LOCUS       NM_001039031            2403 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus triokinase and FMN cyclase (Tkfc), mRNA.
ACCESSION   NM_001039031
VERSION     NM_001039031.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2403)
  AUTHORS   Rodrigues,J.R., Couto,A., Cabezas,A., Pinto,R.M., Ribeiro,J.M.,
            Canales,J., Costas,M.J. and Cameselle,J.C.
  TITLE     Bifunctional homodimeric triokinase/FMN cyclase: contribution of
            protein domains to the activities of the human enzyme and molecular
            dynamics simulation of domain movements
  JOURNAL   J Biol Chem 289 (15), 10620-10636 (2014)
   PUBMED   24569995
REFERENCE   2  (bases 1 to 2403)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (bases 1 to 2403)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 2403)
  AUTHORS   Diao,F., Li,S., Tian,Y., Zhang,M., Xu,L.G., Zhang,Y., Wang,R.P.,
            Chen,D., Zhai,Z., Zhong,B., Tien,P. and Shu,H.B.
  TITLE     Negative regulation of MDA5- but not RIG-I-mediated innate
            antiviral signaling by the dihydroxyacetone kinase
  JOURNAL   Proc Natl Acad Sci U S A 104 (28), 11706-11711 (2007)
   PUBMED   17600090
REFERENCE   5  (bases 1 to 2403)
  AUTHORS   Cabezas,A., Costas,M.J., Pinto,R.M., Couto,A. and Cameselle,J.C.
  TITLE     Identification of human and rat FAD-AMP lyase (cyclic FMN forming)
            as ATP-dependent dihydroxyacetone kinases
  JOURNAL   Biochem Biophys Res Commun 338 (4), 1682-1689 (2005)
   PUBMED   16289032
REFERENCE   6  (bases 1 to 2403)
  AUTHORS   Hagopian,K., Ramsey,J.J. and Weindruch,R.
  TITLE     Fructose metabolizing enzymes from mouse liver: influence of age
            and caloric restriction
  JOURNAL   Biochim Biophys Acta 1721 (1-3), 37-43 (2005)
   PUBMED   15652177
REFERENCE   7  (bases 1 to 2403)
  AUTHORS   Massillon,D., Stalmans,W., van de Werve,G. and Bollen,M.
  TITLE     Identification of the glycogenic compound 5-iodotubercidin as a
            general protein kinase inhibitor
  JOURNAL   Biochem J 299 (Pt 1) (Pt 1), 123-128 (1994)
   PUBMED   8166629
REFERENCE   8  (bases 1 to 2403)
  AUTHORS   Beutler,E. and Guinto,E.
  TITLE     Dihydroxyacetone metabolism by human erythrocytes: demonstration of
            triokinase activity and its characterization
  JOURNAL   Blood 41 (4), 559-568 (1973)
   PUBMED   4688871
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098925.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098925.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2403
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2403
                     /gene="Tkfc"
                     /gene_synonym="Dak; RGD1311026"
                     /note="triokinase and FMN cyclase"
                     /db_xref="GeneID:361730"
                     /db_xref="RGD:1311026"
     exon            1..170
                     /gene="Tkfc"
                     /gene_synonym="Dak; RGD1311026"
                     /inference="alignment:Splign:2.1.0"
     exon            171..282
                     /gene="Tkfc"
                     /gene_synonym="Dak; RGD1311026"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..2016
                     /gene="Tkfc"
                     /gene_synonym="Dak; RGD1311026"
                     /EC_number="2.7.1.29"
                     /EC_number="4.6.1.15"
                     /EC_number="2.7.1.28"
                     /note="bifunctional ATP-dependent dihydroxyacetone
                     kinase/FAD-AMP lyase (cyclizing); dihydroxyacetone kinase
                     2 homolog"
                     /codon_start=1
                     /product="triokinase/FMN cyclase"
                     /protein_id="NP_001034120.1"
                     /db_xref="GeneID:361730"
                     /db_xref="RGD:1311026"
                     /translation="MSSKKMVNSVEGCAGDALAGFVACNPDLQLLQGYRVALRSDLDS
                     LKGRVALLSGGGSGHEPAHAGFIGKGMLTGVIAGAVFASPAVGSILAAIRAVAQAGTA
                     GTLLIVKNYTGDRLNFGLAMEQAKAEGISVEMVVIEDDSAFTVLKKAGRRGLCGTILI
                     HKVAGALAEEGMGLEEITKKVSVIAKAIGTLGVSLSPCSVPGTKPTFELAADEMELGL
                     GIHGEAGVRRIKLVPVDQIVTLMLDHMTDTSNISHVPVKSGSSVVLMVNNLGGLSFLE
                     LGIIADAAIRLLEGRGVKVARALVGTFMSALEMRGVSLTLMLVDEPLLKLIDAETNAK
                     AWPHMSKVSVTGRNRIRAAPTEPAEAPEATAAGGVASKQMTLVLDRISTTLIGLEEHL
                     NALDRAAGDGDCGSTHSRAAKAIQGWLKEGPTPASPAQVLSKLSVLLLEKMGGSSGAL
                     YGLFLTAAAQPLKANTDLPAWSAAMDAGLKAMQKYGKAAPGDRTMLDSLWAAAQELQA
                     WKSPGASLLPVLTKAVKSAEAAAEATKNMEAGAGRASYISSAQLDQPDPGAVAAAAIF
                     RAILEVLQTKAA"
     exon            283..472
                     /gene="Tkfc"
                     /gene_synonym="Dak; RGD1311026"
                     /inference="alignment:Splign:2.1.0"
     exon            473..583
                     /gene="Tkfc"
                     /gene_synonym="Dak; RGD1311026"
                     /inference="alignment:Splign:2.1.0"
     exon            584..765
                     /gene="Tkfc"
                     /gene_synonym="Dak; RGD1311026"
                     /inference="alignment:Splign:2.1.0"
     exon            766..844
                     /gene="Tkfc"
                     /gene_synonym="Dak; RGD1311026"
                     /inference="alignment:Splign:2.1.0"
     exon            845..934
                     /gene="Tkfc"
                     /gene_synonym="Dak; RGD1311026"
                     /inference="alignment:Splign:2.1.0"
     exon            935..969
                     /gene="Tkfc"
                     /gene_synonym="Dak; RGD1311026"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1054
                     /gene="Tkfc"
                     /gene_synonym="Dak; RGD1311026"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1144
                     /gene="Tkfc"
                     /gene_synonym="Dak; RGD1311026"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1261
                     /gene="Tkfc"
                     /gene_synonym="Dak; RGD1311026"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1381
                     /gene="Tkfc"
                     /gene_synonym="Dak; RGD1311026"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1519
                     /gene="Tkfc"
                     /gene_synonym="Dak; RGD1311026"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1626
                     /gene="Tkfc"
                     /gene_synonym="Dak; RGD1311026"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1730
                     /gene="Tkfc"
                     /gene_synonym="Dak; RGD1311026"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1764
                     /gene="Tkfc"
                     /gene_synonym="Dak; RGD1311026"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1854
                     /gene="Tkfc"
                     /gene_synonym="Dak; RGD1311026"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..2370
                     /gene="Tkfc"
                     /gene_synonym="Dak; RGD1311026"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttggtcaa ttacgcccta agaggccgcc tgctggtccc cctgccacgg tccgcgcccc
       61 tttccttcct cagattctgc cgccttccct cctctatagc tccaggcgtc ctcaaggttt
      121 tccctctttt agaacaggaa gaactgcaga ggactagacc ggggagagag gtgctgctgc
      181 cgtctctact tcagaccagt tagcagcagt caggactgtc aaccctgcag caactcagag
      241 cagaagtgtg agctcgactt gtttcgaagc tttcccacca tgagctccaa gaagatggtg
      301 aattctgtgg aagggtgtgc tggtgatgcc cttgctgggt ttgttgcctg taaccctgac
      361 ttgcagctcc tgcaagggta ccgtgtagcc ctacgttctg acctggacag cctcaagggc
      421 cgggtggcac ttctgtcagg tggaggctca ggccatgagc ctgcccatgc cggttttatc
      481 gggaaaggaa tgctgacagg tgtcattgca ggagcagtgt ttgcctctcc tgctgtgggc
      541 agcatcctgg cagccattag agctgtggcc caggcaggca cagccggcac cctcctcatc
      601 gtgaagaact acactgggga tcggctcaac tttggacttg ccatggagca ggccaaggcc
      661 gagggcatct ctgtggagat ggtggtaatt gaggatgaca gcgccttcac tgtcctgaag
      721 aaggcaggcc ggcgtggcct gtgtggcaca atacttatcc acaaggtagc aggtgctcta
      781 gctgaggaag gtatggggct ggaggagatc acaaagaagg tgagcgtgat cgccaaggcc
      841 ataggtactc tgggggtgag cttgtctccc tgcagtgtcc ctggtaccaa acccaccttt
      901 gagcttgcag ctgatgaaat ggagctaggc ctggggatcc atggggaagc cggtgttcgt
      961 cggataaagc tggtacctgt tgatcagatt gtcactctta tgcttgacca catgacagac
     1021 acctccaata tatcccatgt gcctgtgaag tcaggctctt cagtggtgct gatggtcaac
     1081 aatctgggtg gcctgtcttt cctggaactg ggcatcatag ctgatgctgc catacgcctg
     1141 ctggagggcc gtggggtgaa ggtcgcccgt gccctggtgg gtaccttcat gtcagcacta
     1201 gagatgcgtg gtgtttccct tactttgatg cttgtggatg aacccctgct gaagctgata
     1261 gatgctgaaa ctaatgcaaa agcctggcct cacatgtcca aggtctctgt gactggaagg
     1321 aatcggattc gggcagctcc cacagagcct gcagaagccc ctgaagccac tgcagcagga
     1381 ggtgtagcat caaagcagat gacacttgtg ctggatcgga tatccaccac gctcatcgga
     1441 ctggaggagc acctgaatgc cctggacagg gctgctggtg atggggactg tggttctacc
     1501 catagccgtg ctgccaaagc cattcagggg tggttaaagg aaggcccaac tccagccagc
     1561 cctgcccagg tgctctccaa actgtctgtc ctgctgctgg agaagatggg aggctcatct
     1621 ggggcgctct acggcctgtt cctgactgca gctgcccagc ctctcaaggc caacactgac
     1681 ctcccagcct ggtctgctgc tatggatgcc ggcctaaagg ccatgcagaa gtatggaaag
     1741 gctgcaccag gagacaggac aatgctggat tctctgtggg cagcagcaca ggagctccaa
     1801 gcctggaaga gcccaggggc cagtctcctc ccagtcctga ctaaagcagt caaaagtgcc
     1861 gaagctgcag ccgaggccac caagaacatg gaagctggtg ctgggagagc gagttacatc
     1921 agctctgcac aactagatca gccagaccct ggagcagttg cggctgcagc catcttccgt
     1981 gccatcctgg aggtcttgca gacgaaggca gcttaactgc tttcctcctc ctccgctcct
     2041 ctcagtttgt tacttcctct tgccttctga taatctcctc ccttcctccc ctgacaccca
     2101 tccctgcatg gagcaggaca tccttcacca caccctccag aactgttctg tgaagagtgt
     2161 ctggctgggt gggtcacatg cctcagcagc actgttcgtt ccctcctcca gaagaggaat
     2221 cgctcagatc ttgtccatcc caccctaacc agctctgggt gtcagtgatt tggcttctcc
     2281 tgagcctcta acttgcaggc ctcttcctct ggaaggcctc ctatacccag tcagtacatg
     2341 aaagaaggct aataaaatcc attgaagcca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2401 aaa
//
