LOCUS       NM_001173433            2892 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus TLE family member 1, transcriptional corepressor
            (Tle1), mRNA.
ACCESSION   NM_001173433 XM_001066887 XM_002726541 XM_002726542 XM_002726543
            XM_002726544 XM_002726545 XM_002729490 XM_002729491 XM_002729492
            XM_002729493 XM_002729494 XM_342851
VERSION     NM_001173433.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2892)
  AUTHORS   Xue,L., Hu,M., Zhu,Q., Li,Y., Zhou,G., Zhang,X., Zhou,Y., Zhang,J.
            and Ding,P.
  TITLE     GRg1 inhibits the TLR4/NF-kB signaling pathway by upregulating
            miR-216a-5p to reduce growth factors and inflammatory cytokines in
            DR
  JOURNAL   Mol Biol Rep 50 (11), 9379-9394 (2023)
   PUBMED   37819496
  REMARK    GeneRIF: GRg1 inhibits the TLR4/NF-kB signaling pathway by
            upregulating miR-216a-5p to reduce growth factors and inflammatory
            cytokines in DR.
REFERENCE   2  (bases 1 to 2892)
  AUTHORS   van Tienen,L.M., Mieszczanek,J., Fiedler,M., Rutherford,T.J. and
            Bienz,M.
  TITLE     Constitutive scaffolding of multiple Wnt enhanceosome components by
            Legless/BCL9
  JOURNAL   Elife 6, e20882 (2017)
   PUBMED   28296634
  REMARK    Erratum:[Elife. 2017 Mar 30;6:. PMID: 28358670]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2892)
  AUTHORS   Chodaparambil,J.V., Pate,K.T., Hepler,M.R., Tsai,B.P.,
            Muthurajan,U.M., Luger,K., Waterman,M.L. and Weis,W.I.
  TITLE     Molecular functions of the TLE tetramerization domain in Wnt target
            gene repression
  JOURNAL   EMBO J 33 (7), 719-731 (2014)
   PUBMED   24596249
REFERENCE   4  (bases 1 to 2892)
  AUTHORS   Brunquell,C., Biliran,H., Jennings,S., Ireland,S.K., Chen,R. and
            Ruoslahti,E.
  TITLE     TLE1 is an anoikis regulator and is downregulated by Bit1 in breast
            cancer cells
  JOURNAL   Mol Cancer Res 10 (11), 1482-1495 (2012)
   PUBMED   22952044
REFERENCE   5  (bases 1 to 2892)
  AUTHORS   Dastidar,S.G., Narayanan,S., Stifani,S. and D'Mello,S.R.
  TITLE     Transducin-like enhancer of Split-1 (TLE1) combines with Forkhead
            box protein G1 (FoxG1) to promote neuronal survival
  JOURNAL   J Biol Chem 287 (18), 14749-14759 (2012)
   PUBMED   22354967
  REMARK    GeneRIF: TLE1 cooperates with FoxG1 to promote neuronal survival in
            a CK2- and PI3K-Akt-dependent manner.
REFERENCE   6  (bases 1 to 2892)
  AUTHORS   Jan,Y., Matter,M., Pai,J.T., Chen,Y.L., Pilch,J., Komatsu,M.,
            Ong,E., Fukuda,M. and Ruoslahti,E.
  TITLE     A mitochondrial protein, Bit1, mediates apoptosis regulated by
            integrins and Groucho/TLE corepressors
  JOURNAL   Cell 116 (5), 751-762 (2004)
   PUBMED   15006356
  REMARK    Erratum:[Cell. 2005 Aug 12;122(3):485-6]
REFERENCE   7  (bases 1 to 2892)
  AUTHORS   Lepourcelet,M. and Shivdasani,R.A.
  TITLE     Characterization of a novel mammalian Groucho isoform and its role
            in transcriptional regulation
  JOURNAL   J Biol Chem 277 (49), 47732-47740 (2002)
   PUBMED   12359720
REFERENCE   8  (bases 1 to 2892)
  AUTHORS   Wang,J.C., Waltner-Law,M., Yamada,K., Osawa,H., Stifani,S. and
            Granner,D.K.
  TITLE     Transducin-like enhancer of split proteins, the human homologs of
            Drosophila groucho, interact with hepatic nuclear factor 3beta
  JOURNAL   J Biol Chem 275 (24), 18418-18423 (2000)
   PUBMED   10748198
REFERENCE   9  (bases 1 to 2892)
  AUTHORS   Levanon,D., Goldstein,R.E., Bernstein,Y., Tang,H., Goldenberg,D.,
            Stifani,S., Paroush,Z. and Groner,Y.
  TITLE     Transcriptional repression by AML1 and LEF-1 is mediated by the
            TLE/Groucho corepressors
  JOURNAL   Proc Natl Acad Sci U S A 95 (20), 11590-11595 (1998)
   PUBMED   9751710
REFERENCE   10 (bases 1 to 2892)
  AUTHORS   Grbavec,D. and Stifani,S.
  TITLE     Molecular interaction between TLE1 and the carboxyl-terminal domain
            of HES-1 containing the WRPW motif
  JOURNAL   Biochem Biophys Res Commun 223 (3), 701-705 (1996)
   PUBMED   8687460
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before May 13, 2010 this sequence version replaced
            XM_002726541.1, XM_001066887.2, XM_002726542.1, XM_002726543.1,
            XM_002726544.1, XM_002726545.1, XM_002729490.1, XM_342851.4,
            XM_002729491.1, XM_002729492.1, XM_002729493.1, XM_002729494.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JAXUCZ010000005.1  90980795-90980928   c
            135-235             JAXUCZ010000005.1  90980056-90980156   c
            236-299             JAXUCZ010000005.1  90978668-90978731   c
            300-344             JAXUCZ010000005.1  90978524-90978568   c
            345-407             JAXUCZ010000005.1  90953202-90953264   c
            408-482             JAXUCZ010000005.1  90951658-90951732   c
            483-687             JAXUCZ010000005.1  90937487-90937691   c
            688-704             JAXUCZ010000005.1  90936748-90936764   c
            705-815             JAXUCZ010000005.1  90924738-90924848   c
            816-869             JAXUCZ010000005.1  90921479-90921532   c
            870-1022            JAXUCZ010000005.1  90920821-90920973   c
            1023-1167           JAXUCZ010000005.1  90919346-90919490   c
            1168-1364           JAXUCZ010000005.1  90918129-90918325   c
            1365-1441           JAXUCZ010000005.1  90916670-90916746   c
            1442-1691           JAXUCZ010000005.1  90906160-90906409   c
            1692-1939           JAXUCZ010000005.1  90904739-90904986   c
            1940-2087           JAXUCZ010000005.1  90902390-90902537   c
            2088-2238           JAXUCZ010000005.1  90900343-90900493   c
            2239-2315           JAXUCZ010000005.1  90898858-90898934   c
            2316-2892           JAXUCZ010000005.1  90898182-90898758   c
FEATURES             Location/Qualifiers
     source          1..2892
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q31"
     gene            1..2892
                     /gene="Tle1"
                     /note="TLE family member 1, transcriptional corepressor"
                     /db_xref="GeneID:362533"
                     /db_xref="RGD:1309237"
     exon            1..134
                     /gene="Tle1"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..2423
                     /gene="Tle1"
                     /note="transducin-like enhancer of split 1 (E(sp1)
                     homolog, Drosophila); transducin like enhancer of split 1"
                     /codon_start=1
                     /product="transducin-like enhancer protein 1"
                     /protein_id="NP_001166904.1"
                     /db_xref="GeneID:362533"
                     /db_xref="RGD:1309237"
                     /translation="MFPQSRHPTPHQAAGQPFKFTIPESLDRIKEEFQFLQAQYHSLK
                     LECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQ
                     QVAQAVERAKQVTMAELNAIIGQQQLQAQHLSHGHGPPVPLTPHPSGLQPPGIPPLGG
                     SASLLALSSALSGQSHLAIKDDKKHHDAERHRDREPGTSNSLLVPDSLRGTDKRRNGP
                     EFSSDIKKRKVDDKDNYDSDGDKSDDNLVVDVSNEDPSSPHASPTHSPRENGIDKNRL
                     LKKDASGSPASTASSGSSSSLKSKEVNLHEKANTPVLKSSTPTPRSDMPTPGTSATPG
                     LRPGLGKPPAMEPLVNQAAAGLRTPLAVPGPYPAPFGMVPHAGMNGELTSPGAAYAGL
                     HSMSPQMSAAAAAAAAAVVAYGRSPMVGFDPPPHMRVPSIPPNLAGIPGGKPAYSFHV
                     TADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVK
                     VWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRI
                     KAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDI
                     SNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVE
                     VLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESS
                     SVLSCDISVDDKYIVTGSGDKKATVYEVIY"
     exon            135..235
                     /gene="Tle1"
                     /inference="alignment:Splign:2.1.0"
     exon            236..299
                     /gene="Tle1"
                     /inference="alignment:Splign:2.1.0"
     exon            300..344
                     /gene="Tle1"
                     /inference="alignment:Splign:2.1.0"
     exon            345..407
                     /gene="Tle1"
                     /inference="alignment:Splign:2.1.0"
     exon            408..482
                     /gene="Tle1"
                     /inference="alignment:Splign:2.1.0"
     exon            483..687
                     /gene="Tle1"
                     /inference="alignment:Splign:2.1.0"
     exon            688..704
                     /gene="Tle1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..815
                     /gene="Tle1"
                     /inference="alignment:Splign:2.1.0"
     exon            816..869
                     /gene="Tle1"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1022
                     /gene="Tle1"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1167
                     /gene="Tle1"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1364
                     /gene="Tle1"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1441
                     /gene="Tle1"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1691
                     /gene="Tle1"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1939
                     /gene="Tle1"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2087
                     /gene="Tle1"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2238
                     /gene="Tle1"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2315
                     /gene="Tle1"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2892
                     /gene="Tle1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgtgcgcc ggcctgctgc gctgcttcgc gttcctcggt ggaattcaag ttggaagtgg
       61 cgcggaggat agagctatcc cggaacagag ccgcggctgc tgccagagcg atgttccctc
      121 agagccggca cccaacgccg caccaggctg caggccagcc ctttaagttc actatcccgg
      181 agtccctgga ccggattaaa gaggaattcc agttcctgca ggcgcagtat cacagtctta
      241 aattggagtg tgagaaattg gcaagtgaaa agacagaaat gcagagacac tacgtgatgt
      301 attatgaaat gtcatatgga ttaaacattg aaatgcataa acagaccgaa atcgccaaga
      361 gattgaatac catttgtgca caagtcatcc catttctgtc tcaggaacat caacaacagg
      421 tggcccaggc tgtcgaacgt gccaaacagg tgaccatggc agagttgaat gccatcatcg
      481 ggcagcagca gttgcaagct cagcatctct cccatggcca tggaccccca gtacctctca
      541 cgcctcaccc ttcaggactt cagcctcctg gcatcccgcc ccttgggggc agtgccagcc
      601 ttctcgcgct gtctagtgct ctgagtgggc agtctcactt ggcaataaaa gatgacaaga
      661 agcaccatga tgcagagcgc cacagagaca gagagccggg cacgagtaat tccctcttgg
      721 tcccagacag cctaagaggc acagataaac gcagaaatgg tccagagttt tccagtgaca
      781 tcaaaaaacg gaaggtggat gataaggata actatgacag tgatggggac aagagtgacg
      841 acaacttagt tgtggatgtg tctaatgagg acccttcttc tccacatgca agccccacac
      901 actcaccccg ggaaaacgga attgacaaaa accgtctgtt gaagaaagat gcttcaggta
      961 gcccggcatc cacagcctcc tctggaagtt cctcatccct gaaatccaaa gaagtgaacc
     1021 tgcatgaaaa agccaacacg cctgttctga aatccagcac accaacgcct cggagtgaca
     1081 tgccaacccc gggcaccagc gctactccag gcctccgtcc aggtctcggc aagcctccag
     1141 ccatggagcc ccttgtcaac caagcagcag ctggcctgag gacgcccctg gcagtgcctg
     1201 gcccataccc tgcccccttt ggcatggtgc cccatgcagg catgaacgga gagctgacca
     1261 gccctggcgc tgcctatgca ggtctacaca gcatgtctcc acagatgagc gctgcagctg
     1321 ctgcagctgc tgctgctgtg gtggcctatg ggcgctcccc aatggttggt tttgatcctc
     1381 ctcctcacat gagagtacct tctatccctc ccaacctggc aggaatacct ggcgggaaac
     1441 cagcatactc cttccacgtt acggctgacg gacaaatgca gcctgtccct tttccccctg
     1501 acgccctcat tggacctggg attccccgac atgctcggca gatcaatacc ctcaaccacg
     1561 gggaggtggt gtgtgcagtg accatcagca accccacaag gcacgtgtac acaggtggca
     1621 agggctgcgt taaggtctgg gacatcagcc accctggcaa caagagcccc gtctctcagc
     1681 tggattgtct gaacagagat aactacatcc gttcctgtaa attgctacct gatggctgta
     1741 ctctcatagt gggaggggaa gccagtactc tatccatctg ggacctggca gctccaactc
     1801 cccgaattaa ggcagagctg acatcctcag cccctgcctg ctatgctctg gccatcagcc
     1861 ctgactccaa ggtctgcttc tcatgctgca gtgatggcaa catcgcagta tgggacctgc
     1921 acaaccagac cctggtgagg caattccagg gccacacaga cggagccagc tgtattgaca
     1981 tttctaatga tggcaccaag ctctggacag gcggtttaga caacactgtg aggtcctggg
     2041 acctgagaga aggaaggcag ctgcagcagc atgatttcac ttcacagatc ttctccttgg
     2101 gatactgccc aactggggag tggcttgccg tgggcatgga aagcagcaac gtggaagttc
     2161 tgcatgtgaa caagcctgac aaataccagc ttcacctcca cgagagttgt gtgctgtccc
     2221 taaaatttgc ttattgtggc aagtggtttg tgagtactgg aaaagacaac ctcctaaatg
     2281 cctggcggac accatatgga gccagcatat tccagtccaa agaatcttca tcagtgctta
     2341 gctgtgacat ctctgtggat gataaataca tagtcactgg ctcaggggac aaaaaggcta
     2401 ccgtttatga ggtcatctac tgagaatacc atggcttcat atttacagtt gaattgggcc
     2461 aaatgtttgg aatttgtaga aatagaactt ataatttaaa aaaaacaaaa acaacatcaa
     2521 aaaaactgaa gaaacctgtt tccaaatctt gacacagaac tgctttgcgt ctacaaaaag
     2581 aaggcaccaa gtctatcagt agacactcac ctgtctaact ttggacacca caatcacacc
     2641 gaggccacag gtgtggaata gaggagcaag ctgctgtctg ccgtcctgcc tttgctgact
     2701 gcgagcttac agttctgttt ctcgcagttc aattcacctt gagtctttgt agagcagtgg
     2761 tgtctccagt gaacttgttt cttggttttg catcttgtga tttttttttc tttttgtatt
     2821 tttgttgttt caacatttgt ataaattgta aatatatttg gtttattaca gtaaaacctt
     2881 tagtaccagt aa
//
