LOCUS       NM_001039013            2431 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus TLE family member 2, transcriptional corepressor
            (Tle2), mRNA.
ACCESSION   NM_001039013 XM_216845
VERSION     NM_001039013.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2431)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   2  (bases 1 to 2431)
  AUTHORS   Arce,L., Pate,K.T. and Waterman,M.L.
  TITLE     Groucho binds two conserved regions of LEF-1 for HDAC-dependent
            repression
  JOURNAL   BMC Cancer 9, 159 (2009)
   PUBMED   19460168
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC100652.1.
            
            On Jan 12, 2006 this sequence version replaced XM_216845.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100652.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2431
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2431
                     /gene="Tle2"
                     /note="TLE family member 2, transcriptional corepressor"
                     /db_xref="GeneID:299636"
                     /db_xref="RGD:1306665"
     exon            1..89
                     /gene="Tle2"
                     /inference="alignment:Splign:2.1.0"
     exon            90..201
                     /gene="Tle2"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..2268
                     /gene="Tle2"
                     /note="transducin-like enhancer of split 2, homolog of
                     Drosophila E(spl); transducin-like enhancer of split 2
                     homolog; transducin-like enhancer of split 2 (E(sp1)
                     homolog, Drosophila)"
                     /codon_start=1
                     /product="transducin-like enhancer protein 2"
                     /protein_id="NP_001034102.1"
                     /db_xref="GeneID:299636"
                     /db_xref="RGD:1306665"
                     /translation="MYPQGRHPTPLQSGQPFKFSVLEICDRIKEEFQFLQAQYHSLKL
                     ECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLSAICAQMVPFLTQEHQQQ
                     VLQAVDRAKQVTVGELNNLLGQQNQLQPLSHAPPVPLTPRPAGLVGAGATGLLALSGA
                     LAAQAQLVAAVKEDRVGVDTEGSRVDRAASRSSSPSPPESLAEEEHPSSRGSNGKQQR
                     AEDKNMSGPYDSEEDKSDYNLVVDEDQPSEPPSPATTPCGKAPLCIPARRDLTDSPAS
                     LASSLGSPLPRSKDLALNDLSTGTPASGSCGPSPPQDSSTPGPSSASHLCQLATQPAP
                     PTDSIALRSPLTLSSPFTSSFSLGSHSTLNGDLSMPGSYVSLHLSPQMQPVPFPSDAL
                     VGTGIPRHARQLHTLAHGEVVCAVTISSSTQHVYTGGKGCVKVWDVGQPGSKTPVAQL
                     DCLNRDNYIRSCKLLPDGQSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAI
                     SPDAKVCFSCCSDGNIVVWDLQNQAMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTV
                     RCWDLREGRQLQQHDFSSQIFSLGHCPSQDWLAVGMESSHVEVLHVRKPEKYQLRLHE
                     SCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISRNNKYIVT
                     GSGDKKATVYEVVY"
     exon            202..299
                     /gene="Tle2"
                     /inference="alignment:Splign:2.1.0"
     exon            300..363
                     /gene="Tle2"
                     /inference="alignment:Splign:2.1.0"
     exon            364..408
                     /gene="Tle2"
                     /inference="alignment:Splign:2.1.0"
     exon            409..471
                     /gene="Tle2"
                     /inference="alignment:Splign:2.1.0"
     exon            472..546
                     /gene="Tle2"
                     /inference="alignment:Splign:2.1.0"
     exon            547..730
                     /gene="Tle2"
                     /inference="alignment:Splign:2.1.0"
     exon            731..750
                     /gene="Tle2"
                     /inference="alignment:Splign:2.1.0"
     exon            751..861
                     /gene="Tle2"
                     /inference="alignment:Splign:2.1.0"
     exon            862..906
                     /gene="Tle2"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1056
                     /gene="Tle2"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1195
                     /gene="Tle2"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1320
                     /gene="Tle2"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1536
                     /gene="Tle2"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1784
                     /gene="Tle2"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1932
                     /gene="Tle2"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2083
                     /gene="Tle2"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2160
                     /gene="Tle2"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2410
                     /gene="Tle2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagcgccga ccccgggcgg cggccacgga cctgcggcgc tgactgcagc tgcccctggg
       61 ctggacaacc cgggacgcgc tggctggagc tccacctctg caccccagct cccctttgcc
      121 acatcctcaa gcctccacga agctggggga cccttttctc acctatccat cagcaggatg
      181 tacccccagg gaaggcaccc gaccccgctg cagtctggcc agcctttcaa gttctcagtc
      241 ctggaaatct gtgaccggat caaagaggaa tttcagtttc tccaagctca ataccacagc
      301 cttaagctag agtgtgagaa gctggccagc gagaagacag aaatgcaaag gcattatgtg
      361 atgtactatg agatgtccta cggactcaac attgagatgc acaaacaggc tgagatcgtg
      421 aagcgcctca gtgcaatctg tgcccagatg gtcccattcc tcactcagga gcatcagcag
      481 caggtgctcc aggctgtgga ccgagccaag caggtgaccg tgggggaact gaacaacctc
      541 ttggggcagc agaatcagct ccagccgctg tcccatgcac cccctgtgcc tctcacccca
      601 cgcccagctg gcctggtggg tgccggggcc actgggctgc tggccctctc tggggcgctg
      661 gctgcgcagg cccagctggt ggctgctgtt aaggaagacc gtgtgggtgt ggacaccgag
      721 gggtccagag tggacagagc tgccagcagg agttcatccc cctcaccccc tgagagtctg
      781 gcggaagagg agcatcctag cagccgaggc agtaacggga agcagcagag agccgaagac
      841 aagaatatgt cagggcctta tgacagtgag gaagacaaga gtgactataa cctggtagtg
      901 gatgaggacc aaccgtcaga gccccccagc cctgcgacca ccccctgtgg gaaggcgccc
      961 ctctgcatcc ctgcccgcag ggacctcacg gacagtccag cctccctggc ttccagcttg
     1021 ggctcaccac tccccagaag caaagaccta gccctgaacg atctctccac aggtactccc
     1081 gcctctgggt catgtggtcc ctctccaccc caggactcgt ccaccccagg gcccagctca
     1141 gccagtcacc tctgccagct ggctactcag ccggcaccgc ccacagacag cattgccctg
     1201 aggagtcccc tgaccctgtc cagccctttc acctcgtcct tcagcctggg ctcccacagc
     1261 accctcaatg gggacctctc catgcctggc tcctatgtca gcctccacct gtccccccag
     1321 atgcaaccgg tgcccttccc atcggatgca ctggtaggca ctggcatccc tcgccacgcg
     1381 aggcagctgc acacactggc ccatggtgag gtggtgtgtg ccgtcaccat cagcagctcc
     1441 acgcagcacg tgtacactgg cggcaaaggc tgcgtgaagg tttgggacgt gggccagccg
     1501 ggcagcaaga cacctgtggc acagctggat tgcctgaacc gggacaacta cattcgctcc
     1561 tgcaagctgc tgcctgacgg gcagagcctg atcgtgggtg gcgaggccag taccctgtcc
     1621 atttgggacc tggcagcacc cacaccacgc atcaaagcag agctgacctc gtccgccccc
     1681 gcctgttacg cgctggccat cagcccggat gccaaggtct gcttctcctg ctgcagcgac
     1741 ggtaacatcg tggtctggga cctgcagaac caggccatgg tcagacagtt ccagggccac
     1801 acggacgggg ccagctgcat tgacatatca gactacggga cccggctgtg gactgggggc
     1861 ctggacaaca ccgtgcgctg ctgggatctg cgcgagggcc gccagctgca gcaacatgac
     1921 ttcagttccc agatcttctc gttgggccac tgtcccagtc aggactggct ggccgtgggg
     1981 atggaaagca gccacgtgga ggtcctgcat gtgcgcaagc ctgagaagta ccagctccgc
     2041 ctgcatgaga gctgcgtgct gtcgctcaag ttcgcttcct gcggacgctg gtttgtgagc
     2101 acaggcaagg ataacctgct caatgcctgg aggacaccct atggggccag cattttccag
     2161 tccaaagagt cttcttctgt gttgagctgc gacatctcca ggaacaacaa gtacattgtg
     2221 acaggctcag gggacaagaa ggccactgtg tatgaggtgg tgtactgaac catgtgctgc
     2281 cttttcaagc cacctgccct ggatggcagg ccactcggga catgggtccc tttgcccaca
     2341 cttggcttgc tccctcccgg atgggtggga ctgggggcac tggggaaata taagattatt
     2401 tatcaacttg aaaaaaaaaa aaaaaaaaaa a
//
