901 agatgcagcg ccattatgtg atgtactatg agatgtccta cggcttgaat atcgaaatgc
      961 acaagcagac agagatcgcg aagagactga acacgattct agcccagatc atgccttttt
     1021 tgtcacagga gcatcagcag caagtggcgc aggctgtgga acgcgccaag caggtcacca
     1081 tgacggagct gaacgccatc atcgggcagc agcaactcca ggcacagcac ctctcccatg
     1141 ccacacatgg tcccccggtc cagctgccac cccacccgtc aggcctccaa cctcctggga
     1201 ttcccccagt gacaggaagc agctctgggt tgctggcact tggtgccctg ggaagccaag
     1261 cccacttggc agtgaaggat gagaagaacc atcatgaact ggatcacaga gagagagagt
     1321 ccagcacgaa caattctgtg tcaccctcag aaagcctccg ggccagtgag aagcaccggg
     1381 gctctgcaga ctacagcatg gaagccaaga agcggaaagc ggaagagaaa gacagcctga
     1441 gccgatacga cagcgatggg gacaagagtg atgacctggt agtggatgtc tccaatgagg
     1501 acccagcgac accccgggtg agcccagcac actcccctcc tgaaaatggg ctggacaaag
     1561 cccgaggtct gaagaaagac gcccccacca gcccagcctc tgtggcttcc tccagcagca
     1621 cgccttcctc caagaccaaa gaccttggtc ataatgacaa atcttccaca cctgggctca
     1681 agtccaacac accaacgcca aggaacgatg ccccaactcc aggcaccagc accaccccgg
     1741 ggctccggtc aatgccgggc aaacctccag gcatggaccc gatagcctcg gccctgcgca
     1801 cacccatctc cctcaccagc tcctatgcag caccctttgc catgatgagc caccacgaga
     1861 tgaatggctc cctcaccagc ccaagcgcct atgctggcct acacaacatc ccatcccaga
     1921 tgagcgccgc cgcagcagct gcagccgccg cctatggccg atcgccaatg gttggttttg
     1981 accctcatcc cccgatgcgg gccacaggcc tgccctccag tcttgcctcc attcctggag
     2041 ggaaaccggc gtactccttc catgtgagtg ccgacgggca gatgcaacct gtgcccttcc
     2101 cccatgatgc gctagcaggc cccggcattc ccaggcatgc ccggcagatc aacacactca
     2161 gccatgggga ggtggtatgt gccgtgacca tcagcaaccc cacgaggcac gtctacacag
     2221 gcggcaaggg ctgtgtgaag atatgggaca tcagccagcc gggcagcaag agtcccatct
     2281 cccagctgga ctgcctgaac agggacaact acatccgctc atgcaagctt ctccctgatg
     2341 ggcgcacgct cattgtgggt ggtgaggcca gcacactcac catctgggac ctggcctcgc
     2401 ccacgccccg catcaaggct gagctgacgt cctcggctcc agcctgttac gccctggcca
     2461 tcagtcctga tgccaaagtc tgtttctcct gctgcagtga tgggaacatt gcagtttggg
     2521 atctgcacaa ccagaccctg gtcaggcagt tccagggcca cacggatggg gccagctgta
     2581 tagacatctc tcatgatggc actaaactgt ggaccggggg cctggacaac actgtgcgct
     2641 cctgggacct gcgtgaaggg cggcagctac agcaacacga cttcacctcc cagatcttct
     2701 ccctgggtta ctgccccact ggggagtggc tcgccgtggg catggagagc agcaacgtag
     2761 aggttctgca ccacaccaag ccggacaagt accaactgca tctgcacgag agctgcgtgc
     2821 tgtccctcaa gtttgcctac tgtggcaagt ggtttgtgag cactgggaaa gacaaccttc
     2881 tcaatgcctg gaggacgcct tacggagcca gcatcttcca gtctaaagaa tcctcgtccg
     2941 tcttgagctg tgatatttca gcggatgaca aatatattgt aacgggctct ggtgacaaga
     3001 aggccacagt ttacgaggtc atctactgaa caaggactct aagaggcctg tcaaactctg
     3061 ggagacaccc acgcggccct gacagggaga tgctggccag gccccgagga tggcagaaga
     3121 gtgagggaca gcattgtggg gctgccctcc ggaaggtgga gaggacgcac gcccctttgt
     3181 ggattgctgt gtctgacaga cttgaaggac tttctcctct ccccctcacc agtgctggca
     3241 gatgcttcaa ttagatttct ctggaggctt ctgctttcgt ttcccacaca gacaccctca
     3301 tgagtctctg tctcttcctc ccctgtctga tctgtcccct ccctactccg ggttgggggc
     3361 atgctggagt agacattgtt gtttctgggg aggggcgcct cgttctgatt gtgcagtgca
     3421 caaggtttgt gaacaatgta aataagagac tgtggttgct gactggccag tgagggagga
     3481 ggccccttcc caccagtgct cgccgtgtat tttgcctgct gtatttgtaa cccactcgcg
     3541 gtggtggctt ttctttcttt cttttcttaa gatttttttt aaacagatgt tctgtgggga
     3601 aagtaggcag agatagagag tcggggagtg gaatgagaag cttcctgggg atgggcaaac
     3661 cagcctggcc cactgggact gaagtatatc tccacacggg ttttagcacc atcttcagat
     3721 ggaatgatag gcagatggac agacaagctg atggacagac agtactggga tgggccagct
     3781 tgggctatta tccacaggaa cagcgaggat ttcctgtggg tttctctgct ccatcttctc
     3841 ttgccttgcc ctcacacctc ctgacctcca tctctttctg cccccctccc cccgctcgcc
     3901 tctcccactg gaccccatct ttctctttgg tgcacactca atcattgtga tgaggaatgg
     3961 aagttcaagg gaactccctc tctgactctc ctccgccagc ctagaaagga ttccatatgg
     4021 gggtgggagg gagacaagcg actcagctca gggagctacc agagaaaaac agcaactggt
     4081 gtgggtgctt ttttttttaa tttgaataaa aataattaga agtgatatcc tttgataaga
     4141 tgccgtctcc cctttcctgc tctcagccct ttctgctccc tgaagccggg gatatggtga
     4201 cccccagggt cgtaagtcta agaagatggg cgggggagcg ggctgggggc tggggcagac
     4261 ggaatgtcat ctgcagatat cacccctagg gtaccaatgt ttgtggtatt aggtttgctt
     4321 tgttttgttt tggtcttttg ttgttttatt aaagaaaagc taaagaccgt gtgagccctg
     4381 ctggtgggct ttccatggat gtagcatatg gaagagagtt tttatattgc atttttatgg
     4441 attattttat aatgtgggac tcagtctggg aagaaagatg agggtgtcta aaacctgccc
     4501 atctccagtg ctccaactga gcggctgccc cgaacaggat gtatgttggg acatggaaag
     4561 accgtggcac cccgcacctt cctgagaggc atgtcgacat gcctgtctgg agtctgtcca
     4621 tctgtctctg ggtttcagat gatcactggc caccacttgt taaggctcta gccagaaggg
     4681 agggttaggg tggaagagag ttattcctga agaaaaaaga aaaattgaaa catcattgta
     4741 atgaagcttt ttatattttt aaaagttac
//
